UA35555C2 - benzimidazole Derivatives and pharmaceutical composition HAVING ANTAGONISTIC activity relative to angiotensin - Google Patents
benzimidazole Derivatives and pharmaceutical composition HAVING ANTAGONISTIC activity relative to angiotensinInfo
- Publication number
- UA35555C2 UA35555C2 UA93002794A UA93002794A UA35555C2 UA 35555 C2 UA35555 C2 UA 35555C2 UA 93002794 A UA93002794 A UA 93002794A UA 93002794 A UA93002794 A UA 93002794A UA 35555 C2 UA35555 C2 UA 35555C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pharmaceutical composition
- benzimidazole
- angiotensin
- pyridine
- antagonistic activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to novel pyrimidine–containing derivatives having biological activity and pharmaceutical composition based thereon. Derivatives of benzimidazole of the general formula (1) EMBED ISISServer (1) where: r1 = C1-Сз-alkyl or C1, R2 = in position 6: benzimidazole-2-yl, tetrahydrobenzimidazole-1-yl, 1-methyl benzimidazole-2-yl, phthalimidobenzimidazole-1-yl, 1-oxoimidazole-2-yl, 1-oxoisoindole-2-yl, 2-oxopiperidine-1-yl, butansultam-1-yl, N-benzosulfonylmethylamino, imidazo[1,2-a]pyridine-2-yl, 5, 6, 7, 8-tetrahydroimidazo[1,2-a]pyridine-2-yl, imidazo[2,1-b]thiazol-6-yl, pyridine-2-yl, 1-isopropylimidazole-4-yl, isopropylcarbonylamino, 2,3-dimethylmaleinimido, morpholinecarbonylamino, cyclohexylaminocarbonylamino, amidino or, in the position 7, group of the formula EMBED ISISServer where: n=2-5, Rз = Et, n-Pr, n-Bu, R4 = CO2H or 1H-tetrazol-5-yl, in the form of a mixture of isomers, separate isomers, hydrates and salts.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4103492A DE4103492A1 (en) | 1991-02-06 | 1991-02-06 | New 1-(1,4-bi:phenyl-methyl) benzimidazole(s) as angiotensin II antagonists |
DE4137812A DE4137812A1 (en) | 1991-02-06 | 1991-11-16 | New 1-(1,4-bi:phenyl-methyl) benzimidazole(s) as angiotensin II antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
UA35555C2 true UA35555C2 (en) | 2001-04-16 |
Family
ID=6424446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA93002794A UA35555C2 (en) | 1991-02-06 | 1993-04-16 | benzimidazole Derivatives and pharmaceutical composition HAVING ANTAGONISTIC activity relative to angiotensin |
Country Status (9)
Country | Link |
---|---|
KR (1) | KR100218820B1 (en) |
BR (1) | BR1100667A (en) |
DE (4) | DE4103492A1 (en) |
EE (1) | EE03085B1 (en) |
NO (1) | NO1999024I1 (en) |
TW (1) | TW208015B (en) |
UA (1) | UA35555C2 (en) |
YU (1) | YU48849B (en) |
ZA (1) | ZA92816B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
DE10314702A1 (en) * | 2003-03-31 | 2004-10-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for the preparation of telmisartan |
CN113307775B (en) * | 2021-04-16 | 2022-04-22 | 河北戴桥医药科技有限公司 | Preparation method of telmisartan |
-
1991
- 1991-02-06 DE DE4103492A patent/DE4103492A1/en not_active Ceased
- 1991-05-25 DE DE4117121A patent/DE4117121A1/en not_active Withdrawn
- 1991-11-16 DE DE4137812A patent/DE4137812A1/en not_active Withdrawn
-
1992
- 1992-01-30 YU YU9892A patent/YU48849B/en unknown
- 1992-01-31 DE DE201112000013 patent/DE122011000013I1/en active Pending
- 1992-02-01 TW TW081100820A patent/TW208015B/zh not_active IP Right Cessation
- 1992-02-05 ZA ZA92816A patent/ZA92816B/en unknown
- 1992-02-06 KR KR1019920001730A patent/KR100218820B1/en not_active IP Right Cessation
-
1993
- 1993-04-16 UA UA93002794A patent/UA35555C2/en unknown
-
1994
- 1994-11-23 EE EE9400234A patent/EE03085B1/en not_active IP Right Cessation
-
1997
- 1997-05-07 BR BR1100667-6A patent/BR1100667A/en active Search and Examination
-
1999
- 1999-11-30 NO NO1999024C patent/NO1999024I1/en unknown
Also Published As
Publication number | Publication date |
---|---|
YU48849B (en) | 2002-06-19 |
YU9892A (en) | 1999-03-04 |
KR920016431A (en) | 1992-09-24 |
DE4137812A1 (en) | 1993-05-19 |
EE03085B1 (en) | 1998-04-15 |
NO1999024I1 (en) | 1999-11-30 |
DE4103492A1 (en) | 1992-10-08 |
BR1100667A (en) | 2000-06-13 |
DE122011000013I1 (en) | 2011-12-01 |
TW208015B (en) | 1993-06-21 |
KR100218820B1 (en) | 1999-09-01 |
ZA92816B (en) | 1993-07-05 |
DE4117121A1 (en) | 1992-12-17 |
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