Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/42—Amides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/16—Amides, e.g. hydroxamic acids
  • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
  • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
  • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q3/00—Manicure or pedicure preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Definitions

• the present invention relates to a preparation comprising urea, a hydrophilic film-forming agent and water or an alcohol/water mixture.
• the preparation is useful in the removal of abnormal keratinous material, as is to be observed, for example, in onychomycoses, psoriasis of the nail, or warts.
• abnormal keratinous material histological hyperparakeratosis is discernibleas an abnormally changed layer structure of the skin or of the nail and may be treated with the presently disclosed preparation.
• brittle nails can be rehydrated, thus regenerating, for example, the physiological barrier function of the nails.
• Urea has been used in dermatological practice for decades in the form of creams and lotions. Urea changes the structure and the properties of the keratin in the horny layer of the nails. It generally has a hygroscopic action in the horny layer (depending on the carrier), and an antiproliferative action on the epidermis. Urea cleaves disulfide bonds and hydrogen bonds. Through this action, the dead keratinized material is loosened and can then be mechanically detached.
• salicylic acid preparations are customarily used in the form of semisolid preparations such as salicyl petroleum jelly (approximately 20%-60%) or plasters (Guttaplast®).
• semisolid preparations such as salicyl petroleum jelly (approximately 20%-60%) or plasters (Guttaplast®).
• the invention provides a preparation comprising a hydrophilic film-forming agent, urea, water and/or an alcohol/water mixture, which overcomes the disadvantages mentioned for the prior art compounds.
• the preparation according to the invention is an aqueous or aqueous-alcoholic solution, in which the hydrophilic film-forming agent and urea are dissolved or optionally suspended.
• a solution is advantageous.
• the preparation After application to the abnormal keratinous material such as warts or fingernails, the preparation rapidly forms an adherent film which is resistant to wiping and rubbing off.
• the urea penetrates into the abnormal keratin and assists its detachment. Additional covering with plasters, application of a special protective film for the areas of skin surrounding the target site, and daily bathing are not necessary.
• the preparation according to the invention also prevents undesirable precipitation reactions of the urea that occur locally on the keratinous material being treated. Such precipitation leads to unsightly changes or to possible impairment of the local bioavailability of the urea.
• the preparation according to the invention makes possible a uniform distribution of the urea on the keratinous material as a result of its composition and its pharmaceutical properties.
• the present invention provides markedly improved drug targeting by permitting focused application to the target organ or target site with decreased risk for exposure to the adjacent tissue, and an improved user-friendliness (handling) in the application of the preparation.
• the preparation according to the invention therefore provides a formulation comprising
• the preparation can contain further volatile and nonvolatile constituents as long as the amount of urea, based on the nonvolatile constituents of the preparations, is within the specified range.
• the amounts of urea are in each case based on the nonvolatile constituents of the preparation according to the invention and can be from 41 percent by weight to 69 percent by weight, from 45 percent by weight to 65 percent by weight, from 46 percent by weight to 63 percent by weight, or from 55 percent by weight to 63 percent by weight.
• Possible hydrophilic film-forming agents include, for example, acrylic/methacrylic acid ester copolymers, polyvinylpyrrolidones, polyvinyl alcohols, vinyl acetate/vinylpyrrolidone copolymers, vinyl acetate/crotonic acid copolymers, methyl vinyl ether/maleic acid copolymers, polyesters, polyester amides, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, and a mixture of two or more of the film-forming agents mentioned.
• the hydrophilic film-forming agent is a polyvinylpyrrolidone.
• the hydrophilic film-forming agents are employed in amounts from 30 percent by weight to 60 percent by weight, relative to the nonvolatile constituents of the preparation.
• the amount of the hydrophilic film-forming agents needed will typically depend on the amount of urea in the preparation.
• suitable alcohols include, for example, (C 1 -C 6 )-alcohols such as methanol, ethanol, propanol, isopropanol (2-propanol), butanol, pentanol hexanol or mixtures thereof.
• ethanol, n-propanol or 2-propanol are employed.
• the ratio of alcohol to water typically ranges from 9:1 to 1:9; In one embodiment, the mixture comprises 2 parts of alcohols to 3 parts of water.
• Suitable additional excipients include plasticizers, such as glycerol triacetate or 1,2-propylene glycol, and agents for adjusting the pH of the preparations, such as lactic acid or citric acid.
• the preparation comprises lactic acid in an amount from 0.5 percent by weight to 5 percent by weight, based on the weight of the entire preparation.
• the preparations according to the invention can furthermore contain additives that are customary in cosmetics, such as plasticizers based on phthalate, glyceryl triacetate or camphor, colorants or color pigments, pearl luster agents, sulfonamide resins, sedimentation-delaying agents, silicates, odoriferous substances, wetting agents such as sodium dioctylsulfosuccinate, lanolin derivatives, sunscreen agents such as 2-hydroxy-4-methoxybenzophenone or antibacterially active substances.
• Colored or pigmented nail varnishes for example, have the advantage that the preparation according to the invention can be tailored to the perception of beauty of the patient and the nail changes existing in the meantime are not immediately visible to third parties.
• the preparation according to the invention is typically prepared by introducing urea and a hydrophilic film-forming agent into water or a water/alcohol mixture and subsequently mixing.
• aqueous-alcoholic solutions are prepared in which the urea is present in dissolved form in an amount from 15 percent by weight to 35 percent by weight, based on the weight of the entire solution.
• the amount of hydrophilic film-forming agent employed is from approximately 15 percent by weight to approximately 35 percent by weight, in each case based on the weight of the entire solution.
• the amount of the hydrophilic film-forming agent employed generally depends on the amount of urea present in the preparation.
• the amount of water or aqueous-alcoholic mixture is from 30 percent by weight to 60 percent by weight, or from 35 percent by weight to 55 percent by weight, in each case based on the weight of the entire solution.
• the preparation according to the invention is typically applied as a solution to the keratinous materials to be treated. It dries rapidly, forming an adherent film which is resistant to wiping and rubbing off.
• the solution can be applied, for example, with a brush.
• the invention further relates to use of the preparation according to the invention for the detachment of abnormal keratinous material.
• abnormal keratinous material is understood as meaning keratinous material in humans and animals such as warts, calluses, hard skin, or toenails and fingernails that have been changed by fungal attack or psoriatic disease. With respect to the abnormal keratinous material, histological hyperparakeratosis is discernibleas an abnormally modified layer structure of the skin or the nail.
• the invention also relates to the use of a preparation comprising
• the amounts of urea are in each case based on the nonvolatile constituents of the use according to the invention and can be from 35 to 85 percent by weight, from 39 percent by weight to 83 percent by weight, from 46 percent by weight to 63 percent by weight, or from 55 percent by weight to 63 percent by weight.
• the hydrophilic film-forming agents are typically employed in amounts from 10 percent by weight to 70 percent by weight, based on the nonvolatile constituents.
• the amount of the hydrophilic film-forming agents employed depends on the amount of urea. For example, mixtures of approximately 25 percent by weight to 35 percent by weight of urea with 15 percent by weight to 20 percent by weight of hydrophilic film-forming agent may be employed, where the weight percentages are relative to the nonvolatile constituents. Such preparations will generally have a shorter drying time than formulations having a higher or lower content of hydrophilic film-forming agent.
• suitable alcohols, film-forming agents, and additional excipients and nonvolatile constituents are as described above for the pharmaceutical preparation
• suitable alcohols, film-forming agents, and additional excipients and nonvolatile constituents are as described above for the pharmaceutical preparation
• amounts of water and/or alcohol, film-forming agents, and additional excipients and non-volatile constituents are also as described above.
• the invention also relates to the use of an aqueous solution comprising urea in an amount from 15 percent to 35 percent, or from 25 percent to 33 percent, based on the weight of the entire solution; and a hydrophilic film-forming agent in an amount from approximately 15 percent to approximately 35 percent, or from 17 percent to 25 percent, in each case based on the weight of the entire solution, for the production of a pharmaceutical for the treatment of abnormal keratinous material.
• the abnormal keratinous material is detached by applying the preparation, allowing a suitable amount of time for the action of the dried preparation on the keratinous material being treated, and subsequent mechanical removal of the abnormal keratinous material.
• the invention further relates to the use of the preparation according to the invention for the hydration of brittle toenails or fingernails.
• a preparation according to the invention has the following composition:
• a preparation according to the invention has the following composition:
• a preparation according to the invention has the following composition:
• a preparation according to the invention has the following composition:
• a preparation according to the invention has the following composition:
• a preparation according to the invention has the following composition:
• Example 3 The toenails of two affected patients were treated with the preparation as in Example 3.
• the preparation of Example 3 was applied once daily to the affected nails with a brush before going to bed.
• the urea-containing film which formed after the application to the nails was wipe-resistant and waterproof. Special protection of the skin areas surrounding the nails and the application of plaster dressings were therefore not necessary. Because of the high water content of the preparations, the affected toenails were not additionally bathed.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Epidemiology (AREA)
• Birds (AREA)
• Medicinal Chemistry (AREA)
• Dermatology (AREA)
• Pharmacology & Pharmacy (AREA)
• Chemical & Material Sciences (AREA)
• Bioinformatics & Cheminformatics (AREA)
• General Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• Engineering & Computer Science (AREA)
• Cosmetics (AREA)
• Medicinal Preparation (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

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Applications Claiming Priority (2)

Related Child Applications (1)

Publications (1)

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Family Applications After (1)

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Cited By (10)

Families Citing this family (4)

Citations (17)

Family Cites Families (7)

• 2001
  • 2001-05-30 DE DE10126501A patent/DE10126501A1/de not_active Withdrawn
• 2002
  • 2002-05-17 PT PT02732724T patent/PT1395231E/pt unknown
  • 2002-05-17 JP JP2003501422A patent/JP4359140B2/ja not_active Expired - Fee Related
  • 2002-05-17 CA CA2448829A patent/CA2448829C/en not_active Expired - Fee Related
  • 2002-05-17 WO PCT/EP2002/005469 patent/WO2002098380A1/de not_active Ceased
  • 2002-05-17 DE DE50203283T patent/DE50203283D1/de not_active Expired - Lifetime
  • 2002-05-17 EP EP02732724A patent/EP1395231B1/de not_active Expired - Lifetime
  • 2002-05-17 DK DK02732724T patent/DK1395231T3/da active
  • 2002-05-17 ES ES02732724T patent/ES2242027T3/es not_active Expired - Lifetime
  • 2002-05-17 MX MXPA03009984A patent/MXPA03009984A/es active IP Right Grant
  • 2002-05-17 AT AT02732724T patent/ATE296607T1/de active
  • 2002-05-29 US US10/156,070 patent/US20020197291A1/en not_active Abandoned
• 2004
  • 2004-01-15 US US10/757,433 patent/US7476396B2/en not_active Expired - Fee Related

Patent Citations (18)

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