UA35555C2 - Производные бензимидазола и фармацевтическая композиция, которая имеет антагонистическую активность по отношению к ангиотензину - Google Patents
Производные бензимидазола и фармацевтическая композиция, которая имеет антагонистическую активность по отношению к ангиотензинуInfo
- Publication number
- UA35555C2 UA35555C2 UA93002794A UA93002794A UA35555C2 UA 35555 C2 UA35555 C2 UA 35555C2 UA 93002794 A UA93002794 A UA 93002794A UA 93002794 A UA93002794 A UA 93002794A UA 35555 C2 UA35555 C2 UA 35555C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pharmaceutical composition
- benzimidazole
- angiotensin
- pyridine
- antagonistic activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к новым пиримидинсодержащим производным, обладающим биологической активностью, и фармацевтической композиции на их основе. Производные бензимидазола общей формулы (1) EMBED ISISServer (1) где: r1 = C1-Сз-алкил или С1, R2 = в положении 6: бензимидазол-2-ил, тетрагидробензимидазол-1-ил, 1-метилбензимидазол-2-ил, фталимидобензимидазол-1-ил, 1-оксоимидазол-2-ил, 1-оксоизоиндол-2-ил, 2-оксопиперидин-1-ил, бутансультам-1-ил, N-бензолсульфонилметиламино, имидазо[1,2-а]пиридин-2-ил, 5, 6, 7, 8-тетрагидроимидазо[1,2-а]пиридин-2-ил, имидазо[2,1-b]тиазол-6-ил, пиридин-2-ил, 1-изопропилимидазол-4-ил, изопропилкарбониламино, 2, 3-диметилмалеинимидо, морфолинкарбониламино, циклогексиламинкарбониламино, амидино или, в положении 7, группу формулы EMBED ISISServer где: n=2-5, RЗ = Et, n-Pr, n-Bu, R4 = СО2Н или 1Н-тетразол-5-ил, в виде смеси изомеров, отдельных изомеров, гидратов и солей.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4103492A DE4103492A1 (de) | 1991-02-06 | 1991-02-06 | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE4137812A DE4137812A1 (de) | 1991-02-06 | 1991-11-16 | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
UA35555C2 true UA35555C2 (ru) | 2001-04-16 |
Family
ID=6424446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA93002794A UA35555C2 (ru) | 1991-02-06 | 1993-04-16 | Производные бензимидазола и фармацевтическая композиция, которая имеет антагонистическую активность по отношению к ангиотензину |
Country Status (9)
Country | Link |
---|---|
KR (1) | KR100218820B1 (ru) |
BR (1) | BR1100667A (ru) |
DE (4) | DE4103492A1 (ru) |
EE (1) | EE03085B1 (ru) |
NO (1) | NO1999024I1 (ru) |
TW (1) | TW208015B (ru) |
UA (1) | UA35555C2 (ru) |
YU (1) | YU48849B (ru) |
ZA (1) | ZA92816B (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
DE10314702A1 (de) * | 2003-03-31 | 2004-10-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von Telmisartan |
CN113307775B (zh) * | 2021-04-16 | 2022-04-22 | 河北戴桥医药科技有限公司 | 一种替米沙坦的制备方法 |
-
1991
- 1991-02-06 DE DE4103492A patent/DE4103492A1/de not_active Ceased
- 1991-05-25 DE DE4117121A patent/DE4117121A1/de not_active Withdrawn
- 1991-11-16 DE DE4137812A patent/DE4137812A1/de not_active Withdrawn
-
1992
- 1992-01-30 YU YU9892A patent/YU48849B/sh unknown
- 1992-01-31 DE DE201112000013 patent/DE122011000013I1/de active Pending
- 1992-02-01 TW TW081100820A patent/TW208015B/zh not_active IP Right Cessation
- 1992-02-05 ZA ZA92816A patent/ZA92816B/xx unknown
- 1992-02-06 KR KR1019920001730A patent/KR100218820B1/ko not_active IP Right Cessation
-
1993
- 1993-04-16 UA UA93002794A patent/UA35555C2/ru unknown
-
1994
- 1994-11-23 EE EE9400234A patent/EE03085B1/xx not_active IP Right Cessation
-
1997
- 1997-05-07 BR BR1100667-6A patent/BR1100667A/pt active Search and Examination
-
1999
- 1999-11-30 NO NO1999024C patent/NO1999024I1/no unknown
Also Published As
Publication number | Publication date |
---|---|
KR100218820B1 (ko) | 1999-09-01 |
KR920016431A (ko) | 1992-09-24 |
DE4103492A1 (de) | 1992-10-08 |
YU48849B (sh) | 2002-06-19 |
DE122011000013I1 (de) | 2011-12-01 |
YU9892A (sh) | 1999-03-04 |
EE03085B1 (et) | 1998-04-15 |
ZA92816B (en) | 1993-07-05 |
TW208015B (ru) | 1993-06-21 |
DE4137812A1 (de) | 1993-05-19 |
BR1100667A (pt) | 2000-06-13 |
NO1999024I1 (no) | 1999-11-30 |
DE4117121A1 (de) | 1992-12-17 |
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