CA2311129A1 - Utilisation de composes de diphenyle indanone, indane et indole substitues dans le traitement ou la prevention de la drepanocytose, des maladies inflammatoires caracterisees par une proliferation cellulaire anormale et par la diarrhee chez l'homme et l'animal - Google Patents
Utilisation de composes de diphenyle indanone, indane et indole substitues dans le traitement ou la prevention de la drepanocytose, des maladies inflammatoires caracterisees par une proliferation cellulaire anormale et par la diarrhee chez l'homme et l'animal Download PDFInfo
- Publication number
- CA2311129A1 CA2311129A1 CA002311129A CA2311129A CA2311129A1 CA 2311129 A1 CA2311129 A1 CA 2311129A1 CA 002311129 A CA002311129 A CA 002311129A CA 2311129 A CA2311129 A CA 2311129A CA 2311129 A1 CA2311129 A1 CA 2311129A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- substituted
- independently selected
- absent
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CC(c1ccccc1)(C1=CCCC=C1)C1=CC=C*C=C1 Chemical compound CC(c1ccccc1)(C1=CCCC=C1)C1=CC=C*C=C1 0.000 description 3
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
La présente invention porte sur des composés 3,3-diphényle indanone, indane et indole substitués, et sur leurs analogues, qui sont des inhibiteurs spécifiques, puissants et sûrs des vannes à potassium activées par Ca?2+¿ (canal Gardos) des hématies, de la prolifération cellulaire mammalienne et/ou de la sécrétion de chlorure électrogénique transépithélial stimulée par le sécrétagogue dans les cellules intestinales. Ces composés peuvent être utilisés pour réduire la déshydratation drépanocytaire et/ou retarder l'apparition de la falciformation ou déformation des hématies in situ dans des méthodes thérapeutiques utilisées dans le traitement ou la prévention de la drépanocytose. Ces composés peuvent être également utilisés pour inhiber la prolifération des cellules mammaliennes in situ dans des méthodes thérapeutiques utilisées dans le traitement ou la prévention de maladies caractérisées par une prolifération cellulaire anormale, ainsi que pour inhiber la sécrétion de chlorure dans les cellules intestinales dans des méthodes thérapeutiques utilisées dans le traitement de la diarrhée chez l'homme et l'animal.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97559597A | 1997-11-20 | 1997-11-20 | |
US08/975,595 | 1997-11-20 | ||
US15933698A | 1998-09-23 | 1998-09-23 | |
US09/159,336 | 1998-09-23 | ||
US09/159,331 US20020004519A1 (en) | 1998-09-23 | 1998-09-23 | Method for reducing chloride secetion by intestinal epithlial cells in situ |
US09/159,331 | 1998-09-23 | ||
PCT/US1998/024968 WO1999026624A1 (fr) | 1997-11-20 | 1998-11-20 | Utilisation de composes de diphenyle indanone, indane et indole substitues dans le traitement ou la prevention de la drepanocytose, des maladies inflammatoires caracterisees par une proliferation cellulaire anormale et par la diarrhee chez l'homme et l'animal |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2311129A1 true CA2311129A1 (fr) | 1999-06-03 |
Family
ID=27388300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002311129A Abandoned CA2311129A1 (fr) | 1997-11-20 | 1998-11-20 | Utilisation de composes de diphenyle indanone, indane et indole substitues dans le traitement ou la prevention de la drepanocytose, des maladies inflammatoires caracterisees par une proliferation cellulaire anormale et par la diarrhee chez l'homme et l'animal |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1032385A1 (fr) |
JP (1) | JP2001523717A (fr) |
AU (1) | AU1598899A (fr) |
CA (1) | CA2311129A1 (fr) |
IL (1) | IL136208A0 (fr) |
WO (1) | WO1999026624A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6800658B2 (en) | 1997-11-20 | 2004-10-05 | Children's Medical Center Corporation | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation |
US6291449B1 (en) | 1998-09-23 | 2001-09-18 | Children's Medical Center Corporation | Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours |
NL1034882C2 (nl) | 2008-01-02 | 2009-07-06 | Gear Chain Ind Bv | Inrichting voor het rekken van een transmissieketting. |
WO2013014659A1 (fr) * | 2011-07-22 | 2013-01-31 | Venantius Limited | Dérivés d'indène pouvant être utilisés dans le traitement des maladies inflammatoires de l'intestin |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5273992A (en) * | 1992-11-02 | 1993-12-28 | Beth Israel Hospital Assoc. Inc. | Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ |
DE69534632T2 (de) * | 1994-09-16 | 2006-06-14 | Childrens Medical Center | Clotrimazol-Metaboliten bei der Behandlung von Sichelzellenkrankheit |
AU6966696A (en) * | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
JP4376970B2 (ja) * | 1996-03-20 | 2009-12-02 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 鎌状赤血球症のためのトリアリールメタン化合物 |
-
1998
- 1998-11-20 AU AU15988/99A patent/AU1598899A/en not_active Abandoned
- 1998-11-20 IL IL13620898A patent/IL136208A0/xx unknown
- 1998-11-20 CA CA002311129A patent/CA2311129A1/fr not_active Abandoned
- 1998-11-20 JP JP2000521826A patent/JP2001523717A/ja not_active Withdrawn
- 1998-11-20 EP EP98960381A patent/EP1032385A1/fr not_active Withdrawn
- 1998-11-20 WO PCT/US1998/024968 patent/WO1999026624A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2001523717A (ja) | 2001-11-27 |
IL136208A0 (en) | 2001-05-20 |
WO1999026624A1 (fr) | 1999-06-03 |
AU1598899A (en) | 1999-06-15 |
EP1032385A1 (fr) | 2000-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |