US10385018B2 - 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors - Google Patents

4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors Download PDF

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US10385018B2
US10385018B2 US14/438,410 US201314438410A US10385018B2 US 10385018 B2 US10385018 B2 US 10385018B2 US 201314438410 A US201314438410 A US 201314438410A US 10385018 B2 US10385018 B2 US 10385018B2
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dihydro
oxo
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carboxylic acid
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US20150274662A1 (en
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Gianluca Mariano Enrico Papeo
Mikhail Yurievitch Krasavin
Paolo Orsini
Alessandra Scolaro
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Nerviano Medical Sciences SRL
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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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US14/438,410 2012-10-26 2013-10-23 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors Active US10385018B2 (en)

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EP12190130 2012-10-26
EP12190130.0 2012-10-26
EP12190130 2012-10-26
PCT/EP2013/072165 WO2014064149A1 (en) 2012-10-26 2013-10-23 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors

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US17/018,504 Active US11420940B2 (en) 2012-10-26 2020-09-11 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
US17/863,941 Active US11773064B2 (en) 2012-10-26 2022-07-13 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors

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US17/018,504 Active US11420940B2 (en) 2012-10-26 2020-09-11 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
US17/863,941 Active US11773064B2 (en) 2012-10-26 2022-07-13 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors

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JP (1) JP6314147B2 (es)
KR (1) KR102221199B1 (es)
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US11420940B2 (en) 2012-10-26 2022-08-23 Nerviano Medical Sciences S.R.L. 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors

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CN111100116A (zh) * 2019-11-14 2020-05-05 南京大学 一类新型的含甲基吲哚的以吡唑啉为骨架的苯胺衍生物的制备方法及应用
CN111205263A (zh) * 2020-04-22 2020-05-29 北京鑫开元医药科技有限公司 一种双环醇的制备方法及用途
WO2022225934A1 (en) 2021-04-19 2022-10-27 Xinthera, Inc. Parp1 inhibitors and uses thereof
US20230159525A1 (en) 2021-10-01 2023-05-25 Xinthera, Inc. Azetidine and pyrrolidine parp1 inhibitors and uses thereof
US11939329B2 (en) 2022-01-21 2024-03-26 Xinthera, Inc. PARP1 inhibitors and uses thereof
TW202400596A (zh) 2022-04-28 2024-01-01 美商辛瑟拉股份有限公司 三環parp1抑制劑及其用途
WO2023242302A1 (en) 2022-06-15 2023-12-21 Astrazeneca Ab Combination therapy for treating cancer

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US11420940B2 (en) 2012-10-26 2022-08-23 Nerviano Medical Sciences S.R.L. 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
US11773064B2 (en) 2012-10-26 2023-10-03 Nerviano Medical Sciences S.R.L. 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors

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