UA5929A1 - Method for producing biologically active mucopolysaccharides - Google Patents

Method for producing biologically active mucopolysaccharides

Info

Publication number
UA5929A1
UA5929A1 UA3965564A UA3965564A UA5929A1 UA 5929 A1 UA5929 A1 UA 5929A1 UA 3965564 A UA3965564 A UA 3965564A UA 3965564 A UA3965564 A UA 3965564A UA 5929 A1 UA5929 A1 UA 5929A1
Authority
UA
Ukraine
Prior art keywords
mucopolysaccharides
biologically active
heparin
separation
reaction mixture
Prior art date
Application number
UA3965564A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Лормо Жан-Клод
Шоай Жан
Original Assignee
Шоай С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шоай С.А. filed Critical Шоай С.А.
Publication of UA5929A1 publication Critical patent/UA5929A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)

Abstract

The method for producing the biologically active mucopolysaccharides comprises the treatment of heparin with depolymerizing agent followed by the separation of the end-product by ethanol precipitation. Sodium nitrite is used as depolymerizing agent. Heparin is used at the concentration of 5 mass %, sodium nitrite – 0.0435 M. The incubation is performed at pH 2.5 until NO-2 ions are no longer detectable. Prior to the separation of the end-product, pH of the reaction mixture is adjusted to 7 with sodium hydroxide solution. Ethanol is added at a 2:1 ratio to the reaction mixture. The precipitate is re-dissolved in the aqueous solution of NaCl at pH 3.8.
UA3965564A 1984-10-18 1985-10-17 Method for producing biologically active mucopolysaccharides UA5929A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8415978A FR2572080B1 (en) 1984-10-18 1984-10-18 PROCESS FOR THE PREPARATION OF MUCOPOLYSACCHARIDE COMPOSITIONS WITH HIGH ANTITHROMBOTIC ACTIVITY, THE COMPOSITIONS OBTAINED AND THEIR APPLICATION AS MEDICAMENTS

Publications (1)

Publication Number Publication Date
UA5929A1 true UA5929A1 (en) 1994-12-29

Family

ID=9308784

Family Applications (1)

Application Number Title Priority Date Filing Date
UA3965564A UA5929A1 (en) 1984-10-18 1985-10-17 Method for producing biologically active mucopolysaccharides

Country Status (18)

Country Link
JP (1) JPS61101502A (en)
KR (1) KR920006002B1 (en)
AR (1) AR243539A1 (en)
CS (1) CS270420B2 (en)
DD (1) DD239798A5 (en)
DZ (1) DZ844A1 (en)
EG (1) EG17478A (en)
FI (1) FI81810C (en)
FR (1) FR2572080B1 (en)
HU (1) HU197931B (en)
IL (1) IL76701A (en)
MA (1) MA20554A1 (en)
NO (1) NO166369C (en)
PL (1) PL146770B1 (en)
SU (1) SU1570651A3 (en)
UA (1) UA5929A1 (en)
YU (1) YU45285B (en)
ZA (1) ZA857902B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64121B1 (en) * 1989-10-04 1995-07-12 Akzo Nv Sulphated glycosaminoglycuronan with antithrombotic activity
CN103209997B (en) * 2010-09-14 2016-03-16 国立大学法人宫崎大学 high-purity heparin and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2478646A2 (en) * 1980-03-20 1981-09-25 Choay Sa MUCOPOLYSACCHARIDIC COMPOSITION HAVING A COAGULATION REGULATING ACTIVITY, MEDICAMENT CONTAINING THE SAME, AND METHOD FOR OBTAINING THE SAME
FR2440376A1 (en) * 1978-11-06 1980-05-30 Choay Sa MUCOPOLYSACCHARIDIC COMPOSITION HAVING REGULATORY COAGULATION ACTIVITY, MEDICAMENT CONTAINING SAME AND METHOD FOR OBTAINING SAME
FR2495935A1 (en) * 1980-12-15 1982-06-18 Choay Sa Muco:polysaccharide fractions derived from heparin - with selective inhibitory action against factor Xa but low anticoagulant activity
FR2503714B1 (en) * 1981-04-10 1986-11-21 Choay Sa PROCESS FOR OBTAINING BIOLOGICALLY ACTIVE MUCOPOLYSACCHARIDES, OF HIGH PURITY, BY DEPOLYMERIZATION OF HEPARIN

Also Published As

Publication number Publication date
CS270420B2 (en) 1990-06-13
EG17478A (en) 1991-03-30
NO166369B (en) 1991-04-02
FI854073A0 (en) 1985-10-18
YU45285B (en) 1992-05-28
FR2572080A1 (en) 1986-04-25
PL255832A1 (en) 1987-02-09
YU166085A (en) 1988-06-30
DZ844A1 (en) 2004-09-13
NO166369C (en) 1991-07-17
CS746785A2 (en) 1989-11-14
DD239798A5 (en) 1986-10-08
ZA857902B (en) 1987-03-25
HU197931B (en) 1989-06-28
FI854073L (en) 1986-04-19
JPH0552841B2 (en) 1993-08-06
KR860003275A (en) 1986-05-21
MA20554A1 (en) 1986-07-01
IL76701A (en) 1990-09-17
AR243539A1 (en) 1993-08-31
HUT38657A (en) 1986-06-30
FR2572080B1 (en) 1987-06-26
JPS61101502A (en) 1986-05-20
FI81810B (en) 1990-08-31
PL146770B1 (en) 1989-03-31
NO854154L (en) 1986-04-21
IL76701A0 (en) 1986-02-28
KR920006002B1 (en) 1992-07-25
FI81810C (en) 1990-12-10
SU1570651A3 (en) 1990-06-07

Similar Documents

Publication Publication Date Title
ES8701883A1 (en) Stimulation of biooxidation processes in subterranean formations.
NZ506157A (en) Process for making a stable organosilanized colloidal silica suspension
ES8606367A1 (en) Improved process for preparing N,N-diacetic acid aminomethylenephosphonic acid.
AU3226984A (en) Aqueous, injectable solutions of cis-platimum
PT86400A (en) Process for preparing aqueous solutions containing a mixture of hysozyme hydrochloride and dipotassium glycyrrhizate
DE59103710D1 (en) COMPOSITION FOR TREATING WATER POLLUTED WITH METAL IONS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE.
AU590537B2 (en) Method for producing foamable compositions
DE3464240D1 (en) Substituted indonaphthols used in detecting ions
ES471032A1 (en) Purification process
UA5929A1 (en) Method for producing biologically active mucopolysaccharides
GR82091B (en)
ES8700692A1 (en) Silver pseudomonate, compositions containing it and its use in treating pseudomonal infections.
ES2010854A6 (en) An aqueous composition of an amine salt of a phosphoric acid
ES8609161A1 (en) Scale inhibiting composition.
CA2045220A1 (en) Process for the production of chlorine dioxide
SG43893G (en) Process for the preparation of an aqueous solution of a heteropoly-saccharide
ATE36516T1 (en) PURIFICATION OF 4-FLUORO-4'-HYDROXY-BENZOPHENONE.
ES2046680T3 (en) ACTIVE CARBON PRETREATMENT PROCEDURE.
DE3268154D1 (en) Selective acylation of hydroxy-amino-arylsulfonic acids
JPS57165404A (en) Preparation of high polymeric flocculant
DE3270177D1 (en) Process for purifying elastase
JPS575879A (en) Chemical forming treatment of tin plated can
SU1176477A1 (en) Process for preparing ammifurin
GB1476919A (en) Process for the preparation of n-acetoacetyl-2,5-dimethoxy- 4-chloroanilide
JPS5577867A (en) Method of controlling quality of pickles