UA27763C2 - Рекомбінантна молекула днк, що кодує молекулу адгезії icam-3, молекула адгезії icam-3, антитіло, здатне зв'язуватись з такою молекулою, фармацевтична композиція - Google Patents

Рекомбінантна молекула днк, що кодує молекулу адгезії icam-3, молекула адгезії icam-3, антитіло, здатне зв'язуватись з такою молекулою, фармацевтична композиція

Info

Publication number
UA27763C2
UA27763C2 UA93003881A UA93003881A UA27763C2 UA 27763 C2 UA27763 C2 UA 27763C2 UA 93003881 A UA93003881 A UA 93003881A UA 93003881 A UA93003881 A UA 93003881A UA 27763 C2 UA27763 C2 UA 27763C2
Authority
UA
Ukraine
Prior art keywords
icam
adhesion molecule
matuchatus
bind
antibody
Prior art date
Application number
UA93003881A
Other languages
English (en)
Ukrainian (uk)
Inventor
Фоужеролліс Антонін Р. Де
Тімоті А. Спрінгер
Original Assignee
Сентер Фор Блад Рісерч, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сентер Фор Блад Рісерч, Інк. filed Critical Сентер Фор Блад Рісерч, Інк.
Publication of UA27763C2 publication Critical patent/UA27763C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
UA93003881A 1991-06-11 1992-06-11 Рекомбінантна молекула днк, що кодує молекулу адгезії icam-3, молекула адгезії icam-3, антитіло, здатне зв'язуватись з такою молекулою, фармацевтична композиція UA27763C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71287991A 1991-06-11 1991-06-11
PCT/US1992/004896 WO1992022323A1 (en) 1991-06-11 1992-06-11 Intercellular adhesion molecule-3 and its binding ligands

Publications (1)

Publication Number Publication Date
UA27763C2 true UA27763C2 (uk) 2000-10-16

Family

ID=24863928

Family Applications (1)

Application Number Title Priority Date Filing Date
UA93003881A UA27763C2 (uk) 1991-06-11 1992-06-11 Рекомбінантна молекула днк, що кодує молекулу адгезії icam-3, молекула адгезії icam-3, антитіло, здатне зв'язуватись з такою молекулою, фармацевтична композиція

Country Status (21)

Country Link
EP (1) EP0590051A4 (de)
JP (1) JP3288042B2 (de)
KR (2) KR100291844B1 (de)
CN (1) CN1188528C (de)
BG (1) BG61682B1 (de)
BR (1) BR9206142A (de)
CA (1) CA2110387A1 (de)
CZ (1) CZ283478B6 (de)
FI (1) FI935500A (de)
HU (1) HU217176B (de)
IE (1) IE921893A1 (de)
IL (1) IL102176A (de)
MX (1) MX9202804A (de)
NO (1) NO317658B1 (de)
NZ (1) NZ243114A (de)
RO (1) RO115415B1 (de)
RU (1) RU2130782C1 (de)
SK (1) SK279937B6 (de)
UA (1) UA27763C2 (de)
WO (1) WO1992022323A1 (de)
ZA (1) ZA924276B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629162A (en) * 1991-06-11 1997-05-13 The Center For Blood Research Method of identifying agents which modulate ICAM-3 binding to LFA-1
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US5869262A (en) * 1992-01-27 1999-02-09 Icos Corporation Method for monitoring an inflammatory disease state by detecting circulating ICAM-R
WO1999018441A1 (en) * 1992-01-27 1999-04-15 Icos Corporation Icam-4 and diagnostic uses thereof
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
JP3616090B2 (ja) * 1992-01-27 2005-02-02 イコス コーポレイション 細胞間接着分子関連タンパク質
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
WO1994017100A1 (en) * 1993-01-22 1994-08-04 Icos Corporation Icam-related protein
EP0726942B1 (de) * 1993-11-02 2001-12-19 Innogenetics N.V. Monoklonale antikörper gegen schaumzellen und ihre pharmazeutische und diagnostische anwendung
US6884590B1 (en) 1994-02-11 2005-04-26 Cedars-Sinai Medical Center Methods of screening for ulcerative colitis and crohn's disease
US5681699A (en) * 1994-02-11 1997-10-28 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and Crohn's disease
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
RU2208230C2 (ru) * 1997-10-02 2003-07-10 Айкос Корпорейшн Icam-4 и его диагностическое использование
PL354063A1 (en) 1999-08-13 2003-12-15 Biogen, Inc.Biogen, Inc. Cell adhesion inhibitors
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
AU2003278541A1 (en) * 2002-09-20 2004-04-08 Stichting Katholieke Universiteit Method of treating rheumatoid arthritis by interfering with expression of dc-sign by macrophages and diagnosis thereof
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
CA2657621A1 (en) 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
GB201016864D0 (en) 2010-10-06 2010-11-17 Univ Aston Therapeutic methods
KR102343212B1 (ko) 2013-03-27 2021-12-23 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
US10316083B2 (en) 2013-07-19 2019-06-11 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway
JP7082945B2 (ja) 2016-03-17 2022-06-09 シーダーズ―シナイ メディカル センター Ｒｎａｓｅｔ２により炎症性腸疾患を診断する方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2011633C (en) * 1989-03-09 2007-05-15 Timothy A. Springer Intercellular adhesion molecule - 2 and its binding ligands

Also Published As

Publication number Publication date
MX9202804A (es) 1992-12-01
FI935500A (fi) 1994-02-09
IE921893A1 (en) 1992-12-16
HU9303529D0 (en) 1994-04-28
EP0590051A4 (de) 1994-10-12
NO317658B1 (no) 2004-11-29
JPH06509706A (ja) 1994-11-02
CZ283478B6 (cs) 1998-04-15
RU2130782C1 (ru) 1999-05-27
JP3288042B2 (ja) 2002-06-04
NO934491D0 (no) 1993-12-09
IL102176A (en) 2001-09-13
ZA924276B (en) 1993-03-31
SK279937B6 (sk) 1999-06-11
HU217176B (hu) 1999-12-28
AU670243B2 (en) 1996-07-11
NZ243114A (en) 1995-03-28
BR9206142A (pt) 1994-12-27
CA2110387A1 (en) 1992-12-23
CN1069522A (zh) 1993-03-03
WO1992022323A1 (en) 1992-12-23
AU2237692A (en) 1993-01-12
CN1188528C (zh) 2005-02-09
IL102176A0 (en) 1993-01-14
FI935500A0 (fi) 1993-12-08
SK139593A3 (en) 1994-10-05
CZ270293A3 (en) 1994-08-17
RO115415B1 (ro) 2000-02-28
HUT66617A (en) 1994-12-28
NO934491L (no) 1994-02-11
KR100291844B1 (ko) 2001-09-17
KR100333120B1 (ko) 2002-04-18
BG61682B1 (bg) 1998-03-31
EP0590051A1 (de) 1994-04-06
BG98287A (bg) 1994-08-30

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