UA5929A1 - Method for producing biologically active mucopolysaccharides - Google Patents
Method for producing biologically active mucopolysaccharidesInfo
- Publication number
- UA5929A1 UA5929A1 UA3965564A UA3965564A UA5929A1 UA 5929 A1 UA5929 A1 UA 5929A1 UA 3965564 A UA3965564 A UA 3965564A UA 3965564 A UA3965564 A UA 3965564A UA 5929 A1 UA5929 A1 UA 5929A1
- Authority
- UA
- Ukraine
- Prior art keywords
- mucopolysaccharides
- biologically active
- heparin
- separation
- reaction mixture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
Abstract
The method for producing the biologically active mucopolysaccharides comprises the treatment of heparin with depolymerizing agent followed by the separation of the end-product by ethanol precipitation. Sodium nitrite is used as depolymerizing agent. Heparin is used at the concentration of 5 mass %, sodium nitrite – 0.0435 M. The incubation is performed at pH 2.5 until NO-2 ions are no longer detectable. Prior to the separation of the end-product, pH of the reaction mixture is adjusted to 7 with sodium hydroxide solution. Ethanol is added at a 2:1 ratio to the reaction mixture. The precipitate is re-dissolved in the aqueous solution of NaCl at pH 3.8.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8415978A FR2572080B1 (en) | 1984-10-18 | 1984-10-18 | PROCESS FOR THE PREPARATION OF MUCOPOLYSACCHARIDE COMPOSITIONS WITH HIGH ANTITHROMBOTIC ACTIVITY, THE COMPOSITIONS OBTAINED AND THEIR APPLICATION AS MEDICAMENTS |
Publications (1)
Publication Number | Publication Date |
---|---|
UA5929A1 true UA5929A1 (en) | 1994-12-29 |
Family
ID=9308784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA3965564A UA5929A1 (en) | 1984-10-18 | 1985-10-17 | Method for producing biologically active mucopolysaccharides |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS61101502A (en) |
KR (1) | KR920006002B1 (en) |
AR (1) | AR243539A1 (en) |
CS (1) | CS270420B2 (en) |
DD (1) | DD239798A5 (en) |
DZ (1) | DZ844A1 (en) |
EG (1) | EG17478A (en) |
FI (1) | FI81810C (en) |
FR (1) | FR2572080B1 (en) |
HU (1) | HU197931B (en) |
IL (1) | IL76701A (en) |
MA (1) | MA20554A1 (en) |
NO (1) | NO166369C (en) |
PL (1) | PL146770B1 (en) |
SU (1) | SU1570651A3 (en) |
UA (1) | UA5929A1 (en) |
YU (1) | YU45285B (en) |
ZA (1) | ZA857902B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE64121B1 (en) * | 1989-10-04 | 1995-07-12 | Akzo Nv | Sulphated glycosaminoglycuronan with antithrombotic activity |
CN103209997B (en) * | 2010-09-14 | 2016-03-16 | 国立大学法人宫崎大学 | high-purity heparin and preparation method thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2478646A2 (en) * | 1980-03-20 | 1981-09-25 | Choay Sa | MUCOPOLYSACCHARIDIC COMPOSITION HAVING A COAGULATION REGULATING ACTIVITY, MEDICAMENT CONTAINING THE SAME, AND METHOD FOR OBTAINING THE SAME |
FR2440376A1 (en) * | 1978-11-06 | 1980-05-30 | Choay Sa | MUCOPOLYSACCHARIDIC COMPOSITION HAVING REGULATORY COAGULATION ACTIVITY, MEDICAMENT CONTAINING SAME AND METHOD FOR OBTAINING SAME |
FR2495935A1 (en) * | 1980-12-15 | 1982-06-18 | Choay Sa | Muco:polysaccharide fractions derived from heparin - with selective inhibitory action against factor Xa but low anticoagulant activity |
FR2503714B1 (en) * | 1981-04-10 | 1986-11-21 | Choay Sa | PROCESS FOR OBTAINING BIOLOGICALLY ACTIVE MUCOPOLYSACCHARIDES, OF HIGH PURITY, BY DEPOLYMERIZATION OF HEPARIN |
-
1984
- 1984-10-18 FR FR8415978A patent/FR2572080B1/en not_active Expired
-
1985
- 1985-02-27 KR KR1019850007686A patent/KR920006002B1/en not_active IP Right Cessation
- 1985-10-13 EG EG650/85A patent/EG17478A/en active
- 1985-10-14 DZ DZ850225A patent/DZ844A1/en active
- 1985-10-14 IL IL76701A patent/IL76701A/en not_active IP Right Cessation
- 1985-10-15 ZA ZA857902A patent/ZA857902B/en unknown
- 1985-10-15 AR AR85301959A patent/AR243539A1/en active
- 1985-10-17 DD DD85281840A patent/DD239798A5/en not_active IP Right Cessation
- 1985-10-17 YU YU1660/85A patent/YU45285B/en unknown
- 1985-10-17 UA UA3965564A patent/UA5929A1/en unknown
- 1985-10-17 SU SU853965564A patent/SU1570651A3/en active
- 1985-10-18 FI FI854073A patent/FI81810C/en not_active IP Right Cessation
- 1985-10-18 HU HU854046A patent/HU197931B/en unknown
- 1985-10-18 JP JP60233118A patent/JPS61101502A/en active Granted
- 1985-10-18 MA MA20778A patent/MA20554A1/en unknown
- 1985-10-18 CS CS857467A patent/CS270420B2/en not_active IP Right Cessation
- 1985-10-18 NO NO854154A patent/NO166369C/en not_active IP Right Cessation
- 1985-10-18 PL PL1985255832A patent/PL146770B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CS270420B2 (en) | 1990-06-13 |
EG17478A (en) | 1991-03-30 |
NO166369B (en) | 1991-04-02 |
FI854073A0 (en) | 1985-10-18 |
YU45285B (en) | 1992-05-28 |
FR2572080A1 (en) | 1986-04-25 |
PL255832A1 (en) | 1987-02-09 |
YU166085A (en) | 1988-06-30 |
DZ844A1 (en) | 2004-09-13 |
NO166369C (en) | 1991-07-17 |
CS746785A2 (en) | 1989-11-14 |
DD239798A5 (en) | 1986-10-08 |
ZA857902B (en) | 1987-03-25 |
HU197931B (en) | 1989-06-28 |
FI854073L (en) | 1986-04-19 |
JPH0552841B2 (en) | 1993-08-06 |
KR860003275A (en) | 1986-05-21 |
MA20554A1 (en) | 1986-07-01 |
IL76701A (en) | 1990-09-17 |
AR243539A1 (en) | 1993-08-31 |
HUT38657A (en) | 1986-06-30 |
FR2572080B1 (en) | 1987-06-26 |
JPS61101502A (en) | 1986-05-20 |
FI81810B (en) | 1990-08-31 |
PL146770B1 (en) | 1989-03-31 |
NO854154L (en) | 1986-04-21 |
IL76701A0 (en) | 1986-02-28 |
KR920006002B1 (en) | 1992-07-25 |
FI81810C (en) | 1990-12-10 |
SU1570651A3 (en) | 1990-06-07 |
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