US20010018054A1 - Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis - Google Patents
Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis Download PDFInfo
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- US20010018054A1 US20010018054A1 US09/853,580 US85358001A US2001018054A1 US 20010018054 A1 US20010018054 A1 US 20010018054A1 US 85358001 A US85358001 A US 85358001A US 2001018054 A1 US2001018054 A1 US 2001018054A1
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Definitions
- the CTL inducing composition comprises the antigen to which the CTL response is desired and a non-toxic antigen formulation which comprises, consists or consists essentially of a stabilizing detergent, a micelle-forming agent, and a biodegradable and biocompatible oil.
- TGF ⁇ was originally identified by its ability to impart a transformed phenotype to normal fibroblasts and found to be produced by virtually all the cells (Wakefield et al., J. Cell. Biol., 105:965-75 (1987)). In humans, it is found in three different isoforms, TGF ⁇ 1, 2 and 3. TGF ⁇ is a pleiotropic cytokine which affects a wide range of -biological activities, including immunosuppression, inflammation, hematopoiesis and wound repair (Sporn et al., Science, 233:532 (1986); Pallidino et al., Ann. NY Acad. Sci., 593:181 (1990); Roberts et al., Adv. Cancer Res., 51:107 (1988).
- RAGE-1 Gaugler et al., Immunogenetics, 44:323-330 (1996)
- N-acetylglucosaminyltransferase-V Guilloux et al., J. Exp. Med., 183:1173-1183 (1996)
- p15 Robots et al., J. Immunol., 154:5944-5950 (1995)
- tumor specific mutated antigens mutated B-catenin (Robbins et al., J. Exp.
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- Medicinal Preparation (AREA)
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Cited By (5)
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| US20040137071A1 (en) * | 2000-02-28 | 2004-07-15 | Genesegues, Inc. | Nanocapsule encapsulation system and method |
| US20070098713A1 (en) * | 2002-04-08 | 2007-05-03 | Genesegues, Inc. | Nanoparticle delivery systems and methods of use thereof |
| US7491395B2 (en) | 2002-11-20 | 2009-02-17 | Bestewil Holding B.V. | Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination |
| US20140328860A1 (en) * | 2011-11-22 | 2014-11-06 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting tgf beta signaling |
| US10987308B2 (en) | 2014-09-03 | 2021-04-27 | Genesegues, Inc. | Therapeutic nanoparticles and related compositions, methods and systems |
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| US6197311B1 (en) | 1991-07-25 | 2001-03-06 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| US7244232B2 (en) * | 2001-03-07 | 2007-07-17 | Biomed Solutions, Llc | Process for identifying cancerous and/or metastatic cells of a living organism |
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| WO2005005636A1 (ja) | 2003-07-15 | 2005-01-20 | Chugai Seiyaku Kabushiki Kaisha | 形質転換細胞によるIｇMの産生とその定量方法 |
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| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| WO2009055005A2 (en) * | 2007-10-23 | 2009-04-30 | The Regents Of The University Of Colorado | Competitive inhibitors of invariant chain expression and/or ectopic clip binding |
| KR20110139292A (ko) | 2009-04-20 | 2011-12-28 | 화이자 인코포레이티드 | 단백질 글리코실화의 제어 및 그와 관련된 조성물 및 방법 |
| BR112012007821A2 (pt) * | 2009-10-09 | 2017-05-30 | Sanofi Sa | polipeptídeos para ligação ao "receptor de produtos finais de glicação avançada" bem como composições e métodos envolvendo os mesmos |
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| CN116655801A (zh) | 2013-08-22 | 2023-08-29 | 阿塞勒隆制药公司 | TGF-β受体II型变体及其用途 |
| AU2016301380B2 (en) | 2015-08-04 | 2021-07-01 | Acceleron Pharma Inc. | Methods for treating myeloproliferative disorders |
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| HRP20230706T1 (hr) | 2017-05-04 | 2023-10-13 | Acceleron Pharma Inc. | Fuzijski proteini tgf-beta receptora tipa ii i njihove upotrebe |
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| US5514670A (en) * | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
| US5585103A (en) * | 1991-07-25 | 1996-12-17 | Idec Pharmaceutical Corporation | Induction of cytotoxic T-lymphocyte responses |
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| US20020004052A1 (en) * | 1990-05-08 | 2002-01-10 | David Berd | Composition comprising a tumor cell extract and method of using the composition |
| US6197311B1 (en) * | 1991-07-25 | 2001-03-06 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| US5709860A (en) * | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
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- 1998-09-16 ZA ZA988461A patent/ZA988461B/xx unknown
- 1998-09-17 EP EP98949313A patent/EP1015031A4/en not_active Withdrawn
- 1998-09-17 CN CNB988112809A patent/CN1234413C/zh not_active Expired - Fee Related
- 1998-09-17 IN IN2797DE1998 patent/IN190792B/en unknown
- 1998-09-17 JP JP2000511527A patent/JP2001516727A/ja active Pending
- 1998-09-17 WO PCT/US1998/018495 patent/WO1999013912A1/en not_active Application Discontinuation
- 1998-09-17 RU RU2000109595/14A patent/RU2219947C2/ru not_active IP Right Cessation
- 1998-09-17 CA CA002303178A patent/CA2303178A1/en not_active Abandoned
- 1998-09-17 AU AU95658/98A patent/AU742216B2/en not_active Ceased
- 1998-09-17 AR ARP980104649A patent/AR013012A1/es not_active Application Discontinuation
- 1998-09-17 KR KR1020007002864A patent/KR100540267B1/ko not_active Expired - Fee Related
- 1998-09-17 CO CO98053593A patent/CO4790100A1/es unknown
- 1998-09-17 IL IL13493798A patent/IL134937A0/xx not_active IP Right Cessation
- 1998-11-04 SA SA98190719A patent/SA98190719B1/ar unknown
-
1999
- 1999-01-29 TW TW087115599A patent/TWI252108B/zh not_active IP Right Cessation
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2000
- 2000-03-07 IL IL134937A patent/IL134937A/en unknown
- 2000-03-17 NO NO20001413A patent/NO20001413L/no not_active Application Discontinuation
-
2001
- 2001-05-14 US US09/853,580 patent/US20010018054A1/en not_active Abandoned
- 2001-05-14 US US09/853,581 patent/US6998125B2/en not_active Expired - Lifetime
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2003
- 2003-12-24 US US10/743,739 patent/US20040137014A1/en not_active Abandoned
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2005
- 2005-12-12 US US11/298,567 patent/US20060153848A1/en not_active Abandoned
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| US5585103A (en) * | 1991-07-25 | 1996-12-17 | Idec Pharmaceutical Corporation | Induction of cytotoxic T-lymphocyte responses |
| US5514670A (en) * | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040137071A1 (en) * | 2000-02-28 | 2004-07-15 | Genesegues, Inc. | Nanocapsule encapsulation system and method |
| US20070098713A1 (en) * | 2002-04-08 | 2007-05-03 | Genesegues, Inc. | Nanoparticle delivery systems and methods of use thereof |
| US7491395B2 (en) | 2002-11-20 | 2009-02-17 | Bestewil Holding B.V. | Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination |
| US20140328860A1 (en) * | 2011-11-22 | 2014-11-06 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting tgf beta signaling |
| US9782452B2 (en) * | 2011-11-22 | 2017-10-10 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling |
| US10987308B2 (en) | 2014-09-03 | 2021-04-27 | Genesegues, Inc. | Therapeutic nanoparticles and related compositions, methods and systems |
Also Published As
| Publication number | Publication date |
|---|---|
| US20040137014A1 (en) | 2004-07-15 |
| CA2303178A1 (en) | 1999-03-25 |
| NO20001413L (no) | 2000-05-18 |
| MY131805A (en) | 2007-09-28 |
| CN1234413C (zh) | 2006-01-04 |
| AU742216B2 (en) | 2001-12-20 |
| US6998125B2 (en) | 2006-02-14 |
| US20010019715A1 (en) | 2001-09-06 |
| RU2219947C2 (ru) | 2003-12-27 |
| SA98190719B1 (ar) | 2006-08-06 |
| CN1279616A (zh) | 2001-01-10 |
| KR20010024109A (ko) | 2001-03-26 |
| NO20001413D0 (no) | 2000-03-17 |
| ZA988461B (en) | 1999-03-30 |
| JP2001516727A (ja) | 2001-10-02 |
| HK1033653A1 (en) | 2001-09-14 |
| KR100540267B1 (ko) | 2006-01-10 |
| TWI252108B (en) | 2006-04-01 |
| IL134937A (en) | 2008-04-13 |
| EP1015031A1 (en) | 2000-07-05 |
| US20060153848A1 (en) | 2006-07-13 |
| IL134937A0 (en) | 2001-05-20 |
| WO1999013912A1 (en) | 1999-03-25 |
| CO4790100A1 (es) | 1999-05-31 |
| IN190792B (enrdf_load_stackoverflow) | 2003-08-23 |
| AU9565898A (en) | 1999-04-05 |
| AR013012A1 (es) | 2000-11-22 |
| EP1015031A4 (en) | 2004-03-17 |
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Owner name: BIOGEN IDEC INC., CALIFORNIA Free format text: CHANGE OF NAME;ASSIGNOR:IDEC PHARMACEUTICALS CORPORATION;REEL/FRAME:015044/0873 Effective date: 20031112 |