US20030040492A1 - Carbohydrate formulation (prebiotic adjuvant) for enhancement of immune response - Google Patents
Carbohydrate formulation (prebiotic adjuvant) for enhancement of immune response Download PDFInfo
- Publication number
- US20030040492A1 US20030040492A1 US10/228,722 US22872202A US2003040492A1 US 20030040492 A1 US20030040492 A1 US 20030040492A1 US 22872202 A US22872202 A US 22872202A US 2003040492 A1 US2003040492 A1 US 2003040492A1
- Authority
- US
- United States
- Prior art keywords
- prebiotic
- composition
- oligosaccharide
- fructo
- inulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 82
- 235000013406 prebiotics Nutrition 0.000 title claims abstract description 57
- 230000028993 immune response Effects 0.000 title claims abstract description 23
- 238000009472 formulation Methods 0.000 title description 8
- 150000001720 carbohydrates Chemical class 0.000 title description 7
- 239000002671 adjuvant Substances 0.000 title 1
- 235000016709 nutrition Nutrition 0.000 claims abstract description 25
- 201000005505 Measles Diseases 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 21
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims abstract description 19
- 229940107187 fructooligosaccharide Drugs 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 10
- 230000002265 prevention Effects 0.000 claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 230000002708 enhancing effect Effects 0.000 claims abstract description 5
- 229920001202 Inulin Polymers 0.000 claims description 22
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 22
- 229940029339 inulin Drugs 0.000 claims description 22
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- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 8
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- 230000000529 probiotic effect Effects 0.000 claims description 7
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 5
- 241000186016 Bifidobacterium bifidum Species 0.000 claims description 5
- 229920002488 Hemicellulose Polymers 0.000 claims description 5
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 5
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 5
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 5
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- DNISEZBAYYIQFB-PHDIDXHHSA-N (2r,3r)-2,3-diacetyloxybutanedioic acid Chemical class CC(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(C)=O DNISEZBAYYIQFB-PHDIDXHHSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Definitions
- the present invention relates to a carbohydrate formulation for enhancement of an immune response, a nutritional composition for enhancement of an immune response; and to the use of a prebiotic formulation in the manufacture of a medicament or nutritional composition for enhancement or improvement of an immune response to a vaccination, in particular measles vaccination, and prevention and supportive treatment of diseases and infections e.g. bacterial, viral and parasitic.
- the invention also relates to a method of enhancing an immune response which comprises administering an effective amount of a prebiotic mixture; and a method of prevention or supportive treatment of diseases which comprises administering an effective amount of a prebiotic formulation.
- prebiotics comprise carbohydrates and more specifically, oligosaccharides. Furthermore it is known that they have widely been used as functional food ingredients. They resist hydrolysis by enzymes of the human digestive tract, can reach the colon undegraded and provide a carbohydrate substance particularly suited to the growth of bifidobacteria.
- Oligosachharides may be produced from glucose, galactose, xylose, maltose, sucrose, lactose, starch, xylan, hemicellulose, inulin, or a mixture thereof. Purified commercially available products such as fructo-oligosaccharides contain greater than about 95% solids in the form of oligosaccharides.
- measles is a major public health problem, infecting approximately 70 million children annually, and it is estimated that 2 million die each year from the disease itself or its complications. In addition to fever and rash, the consequences of measles include acute diarrhea or dysentery, pneumonia, encephalitis, and blindness due to acute vitamin A deficiency. Thus in developing countries, case fatality rates may reach 10-20% (Semba R. D. Clin. Infect. Dis. 1994; 19:489-499).
- Measles prevention is possible by maintaining a high level of immunization through vaccination with attenuated live vaccine.
- Measles vaccine is usually given at 15 months but may be given earlier (at 6-9 months of age) in areas where disease is frequently occurring and poses a threat to health and life of children.
- the response to measles vaccination at less than 12 months of age is suboptimal because infants may transplacentally acquire maternal antibodies that disappear at a variable rate. Because the seroconversion rate following immunization is not 100% and there may be some waning of immunity with time, a second immunization against measles is usually indicated.
- An elevated response to early measles vaccination may therefore offer substantial and longer lasting protection until a second vaccine is administered, and the present invention provides a solution that addresses the problems set out above.
- the present invention provides a composition comprising at least one prebiotic for enhancement of an immune response.
- the invention provides use of a prebiotic in the manufacture of a medicament or nutritional composition for enhancement of an immune response.
- the invention provides use of a prebiotic or composition in the manufacture of a medicament or nutritional composition for the prevention or supportive treatment of measles.
- the invention provides a method of enhancing an immune response which comprises administering an effective amount of a prebiotic or composition comprising at least one prebiotic.
- the invention provides a method of prevention or supportive treatment of diseases such as measles which comprises administering an effective amount of a prebiotic or composition comprising at least one prebiotic.
- an embodiment of the composition is a nutritional composition which comprises at least one prebiotic.
- the prebiotic comprises an oligosachharide produced from glucose, galactose, xylose, maltose, sucrose, lactose, starch, xylan, hemicellulose, inulin, or a mixture thereof.
- the oligosaccharide comprises fructo-oligosaccharide.
- the prebiotic is a mixture of fructo-oligosaccharide and inulin, comprising PREBIO1® or a mixture of commercially available RAFTILOSE® and RAFTILINE®.
- the prebiotic advantageously comprises about 50% to about 90% fructo-oligosaccharide. More preferably, it comprises about 60% to about 80% fructo-oligosaccharide. Most preferably, it comprises about 70% fructo-oligosaccharide.
- the prebiotic comprises about 10% to about 50% inulin. More preferably, it comprises about 20% to about 40% inulin. Most preferably, it comprises about 30% inulin.
- the composition may include a prebiotic in addition to the prebiotic.
- the probiotic is selected from the group consisting of Bifidobacterium bifidum and streptococcus thermophilus.
- the Bifidobacterium bifidum is Bifidobacterium lactis.
- An advantage of the present invention is that it provides an elevated immune response after vaccination and therefore offers substantial protection until a second follow-up vaccine can be administered.
- Another advantage of the present invention is that it provides an elevated response to early measles vaccination may therefore offer substantial protection against measles until a second measles vaccine is administered.
- Yet another advantage of the present invention is that it may be employed to enhance an immune response, e.g., protection against measles, by simple consumption of food before, during, and after the vaccination period.
- an immune response e.g., protection against measles
- intravenous or subcutaneous administration of a drug requires expertise, and compared to oral administration it is not as safe, convenient or acceptable to the patient.
- the invention provides the clear advantage of a nutritional and/or therapeutic product which may be administered orally although other forms of administration can be used.
- a nutritional composition comprises a milk based cereal together with a prebiotic formulation.
- the milk based cereal is an infant cereal which acts as a carrier for the prebiotic formulation.
- the most preferred prebiotic comprises a mixture of fructo-oligosaccharides and inulin in the amounts by weight of 70% fructo-oligosaccharides and 30% inulin.
- the composition may include a source of protein and/or a source of carbohydrate and/or a source of fat.
- Dietary protein is preferred as a source of protein.
- the dietary protein may be any suitable dietary protein; for example animal protein, such as milk protein, meat protein or egg protein; vegetable protein, such as soy protein, wheat protein, rice protein, and pea protein; a mixture of free amino acids; or a combination thereof. Milk proteins such as casein, whey proteins or soy protein or a mixture thereof are particularly preferred.
- the composition may comprise a fat source, and if so the fat source preferably provides about 5% to about 55% of the energy of the composition; for example about 20% to about 50% of the energy.
- Lipid making up the fat source may be any suitable fat or fat mixture. For example soy oil, palm oil, coconut oil, safflower oil, sunflower oil, corn oil, canola oil, lecithins or animal fat such as milk fat may be added if desired.
- a source of carbohydrate may also be included. If so, it preferably provides about 40% to about 80% of the energy of the composition. Any suitable carbohydrate may be used, for example sucrose, lactose, glucose, fructose, corn syrup solids, maltodextrin, or a mixture thereof.
- dietary fibers can be included, if desired. When present, it comprises up to about 5% of the weight of the nutritional composition.
- the dietary fibers may be provided from any suitable origin, including for example soy, pea, oat, pectin, guar gum, gum arabic, fructo-oligosaccharide or a mixture thereof.
- Suitable vitamins and minerals may be included in the nutritional composition in an amount to meet the appropriate or desirable guidelines.
- One or more food grade emulsifiers may be included in the nutritional composition if desired; for example diacetyl tartaric acid esters of mono- and di-glycerides, lecithin and mono- or di-glycerides or a mixture thereof. Similarly suitable salts and/or stabilizers may be included.
- the nutritional composition for enhancing an immune response e.g., following measles, vaccination is preferably enterally administrable; for example in the form of a powder, tablet, capsule, a liquid concentrate, solid product or a ready-to-drink beverage. If it is desired to produce a powdered nutritional formula, the homogenized mixture is transferred to a suitable drying apparatus such as a spray drier or freeze drier and converted to powder.
- a suitable drying apparatus such as a spray drier or freeze drier and converted to powder.
- a usual food product may be enriched with the an embodiment of composition.
- the amount of the composition added is preferably at least about 0.01% by weight.
- composition may be included in article of confectionery, for example a sweet or sweetened beverage.
- composition was made by blending a cereal product with 4% prebiotic (70% fructo-oligosaccharide, 30% inulin). Its composition is indicated below: component amount in % Cereal product 96% Prebiotic 4%
- IgG antibodies increased 6.6 and 4.2 fold in groups S and C respectively (p ⁇ 0.03).
- the post-vaccination IgG positivity rates were 96% (S) and 88% (C). Mild reactions were significantly more often observed in group S (p ⁇ 0.01). No differences in growth and overall health status were observed.
- a food supplement was prepared by mixing or blending fructo-oligosaccharide with inulin in the proportions by weight of about 70% fructo-oligosaccharide to about 30% inulin.
- the resulting prebiotic mixture may be added or blended with any suitable carrier, for example a fermented milk, a yogurt, a fresh cheese, a renneted milk, a confectionery bar, breakfast cereal flakes or bars, a drink, milk powder, soy-based product, non-milk fermented product or a nutritional supplement for clinical nutrition.
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Priority Applications (1)
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| EP00200735.9 | 2000-03-01 | ||
| PCT/EP2001/001627 WO2001064225A1 (en) | 2000-03-01 | 2001-02-14 | Carbohydrate formulation (prebiotic adjuvant) for enhancement of immune response |
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| UA (1) | UA73763C2 (de) |
| WO (1) | WO2001064225A1 (de) |
| ZA (1) | ZA200207849B (de) |
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| US20050118299A1 (en) * | 2003-12-01 | 2005-06-02 | The Iams Company | Companion animal compositions comprising short chain oligofructose |
| US20070042036A1 (en) * | 2005-08-19 | 2007-02-22 | Eichi Kikuchi | Fat-soluble drug composition |
| US20090176734A1 (en) * | 2005-06-01 | 2009-07-09 | Mead Johnson & Co. | Method For Simulating The Functional Attributes Of Human Milk Oligosaccharides In Formula-Fed Infants |
| US20100104727A1 (en) * | 2008-10-24 | 2010-04-29 | Mead Johnson & Co. | Methods For Preserving Endogenous TGF-Beta |
| US20100104696A1 (en) * | 2008-10-24 | 2010-04-29 | Mead Johnson & Co. | Nutritional Composition With Improved Digestibility |
| US20100105615A1 (en) * | 2005-06-30 | 2010-04-29 | Rosales Francisco J | Nutritional Composition To Promote Healthy Development And Growth |
| US20100284980A1 (en) * | 2009-05-11 | 2010-11-11 | Rosales Francisco J | Nutritional Composition To Promote Healthy Development And Growth |
| US20100316619A1 (en) * | 2009-02-12 | 2010-12-16 | Anja Wittke | Nutritional composition with prebiotic component |
| US20110104335A1 (en) * | 2007-08-24 | 2011-05-05 | Luc Rumbaut | Process and confectionery product produced thereby |
| WO2011060123A1 (en) * | 2009-11-12 | 2011-05-19 | Nestec S.A. | Nutritional composition for promoting gut microbiota balance and health |
| US20110223248A1 (en) * | 2007-12-12 | 2011-09-15 | Ritter Pharmaceuticals, Inc. | Methods and compositions for treating lactose intolerance |
| US20110236480A1 (en) * | 2009-02-24 | 2011-09-29 | Ritter Pharmaceuticals, Inc. | Prebiotic formulations and methods of use |
| US9226933B2 (en) | 2004-07-22 | 2016-01-05 | Ritter Pharmaceuticals, Inc. | Methods and compositions for treating lactose intolerance |
| US9579340B2 (en) | 2009-02-24 | 2017-02-28 | Ritter Pharmaceuticals, Inc. | Prebiotic formulations and methods of use |
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| KR20020043078A (ko) * | 2000-12-01 | 2002-06-08 | 한인규 | 올리고당이 포함된 복합생균제 |
| GB0229015D0 (en) | 2002-12-12 | 2003-01-15 | Novartis Nutrition Ag | New Compound |
| US8394370B2 (en) * | 2003-06-23 | 2013-03-12 | Nestec S.A. | Nutritional formula for optimal gut barrier function |
| NO320546B1 (no) * | 2003-12-12 | 2005-12-19 | Nova Biotics As | Prebiotiske kombinasjonsprodukter |
| US20080003329A1 (en) * | 2006-06-30 | 2008-01-03 | Ricardo Rueda | Enriched infant formulas |
| US20100055083A1 (en) * | 2006-10-18 | 2010-03-04 | Ray Edward Kowalski | Encapsulation of heat and moisture sensitive substances |
| DE102007008664B4 (de) * | 2007-02-20 | 2021-07-29 | Vitacare Gmbh & Co. Kg | Mittel zur Anwendung bei Fructoseintoleranz |
| AR072141A1 (es) | 2008-06-13 | 2010-08-11 | Nutricia Nv | Composicion nutricional para lactantes nacidos por cesarea |
| WO2010008491A2 (en) * | 2008-06-25 | 2010-01-21 | Ritter Natural Sciences, Llc | Lactose compositions with decreased lactose content |
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| NL2007268C2 (en) | 2011-08-16 | 2013-02-19 | Friesland Brands Bv | Nutritional compositions comprising human milk oligosaccharides and uses thereof. |
| US20150086587A1 (en) * | 2012-03-28 | 2015-03-26 | Kansas State University Research Foundation | Vaccine adjuvant |
| WO2013187755A1 (en) | 2012-06-14 | 2013-12-19 | N.V. Nutricia | Fermented infant formula with non digestible oligosaccharides |
| CN103330935A (zh) * | 2013-06-17 | 2013-10-02 | 中山大学 | 果糖作为疫苗佐剂的应用 |
| US20190000873A1 (en) * | 2015-08-04 | 2019-01-03 | Südzucker AG | Prophylactic use of inulin against sinusitis |
| WO2019031961A1 (en) | 2017-08-11 | 2019-02-14 | N.V. Nutricia | OLIGOSACCHARIDE OF HUMAN MILK TO IMPROVE PHYSICAL IMMUNE CONDITION |
| JP7469037B2 (ja) * | 2019-02-28 | 2024-04-16 | 森永乳業株式会社 | 発酵乳 |
| CN111529703B (zh) * | 2020-06-17 | 2023-09-15 | 湖南循天然营养有限公司 | 一种组合物及其制备方法与在制备免疫佐剂中的应用 |
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- 2001-02-14 AT AT01903767T patent/ATE283697T1/de not_active IP Right Cessation
- 2001-02-14 UA UA2002097766A patent/UA73763C2/uk unknown
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- 2001-02-14 KR KR1020027011308A patent/KR20020081375A/ko not_active Application Discontinuation
- 2001-02-14 BR BR0108828-9A patent/BR0108828A/pt not_active Application Discontinuation
- 2001-02-14 MX MXPA02008447A patent/MXPA02008447A/es active IP Right Grant
- 2001-02-14 AU AU3174601A patent/AU3174601A/xx active Pending
- 2001-02-14 AU AU2001231746A patent/AU2001231746C1/en not_active Ceased
- 2001-02-14 ES ES01903767T patent/ES2232591T3/es not_active Expired - Lifetime
- 2001-02-14 WO PCT/EP2001/001627 patent/WO2001064225A1/en active IP Right Grant
- 2001-02-14 PT PT01903767T patent/PT1261355E/pt unknown
- 2001-02-14 EP EP01903767A patent/EP1261355B1/de not_active Expired - Lifetime
- 2001-02-14 PL PL01365136A patent/PL365136A1/xx unknown
- 2001-02-14 HU HU0204546A patent/HUP0204546A3/hu unknown
- 2001-02-14 DE DE60107544T patent/DE60107544T2/de not_active Expired - Lifetime
- 2001-03-01 AR ARP010100985A patent/AR027968A1/es not_active Application Discontinuation
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2002
- 2002-08-22 NO NO20024011A patent/NO20024011L/no unknown
- 2002-08-26 US US10/228,722 patent/US20030040492A1/en not_active Abandoned
- 2002-09-30 ZA ZA200207849A patent/ZA200207849B/en unknown
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2003
- 2003-06-02 HK HK03103906A patent/HK1051650A1/xx not_active IP Right Cessation
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2004
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Also Published As
| Publication number | Publication date |
|---|---|
| DE60107544T2 (de) | 2005-12-15 |
| ZA200207849B (en) | 2003-12-30 |
| ES2232591T3 (es) | 2005-06-01 |
| BR0108828A (pt) | 2002-12-10 |
| AU2001231746C1 (en) | 2005-10-06 |
| CA2400969A1 (en) | 2001-09-07 |
| JP4838477B2 (ja) | 2011-12-14 |
| CN1243551C (zh) | 2006-03-01 |
| AU3174601A (en) | 2001-09-12 |
| UA73763C2 (en) | 2005-09-15 |
| KR20020081375A (ko) | 2002-10-26 |
| CA2400969C (en) | 2011-04-19 |
| PL365136A1 (en) | 2004-12-27 |
| AR027968A1 (es) | 2003-04-16 |
| NO20024011D0 (no) | 2002-08-22 |
| HK1051650A1 (en) | 2003-08-15 |
| MXPA02008447A (es) | 2002-12-13 |
| PT1261355E (pt) | 2005-02-28 |
| HUP0204546A2 (en) | 2003-05-28 |
| WO2001064225A1 (en) | 2001-09-07 |
| US7101553B2 (en) | 2006-09-05 |
| EP1261355A1 (de) | 2002-12-04 |
| ATE283697T1 (de) | 2004-12-15 |
| DE60107544D1 (de) | 2005-01-05 |
| EP1261355B1 (de) | 2004-12-01 |
| IL151280A0 (en) | 2003-04-10 |
| US20040191234A1 (en) | 2004-09-30 |
| JP2003533438A (ja) | 2003-11-11 |
| NO20024011L (no) | 2002-08-22 |
| CN1422158A (zh) | 2003-06-04 |
| HUP0204546A3 (en) | 2003-10-28 |
| AU2001231746B2 (en) | 2004-12-23 |
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