UA78577C2 - Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof - Google Patents

Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof Download PDF

Info

Publication number
UA78577C2
UA78577C2 UAA200500488A UA2005000488A UA78577C2 UA 78577 C2 UA78577 C2 UA 78577C2 UA A200500488 A UAA200500488 A UA A200500488A UA 2005000488 A UA2005000488 A UA 2005000488A UA 78577 C2 UA78577 C2 UA 78577C2
Authority
UA
Ukraine
Prior art keywords
alkyl
phenyl
mean
agonists
compounds
Prior art date
Application number
UAA200500488A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of UA78577C2 publication Critical patent/UA78577C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568Four-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UAA200500488A 2002-06-19 2003-04-06 Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof UA78577C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10227508A DE10227508A1 (de) 2002-06-19 2002-06-19 Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
PCT/EP2003/005816 WO2004000805A1 (de) 2002-06-19 2003-06-04 Säuregruppen-substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Publications (1)

Publication Number Publication Date
UA78577C2 true UA78577C2 (en) 2007-04-10

Family

ID=29719283

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200500488A UA78577C2 (en) 2002-06-19 2003-04-06 Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof

Country Status (29)

Country Link
EP (1) EP1517891B1 (zh)
JP (1) JP2005533073A (zh)
KR (1) KR20050008835A (zh)
CN (1) CN100467448C (zh)
AR (1) AR039690A1 (zh)
AU (1) AU2003238210B2 (zh)
BR (1) BR0311896A (zh)
CA (1) CA2490112A1 (zh)
DE (1) DE10227508A1 (zh)
EC (1) ECSP045497A (zh)
HK (1) HK1079511A1 (zh)
HN (1) HN2003000185A (zh)
HR (1) HRPK20041201B3 (zh)
IL (1) IL165789A0 (zh)
MA (1) MA27206A1 (zh)
MX (1) MXPA04012093A (zh)
NO (1) NO20050134L (zh)
OA (1) OA12869A (zh)
PA (1) PA8576101A1 (zh)
PE (1) PE20040564A1 (zh)
PL (1) PL372700A1 (zh)
RS (1) RS108404A (zh)
RU (1) RU2287522C2 (zh)
SV (1) SV2004001548A (zh)
TN (1) TNSN04250A1 (zh)
TW (1) TW200413311A (zh)
UA (1) UA78577C2 (zh)
UY (1) UY27853A1 (zh)
WO (1) WO2004000805A1 (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
BRPI0418004A (pt) 2003-12-23 2007-04-17 Astrazeneca Ab composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis, métodos para tratar ou prevenir condições hiperlipidêmicas, aterosclerose, mal de alzheimer, e tumores associados com colesterol, formulação farmacêutica, combinação, e, processo para preparar um composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis
NZ555320A (en) 2004-12-03 2010-11-26 Schering Corp Substituted piperazines as CB1 antagonists
US8361999B2 (en) 2005-04-04 2013-01-29 Pontificia Universidad Catolica De Chile Methods of treating cholesterol gallstone disease with ezetimibe
ES2337727T3 (es) 2005-06-20 2010-04-28 Schering Corporation Derivados de piperidina utiles como antagonistas de histamina h3.
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
CN103382174A (zh) * 2006-06-23 2013-11-06 雅培制药有限公司 作为组胺h3受体调节物的环丙胺衍生物
EP2061767B1 (de) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
DE102007002260A1 (de) 2007-01-16 2008-07-31 Sanofi-Aventis Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN101200443B (zh) * 2007-10-17 2011-06-29 中国药科大学 氮杂环丁酮衍生物、其制备方法及含有它们的药物组合
DE102007063671A1 (de) 2007-11-13 2009-06-25 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CA2754384A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
CN102482312A (zh) 2009-08-26 2012-05-30 赛诺菲 新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
DE10042447A1 (de) * 2000-08-29 2002-03-28 Aventis Pharma Gmbh Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports
PL362512A1 (en) * 2000-12-21 2004-11-02 Avantis Pharma Deutschland Gmbh Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
AU2002216097B2 (en) * 2000-12-21 2006-09-07 Sanofi-Aventis Deutschland Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
IL156552A0 (en) * 2000-12-21 2004-01-04 Aventis Pharma Gmbh Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use

Also Published As

Publication number Publication date
OA12869A (en) 2006-09-15
CA2490112A1 (en) 2003-12-31
PE20040564A1 (es) 2004-10-25
ECSP045497A (es) 2005-03-10
SV2004001548A (es) 2004-03-19
EP1517891B1 (de) 2013-04-03
HRP20041201A2 (en) 2005-08-31
AU2003238210B2 (en) 2008-10-23
NO20050134D0 (no) 2005-01-11
AU2003238210A1 (en) 2004-01-06
JP2005533073A (ja) 2005-11-04
BR0311896A (pt) 2005-04-05
MA27206A1 (fr) 2005-01-03
EP1517891A1 (de) 2005-03-30
RU2005101093A (ru) 2005-07-20
HN2003000185A (es) 2005-10-20
TNSN04250A1 (en) 2007-03-12
HK1079511A1 (en) 2006-04-07
CN1662495A (zh) 2005-08-31
CN100467448C (zh) 2009-03-11
RU2287522C2 (ru) 2006-11-20
PL372700A1 (en) 2005-07-25
MXPA04012093A (es) 2005-04-19
PA8576101A1 (es) 2004-02-07
RS108404A (en) 2007-02-05
TW200413311A (en) 2004-08-01
HRPK20041201B3 (en) 2006-12-31
WO2004000805A1 (de) 2003-12-31
AR039690A1 (es) 2005-03-09
IL165789A0 (en) 2006-01-15
NO20050134L (no) 2005-03-18
KR20050008835A (ko) 2005-01-21
UY27853A1 (es) 2003-12-31
DE10227508A1 (de) 2004-01-08

Similar Documents

Publication Publication Date Title
UA78577C2 (en) Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof
US6498156B2 (en) Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use
ES2277890T3 (es) Nuevas difenilazetidinonas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para el tratamiento de trastornos del metabolismo de lipidos.
RU2315754C2 (ru) Циклическизамещенные дифенилазетидиноны, применение их для получения лекарственного средства
RU2315753C2 (ru) Катионозамещенные дифенилазетидиноны, способ их получения, лекарственные средства, содержащие эти соединения, и их применение
KR20030063462A (ko) 디페닐 아제티디논 유도체, 이의 제조 방법, 이들화합물을 함유하는 약제 및 이의 용도
KR20040003007A (ko) 카복스아미드 치환된 페닐우레아 유도체 및 약물로서의이의 제조방법
US7388004B2 (en) Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US20040077623A1 (en) Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
RU2286985C2 (ru) Новые 1,2-дифенилазетидиноны, их применение для лечения нарушений липидного обмена, лекарственное средство и способ его получения
RU2282628C2 (ru) Производные дифенилазетидинона, фармацевтическая композиция на их основе и способ ее получения
NZ537302A (en) Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
KR20050016583A (ko) 환 치환된 디페닐 아제티디논, 이의 제조방법, 이를함유하는 약제 및 이의 용도
ZA200409380B (en) Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compunds and use thereof.