UA64714C2 - Dervatives of substituted 2-methyl benzimidazole, a method for preparing thereof, a pharmaceutical composition and a method for treatment of gastrointestinal diseases - Google Patents
Dervatives of substituted 2-methyl benzimidazole, a method for preparing thereof, a pharmaceutical composition and a method for treatment of gastrointestinal diseases Download PDFInfo
- Publication number
- UA64714C2 UA64714C2 UA98126867A UA98126867A UA64714C2 UA 64714 C2 UA64714 C2 UA 64714C2 UA 98126867 A UA98126867 A UA 98126867A UA 98126867 A UA98126867 A UA 98126867A UA 64714 C2 UA64714 C2 UA 64714C2
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- UA
- Ukraine
- Prior art keywords
- compound according
- compound
- formula
- pharmaceutically acceptable
- acceptable salt
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 10
- 208000018522 Gastrointestinal disease Diseases 0.000 title claims description 8
- LDZYRENCLPUXAX-UHFFFAOYSA-N 2-methyl-1h-benzimidazole Chemical class C1=CC=C2NC(C)=NC2=C1 LDZYRENCLPUXAX-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 16
- 230000002265 prevention Effects 0.000 claims abstract description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
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- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- UWYVPFMHMJIBHE-OWOJBTEDSA-N hydroxymaleic acid group Chemical group O/C(/C(=O)O)=C/C(=O)O UWYVPFMHMJIBHE-OWOJBTEDSA-N 0.000 description 1
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- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
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- GRNIQEQKQMSSSZ-UHFFFAOYSA-N n-[(2,6-diethylphenyl)methyl]-2-methyl-1h-benzimidazol-4-amine Chemical compound CCC1=CC=CC(CC)=C1CNC1=CC=CC2=C1NC(C)=N2 GRNIQEQKQMSSSZ-UHFFFAOYSA-N 0.000 description 1
- QTGWIBNVFTVALF-UHFFFAOYSA-N n-benzyl-2-methyl-1h-benzimidazol-4-amine Chemical compound C=12NC(C)=NC2=CC=CC=1NCC1=CC=CC=C1 QTGWIBNVFTVALF-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 229960000564 nitrofurantoin Drugs 0.000 description 1
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
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- 210000000496 pancreas Anatomy 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- ANRIQLNBZQLTFV-DZUOILHNSA-N pentagastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1[C]2C=CC=CC2=NC=1)NC(=O)CCNC(=O)OC(C)(C)C)CCSC)C(N)=O)C1=CC=CC=C1 ANRIQLNBZQLTFV-DZUOILHNSA-N 0.000 description 1
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- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- DDFYFBUWEBINLX-UHFFFAOYSA-M tetramethylammonium bromide Chemical compound [Br-].C[N+](C)(C)C DDFYFBUWEBINLX-UHFFFAOYSA-M 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
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- 239000002132 β-lactam antibiotic Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9602286A SE9602286D0 (sv) | 1996-06-10 | 1996-06-10 | New compounds |
| PCT/SE1997/000991 WO1997047603A1 (en) | 1996-06-10 | 1997-06-05 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA64714C2 true UA64714C2 (en) | 2004-03-15 |
Family
ID=20402945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA98126867A UA64714C2 (en) | 1996-06-10 | 1997-05-06 | Dervatives of substituted 2-methyl benzimidazole, a method for preparing thereof, a pharmaceutical composition and a method for treatment of gastrointestinal diseases |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6465505B1 (cs) |
| EP (1) | EP0906288B1 (cs) |
| JP (1) | JP2000512291A (cs) |
| CN (1) | CN1101385C (cs) |
| AR (1) | AR007352A1 (cs) |
| AT (1) | ATE227273T1 (cs) |
| AU (1) | AU712173B2 (cs) |
| BR (1) | BR9709666A (cs) |
| CA (1) | CA2256687C (cs) |
| CZ (1) | CZ291469B6 (cs) |
| DE (1) | DE69716904T2 (cs) |
| DK (1) | DK0906288T3 (cs) |
| EE (1) | EE03682B1 (cs) |
| ES (1) | ES2184097T3 (cs) |
| HU (1) | HUP0002952A3 (cs) |
| ID (1) | ID18431A (cs) |
| IL (1) | IL127432A0 (cs) |
| IS (1) | IS1864B (cs) |
| MY (1) | MY119012A (cs) |
| NO (1) | NO311672B1 (cs) |
| NZ (1) | NZ332965A (cs) |
| PL (1) | PL330525A1 (cs) |
| PT (1) | PT906288E (cs) |
| RU (1) | RU2184113C2 (cs) |
| SA (1) | SA97180427B1 (cs) |
| SE (1) | SE9602286D0 (cs) |
| SK (1) | SK282704B6 (cs) |
| TR (1) | TR199802554T2 (cs) |
| TW (1) | TW470742B (cs) |
| UA (1) | UA64714C2 (cs) |
| WO (1) | WO1997047603A1 (cs) |
| ZA (1) | ZA974681B (cs) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
| AR043063A1 (es) * | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| NZ542177A (en) * | 2003-04-04 | 2009-02-28 | Altana Pharma Ag | Cyclic benzimidazoles for use against gastrointestinal disorders |
| AR046893A1 (es) * | 2003-12-16 | 2005-12-28 | Altana Pharma Ag | Bencimidazoles triciclicos |
| AR048869A1 (es) * | 2004-04-26 | 2006-06-07 | Altana Pharma Ag | Bencimidazoles triciclicos |
| AR049168A1 (es) * | 2004-05-18 | 2006-07-05 | Altana Pharma Ag | Derivados de benzimidazol |
| EP1758900B1 (en) * | 2004-06-09 | 2007-10-03 | Nycomed GmbH | Substituted tricyclic benzimidazoles |
| CA2582256A1 (en) * | 2004-10-01 | 2006-04-13 | Altana Pharma Ag | Substituted tricyclic benzimidazoles |
| AR051041A1 (es) * | 2004-10-04 | 2006-12-13 | Altana Pharma Ag | Bencimidazoles triciclicos condensados |
| JP2008543824A (ja) * | 2005-06-14 | 2008-12-04 | ファイザー株式会社 | アシッドポンプアンタゴニストとしてのクロマン置換ベンゾイミダゾール誘導体 |
| EP1926714A1 (en) * | 2005-08-22 | 2008-06-04 | Nycomed GmbH | Isotopically substituted benzimidazole derivatives |
| ATE471319T1 (de) * | 2005-12-19 | 2010-07-15 | Raqualia Pharma Inc | Chromansubstituierte benzimidazole und ihre verwendung als säurepumpenhemmer |
| WO2007072142A2 (en) * | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Benzimidazole-5-carboxamide derivatives |
| US20080027044A1 (en) * | 2006-06-13 | 2008-01-31 | Kim Lewis | Prodrug antibiotic screens |
| WO2008060522A2 (en) * | 2006-11-10 | 2008-05-22 | The Regents Of The University Of California | Atmospheric pressure plasma-induced graft polymerization |
| WO2008156610A2 (en) * | 2007-06-13 | 2008-12-24 | Northeastern University | Antibiotic compounds |
| WO2008151927A2 (en) * | 2007-06-15 | 2008-12-18 | Nycomed Gmbh | 6-n-substituted benz imidazole derivatives as acid pump antagonists |
| US8445076B2 (en) * | 2008-06-11 | 2013-05-21 | The Regents Of The University Of California | Fouling and scaling resistant nano-structured reverse osmosis membranes |
| KR101472686B1 (ko) | 2013-07-09 | 2014-12-16 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
| EP4620957A1 (en) * | 2024-03-22 | 2025-09-24 | Eberhard Karls Universität Tübingen | Imidazo[4,5-b]pyridin-7-amine compounds binding aurora kinase a and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1183503A1 (ru) * | 1983-07-08 | 1985-10-07 | Ростовский Ордена Трудового Красного Знамени Государственный Университет Им.М.А.Суслова | Способ получени @ -замещенных имидазолов или бензимидазолов |
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| EP0266336B1 (de) * | 1986-10-29 | 1991-05-15 | Dieter Prof. Dr. Binder | Neue 1-/ 3-(2-Dialkylaminoäthoxy)-2-thienyl/-3-phenyl-1-propanone und ihre Säureadditionssalze und Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| EP0774462A4 (en) | 1994-08-03 | 1997-10-29 | Fujisawa Pharmaceutical Co | HETEROCYCLIC COMPOUND |
| SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
-
1996
- 1996-06-10 SE SE9602286A patent/SE9602286D0/xx unknown
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1997
- 1997-05-06 UA UA98126867A patent/UA64714C2/uk unknown
- 1997-05-28 ZA ZA974681A patent/ZA974681B/xx unknown
- 1997-05-29 TW TW086107338A patent/TW470742B/zh active
- 1997-05-30 AR ARP970102342A patent/AR007352A1/es unknown
- 1997-06-05 DE DE69716904T patent/DE69716904T2/de not_active Expired - Fee Related
- 1997-06-05 JP JP10501511A patent/JP2000512291A/ja not_active Ceased
- 1997-06-05 PT PT97927552T patent/PT906288E/pt unknown
- 1997-06-05 RU RU99100397/04A patent/RU2184113C2/ru not_active IP Right Cessation
- 1997-06-05 CN CN97196704A patent/CN1101385C/zh not_active Expired - Fee Related
- 1997-06-05 PL PL97330525A patent/PL330525A1/xx unknown
- 1997-06-05 US US08/875,132 patent/US6465505B1/en not_active Expired - Lifetime
- 1997-06-05 BR BR9709666-0A patent/BR9709666A/pt not_active Application Discontinuation
- 1997-06-05 EE EE9800430A patent/EE03682B1/xx not_active IP Right Cessation
- 1997-06-05 AT AT97927552T patent/ATE227273T1/de not_active IP Right Cessation
- 1997-06-05 DK DK97927552T patent/DK0906288T3/da active
- 1997-06-05 AU AU31992/97A patent/AU712173B2/en not_active Ceased
- 1997-06-05 NZ NZ332965A patent/NZ332965A/xx unknown
- 1997-06-05 HU HU0002952A patent/HUP0002952A3/hu unknown
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- 1997-06-05 WO PCT/SE1997/000991 patent/WO1997047603A1/en active IP Right Grant
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- 1997-06-05 EP EP97927552A patent/EP0906288B1/en not_active Expired - Lifetime
- 1997-06-05 CZ CZ19984039A patent/CZ291469B6/cs not_active IP Right Cessation
- 1997-06-05 CA CA002256687A patent/CA2256687C/en not_active Expired - Fee Related
- 1997-06-05 TR TR1998/02554T patent/TR199802554T2/xx unknown
- 1997-06-05 ES ES97927552T patent/ES2184097T3/es not_active Expired - Lifetime
- 1997-06-09 MY MYPI97002563A patent/MY119012A/en unknown
- 1997-09-24 SA SA97180427A patent/SA97180427B1/ar unknown
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1998
- 1998-11-25 IS IS4907A patent/IS1864B/is unknown
- 1998-12-09 NO NO19985764A patent/NO311672B1/no unknown
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