US20030010717A1 - Systems and methods for handling air and/or flushing fluids in a fluid circuit - Google Patents

Systems and methods for handling air and/or flushing fluids in a fluid circuit Download PDF

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Publication number
US20030010717A1
US20030010717A1 US09/905,171 US90517101A US2003010717A1 US 20030010717 A1 US20030010717 A1 US 20030010717A1 US 90517101 A US90517101 A US 90517101A US 2003010717 A1 US2003010717 A1 US 2003010717A1
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US
United States
Prior art keywords
fluid
connector
fluid circuit
fluid passage
circuit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US09/905,171
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English (en)
Inventor
James Brugger
Dennis Treu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NxStage Medical Inc
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NxStage Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NxStage Medical Inc filed Critical NxStage Medical Inc
Priority to US09/905,171 priority Critical patent/US20030010717A1/en
Assigned to NXSTAGE MEDICAL, INC. reassignment NXSTAGE MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BRUGGER, JAMES, TREU, DENNIS M.
Priority to EP02746907.1A priority patent/EP1414543B1/de
Priority to PCT/US2002/021447 priority patent/WO2003006139A1/en
Publication of US20030010717A1 publication Critical patent/US20030010717A1/en
Assigned to NXSTAGE MEDICAL, INC. reassignment NXSTAGE MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BRUGGER, JAMES, TREU, DENNIS
Priority to US10/772,888 priority patent/US7226538B2/en
Priority to US11/742,715 priority patent/US7588684B2/en
Priority to US12/508,900 priority patent/US7790043B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/288—Priming
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3468—Substitution fluids using treated filtrate as substitution fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A61M1/3646—Expelling the residual body fluid after use, e.g. back to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3462—Circuits for the preparation thereof

Definitions

  • the invention generally relates to fluid processing systems and methods.
  • the invention relates to systems and methods that process blood or fluids that are introduced into the body, for example, during filtration, dialysis, or other diagnostic or therapeutic purposes.
  • the invention provides systems and methods for handling air in a fluid processing circuit.
  • the invention also provides systems and methods for rinsing or flushing residual fluids from a fluid processing circuit after processing is concluded.
  • One aspect of the invention provides systems and methods for priming a fluid circuit.
  • the systems and methods couple a connector assembly to a fluid reservoir.
  • the connector assembly comprises a first fluid passage and a second fluid passage.
  • the systems and methods circulate fluid in the fluid circuit through the fluid reservoir, by conveying fluid into the inlet of the fluid circuit from the reservoir through the second fluid passage while conveying fluid from the outlet of the fluid circuit into the reservoir through the first fluid passage.
  • the systems and methods accumulate air residing in the fluid circuit in the fluid reservoir, thereby removing air from the fluid circuit.
  • the systems and methods releasably couple the first fluid passage to the outlet of the fluid circuit, and also releasably couple the second fluid passage to the inlet of the fluid circuit.
  • the systems and methods couple the first and second passages together in a loop after the accumulating step.
  • the systems and methods convey fluid into the fluid reservoir at a higher gravity height than fluid is conveyed from the fluid reservoir.
  • Another aspect of the invention provides systems and methods for both priming and flushing a fluid circuit.
  • the systems and methods provide a connector assembly comprising a first fluid passage that is releasably coupled to an outlet of the fluid circuit and a second fluid passage that is releasably coupled to an inlet of the fluid circuit.
  • the systems and methods couple the connector assembly to a fluid reservoir.
  • the systems and methods prime the fluid circuit through the fluid reservoir by conveying fluid into the inlet of the fluid circuit from the reservoir through the second fluid passage while conveying fluid from the outlet of the fluid circuit into the reservoir through the first fluid passage.
  • the systems and methods release the coupling between the connector assembly and the inlet and outlet of the fluid circuit, while keeping the connector assembly coupled to the fluid reservoir.
  • the systems and methods then process a selected fluid using the fluid circuit. After the processing step, the systems and methods couple the inlet of the fluid circuit to the second fluid passage. The systems and methods then rinse residue of the selected fluid from the fluid circuit by conveying fluid into the inlet of the fluid circuit from the reservoir through the second fluid passage, while conveying the selected fluid residue from the outlet of the fluid circuit in a path that bypasses the reservoir.
  • the first and second fluid passages are coupled together in a loop.
  • a fluid processing apparatus comprising a fluid container, and a connector assembly coupled to the fluid container.
  • the connector assembly includes a first fluid passage that is releasably coupled by a luer connector to an outlet of a fluid circuit.
  • the connector assembly also includes a second fluid passage that does not communicate with the first fluid passage and that is releasably coupled by a luer connector to a inlet of the fluid circuit.
  • fluid can be circulated by the connector assembly through the fluid container in a loop that includes the fluid circuit to collect in the fluid source air residing in the fluid circuit.
  • the connector assembly can, in one embodiment, comprise a single connector body that includes both the first and second fluid passages.
  • the connector body includes a distal end having a taper to form a spike, which can be coupled to the fluid reservoir, e.g., by penetrating a port tube membrane.
  • the connector assembly can comprise, in another embodiment, a first connector body that includes the first fluid passage and a second connector body that includes the second fluid passage.
  • each of the first and second connector bodies includes a distal end having a taper to form a spike, which can be coupled to the fluid reservoir, e.g., by penetrating a port tube membrane.
  • the connector comprises a body in which there are first and second fluid passages that do not communicate with each other.
  • a first assembly communicates with the first fluid passage and includes a first fitting to releasably couple the first fluid passage to an outlet of a fluid circuit.
  • a second assembly communicates with the second fluid passage and includes a second fitting to releasably couple the second fluid passage to an inlet of the fluid circuit.
  • the fluid circuit used in association with the invention in all of its various aspects can itself take various forms and functions.
  • the fluid circuit can, for example, comprise at least a portion of a hemofiltration system, or a hemodialysis system, or a hemodiafiltration system, or a peritoneal dialysis system.
  • the invention makes possible the use of fluid circuits free of drip chambers, thereby minimizing the quantity of priming fluid discarded during priming.
  • FIG. 1 is a schematic view of a generic fluid processing system
  • FIG. 2. is a schematic view of a priming system that can be used with the fluid processing system shown in FIG. 1, which includes a dual lumen connector assembly;
  • FIG. 3A is an enlarged side sectional view of the dual lumen connector assembly that forms a part of the priming system shown in FIG. 2;
  • FIG. 3B is an enlarged side sectional view of the dual lumen connector assembly shown in FIG. 3A when performing a priming function
  • FIG. 3C is an enlarged side sectional view of the dual lumen connector assembly shown in FIG. 3A formed into a closed loop that preserves its sterility after performing the priming function shown in FIG. 3B and before performing a rinse-back function;
  • FIG. 4. is a schematic view of a rinse-back system that can be used with the fluid processing system shown in FIG. 1, and which includes the same dual lumen connector assembly that previously performed the priming function shown in FIG. 3B;
  • FIG. 5. is a schematic view of a system with a dual lumen connector assembly as shown in FIG. 3A, which is supplied to an operator preconnected to a fluid circuit;
  • FIG. 6A is a schematic view of an alternative fluid priming assembly comprising a priming container with integrally connected first and second tubing assemblies that can be used with the fluid processing system shown in FIG. 1;
  • FIG. 6B is a schematic view of a system formed after connecting the fluid priming assembly shown in FIG. 6A with the fluid circuit shown in FIG. 1;
  • FIG. 7 is a schematic view of an alternative embodiment of a fluid priming assembly, which is supplied to an operator preconnected to a fluid circuit;
  • FIG. 8 is a schematic view of a container that carries replacement fluid and that includes both an associated fluid priming assembly and replacement fluid inlet path.
  • FIG. 1 schematically shows the components of a generic fluid processing system 10 .
  • the system 10 has a first inlet 12 for receiving fluid and an outlet 14 for discharging fluid.
  • a fluid circuit 16 is coupled between the first inlet 12 and the outlet 14 , through which the incoming fluid flows and is then discharged.
  • the fluid circuit 16 processes the fluid in a desired manner and can be conventional.
  • the fluid circuit 16 may also include a second inlet 18 through which a processing fluid is introduced into the fluid circuit 16 .
  • the processing fluid is drawn from a source 20 , which can be fluid containers or a sterile fluid generating source.
  • the sterile fluid can be generated, e.g., by treating water from an external source, or by sterile filtering a fluid waste product of the fluid circuit 16 itself, e.g., as disclosed in application Ser. No. 09/027,301 filed Feb. 19, 1998 and entitled “Hemofiltration System Including Ultrafiltrate Purification and Reinfusion System,” which is incorporated herein by reference.
  • the fluid processing system 10 can take various forms. It can, for example, comprise a blood processing system for conducting hemofiltration, or hemodialysis, or hemodiafiltration.
  • the system 10 can also comprise a peritoneal dialysis system.
  • the system 10 forms a part of a hemofiltration system.
  • the system receives through the first inlet 12 blood from an individual, e.g., through a suitable incoming blood line 22 , which can comprise an access site for withdrawing blood from an individual, e.g., by connection to an artery, a vein, or a fistula.
  • An in-line pinch clamp 46 or the like can be provided in the blood line 22 .
  • a pumping mechanism P in the fluid circuit 16 pumps the blood through a hemofilter HF, where toxins (WASTE) are removed.
  • the treated blood is discharged through the outlet 14 for return to the circulatory system of the individual, e.g., through a suitable outgoing blood line 24 , which can comprise an access site for returning blood to an individual, e.g., typically by connection to a vein.
  • a suitable outgoing blood line 24 can comprise an access site for returning blood to an individual, e.g., typically by connection to a vein.
  • An in-line pinch clamp 46 or the like can also be provided in the blood line 24 .
  • a replacement fluid is typically added to the treated blood through the second inlet 18 , to make up for the fluid lost during toxin removal.
  • the replacement fluid is added in volumetric proportion to the amount of fluid removed from the blood.
  • the replacement fluid is drawn from the source 20 , which communicates with to the second inlet 18 .
  • the system 10 includes a fluid priming assembly 26 (shown in FIGS. 2; 3 A/B/C; and 4 ).
  • the purposes of the fluid priming assembly 26 are (1) to prime the system and thereby remove residual air from the fluid circuit 16 prior to use, and (2) to “rinse back” or flush residual blood from the fluid circuit 16 after use.
  • FIGS. 2; 3 A/B/C; and 4 Details of the fluid priming assembly 26 are illustrated in FIGS. 2; 3 A/B/C; and 4 ).
  • the fluid priming assembly 26 includes a connector 30 formed, e.g., from hard, medical grade plastic.
  • a connector 30 formed, e.g., from hard, medical grade plastic.
  • These passages 36 and 38 can be formed, e.g., by conventional molding techniques.
  • These passages 36 and 38 are discrete, such that the second fluid passage 38 does not communicate with the first fluid passage 36 within the body of the connector 30 .
  • the connector 30 is intended to be coupled in fluid communication with a container 32 of priming solution.
  • the priming container 32 can comprise, e.g., flexible bag containing saline or other suitable priming solution.
  • the priming container 32 is positioned above the fluid circuit 16 .
  • the processing fluid source 20 can also be used as the source of priming solution.
  • the connector 30 may be coupled to the priming container 32 in various conventional ways, e.g., through a luer fitting or by penetration of a port tube membrane 34 .
  • the priming container 32 includes a port tube membrane 34 .
  • the tip end of the connector 30 is tapered to form a spike 56 , providing a configuration similar to vented-type spikes for rigid bottles.
  • the opening 50 of the first fluid passage 36 into the container 32 is located closer to the high tapered end 54 of the spike 56 than the opening 52 of the second fluid passage 38 into the container 32 .
  • the first fluid passage 36 enters the container 32 at a higher gravity position than the second fluid passage 38 . The benefits of this configuration will be discussed later.
  • the fluid priming assembly 26 includes a first flexible tubing assembly 40 (see FIG. 3A) coupled to the connector 30 .
  • the first tubing assembly 40 communicates only with the first fluid passage 36 .
  • the first tubing assembly 40 terminates with a connector 42 to releasably connect the first fluid passage 36 to the fluid circuit 16 .
  • the connector 42 can take various forms, depending upon the configuration of the mating connector in the fluid circuit 16 .
  • the connector 42 comprises a male luer 58 with a removable female-to-female connector 60 carried by the male luer 58 .
  • the removable connector 60 carried by the male luer 58 is adapted to be coupled to a mating male connector 62 on the outlet 14 of the the fluid circuit (as FIG. 2 shows).
  • priming fluid and residual air in the fluid circuit 16 is pumped by way of the first tubing assembly 40 , into the first fluid passage 36 and into the priming container 32 .
  • the fluid priming assembly 26 includes a second flexible tubing assembly 44 (see FIG. 3A) coupled to the connector 30 .
  • the second tubing assembly 44 communicates only with the second fluid passage 38 .
  • the second tubing assembly 44 terminates with a connector 64 to releasably connect the second fluid passage 36 to the fluid circuit 16 .
  • the connector 64 can take various forms, depending upon the configuration of the mating connector in the fluid circuit 16 .
  • the connector 64 comprises a female luer connector that is adapted to be coupled to a mating male connector 66 on the inlet 12 of the fluid circuit (see FIG. 2).
  • vented fluid free of air
  • the connectors 42 and 64 are configured to also enable their connection one to the other in a sterile fashion (see FIG. 3C).
  • the first and second tubing assemblies 40 and 44 can be coupled together to form a closed loop 68 , to maintain sterility after being used to perform a priming function, so that additional functions, e.g., a rinse-back function, can be performed using the same connector 30 and priming container 32 . Further details of this feature will be described later.
  • the connector 30 forms a priming loop 70 that circulates the priming solution through both the priming container 32 and the fluid circuit 16 .
  • Conventional pinch clamps 46 are provided on both the first tubing assembly 40 and the second tubing assembly 44 , as well as the inlet and outlet 12 and 14 . These pinch clamps 46 allow regulation and control of fluid flow through the priming loop 70 and fluid circuit 16 .
  • priming solution is drawn (by the fluid circuit pump P in the inlet line 12 ) through the second tubing assembly 44 from the priming container 32 and into the fluid circuit 16 .
  • Residual air occupying the fluid circuit 16 is displaced by the priming solution and returned with the priming solution through the first tubing assembly 40 back into the priming container 32 .
  • the opening 50 of the first fluid passage 36 (conveying air and fluid into the container 32 ) is located at a higher gravity height than the opening 52 of the second fluid passage 38 (conveying fluid out of the container 32 )
  • air in the fluid outflow discharged by the first fluid passage 36 is not drawn or sucked into the fluid inflow entering the second fluid passage 38 .
  • the air floats upward, away from the second fluid passage 38 and is collected in the air space 72 at the top of the container 32 .
  • the pump P may continue to operate in this fashion until steps are taken to begin fluid processing. For example, when the fluid circuit 16 is being used to conduct hemofiltration, the pump P can be operated to continuously recirculate the priming fluid from the container 32 through the circuit 16 . until the patient is available for attachment to the fluid circuit 16 .
  • the fluid circuit 16 is supplied to the operator with the connector 30 releasably preconnected to the circuit 16 by the connectors 66 / 64 and 62 / 42 .
  • the connector 30 is enclosed in a sterile manner within a cap 80 , which maintains its sterility prior to use.
  • the pinch clamps 46 provided upstream and downstream of the connectors 66 / 64 and 62 / 42 are preferably open.
  • Priming of the fluid circuit 10 commences with the removal of the cap 80 and coupling the connector 30 to the priming container 32 (see FIG. 2).
  • the pump P is operated in a forward flow condition to draw fluid from the priming container 32 and push air into the priming container 32 (as shown in FIG. 3B).
  • the priming solution is circulated in this manner in the loop 70 until priming solution fills the fluid circuit 16 and all air is expelled and collected in the air space 72 at the top of the priming container 32 .
  • a flow restrictor 74 can be placed in the first tubing assembly 40 or in the first fluid passage 36 .
  • the flow restrictor 74 helps to create a positive back pressure at the outlet 14 , to facilitate complete priming of the hemofilter HF (or other blood processing device the system 10 may incorporate).
  • the female-to-female connector 60 is now removed to expose the male luer 58 of the first tubing assembly 40 .
  • the connector 60 can now be discarded.
  • the male luer 58 can then be connected with the female luer 64 on the second tubing assembly 44 (see FIG. 3C).
  • the closed loop 68 is thereby formed between the first and second tubing assemblies 40 and 44 , through the priming container 32 , to maintain sterility within the connector 30 and tubing assemblies 40 and 44 until the rinse-back function is performed.
  • the clamps 46 in the tubing assemblies 40 and 44 may be closed.
  • clamps 46 on inlet and outlet lines 12 and 14 and the incoming and outgoing fluid access lines 22 and 24 can be opened. Operation of the pump P begins, and the primed fluid circuit 16 processes blood and fluid in the desired manner (e.g., hemofiltration).
  • the rinse-back function is performed at the end of the blood processing session.
  • the rinse-back function is illustrated in FIG. 4.
  • the outgoing fluid access assembly 24 is left connected to the outlet 14 , to return residual fluid from the fluid circuit 16 to the individual during the rinse-back function.
  • the operator disconnects the male luer 58 on the first tubing assembly 40 from the female luer 64 on the second tubing assembly 44 , to interrupt the loop 58 .
  • the clamps 46 on the incoming fluid access assembly 22 and inlet 12 are closed.
  • the incoming fluid access assembly 22 is disconnected from the inlet 12 .
  • the female luer 64 of the second tubing assembly 44 is coupled to male luer 66 on the inlet 12 .
  • the pinch clamps 46 in the second tubing assembly 44 and the inlet 12 are opened (the pinch clamp 46 on the first tubing assembly 40 remains closed). Subsequent operation of the pump P draws priming solution from the container 32 into and through the fluid circuit 16 . In this process, residual blood remaining in the fluid circuit 16 is effectively rinsed or flushed from the circuit 16 and ultimately returned to the individual through the outgoing fluid access assembly 24 . This reduces the amount of blood loss by the individual.
  • the operator disconnects the outlet 14 from the outgoing fluid access assembly 24 .
  • the system 10 which includes the fluid circuit 16 connected by the connector 30 to the priming container 32 , can now be discarded as a unit.
  • the arrangement as described performs both a priming function and a rinse back function using the same connector assembly and the same source of solution.
  • the fluid priming assembly 26 can be constructed in various alternative ways.
  • a fluid priming assembly 28 comprises the priming container 32 that is supplied to the operator with the first and second tubing assemblies 40 and 44 attached as individual lengths of flexible tubing integrally coupled directly to priming container 32 , without use of the intermediate dual lumen connector 30 .
  • Each tubing length 40 and 44 includes its own luer connector, respectively 42 and 64 , and an upstream pinch clamp 46 , which is closed at the time it is supplied to the operator.
  • the first tubing assembly connector 42 can be coupled the connector 62 of the outlet 14
  • the second tubing assembly connector 64 is coupled to the connector 66 of the inlet 12 .
  • the container 32 with preconnected first and second tubing assemblies can be supplied to the operator releasably preconnected to the fluid circuit 16 in the manner shown in FIG. 6B.
  • the pinch clamps 46 can be opened and the pump P operated in the manner as previously discussed, to draw fluid from the priming container 32 and push air into the priming container 32 , thereby priming the fluid circuit 16 .
  • a fluid priming assembly 28 comprises the first and second tubing assemblies 40 and 44 taking the form of individual lengths of flexible tubing coupled directly to priming container 32 at time of use by means of separate connectors 82 and 84 .
  • the connectors 82 and 84 can take the form of luer fittings or, as shown in FIG. 7, spikes that penetrate separate port tube membranes 86 on the priming container 32 .
  • the two connectors 82 and 84 (desirably enclosed within caps 80 ) can be supplied to the operator releasably preconnected to the circuit 16 by the connectors 66 / 64 and 62 / 42 , in the same manner as the single connector 30 shown in FIG. 5.
  • the fluid that the container 32 carries can comprise the replacement fluid that is added to make up for fluid lost during toxin removal.
  • the inlet 18 includes a connector 90 that releasably couples to a mating connector 88 carried by a third tubing assembly 92 , which is itself coupled directly to the container 32 .
  • the third tubing assembly 92 can be coupled to the container 32 in the same manner as the first and second tubing assemblies 40 and 44 , i.e., either by integral coupling or by use of instant-of-use luer or spike connectors.
  • the tubing assemblies 40 and 44 convey the replacement fluid to perform a priming and rinse back function at the beginning and end of fluid processing, as previously described, while the third tubing assembly 92 conveys replacement fluid during fluid processing.
  • the container 32 can comprise a container prefilled with replacement fluid, or it can comprise a reservoir that receives replacement fluid from a sterile fluid generating source during fluid processing.
  • the sterile fluid can be generated, e.g., by treating water from an external source or (as FIG. 8 shows) by sterile filtering the fluid waste product of the fluid circuit 16 itself in a replacement fluid generation device 94 , e.g., of a type disclosed in application Ser. No. 09/027,301 filed Feb. 19, 1998 and entitled “Hemofiltration System Including Ultrafiltrate Purification and Reinfusion System,” which is incorporated herein by reference.

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  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
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  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
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US09/905,171 2001-07-13 2001-07-13 Systems and methods for handling air and/or flushing fluids in a fluid circuit Abandoned US20030010717A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US09/905,171 US20030010717A1 (en) 2001-07-13 2001-07-13 Systems and methods for handling air and/or flushing fluids in a fluid circuit
EP02746907.1A EP1414543B1 (de) 2001-07-13 2002-07-08 System zur Behandlung von Luft und/oder zum spülen von Fluiden in einem Fluidkreislauf
PCT/US2002/021447 WO2003006139A1 (en) 2001-07-13 2002-07-08 Systems and methods for handling air and/or flushing fluids in a fluid circuit
US10/772,888 US7226538B2 (en) 2001-07-13 2004-02-04 Fluid processing apparatus
US11/742,715 US7588684B2 (en) 2001-07-13 2007-05-01 Systems and methods for handling air and/or flushing fluids in a fluid circuit
US12/508,900 US7790043B2 (en) 2001-07-13 2009-07-24 Systems and methods for handling air and/or flushing fluids in a fluid circuit

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/905,171 US20030010717A1 (en) 2001-07-13 2001-07-13 Systems and methods for handling air and/or flushing fluids in a fluid circuit

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/772,888 Division US7226538B2 (en) 2001-07-13 2004-02-04 Fluid processing apparatus

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US20030010717A1 true US20030010717A1 (en) 2003-01-16

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Application Number Title Priority Date Filing Date
US09/905,171 Abandoned US20030010717A1 (en) 2001-07-13 2001-07-13 Systems and methods for handling air and/or flushing fluids in a fluid circuit
US10/772,888 Expired - Lifetime US7226538B2 (en) 2001-07-13 2004-02-04 Fluid processing apparatus
US11/742,715 Expired - Lifetime US7588684B2 (en) 2001-07-13 2007-05-01 Systems and methods for handling air and/or flushing fluids in a fluid circuit
US12/508,900 Expired - Fee Related US7790043B2 (en) 2001-07-13 2009-07-24 Systems and methods for handling air and/or flushing fluids in a fluid circuit

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US10/772,888 Expired - Lifetime US7226538B2 (en) 2001-07-13 2004-02-04 Fluid processing apparatus
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EP1414543B1 (de) 2013-09-04
US7588684B2 (en) 2009-09-15
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US7790043B2 (en) 2010-09-07
US20100022938A1 (en) 2010-01-28
US20070260168A1 (en) 2007-11-08

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