ZA200207638B - Improved treatment of neovascularization. - Google Patents
Improved treatment of neovascularization. Download PDFInfo
- Publication number
- ZA200207638B ZA200207638B ZA200207638A ZA200207638A ZA200207638B ZA 200207638 B ZA200207638 B ZA 200207638B ZA 200207638 A ZA200207638 A ZA 200207638A ZA 200207638 A ZA200207638 A ZA 200207638A ZA 200207638 B ZA200207638 B ZA 200207638B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitors
- administration
- angiogenic drug
- angiogenic
- agent
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title description 21
- 206010029113 Neovascularisation Diseases 0.000 title description 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 28
- 238000002428 photodynamic therapy Methods 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- 239000003112 inhibitor Substances 0.000 claims description 18
- 102000003923 Protein Kinase C Human genes 0.000 claims description 8
- 108090000315 Protein Kinase C Proteins 0.000 claims description 8
- 239000003504 photosensitizing agent Substances 0.000 claims description 8
- 150000004032 porphyrins Chemical class 0.000 claims description 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 5
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- BMGQWWVMWDBQGC-IIFHNQTCSA-N midostaurin Chemical compound CN([C@H]1[C@H]([C@]2(C)O[C@@H](N3C4=CC=CC=C4C4=C5C(=O)NCC5=C5C6=CC=CC=C6N2C5=C43)C1)OC)C(=O)C1=CC=CC=C1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 0.000 claims description 5
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 4
- 108010016076 Octreotide Proteins 0.000 claims description 4
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 4
- 229960002700 octreotide Drugs 0.000 claims description 4
- BBNQQADTFFCFGB-UHFFFAOYSA-N purpurin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC(O)=C3C(=O)C2=C1 BBNQQADTFFCFGB-UHFFFAOYSA-N 0.000 claims description 4
- 102000018997 Growth Hormone Human genes 0.000 claims description 3
- 108010051696 Growth Hormone Proteins 0.000 claims description 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 3
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims description 3
- 239000000122 growth hormone Substances 0.000 claims description 3
- 230000001678 irradiating effect Effects 0.000 claims description 3
- YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 claims description 3
- 102000015427 Angiotensins Human genes 0.000 claims description 2
- 108010064733 Angiotensins Proteins 0.000 claims description 2
- 102000003945 NF-kappa B Human genes 0.000 claims description 2
- 108010057466 NF-kappa B Proteins 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 101710096328 Phospholipase A2 Proteins 0.000 claims 1
- 102100026918 Phospholipase A2 Human genes 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 description 11
- 206010060823 Choroidal neovascularisation Diseases 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 230000001772 anti-angiogenic effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000009472 formulation Methods 0.000 description 5
- 230000003902 lesion Effects 0.000 description 3
- 239000000906 photoactive agent Substances 0.000 description 3
- 206010064930 age-related macular degeneration Diseases 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
- 239000002525 vasculotropin inhibitor Substances 0.000 description 2
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
- 239000004072 C09CA03 - Valsartan Substances 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 1
- 229960002411 imatinib Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- KHPKQFYUPIUARC-UHFFFAOYSA-N lumiracoxib Chemical compound OC(=O)CC1=CC(C)=CC=C1NC1=C(F)C=CC=C1Cl KHPKQFYUPIUARC-UHFFFAOYSA-N 0.000 description 1
- DZVCFNFOPIZQKX-LTHRDKTGSA-M merocyanine Chemical compound [Na+].O=C1N(CCCC)C(=O)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 DZVCFNFOPIZQKX-LTHRDKTGSA-M 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000649 photocoagulation Effects 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
- 229960004699 valsartan Drugs 0.000 description 1
- LLDWLPRYLVPDTG-UHFFFAOYSA-N vatalanib succinate Chemical compound OC(=O)CCC(O)=O.C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 LLDWLPRYLVPDTG-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19180700P | 2000-03-24 | 2000-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200207638B true ZA200207638B (en) | 2003-10-16 |
Family
ID=22707008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200207638A ZA200207638B (en) | 2000-03-24 | 2002-09-23 | Improved treatment of neovascularization. |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US20010039438A1 (et) |
| EP (1) | EP1265636A2 (et) |
| JP (1) | JP2003528926A (et) |
| KR (2) | KR20070114856A (et) |
| CN (1) | CN100398153C (et) |
| AR (1) | AR032151A1 (et) |
| AU (2) | AU2001250401B2 (et) |
| BR (1) | BR0109499A (et) |
| CA (1) | CA2403612A1 (et) |
| CZ (1) | CZ20023174A3 (et) |
| EE (1) | EE200200547A (et) |
| HU (1) | HUP0300347A3 (et) |
| IL (1) | IL151833A0 (et) |
| MX (1) | MXPA02009351A (et) |
| NO (1) | NO20024486L (et) |
| NZ (1) | NZ521360A (et) |
| PL (1) | PL359027A1 (et) |
| RU (1) | RU2271222C2 (et) |
| UA (1) | UA75350C2 (et) |
| WO (1) | WO2001074389A2 (et) |
| ZA (1) | ZA200207638B (et) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR032151A1 (es) * | 2000-03-24 | 2003-10-29 | Novartis Ag | Uso de un farmaco anti-angiogenico en conjunto con un agente fotosensible para la preparacion de un medicamento para el tratamiento fotodinamico mejorado de la neovasculatura indeseada |
| US20060258562A1 (en) * | 2000-07-31 | 2006-11-16 | Healor Ltd. | Methods and pharmaceutical compositions for healing wounds |
| AU2002248284A1 (en) * | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
| US7753943B2 (en) * | 2001-02-06 | 2010-07-13 | Qlt Inc. | Reduced fluence rate PDT |
| GB0122318D0 (en) * | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
| PL371929A1 (en) * | 2001-11-09 | 2005-07-11 | Eyetech Pharmaceuticals | Methods for treating ocular neovascular diseases |
| CN1708266A (zh) | 2002-10-03 | 2005-12-14 | 光科学公司 | 用于眼组织中光反应化合物的激发的系统和方法 |
| CN102120031B (zh) | 2003-08-07 | 2012-12-05 | 希尔洛有限公司 | 用于加速伤口愈合的药物组合物和方法 |
| US20050043786A1 (en) * | 2003-08-18 | 2005-02-24 | Medtronic Ave, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
| FR2867189A1 (fr) * | 2004-03-08 | 2005-09-09 | Ludovic Bourre | Nouveaux composes medicamenteux destines au traitement des pathologies dependantes de l'activite proteine kinase |
| US20050244500A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Intravitreal implants in conjuction with photodynamic therapy to improve vision |
| WO2006015016A2 (en) * | 2004-07-30 | 2006-02-09 | Massachusetts Eye And Ear Infirmary | Photodynamic therapy and compositions for treating ocular glaucoma |
| EP2462944A3 (en) | 2005-08-29 | 2012-09-12 | HealOr Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
| US8753673B2 (en) * | 2006-05-23 | 2014-06-17 | Taiwan Liposome Co. Ltd. | Liposome composition for delivery of a therapeutic agent to eyes |
| CA2694927A1 (en) * | 2007-07-30 | 2009-02-05 | Healor Ltd. | Compositions for wound healing comprising insulin and an alpha-pkc inhibitor and being free of calcium and magnesium ions |
| GB0811955D0 (en) | 2008-06-30 | 2008-07-30 | Pci Biotech As | Method |
| EP2156834A1 (en) * | 2008-08-08 | 2010-02-24 | S.I.F.I - Società Industria Farmaceutica Italiana - S.P.A. | Ophthalmic pharmaceutical compositions comprising Sorafenib for the treatment of neoangiogenic pathologies of the eye |
| CN102711756A (zh) | 2010-01-14 | 2012-10-03 | 株式会社三和化学研究所 | 用于预防或治疗伴有眼内血管生成及/或眼内血管通透性增高的疾病的药物 |
| RU2449821C1 (ru) * | 2010-09-01 | 2012-05-10 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "МНИОИ им. П.А.Герцена Минздравсоцразвития России") | Способ модификации фотодинамического лечения |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5095030A (en) | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US4920143A (en) | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
| US4883790A (en) | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5283255A (en) | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5214036A (en) | 1990-03-08 | 1993-05-25 | University Of British Columbia | Benzoporphyrin derivatives for photodynamic therapy |
| US5770592A (en) | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
| CA2087902C (en) | 1992-02-05 | 2006-10-17 | Narendra Raghunathji Desai | Liposome compositions of porphyrin photosensitizers |
| CA2149636C (en) * | 1992-11-20 | 2001-04-03 | Anna M. Richter | Method of activating photosensitive agents |
| US5798349A (en) | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
| US5707608A (en) | 1995-08-02 | 1998-01-13 | Qlt Phototherapeutics, Inc. | Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer |
| US5756541A (en) | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
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| AU2001227837A1 (en) * | 2000-01-12 | 2001-07-24 | Light Sciences Corporation | Novel treatment for eye disease |
| EP1253943B1 (en) * | 2000-02-10 | 2008-09-03 | MASSACHUSETTS EYE & EAR INFIRMARY | Photodynamic therapy for treating conditions of the eye |
| AR032151A1 (es) * | 2000-03-24 | 2003-10-29 | Novartis Ag | Uso de un farmaco anti-angiogenico en conjunto con un agente fotosensible para la preparacion de un medicamento para el tratamiento fotodinamico mejorado de la neovasculatura indeseada |
-
2001
- 2001-03-22 AR ARP010101344A patent/AR032151A1/es unknown
- 2001-03-22 CN CNB018071449A patent/CN100398153C/zh not_active Expired - Fee Related
- 2001-03-22 BR BR0109499-8A patent/BR0109499A/pt not_active Application Discontinuation
- 2001-03-22 RU RU2002127778/15A patent/RU2271222C2/ru not_active IP Right Cessation
- 2001-03-22 AU AU2001250401A patent/AU2001250401B2/en not_active Ceased
- 2001-03-22 KR KR1020077027215A patent/KR20070114856A/ko not_active Application Discontinuation
- 2001-03-22 UA UA2002097520A patent/UA75350C2/uk unknown
- 2001-03-22 IL IL15183301A patent/IL151833A0/xx unknown
- 2001-03-22 WO PCT/EP2001/003265 patent/WO2001074389A2/en active IP Right Grant
- 2001-03-22 KR KR1020027012287A patent/KR20020082487A/ko active Search and Examination
- 2001-03-22 EE EEP200200547A patent/EE200200547A/et unknown
- 2001-03-22 PL PL01359027A patent/PL359027A1/xx unknown
- 2001-03-22 JP JP2001572131A patent/JP2003528926A/ja active Pending
- 2001-03-22 AU AU5040101A patent/AU5040101A/xx active Pending
- 2001-03-22 CA CA002403612A patent/CA2403612A1/en not_active Abandoned
- 2001-03-22 MX MXPA02009351A patent/MXPA02009351A/es not_active Application Discontinuation
- 2001-03-22 EP EP01923695A patent/EP1265636A2/en not_active Withdrawn
- 2001-03-22 NZ NZ521360A patent/NZ521360A/en unknown
- 2001-03-22 CZ CZ20023174A patent/CZ20023174A3/cs unknown
- 2001-03-22 US US09/814,572 patent/US20010039438A1/en not_active Abandoned
- 2001-03-22 HU HU0300347A patent/HUP0300347A3/hu unknown
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2002
- 2002-09-19 NO NO20024486A patent/NO20024486L/no not_active Application Discontinuation
- 2002-09-23 ZA ZA200207638A patent/ZA200207638B/en unknown
-
2006
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2007
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2012
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Also Published As
| Publication number | Publication date |
|---|---|
| PL359027A1 (en) | 2004-08-23 |
| US20120203162A1 (en) | 2012-08-09 |
| IL151833A0 (en) | 2003-04-10 |
| WO2001074389A3 (en) | 2002-07-11 |
| KR20020082487A (ko) | 2002-10-31 |
| HUP0300347A2 (hu) | 2003-06-28 |
| UA75350C2 (en) | 2006-04-17 |
| MXPA02009351A (es) | 2003-02-12 |
| EP1265636A2 (en) | 2002-12-18 |
| NO20024486D0 (no) | 2002-09-19 |
| US20060263392A1 (en) | 2006-11-23 |
| KR20070114856A (ko) | 2007-12-04 |
| WO2001074389A2 (en) | 2001-10-11 |
| RU2271222C2 (ru) | 2006-03-10 |
| US8862224B2 (en) | 2014-10-14 |
| CN100398153C (zh) | 2008-07-02 |
| AR032151A1 (es) | 2003-10-29 |
| JP2003528926A (ja) | 2003-09-30 |
| AU5040101A (en) | 2001-10-15 |
| CZ20023174A3 (cs) | 2003-01-15 |
| AU2001250401B2 (en) | 2005-08-11 |
| NZ521360A (en) | 2004-07-30 |
| US8158669B2 (en) | 2012-04-17 |
| CN1420788A (zh) | 2003-05-28 |
| US20080096865A1 (en) | 2008-04-24 |
| NO20024486L (no) | 2002-09-19 |
| CA2403612A1 (en) | 2001-10-11 |
| EE200200547A (et) | 2004-02-16 |
| US20010039438A1 (en) | 2001-11-08 |
| HUP0300347A3 (en) | 2005-03-29 |
| BR0109499A (pt) | 2002-12-10 |
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