US20010016603A1 - Calcium formate for use as a dietary supplement - Google Patents

Calcium formate for use as a dietary supplement Download PDF

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Publication number
US20010016603A1
US20010016603A1 US09/746,250 US74625000A US2001016603A1 US 20010016603 A1 US20010016603 A1 US 20010016603A1 US 74625000 A US74625000 A US 74625000A US 2001016603 A1 US2001016603 A1 US 2001016603A1
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United States
Prior art keywords
calcium
calcium formate
phosphorus
formate
dose
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US09/746,250
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English (en)
Inventor
Hector DeLuca
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Wisconsin Alumni Research Foundation
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Individual
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27042788&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20010016603(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/469,513 external-priority patent/US6160016A/en
Application filed by Individual filed Critical Individual
Priority to US09/746,250 priority Critical patent/US20010016603A1/en
Assigned to WISCONSIN ALUMNI RESEARCH FOUNDATION reassignment WISCONSIN ALUMNI RESEARCH FOUNDATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DELUCA, HECTOR F.
Publication of US20010016603A1 publication Critical patent/US20010016603A1/en
Priority to US09/961,729 priority patent/US6528542B2/en
Priority to US13/281,754 priority patent/US20120046252A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • Antacids are often used to bind dietary phosphorus to prevent phosphorus retention and prevent its absorption. This process is referred to as phosphorus binding and appears to be a chemical reaction between dietary phosphorus and the cation present in the binder compound, which is usually albumin or calcium. The binding results in the formation of insoluble and unabsorbable phosphate compounds, adsorption of phosphorus ions on the surface of binder particles, or a combination of both.
  • Antacids are used widely, often in large quantities, for indigestion, heartburn or peptic ulcer disease. Despite their consumption in large amounts and often over long periods of time, phosphorus depletion is uncommon in these settings. This fact is additional evidence of the inefficiency of antacids as phosphorus binding agents.
  • the inefficiency of commonly used phosphorus binders creates a clinical dilemma.
  • the dose of the binder must be increased to control hyperphosphatemia, but increased risk of toxicity of the binder results from the increased dose.
  • This toxicity includes bone disease and aluminum dementia from aluminum-containing antacids and hypercalcemia and soft tissue calcification from calcium-containing antacids. These risks are particularly problematic in patients with chronic renal disease.
  • a phosphorus binder available which does not have the risks associated with ingestion of presently available binders.
  • the binder should be more efficient in binding phosphorus and, thus, would not have to be consumed in the large quantities necessary, for example, when calcium carbonate-containing compositions are used.
  • Such a phosphorus binder would be particularly valuable for administration to individuals with chronic renal failure, in whom phosphorus retention is a serious concern and the risk of toxicity from consumption of presently- available binders is greater than in individuals in whom kidney function is normal.
  • U.S. Pat. No. 4,870,105 addresses these concerns by disclosing a calcium acetate phosphorus binder. However, it would be advantageous to find a binder with a smaller anion and, hence, a smaller effective dose.
  • Calcium is an abundant element in the human body and plays an important role in many physiological processes. Nutritional and metabolic deficiencies of calcium can have adverse effects, typically manifested through deficiencies in the structure, function and integrity of the skeletal system. The most common calcium-modulated metabolic bone disorder is osteoporosis.
  • a preferred approach to calcium supplementation is through dietary sources.
  • Dairy products are the major contributors of dietary calcium, as are green vegetables (e.g. broccoli, kale, turnip greens, Chinese cabbage), calcium-set tofu, some legumes, canned fish, seeds and nuts.
  • green vegetables e.g. broccoli, kale, turnip greens, Chinese cabbage
  • calcium-set tofu some legumes, canned fish, seeds and nuts.
  • Breads and cereals can contribute significantly to calcium intake.
  • Calcium supplements may be the preferred way to obtain supplemental calcium.
  • Calcium carbonate is usually recommended for economic reasons.
  • calcium carbonate usage requires sufficient gastric acids for its utilization.
  • Some individuals, especially the elderly, may have limited amounts of gastric acid, and achlorhydric patients have little gastric acid.
  • calcium carbonate is poorly utilized.
  • Using large amounts of calcium carbonate may also lead to constipation and abdominal distention.
  • Calcium lactate or calcium citrate may then be used.
  • the present invention relates to a method of binding phosphorus in the gastrointestinal tract and, thus, reducing phosphorus absorption from the intestine. It also relates to a method of reducing serum phosphate levels because phosphorus bound in the gastrointestinal tract results in lower phosphorus absorption than would otherwise occur. It is particularly useful in the treatment and prevention of hyperphosphatemia in individuals with renal disease or other disease in which the ability to excrete phosphorus from the body (e.g., in the urine) is impaired.
  • the method of the present invention comprises orally administering to an individual a composition which includes calcium formate in sufficient quantity to effectively bind phosphorus, preferably present in food and beverages consumed by the individual, and prevent its absorption in the intestine.
  • the calcium formate is administered at a dose of between 0.5 and 10.0 grams.
  • the present invention is also a method of using calcium formate as a dietary calcium supplement.
  • the method comprises orally administrating to an individual a composition comprising calcium formate in sufficient quantities to improve calcium balance or retention.
  • the calcium formate is administered in a dose between 0.5 and 3.0 g/day as a supplement.
  • the present invention is also a pharmaceutical composition
  • a pharmaceutical composition comprising calcium formate in combination with a pharmaceutically acceptable carrier.
  • the composition comprises 0.5 grams of calcium formate per capsule or tablet.
  • the composition comprises calcium formate and at least one additional therapeutic ingredient.
  • this therapeutic ingredient is a vitamin D compound, typically cholecalciferol.
  • the amount of calcium-containing compound sufficient to inhibit gastrointestinal phosphorus absorption is 10% lighter than therapeutically equivalent amounts of previously known calcium acetate compounds.
  • calcium formate may be supplied orally to an individual in order to supplement the individual's calcium intake.
  • the present invention relates to a calcium formate composition for oral administration to an individual.
  • the composition is useful in reducing phosphorus absorption in the gastrointestinal tract.
  • Calcium formate is shown below to be effective in inhibiting phosphorus absorption when administered orally in in vivo tests and has been shown to prevent the absorption of ingested phosphorus at a lower dose than other calcium-containing binders.
  • calcium formate alone or in combination with other materials, can be used to bind phosphorus in the gastrointestinal tract, thus reducing the percentage of an amount of phosphorus consumed (i.e., of a given “dose” of phosphorus) which is absorbed.
  • this dose would be 0.5-10.0 grams when adjusted to doses intended for human patients.
  • the present invention also relates to a method of inhibiting gastrointestinal phosphorus absorption.
  • the method of the present invention is based on the demonstration that calcium formate is an effective binder of phosphorus when administered orally to an individual.
  • the method comprises orally administering a quantity of calcium formate sufficient to bind with phosphorus in the gastrointestinal tract.
  • this dose is between 10-200 milliequivalents of calcium and is preferably present in either tablet or gelatin capsule form.
  • the oral dose is ingested at mealtimes.
  • phosphorus includes phosphorus and phosphate in its various forms (e.g. HPO 4 ⁇ , PO 4 ⁇ 3 , etc.).
  • calcium formate is administered, alone or in combination with other substances (e.g., in a hard gelatin capsule; along with materials necessary to form a tablet or caplet as a delivery vehicle for the calcium formate; or along with a second phosphorus binder or other pharmaceutically useful substance) in sufficient quantities to reduce phosphorus absorption in the gastrointestinal tract.
  • the calcium formate is administered orally, preferably close in time to food and beverage consumption.
  • at mealtimes we mean within 30 minutes of a meal.
  • anhydrous calcium formate (10-200 milliequivalents calcium) is taken prior to food consumption (e.g., meal time) and a second dose of 0.5-10.0 grams of anhydrous calcium formate is taken after food consumption.
  • the dose or quantity to be taken at a given time varies on an individual-by-individual basis and can be adjusted as needed (e.g., by monitoring serum concentration of phosphorus and calcium).
  • calcium formate is administered, alone or in combination with other substances, in sufficient quantities to supplement an individual's calcium intake.
  • the Examples below indicate that calcium formate in quantities between 0.5 and 3.0 g/day are sufficient to improve calcium balance, bone density and calcium retention.
  • the present invention is also a pharmaceutical composition
  • a pharmaceutical composition comprising calcium formate in a pharmaceutically acceptable carrier, wherein the calcium formate is present in an amount between 0.5-1.0 grams.
  • the pharmaceutical composition comprises calcium formate in amount suitable to inhibit gastrointestinal absorption of phosphorus, provides between 11 and 44 milliequivalents of calcium, and is 10% lighter than the corresponding calcium acetate dose and is the richest form of calcium available.
  • corresponding or “therapeutically equivalent,” we mean a dose that is equally effective.
  • the pharmaceutical composition essentially comprises only calcium formate and at least one pharmaceutically carrier, wherein the calcium formate is present in an amount sufficient to produce between 11 and 44 milliequivalents of calcium.
  • essentially comprises we mean that calcium formate is the only active ingredient in the pharmaceutical composition.
  • the present invention is also a pharmaceutical composition
  • a pharmaceutical composition comprising calcium formate in a pharmaceutically acceptable carrier combined with other therapeutic agents, preferably a vitamin D compound.
  • the calcium formate is combined with vitamin D is cholecalciferol in a range of 125 IU to 400 IU in a tablet or capsule.
  • the animals were then placed on a basal diet that contains 0.02% calcium, i.e. an extremely low calcium diet. These animals served as controls. Another group were placed on the same diet containing calcium formate, providing calcium at 0.25% of the diet. Another group was supplied calcium formate at 0.47% calcium in the diet, and another group was provided 0.47% calcium in the form of calcium carbonate. Growth of the animals reflects the ability of the animals to utilize calcium. Using a growth assay of this type to illustrate the effectiveness of the calcium salt is supported by Steenbock, H. and D.C. Herting, J. Nutr. 57:449-468,1955.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Physiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
US09/746,250 1999-12-22 2000-12-21 Calcium formate for use as a dietary supplement Abandoned US20010016603A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US09/746,250 US20010016603A1 (en) 1999-12-22 2000-12-21 Calcium formate for use as a dietary supplement
US09/961,729 US6528542B2 (en) 1999-12-22 2001-09-24 Calcium formate for use as a dietary supplement
US13/281,754 US20120046252A1 (en) 1999-12-22 2011-10-26 Calcium Formate for Use as a Dietary Supplement

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/469,513 US6160016A (en) 1999-12-22 1999-12-22 Phosphorus binder
US09/649,710 US6489361B1 (en) 1999-12-22 2000-08-25 Phosphorus binder
US09/746,250 US20010016603A1 (en) 1999-12-22 2000-12-21 Calcium formate for use as a dietary supplement

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US09/469,513 Continuation-In-Part US6160016A (en) 1999-12-22 1999-12-22 Phosphorus binder
US09/649,710 Continuation-In-Part US6489361B1 (en) 1999-12-22 2000-08-25 Phosphorus binder

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/961,729 Continuation US6528542B2 (en) 1999-12-22 2001-09-24 Calcium formate for use as a dietary supplement

Publications (1)

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US20010016603A1 true US20010016603A1 (en) 2001-08-23

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ID=27042788

Family Applications (10)

Application Number Title Priority Date Filing Date
US09/746,250 Abandoned US20010016603A1 (en) 1999-12-22 2000-12-21 Calcium formate for use as a dietary supplement
US09/961,729 Expired - Lifetime US6528542B2 (en) 1999-12-22 2001-09-24 Calcium formate for use as a dietary supplement
US10/326,789 Abandoned US20030100609A1 (en) 1999-12-22 2002-12-19 Calcium formate for use as a dietary supplement
US10/636,157 Abandoned US20040029964A1 (en) 1999-12-22 2003-08-07 Calcium formate for use as a dietary supplement
US11/021,533 Expired - Fee Related US7850991B2 (en) 1999-12-22 2004-12-23 Calcium formate for use as a dietary supplement
US12/943,660 Abandoned US20110059927A1 (en) 1999-12-22 2010-11-10 Calcium Formate For Use As A Dietary Supplement
US13/281,754 Abandoned US20120046252A1 (en) 1999-12-22 2011-10-26 Calcium Formate for Use as a Dietary Supplement
US14/172,423 Abandoned US20140155360A1 (en) 1999-12-22 2014-02-04 Calcium Formate for Use as a Dietary Supplement
US15/342,908 Abandoned US20170049808A1 (en) 1999-12-22 2016-11-03 Calcium Formate for Use as a Dietary Supplement
US15/596,587 Abandoned US20170246206A1 (en) 1999-12-22 2017-05-16 Calcium Formate for Use as a Dietary Supplement

Family Applications After (9)

Application Number Title Priority Date Filing Date
US09/961,729 Expired - Lifetime US6528542B2 (en) 1999-12-22 2001-09-24 Calcium formate for use as a dietary supplement
US10/326,789 Abandoned US20030100609A1 (en) 1999-12-22 2002-12-19 Calcium formate for use as a dietary supplement
US10/636,157 Abandoned US20040029964A1 (en) 1999-12-22 2003-08-07 Calcium formate for use as a dietary supplement
US11/021,533 Expired - Fee Related US7850991B2 (en) 1999-12-22 2004-12-23 Calcium formate for use as a dietary supplement
US12/943,660 Abandoned US20110059927A1 (en) 1999-12-22 2010-11-10 Calcium Formate For Use As A Dietary Supplement
US13/281,754 Abandoned US20120046252A1 (en) 1999-12-22 2011-10-26 Calcium Formate for Use as a Dietary Supplement
US14/172,423 Abandoned US20140155360A1 (en) 1999-12-22 2014-02-04 Calcium Formate for Use as a Dietary Supplement
US15/342,908 Abandoned US20170049808A1 (en) 1999-12-22 2016-11-03 Calcium Formate for Use as a Dietary Supplement
US15/596,587 Abandoned US20170246206A1 (en) 1999-12-22 2017-05-16 Calcium Formate for Use as a Dietary Supplement

Country Status (11)

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US (10) US20010016603A1 (de)
EP (1) EP1242067B1 (de)
JP (1) JP2003518058A (de)
AT (1) ATE333871T1 (de)
AU (1) AU782649B2 (de)
CA (1) CA2395530C (de)
CY (1) CY1105732T1 (de)
DE (1) DE60029628T2 (de)
DK (1) DK1242067T3 (de)
ES (1) ES2269218T3 (de)
WO (1) WO2001045695A2 (de)

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WO2001045695A2 (en) * 1999-12-22 2001-06-28 Wisconsin Alumni Research Foundation Calcium formate for use as a phosphorus binder and a dietary supplement
US20040161474A1 (en) * 2002-05-24 2004-08-19 Moerck Rudi E. Rare earth metal compounds methods of making, and methods of using the same
US20060083791A1 (en) 2002-05-24 2006-04-20 Moerck Rudi E Rare earth metal compounds methods of making, and methods of using the same
US20080160086A1 (en) * 2004-02-19 2008-07-03 Scepter Holdings, Inc. Delivery Systems For Calcium
US20060029641A1 (en) * 2004-08-05 2006-02-09 Keller Nathan I Calcium and magnesium nutritional supplement
WO2006044657A2 (en) * 2004-10-15 2006-04-27 Altairnano, Inc. Phosphate binder with reduced pill burden
CA2619643A1 (en) * 2005-08-17 2007-02-22 Altairnano, Inc. Treatment of chronic renal failure and other conditions in domestic animals: compositions and methods
WO2011143475A1 (en) 2010-05-12 2011-11-17 Spectrum Pharmaceuticals, Inc. Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use
US20160053281A1 (en) 2013-08-15 2016-02-25 The University Court Of The University Of Edinburgh Enhanced Expression Of RNA Vectors

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CA2395530A1 (en) 2001-06-28
US20110059927A1 (en) 2011-03-10
ES2269218T3 (es) 2007-04-01
AU2448501A (en) 2001-07-03
EP1242067B1 (de) 2006-07-26
US20020035151A1 (en) 2002-03-21
DE60029628T2 (de) 2007-07-26
US20170246206A1 (en) 2017-08-31
US20040029964A1 (en) 2004-02-12
WO2001045695A3 (en) 2002-01-03
US7850991B2 (en) 2010-12-14
US20120046252A1 (en) 2012-02-23
WO2001045695A2 (en) 2001-06-28
ATE333871T1 (de) 2006-08-15
CY1105732T1 (el) 2010-12-22
DE60029628D1 (de) 2006-09-07
EP1242067A2 (de) 2002-09-25
DK1242067T3 (da) 2006-11-27
US20030100609A1 (en) 2003-05-29
JP2003518058A (ja) 2003-06-03
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US20050106234A1 (en) 2005-05-19
US20170049808A1 (en) 2017-02-23
AU782649B2 (en) 2005-08-18

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