UA42674C2 - Спосіб одержання похідних 3-кето-4-азастероїду та проміжні сполуки для його здійснення - Google Patents
Спосіб одержання похідних 3-кето-4-азастероїду та проміжні сполуки для його здійсненняInfo
- Publication number
- UA42674C2 UA42674C2 UA93004064A UA93004064A UA42674C2 UA 42674 C2 UA42674 C2 UA 42674C2 UA 93004064 A UA93004064 A UA 93004064A UA 93004064 A UA93004064 A UA 93004064A UA 42674 C2 UA42674 C2 UA 42674C2
- Authority
- UA
- Ukraine
- Prior art keywords
- keto
- derivatives
- preparation
- intermediates
- realization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
Cпосіб одержання похідних 4-азастероїду формули III (III) де R1 є -ОН, -OR або NHR, Е1 вибраний із групи: брому, йоду, феніл(триметилсиліл) аміносульфінілу, трихлорметилсульфонілу, шляхом проведення реакції електрофільного заміщення, відповідно до винаходу роблять силилування сполуки формули I (І) з R3 Si-OTf, де R - нижчий алкіл з 1-5 атомами вуглецю, і реакцію отриманого продукту з електрофілом Е, вибраним з групи: фенілдисульфіду, трихлорметилсульфонілхлориду, N-тіоніланіліну, брому і йоду.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/572,811 US5091534A (en) | 1990-08-27 | 1990-08-27 | Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids |
Publications (1)
Publication Number | Publication Date |
---|---|
UA42674C2 true UA42674C2 (uk) | 2001-11-15 |
Family
ID=24289446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA93004064A UA42674C2 (uk) | 1990-08-27 | 1993-03-10 | Спосіб одержання похідних 3-кето-4-азастероїду та проміжні сполуки для його здійснення |
Country Status (6)
Country | Link |
---|---|
US (1) | US5091534A (uk) |
EP (1) | EP0473226B1 (uk) |
JP (1) | JPH0717674B2 (uk) |
CA (1) | CA2049881C (uk) |
DE (1) | DE69121148T2 (uk) |
UA (1) | UA42674C2 (uk) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5120847A (en) * | 1990-08-27 | 1992-06-09 | Merck & Co., Inc. | Process for iodinating or brominating the α-methylenic carbon of a secondary amide |
AU3417493A (en) * | 1991-12-20 | 1993-07-28 | Glaxo Inc. | Inhibitors of 5-alpha-testosterone reductase |
US5302589A (en) * | 1992-08-07 | 1994-04-12 | Glaxo, Inc. | Heterocyclic inhibitors of 5-α-testosterone reductase |
US5468860A (en) | 1992-11-19 | 1995-11-21 | Merck & Co., Inc. | New finasteride processes |
TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
US5470976A (en) * | 1994-09-07 | 1995-11-28 | Merck & Co., Inc. | Process for the stereoselective reduction of steroid enelactams |
US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US5656613A (en) * | 1995-01-04 | 1997-08-12 | Merck & Co., Inc. | Treatment of hyperandrogenic conditions |
US6365597B1 (en) | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
US6187925B1 (en) | 1997-12-23 | 2001-02-13 | Merck & Co., Inc. | Intermediates and process for the synthesis of azasteroids |
CN1468254A (zh) | 2000-09-07 | 2004-01-14 | 雷迪实验室有限公司 | 17-β-(N-叔丁基氨基甲酰基)-4-氮杂-5-α-雄甾-1-烯-3-酮的新颖多晶型物及其制备方法 |
NZ525116A (en) * | 2000-09-07 | 2004-11-26 | Dr | Novel polymorphic form of 17- beta -(N-ter.butyl carbamoyl)-4-AZA-5- alpha -androst-1-en-3-one and a process for preparing it |
SK2732003A3 (en) * | 2000-09-07 | 2004-01-08 | Reddys Lab Ltd Dr | Novel polymorphic form of 17-beta-(N-ter.butyl carbamoyl)-4-aza- 5-alpha-androst-1-en-3-one and a process for preparing it |
ES2185503B1 (es) * | 2001-09-29 | 2004-08-01 | Ragactives, S.L. | Procedimiento para la obtencion de 17beta-(sustituido)-3-oxoalfa1,2-4-azaesteroides e intermedios. |
HU227117B1 (en) | 2002-05-10 | 2010-07-28 | Richter Gedeon Nyrt | Process for dehydrogenation of aza-androstane compounds |
KR100872722B1 (ko) * | 2002-06-28 | 2008-12-05 | 주식회사 중외제약 | 피나스테라이드의 제조방법 |
BR0312672A (pt) * | 2002-07-16 | 2005-04-26 | Siegfried Ltd | Processo para a preparação de compostos |
KR100508019B1 (ko) * | 2003-07-19 | 2005-08-17 | 한미약품 주식회사 | 고순도 1-안드로스텐 유도체의 제조 방법 |
DE502004007503D1 (de) * | 2003-07-21 | 2008-08-14 | Siegfried Generics Int Ag | Verfahren zur herstellung von alpha, beta-ungesattigten ami dverbindungen |
WO2005066195A1 (de) * | 2004-01-02 | 2005-07-21 | Pharmacon Forschung Und Beratung Gmbh | Verfahren zur herstellung von 1,2-ungesättigten azasteroiden |
CN109678918A (zh) * | 2019-01-24 | 2019-04-26 | 台州仙琚药业有限公司 | 5α-雄甾-2-烯-17-酮的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036831A (en) * | 1975-10-28 | 1977-07-19 | Steroid Development Company Establishment | Trimethyl siloxane steroid intermediates |
JPS54109958A (en) * | 1978-02-16 | 1979-08-29 | Patpharma Ets | Steroid compound and its manufacture |
AU527030B2 (en) * | 1978-04-13 | 1983-02-10 | Merck & Co., Inc. | 4-aza-17-substituted-5a-androstan-3-ones |
US4377584A (en) * | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
US4220775A (en) * | 1979-03-15 | 1980-09-02 | Merck & Co., Inc. | Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors |
US4859681A (en) * | 1984-02-27 | 1989-08-22 | Merck & Co., Inc. | 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors |
NZ211145A (en) * | 1984-02-27 | 1988-10-28 | Merck & Co Inc | 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions |
US4760071A (en) * | 1984-02-27 | 1988-07-26 | Merck & Co., Inc. | 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors |
NZ225100A (en) * | 1987-06-29 | 1991-09-25 | Merck & Co Inc | Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates |
-
1990
- 1990-08-27 US US07/572,811 patent/US5091534A/en not_active Expired - Lifetime
-
1991
- 1991-08-21 EP EP91202135A patent/EP0473226B1/en not_active Expired - Lifetime
- 1991-08-21 DE DE69121148T patent/DE69121148T2/de not_active Expired - Fee Related
- 1991-08-26 CA CA002049881A patent/CA2049881C/en not_active Expired - Fee Related
- 1991-08-27 JP JP3215265A patent/JPH0717674B2/ja not_active Expired - Fee Related
-
1993
- 1993-03-10 UA UA93004064A patent/UA42674C2/uk unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0717674B2 (ja) | 1995-03-01 |
EP0473226B1 (en) | 1996-07-31 |
CA2049881C (en) | 1996-10-22 |
JPH04261194A (ja) | 1992-09-17 |
EP0473226A3 (en) | 1993-06-23 |
DE69121148T2 (de) | 1997-03-06 |
DE69121148D1 (de) | 1996-09-05 |
EP0473226A2 (en) | 1992-03-04 |
CA2049881A1 (en) | 1992-02-28 |
US5091534A (en) | 1992-02-25 |
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