UA75350C2 - Method for photodynamic treatment of undesirable subfoveal choroidal neovascularization using antiangiogenic agent - Google Patents
Method for photodynamic treatment of undesirable subfoveal choroidal neovascularization using antiangiogenic agent Download PDFInfo
- Publication number
- UA75350C2 UA75350C2 UA2002097520A UA2002097520A UA75350C2 UA 75350 C2 UA75350 C2 UA 75350C2 UA 2002097520 A UA2002097520 A UA 2002097520A UA 2002097520 A UA2002097520 A UA 2002097520A UA 75350 C2 UA75350 C2 UA 75350C2
- Authority
- UA
- Ukraine
- Prior art keywords
- antiangiogenic
- subject
- photosensitizing agent
- differs
- antiangiogenic drug
- Prior art date
Links
- 238000002428 photodynamic therapy Methods 0.000 title claims abstract description 25
- 239000004037 angiogenesis inhibitor Substances 0.000 title claims description 34
- 238000000034 method Methods 0.000 title claims description 19
- 208000005590 Choroidal Neovascularization Diseases 0.000 title abstract 3
- 206010060823 Choroidal neovascularisation Diseases 0.000 title abstract 3
- 239000003504 photosensitizing agent Substances 0.000 claims description 22
- 230000000250 revascularization Effects 0.000 claims description 14
- 150000004032 porphyrins Chemical group 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- BBNQQADTFFCFGB-UHFFFAOYSA-N purpurin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC(O)=C3C(=O)C2=C1 BBNQQADTFFCFGB-UHFFFAOYSA-N 0.000 claims description 6
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 5
- 108010016076 Octreotide Proteins 0.000 claims description 5
- 229960002700 octreotide Drugs 0.000 claims description 5
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 206010029113 Neovascularisation Diseases 0.000 claims 3
- 238000012656 cationic ring opening polymerization Methods 0.000 claims 1
- 238000012876 topography Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 10
- 239000003112 inhibitor Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 230000004907 flux Effects 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 239000000906 photoactive agent Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 206010064930 age-related macular degeneration Diseases 0.000 description 2
- 230000001772 anti-angiogenic effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003966 growth inhibitor Substances 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
- 238000011450 sequencing therapy Methods 0.000 description 2
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
- 239000004072 C09CA03 - Valsartan Substances 0.000 description 1
- 102000010907 Cyclooxygenase 2 Human genes 0.000 description 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 1
- 102000003923 Protein Kinase C Human genes 0.000 description 1
- 108090000315 Protein Kinase C Proteins 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- BHPNXACHQYJJJS-UHFFFAOYSA-N bacteriochlorin Chemical compound N1C(C=C2N=C(C=C3NC(=C4)C=C3)CC2)=CC=C1C=C1CCC4=N1 BHPNXACHQYJJJS-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000002647 laser therapy Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- KHPKQFYUPIUARC-UHFFFAOYSA-N lumiracoxib Chemical compound OC(=O)CC1=CC(C)=CC=C1NC1=C(F)C=CC=C1Cl KHPKQFYUPIUARC-UHFFFAOYSA-N 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000000649 photocoagulation Effects 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
- 229960004699 valsartan Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19180700P | 2000-03-24 | 2000-03-24 | |
PCT/EP2001/003265 WO2001074389A2 (en) | 2000-03-24 | 2001-03-22 | Improved treatment of neovascularization |
Publications (1)
Publication Number | Publication Date |
---|---|
UA75350C2 true UA75350C2 (en) | 2006-04-17 |
Family
ID=22707008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2002097520A UA75350C2 (en) | 2000-03-24 | 2001-03-22 | Method for photodynamic treatment of undesirable subfoveal choroidal neovascularization using antiangiogenic agent |
Country Status (21)
Country | Link |
---|---|
US (4) | US20010039438A1 (et) |
EP (1) | EP1265636A2 (et) |
JP (1) | JP2003528926A (et) |
KR (2) | KR20070114856A (et) |
CN (1) | CN100398153C (et) |
AR (1) | AR032151A1 (et) |
AU (2) | AU2001250401B2 (et) |
BR (1) | BR0109499A (et) |
CA (1) | CA2403612A1 (et) |
CZ (1) | CZ20023174A3 (et) |
EE (1) | EE200200547A (et) |
HU (1) | HUP0300347A3 (et) |
IL (1) | IL151833A0 (et) |
MX (1) | MXPA02009351A (et) |
NO (1) | NO20024486L (et) |
NZ (1) | NZ521360A (et) |
PL (1) | PL359027A1 (et) |
RU (1) | RU2271222C2 (et) |
UA (1) | UA75350C2 (et) |
WO (1) | WO2001074389A2 (et) |
ZA (1) | ZA200207638B (et) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0109499A (pt) * | 2000-03-24 | 2002-12-10 | Novartis Ag | Tratamento melhorado de neovascularização |
US20060258562A1 (en) * | 2000-07-31 | 2006-11-16 | Healor Ltd. | Methods and pharmaceutical compositions for healing wounds |
AU2002248284A1 (en) * | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
US7753943B2 (en) * | 2001-02-06 | 2010-07-13 | Qlt Inc. | Reduced fluence rate PDT |
GB0122318D0 (en) * | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
OA12720A (en) * | 2001-11-09 | 2006-06-27 | Eyetech Pharmaceuticals | Methods for treating ocular neovascular diseases. |
CN1708266A (zh) * | 2002-10-03 | 2005-12-14 | 光科学公司 | 用于眼组织中光反应化合物的激发的系统和方法 |
CA2535029C (en) | 2003-08-07 | 2013-07-16 | Healor Ltd. | Pharmaceutical compositions and methods for accelerating wound healing |
US20050043786A1 (en) * | 2003-08-18 | 2005-02-24 | Medtronic Ave, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
FR2867189A1 (fr) * | 2004-03-08 | 2005-09-09 | Ludovic Bourre | Nouveaux composes medicamenteux destines au traitement des pathologies dependantes de l'activite proteine kinase |
US20050244500A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Intravitreal implants in conjuction with photodynamic therapy to improve vision |
WO2006015016A2 (en) | 2004-07-30 | 2006-02-09 | Massachusetts Eye And Ear Infirmary | Photodynamic therapy and compositions for treating ocular glaucoma |
EP2452691A3 (en) | 2005-08-29 | 2012-09-05 | HealOr Ltd. | Methods and compositions for prevention of diabetic and aged skin |
US8753673B2 (en) * | 2006-05-23 | 2014-06-17 | Taiwan Liposome Co. Ltd. | Liposome composition for delivery of a therapeutic agent to eyes |
KR20130121678A (ko) * | 2007-07-30 | 2013-11-06 | 힐로 리미티드 | 약제학적 조성물 및 관련 방법 |
GB0811955D0 (en) | 2008-06-30 | 2008-07-30 | Pci Biotech As | Method |
EP2156834A1 (en) * | 2008-08-08 | 2010-02-24 | S.I.F.I - Società Industria Farmaceutica Italiana - S.P.A. | Ophthalmic pharmaceutical compositions comprising Sorafenib for the treatment of neoangiogenic pathologies of the eye |
KR20120129904A (ko) | 2010-01-14 | 2012-11-28 | 공립대학법인 나고야 시립대학 | 안내 혈관 신생 및/또는 안내 혈관 투과성 항진을 수반하는 질환의 예방 또는 치료를 위한 의약 |
RU2449821C1 (ru) * | 2010-09-01 | 2012-05-10 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "МНИОИ им. П.А.Герцена Минздравсоцразвития России") | Способ модификации фотодинамического лечения |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4883790A (en) | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US5283255A (en) | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
US5095030A (en) | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US4920143A (en) | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
US5214036A (en) | 1990-03-08 | 1993-05-25 | University Of British Columbia | Benzoporphyrin derivatives for photodynamic therapy |
US5770592A (en) | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
CA2087902C (en) | 1992-02-05 | 2006-10-17 | Narendra Raghunathji Desai | Liposome compositions of porphyrin photosensitizers |
PT680365E (pt) * | 1992-11-20 | 2000-07-31 | Univ British Columbia | Activacao de agentes fotossensibilizadores |
US5798349A (en) | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
US5707608A (en) | 1995-08-02 | 1998-01-13 | Qlt Phototherapeutics, Inc. | Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer |
US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
US6117862A (en) * | 1998-10-09 | 2000-09-12 | Qlt, Inc. | Model and method for angiogenesis inhibition |
US6214819B1 (en) * | 1998-11-23 | 2001-04-10 | Novartis Ag | Method for treating ocular neovascular diseases |
AU2713500A (en) * | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6271233B1 (en) * | 1999-08-10 | 2001-08-07 | Ciba Vision Corporation | Method for treating ocular neovascular diseases |
EP1267935A2 (en) * | 2000-01-12 | 2003-01-02 | Light Sciences Corporation | Novel treatment for eye disease |
ES2311507T3 (es) * | 2000-02-10 | 2009-02-16 | MASSACHUSETTS EYE & EAR INFIRMARY | Terapia fotodinamica para tratamiento de afecciones oftalmicas. |
BR0109499A (pt) * | 2000-03-24 | 2002-12-10 | Novartis Ag | Tratamento melhorado de neovascularização |
-
2001
- 2001-03-22 BR BR0109499-8A patent/BR0109499A/pt not_active Application Discontinuation
- 2001-03-22 AU AU2001250401A patent/AU2001250401B2/en not_active Ceased
- 2001-03-22 RU RU2002127778/15A patent/RU2271222C2/ru not_active IP Right Cessation
- 2001-03-22 CA CA002403612A patent/CA2403612A1/en not_active Abandoned
- 2001-03-22 CN CNB018071449A patent/CN100398153C/zh not_active Expired - Fee Related
- 2001-03-22 EP EP01923695A patent/EP1265636A2/en not_active Withdrawn
- 2001-03-22 PL PL01359027A patent/PL359027A1/xx unknown
- 2001-03-22 JP JP2001572131A patent/JP2003528926A/ja active Pending
- 2001-03-22 KR KR1020077027215A patent/KR20070114856A/ko not_active Application Discontinuation
- 2001-03-22 EE EEP200200547A patent/EE200200547A/et unknown
- 2001-03-22 NZ NZ521360A patent/NZ521360A/en unknown
- 2001-03-22 MX MXPA02009351A patent/MXPA02009351A/es not_active Application Discontinuation
- 2001-03-22 UA UA2002097520A patent/UA75350C2/uk unknown
- 2001-03-22 IL IL15183301A patent/IL151833A0/xx unknown
- 2001-03-22 US US09/814,572 patent/US20010039438A1/en not_active Abandoned
- 2001-03-22 AU AU5040101A patent/AU5040101A/xx active Pending
- 2001-03-22 CZ CZ20023174A patent/CZ20023174A3/cs unknown
- 2001-03-22 KR KR1020027012287A patent/KR20020082487A/ko active Search and Examination
- 2001-03-22 WO PCT/EP2001/003265 patent/WO2001074389A2/en active IP Right Grant
- 2001-03-22 AR ARP010101344A patent/AR032151A1/es unknown
- 2001-03-22 HU HU0300347A patent/HUP0300347A3/hu unknown
-
2002
- 2002-09-19 NO NO20024486A patent/NO20024486L/no not_active Application Discontinuation
- 2002-09-23 ZA ZA200207638A patent/ZA200207638B/en unknown
-
2006
- 2006-07-11 US US11/484,473 patent/US20060263392A1/en not_active Abandoned
-
2007
- 2007-10-18 US US11/975,325 patent/US8158669B2/en not_active Expired - Fee Related
-
2012
- 2012-04-16 US US13/448,242 patent/US8862224B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ521360A (en) | 2004-07-30 |
HUP0300347A2 (hu) | 2003-06-28 |
NO20024486D0 (no) | 2002-09-19 |
US20120203162A1 (en) | 2012-08-09 |
US20010039438A1 (en) | 2001-11-08 |
AU2001250401B2 (en) | 2005-08-11 |
AR032151A1 (es) | 2003-10-29 |
CN100398153C (zh) | 2008-07-02 |
US8158669B2 (en) | 2012-04-17 |
US20080096865A1 (en) | 2008-04-24 |
RU2271222C2 (ru) | 2006-03-10 |
MXPA02009351A (es) | 2003-02-12 |
CN1420788A (zh) | 2003-05-28 |
EP1265636A2 (en) | 2002-12-18 |
PL359027A1 (en) | 2004-08-23 |
AU5040101A (en) | 2001-10-15 |
IL151833A0 (en) | 2003-04-10 |
KR20070114856A (ko) | 2007-12-04 |
HUP0300347A3 (en) | 2005-03-29 |
CZ20023174A3 (cs) | 2003-01-15 |
JP2003528926A (ja) | 2003-09-30 |
BR0109499A (pt) | 2002-12-10 |
CA2403612A1 (en) | 2001-10-11 |
KR20020082487A (ko) | 2002-10-31 |
EE200200547A (et) | 2004-02-16 |
US8862224B2 (en) | 2014-10-14 |
ZA200207638B (en) | 2003-10-16 |
US20060263392A1 (en) | 2006-11-23 |
WO2001074389A3 (en) | 2002-07-11 |
NO20024486L (no) | 2002-09-19 |
WO2001074389A2 (en) | 2001-10-11 |
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