UA66401C2 - 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same - Google Patents
3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same Download PDFInfo
- Publication number
- UA66401C2 UA66401C2 UA2001064521A UA2001064521A UA66401C2 UA 66401 C2 UA66401 C2 UA 66401C2 UA 2001064521 A UA2001064521 A UA 2001064521A UA 2001064521 A UA2001064521 A UA 2001064521A UA 66401 C2 UA66401 C2 UA 66401C2
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- UA
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- Prior art keywords
- alkyl
- group
- substituted
- cycloalkyl
- tert
- Prior art date
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- -1 aryl nitrone compounds Chemical class 0.000 title claims abstract description 84
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 42
- 150000001875 compounds Chemical class 0.000 claims abstract description 146
- 230000004054 inflammatory process Effects 0.000 claims abstract description 21
- 206010061218 Inflammation Diseases 0.000 claims abstract description 19
- 241000124008 Mammalia Species 0.000 claims abstract description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 108
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 82
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 49
- 125000004432 carbon atom Chemical group C* 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 45
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 44
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 44
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 37
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 33
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 27
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 23
- 125000000304 alkynyl group Chemical group 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 22
- 125000002947 alkylene group Chemical group 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 19
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 19
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 15
- 125000005156 substituted alkylene group Chemical group 0.000 claims description 15
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 12
- 125000005806 3,4,5-trimethoxybenzyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])* 0.000 claims description 11
- 125000001318 4-trifluoromethylbenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C(F)(F)F 0.000 claims description 11
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- 239000001257 hydrogen Substances 0.000 claims description 10
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- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 6
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims description 6
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- 239000001301 oxygen Substances 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 5
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 8
- 125000004104 aryloxy group Chemical group 0.000 description 8
- 230000005764 inhibitory process Effects 0.000 description 8
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 description 8
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- YIBNHAJFJUQSRA-YNNPMVKQSA-N prostaglandin H2 Chemical compound C1[C@@H]2OO[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@H]2C\C=C/CCCC(O)=O YIBNHAJFJUQSRA-YNNPMVKQSA-N 0.000 description 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000012748 slip agent Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 239000001962 taste-modifying agent Substances 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 150000003595 thromboxanes Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229960003414 zomepirac Drugs 0.000 description 1
- ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11054198P | 1998-12-02 | 1998-12-02 | |
| PCT/US1999/028479 WO2000032567A1 (fr) | 1998-12-02 | 1999-12-01 | Composes de 3,4,5-arylnitrones trisubstitues et compositions pharmaceutiques contenant lesdits composes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA66401C2 true UA66401C2 (en) | 2004-05-17 |
Family
ID=22333591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2001064521A UA66401C2 (en) | 1998-12-02 | 1999-01-12 | 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6342523B1 (fr) |
| EP (1) | EP1135367A1 (fr) |
| JP (1) | JP2002531435A (fr) |
| KR (1) | KR20010087407A (fr) |
| CN (1) | CN1334800A (fr) |
| AU (1) | AU773343B2 (fr) |
| BR (1) | BR9915886A (fr) |
| CA (1) | CA2353402A1 (fr) |
| CZ (1) | CZ20011830A3 (fr) |
| EA (1) | EA004931B1 (fr) |
| HK (1) | HK1044147A1 (fr) |
| HU (1) | HUP0104576A3 (fr) |
| IL (1) | IL143506A0 (fr) |
| IS (1) | IS5958A (fr) |
| NO (1) | NO20012727L (fr) |
| NZ (1) | NZ512032A (fr) |
| PL (1) | PL349916A1 (fr) |
| SK (1) | SK7502001A3 (fr) |
| UA (1) | UA66401C2 (fr) |
| WO (1) | WO2000032567A1 (fr) |
| ZA (1) | ZA200104378B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050107366A1 (en) * | 1991-06-18 | 2005-05-19 | Carney John M. | Spin trapping pharmaceutical compositions and methods for use thereof |
| US6730700B2 (en) | 1998-12-02 | 2004-05-04 | Renovis, Inc. | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same |
| US6835754B2 (en) | 2001-01-08 | 2004-12-28 | Renovis, Inc. | Use of aryl nitrone compounds in methods for treating neuropathic pain |
| US20030045461A1 (en) * | 2001-09-06 | 2003-03-06 | Jen-Chang Hsia | Composition and methods of esterified nitroxides gated with carboxylic acids |
| TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
| TW200403240A (en) * | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| US7115666B2 (en) * | 2002-10-15 | 2006-10-03 | Renovis, Inc. | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain |
| US20050059638A1 (en) * | 2003-08-04 | 2005-03-17 | Kelly Michael G. | Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders |
| US20050182060A1 (en) * | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
| US20050215646A1 (en) * | 2004-03-09 | 2005-09-29 | Renovis, Inc. | Methods for treating multiple sclerosis and pharmaceutical compositions therefor |
| JP5611056B2 (ja) | 2008-02-12 | 2014-10-22 | トスク インコーポレーティッド | 毒性を低減するためのドキソルビシンアジュバントおよびその使用法 |
| CN101468970B (zh) * | 2008-04-25 | 2011-05-11 | 暨南大学 | 一种硝酮类化合物及其制备方法和在制药中的应用 |
| CN102311396B (zh) * | 2010-07-05 | 2015-01-07 | 暨南大学 | 一种吡嗪类衍生物和其制备方法及在制药中的应用 |
| WO2013067084A1 (fr) * | 2011-11-01 | 2013-05-10 | The Florida International University Board Of Trustees | Pièges de spin d'azulényl nitrone silylée comme détecteurs de superoxyde chromotropes |
| CN104803880B (zh) * | 2014-01-23 | 2017-11-21 | 广州喜鹊医药有限公司 | 一种具有神经保护作用的化合物及其制备方法和应用 |
| CN109438288B (zh) * | 2018-10-22 | 2021-05-07 | 河南中医药大学 | 一种n-硝酮取代芳香酰胺衍生物及其制备方法 |
| US20240165148A1 (en) | 2021-03-15 | 2024-05-23 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4224340A (en) | 1977-10-06 | 1980-09-23 | William H. Rorer, Inc. | Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds |
| GB2137619A (en) | 1983-03-30 | 1984-10-10 | Gerald Scott | Nitrone compounds and stabilised rubber compositions containing them |
| GB8813339D0 (en) * | 1988-06-06 | 1988-07-13 | Sandoz Ltd | Improvements in/relating to organic compounds |
| FI93954C (fi) | 1988-11-29 | 1995-06-26 | Warner Lambert Co | Menetelmä lääkeaineina käyttökelpoisten 3,5-di-tert-butyyli-4-hydroksifenyylisubstituoitujen 1,2,4- ja 1,3,4-tiadiatsolien sekä oksadiatsolien ja triatsolien valmistamiseksi |
| ES2044829T3 (es) | 1989-10-17 | 1995-01-16 | Oklahoma Med Res Found | Metodo y composiciones para la inhibicion de alteraciones asociadas con las lesiones oxidativas de los tejidos. |
| US5622994A (en) | 1989-10-17 | 1997-04-22 | Oklahoma Medical Research Foundation | Spin trapping pharmaceutical compositions and methods for use thereof |
| US5025032A (en) * | 1989-10-17 | 1991-06-18 | Oklahoma Medical Research Foundation | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
| US5036097A (en) | 1989-10-17 | 1991-07-30 | Oklahoma Medical Research Foundation | Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration |
| US5143928A (en) | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
| US6002001A (en) | 1991-06-18 | 1999-12-14 | Oklahoma Medical Research Foundation | Spin trapping pharmaceutical compositions and methods for use thereof |
| US5270319A (en) | 1991-09-09 | 1993-12-14 | Warner-Lambert Company | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents |
| US5215986A (en) | 1992-06-01 | 1993-06-01 | Warner-Lambert Company | 5-hydroxy-2-pyrimidinylmethylene oxaza heterocycles |
| US5840746A (en) | 1993-06-24 | 1998-11-24 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
| US5455272A (en) | 1993-10-22 | 1995-10-03 | Oklahoma Medical Research Foundation | Spin trap nitronyl hindered phenols |
| US5488145A (en) | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
| NZ332561A (en) * | 1996-04-23 | 2001-01-26 | Centaur Pharmaceuticals Inc | Compositions comprising a nitrone compound for use in treating ocular inflammation |
| JP2000514822A (ja) | 1996-07-19 | 2000-11-07 | センター ファーマシューティカルズ，インコーポレイテッド | フランニトロン化合物 |
| TW429241B (en) * | 1996-09-26 | 2001-04-11 | Sumitomo Pharma | Nitrone derivatives |
| US5994396A (en) | 1997-08-18 | 1999-11-30 | Centaur Pharmaceuticals, Inc. | Furansulfonic acid derivatives and pharmaceutical compositions containing the same |
| MA26553A1 (fr) * | 1997-10-17 | 2004-12-20 | Centaur Pharmaceuticals Inc | Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la |
| CN1136212C (zh) | 1998-01-16 | 2004-01-28 | 桑道药品有限公司 | 噻吩硝酮化合物 |
| EP1047683A1 (fr) | 1998-01-16 | 2000-11-02 | Centaur Pharmaceuticals, Inc. | Composes de nitrone thioether furane |
| WO1999045909A2 (fr) | 1998-03-13 | 1999-09-16 | Centaur Pharmaceuticals | Inhibition de l'angiogenese |
| DE69918826T2 (de) | 1998-05-19 | 2004-12-02 | Renovis, Inc., South San Francisco | Arylnitron therapeutische mittel zur behandlung von entzündlichen darmerkrankungen |
-
1999
- 1999-01-12 UA UA2001064521A patent/UA66401C2/uk unknown
- 1999-12-01 SK SK750-2001A patent/SK7502001A3/sk unknown
- 1999-12-01 CN CN99815924A patent/CN1334800A/zh active Pending
- 1999-12-01 IL IL14350699A patent/IL143506A0/xx unknown
- 1999-12-01 CA CA002353402A patent/CA2353402A1/fr not_active Abandoned
- 1999-12-01 EP EP99962967A patent/EP1135367A1/fr not_active Withdrawn
- 1999-12-01 WO PCT/US1999/028479 patent/WO2000032567A1/fr not_active Application Discontinuation
- 1999-12-01 KR KR1020017006908A patent/KR20010087407A/ko not_active Application Discontinuation
- 1999-12-01 AU AU19298/00A patent/AU773343B2/en not_active Ceased
- 1999-12-01 CZ CZ20011830A patent/CZ20011830A3/cs unknown
- 1999-12-01 NZ NZ512032A patent/NZ512032A/xx unknown
- 1999-12-01 BR BR9915886-8A patent/BR9915886A/pt not_active IP Right Cessation
- 1999-12-01 HU HU0104576A patent/HUP0104576A3/hu unknown
- 1999-12-01 EA EA200100607A patent/EA004931B1/ru not_active IP Right Cessation
- 1999-12-01 US US09/452,529 patent/US6342523B1/en not_active Expired - Fee Related
- 1999-12-01 PL PL99349916A patent/PL349916A1/xx unknown
- 1999-12-01 JP JP2000585209A patent/JP2002531435A/ja not_active Withdrawn
-
2001
- 2001-05-28 ZA ZA200104378A patent/ZA200104378B/en unknown
- 2001-05-31 IS IS5958A patent/IS5958A/is unknown
- 2001-06-01 NO NO20012727A patent/NO20012727L/no not_active Application Discontinuation
-
2002
- 2002-08-05 HK HK02105710.6A patent/HK1044147A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ512032A (en) | 2004-02-27 |
| EP1135367A1 (fr) | 2001-09-26 |
| SK7502001A3 (en) | 2002-02-05 |
| JP2002531435A (ja) | 2002-09-24 |
| AU1929800A (en) | 2000-06-19 |
| EA200100607A1 (ru) | 2001-12-24 |
| WO2000032567A1 (fr) | 2000-06-08 |
| CZ20011830A3 (cs) | 2001-10-17 |
| PL349916A1 (en) | 2002-10-07 |
| CA2353402A1 (fr) | 2000-06-08 |
| IL143506A0 (en) | 2002-04-21 |
| EA004931B1 (ru) | 2004-10-28 |
| NO20012727D0 (no) | 2001-06-01 |
| CN1334800A (zh) | 2002-02-06 |
| HK1044147A1 (zh) | 2002-10-11 |
| IS5958A (is) | 2001-05-31 |
| US6342523B1 (en) | 2002-01-29 |
| HUP0104576A2 (hu) | 2002-05-29 |
| NO20012727L (no) | 2001-07-26 |
| ZA200104378B (en) | 2002-08-28 |
| BR9915886A (pt) | 2001-08-21 |
| AU773343B2 (en) | 2004-05-20 |
| HUP0104576A3 (en) | 2002-11-28 |
| KR20010087407A (ko) | 2001-09-15 |
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