UA76396C2 - Monoclonal antibody, which is able to be bound with receptor ifn -, block the biological activity of ifn- and ifn- and create higher antiviral titer against fn-, than against ifn- (variants), pharmaceutical composition for modulation or blocking biological activity of ifn-, hybridoma expressing denoted antibody (variants), and set for carrying out elisa-analysis of ifnab-bpi and/or ifnab-bpi - Google Patents
Monoclonal antibody, which is able to be bound with receptor ifn -, block the biological activity of ifn- and ifn- and create higher antiviral titer against fn-, than against ifn- (variants), pharmaceutical composition for modulation or blocking biological activity of ifn-, hybridoma expressing denoted antibody (variants), and set for carrying out elisa-analysis of ifnab-bpi and/or ifnab-bpi Download PDFInfo
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- UA76396C2 UA76396C2 UA98116315A UA98116315A UA76396C2 UA 76396 C2 UA76396 C2 UA 76396C2 UA 98116315 A UA98116315 A UA 98116315A UA 98116315 A UA98116315 A UA 98116315A UA 76396 C2 UA76396 C2 UA 76396C2
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- ifn
- iem
- biological activity
- antibody
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11809696A IL118096A0 (en) | 1996-05-01 | 1996-05-01 | Antibodies against interferon alpha/beta receptor |
| PCT/IL1997/000138 WO1997041229A1 (en) | 1996-05-01 | 1997-04-29 | Antibodies against interferon alpha/beta receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA76396C2 true UA76396C2 (en) | 2006-08-15 |
Family
ID=11068814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA98116315A UA76396C2 (en) | 1996-05-01 | 1997-04-29 | Monoclonal antibody, which is able to be bound with receptor ifn -, block the biological activity of ifn- and ifn- and create higher antiviral titer against fn-, than against ifn- (variants), pharmaceutical composition for modulation or blocking biological activity of ifn-, hybridoma expressing denoted antibody (variants), and set for carrying out elisa-analysis of ifnab-bpi and/or ifnab-bpi |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6136309A (pt) |
| EP (2) | EP0927252B1 (pt) |
| JP (1) | JP4308322B2 (pt) |
| KR (2) | KR20000064953A (pt) |
| CN (1) | CN1198929C (pt) |
| AT (1) | ATE342981T1 (pt) |
| AU (1) | AU719995B2 (pt) |
| BR (1) | BR9709202A (pt) |
| CA (1) | CA2253239C (pt) |
| DE (1) | DE69736835T2 (pt) |
| DK (1) | DK0927252T3 (pt) |
| EA (1) | EA002543B1 (pt) |
| ES (1) | ES2274542T3 (pt) |
| HK (1) | HK1019339A1 (pt) |
| IL (2) | IL118096A0 (pt) |
| NO (1) | NO324206B1 (pt) |
| PT (1) | PT927252E (pt) |
| UA (1) | UA76396C2 (pt) |
| WO (1) | WO1997041229A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0563487A1 (en) * | 1992-03-31 | 1993-10-06 | Laboratoire Europeen De Biotechnologie S.A. | Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon |
| US6713609B1 (en) | 1996-07-16 | 2004-03-30 | Genentech, Inc. | Monoclonal antibodies to type I interferon receptor |
| US6376067B1 (en) * | 1998-12-21 | 2002-04-23 | Mitsubishi Polyester Film, Llc | Silicone coated film with back side slip control coating and method of controlling slip of such film |
| RU2181297C2 (ru) | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| AU2007202840B2 (en) * | 2001-01-09 | 2011-07-28 | Baylor Research Institute | Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays |
| WO2002067760A2 (en) * | 2001-01-09 | 2002-09-06 | Baylor Research Institute | Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays |
| US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| UA76640C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Спосіб корекції патологічних імунних реакцій та гомеопатичний лікарський засіб |
| UA76639C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій |
| UA76638C2 (en) * | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| AU2007203559B2 (en) * | 2003-04-23 | 2010-09-02 | E. R. Squibb & Sons, L.L.C. | Compositions and methods for the therapy of inflammatory bowel disease |
| CA2823468A1 (en) * | 2003-04-23 | 2004-11-04 | Medarex, L.L.C. | Compositions and methods for the therapy of inflammatory bowel disease |
| PT1711207E (pt) | 2003-12-10 | 2013-02-13 | Medarex Inc | Anticorpos alfa interferão e seus usos |
| PL1781705T3 (pl) * | 2004-06-21 | 2015-03-31 | Squibb & Sons Llc | Antyciała receptora interferonów alfa I oraz ich zastosowania |
| KR101363120B1 (ko) | 2005-02-10 | 2014-02-13 | 베일러 리서치 인스티튜트 | 항-인터페론 알파 모노클로날 항체 및 사용 방법 |
| US7888481B2 (en) * | 2005-02-10 | 2011-02-15 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| CA2612378A1 (en) * | 2005-06-22 | 2007-01-04 | Genentech, Inc. | Methods and compositions for targeting ifnar2 |
| CN102083859B (zh) | 2008-05-07 | 2014-09-17 | 阿哥斯医疗公司 | 人源化抗人干扰素-α抗体 |
| AU2011278038B2 (en) | 2010-07-15 | 2017-02-02 | Oleg Iliich Epshtein | A method of increasing the effect of an activated-potentiated form of an antibody |
| EP2593138A2 (en) | 2010-07-15 | 2013-05-22 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of treating functional diseases or conditions of gastrointestinal tract |
| CN107074943B (zh) * | 2016-07-14 | 2018-08-24 | 中国科学院生物物理研究所 | I型干扰素受体抗体及其用途 |
| CN115558027B (zh) * | 2022-12-05 | 2023-02-28 | 北京万泰生物药业股份有限公司 | 一种核酸酶的单克隆抗体及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0563487A1 (en) * | 1992-03-31 | 1993-10-06 | Laboratoire Europeen De Biotechnologie S.A. | Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon |
| IL106591A (en) * | 1992-09-03 | 2008-03-20 | Yeda Res & Dev | Interferon alpha/beta binding protein, its preparation and pharmaceutical compositions containing it |
| IL108584A (en) * | 1994-02-07 | 2008-03-20 | Yeda Res & Dev | Cloning of the interferon-binding protein ALPHA / BETA |
| CA2171955A1 (en) * | 1993-09-17 | 1995-03-23 | Michael G. Tovey | Pharmaceutical composition comprising monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon |
-
1996
- 1996-05-01 IL IL11809696A patent/IL118096A0/xx unknown
-
1997
- 1997-04-29 KR KR1019980708393A patent/KR20000064953A/ko active Search and Examination
- 1997-04-29 IL IL126835A patent/IL126835A/en not_active IP Right Cessation
- 1997-04-29 AT AT97919622T patent/ATE342981T1/de active
- 1997-04-29 DK DK97919622T patent/DK0927252T3/da active
- 1997-04-29 PT PT97919622T patent/PT927252E/pt unknown
- 1997-04-29 EA EA199800968A patent/EA002543B1/ru not_active IP Right Cessation
- 1997-04-29 UA UA98116315A patent/UA76396C2/uk unknown
- 1997-04-29 CA CA2253239A patent/CA2253239C/en not_active Expired - Lifetime
- 1997-04-29 JP JP53837897A patent/JP4308322B2/ja not_active Expired - Lifetime
- 1997-04-29 EP EP97919622A patent/EP0927252B1/en not_active Expired - Lifetime
- 1997-04-29 ES ES97919622T patent/ES2274542T3/es not_active Expired - Lifetime
- 1997-04-29 AU AU24027/97A patent/AU719995B2/en not_active Expired
- 1997-04-29 KR KR1020047011388A patent/KR100581798B1/ko not_active IP Right Cessation
- 1997-04-29 DE DE69736835T patent/DE69736835T2/de not_active Expired - Lifetime
- 1997-04-29 CN CNB971951861A patent/CN1198929C/zh not_active Expired - Lifetime
- 1997-04-29 WO PCT/IL1997/000138 patent/WO1997041229A1/en active IP Right Grant
- 1997-04-29 BR BR9709202A patent/BR9709202A/pt active Search and Examination
- 1997-04-29 EP EP06014510A patent/EP1739177A1/en not_active Withdrawn
-
1998
- 1998-04-29 US US09/171,979 patent/US6136309A/en not_active Expired - Lifetime
- 1998-10-29 NO NO19985050A patent/NO324206B1/no not_active IP Right Cessation
-
1999
- 1999-09-30 HK HK99104252A patent/HK1019339A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1220699A (zh) | 1999-06-23 |
| US6136309A (en) | 2000-10-24 |
| EA199800968A1 (ru) | 1999-04-29 |
| HK1019339A1 (en) | 2000-02-03 |
| IL126835A (en) | 2007-07-24 |
| ATE342981T1 (de) | 2006-11-15 |
| EA002543B1 (ru) | 2002-06-27 |
| PT927252E (pt) | 2007-01-31 |
| CA2253239C (en) | 2010-08-10 |
| DE69736835T2 (de) | 2007-11-22 |
| ES2274542T3 (es) | 2007-05-16 |
| DE69736835D1 (de) | 2006-11-30 |
| IL118096A0 (en) | 1996-09-12 |
| KR100581798B1 (ko) | 2006-05-25 |
| AU719995B2 (en) | 2000-05-18 |
| CA2253239A1 (en) | 1997-11-06 |
| BR9709202A (pt) | 1999-08-10 |
| CN1198929C (zh) | 2005-04-27 |
| DK0927252T3 (da) | 2007-02-05 |
| JP2000509276A (ja) | 2000-07-25 |
| AU2402797A (en) | 1997-11-19 |
| EP0927252A1 (en) | 1999-07-07 |
| EP1739177A1 (en) | 2007-01-03 |
| NO324206B1 (no) | 2007-09-10 |
| KR20040075105A (ko) | 2004-08-26 |
| EP0927252B1 (en) | 2006-10-18 |
| NO985050D0 (no) | 1998-10-29 |
| KR20000064953A (ko) | 2000-11-06 |
| JP4308322B2 (ja) | 2009-08-05 |
| WO1997041229A1 (en) | 1997-11-06 |
| NO985050L (no) | 1998-12-29 |
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