JP3288042B2 - 細胞間接着分子−３およびその結合リガンド - Google Patents

細胞間接着分子−３およびその結合リガンド

Info

Publication number
JP3288042B2
JP3288042B2 JP50099993A JP50099993A JP3288042B2 JP 3288042 B2 JP3288042 B2 JP 3288042B2 JP 50099993 A JP50099993 A JP 50099993A JP 50099993 A JP50099993 A JP 50099993A JP 3288042 B2 JP3288042 B2 JP 3288042B2
Authority
JP
Japan
Prior art keywords
icam
cells
cell
lfa
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP50099993A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06509706A (ja
Inventor
デフォッジローリス，アントニン・アール
スプリンガー，ティモシー・エイ
Original Assignee
センター フォア ブラッド リサーチ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by センター フォア ブラッド リサーチ インコーポレイテッド filed Critical センター フォア ブラッド リサーチ インコーポレイテッド
Publication of JPH06509706A publication Critical patent/JPH06509706A/ja
Application granted granted Critical
Publication of JP3288042B2 publication Critical patent/JP3288042B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Adhesives Or Adhesive Processes (AREA)
JP50099993A 1991-06-11 1992-06-11 細胞間接着分子−３およびその結合リガンド Expired - Fee Related JP3288042B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71287991A 1991-06-11 1991-06-11
US712,879 1991-06-11
PCT/US1992/004896 WO1992022323A1 (en) 1991-06-11 1992-06-11 Intercellular adhesion molecule-3 and its binding ligands

Publications (2)

Publication Number Publication Date
JPH06509706A JPH06509706A (ja) 1994-11-02
JP3288042B2 true JP3288042B2 (ja) 2002-06-04

Family

ID=24863928

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50099993A Expired - Fee Related JP3288042B2 (ja) 1991-06-11 1992-06-11 細胞間接着分子−３およびその結合リガンド

Country Status (21)

Country Link
EP (1) EP0590051A4 (de)
JP (1) JP3288042B2 (de)
KR (2) KR100333120B1 (de)
CN (1) CN1188528C (de)
BG (1) BG61682B1 (de)
BR (1) BR9206142A (de)
CA (1) CA2110387A1 (de)
CZ (1) CZ283478B6 (de)
FI (1) FI935500A (de)
HU (1) HU217176B (de)
IE (1) IE921893A1 (de)
IL (1) IL102176A (de)
MX (1) MX9202804A (de)
NO (1) NO317658B1 (de)
NZ (1) NZ243114A (de)
RO (1) RO115415B1 (de)
RU (1) RU2130782C1 (de)
SK (1) SK279937B6 (de)
UA (1) UA27763C2 (de)
WO (1) WO1992022323A1 (de)
ZA (1) ZA924276B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891841A (en) * 1991-06-11 1999-04-06 The Center For Blood Research, Inc. Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
US5880268A (en) * 1992-01-27 1999-03-09 Icos Corporation Modulators of the interaction between ICAM-R and αd /CD18
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
WO1999018441A1 (en) * 1992-01-27 1999-04-15 Icos Corporation Icam-4 and diagnostic uses thereof
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
WO1993014776A1 (en) * 1992-01-27 1993-08-05 Icos Corporation Icam-related protein
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
WO1994017100A1 (en) * 1993-01-22 1994-08-04 Icos Corporation Icam-related protein
WO1995012666A1 (en) * 1993-11-02 1995-05-11 Innogenetics N.V. Human foam cells and methods for preparing them, monoclonal antibodies to said foam cells and their pharmaceutical and diagnostic use
US5681699A (en) * 1994-02-11 1997-10-28 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and Crohn's disease
US6884590B1 (en) 1994-02-11 2005-04-26 Cedars-Sinai Medical Center Methods of screening for ulcerative colitis and crohn's disease
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
AU735917B2 (en) * 1997-10-02 2001-07-19 Icos Corporation ICAM-4 and diagnostic uses thereof
EP1741428A3 (de) 1999-08-13 2007-05-09 Biogen Idec MA, Inc. Hemmer der Zelladhäsion
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
WO2004026909A2 (en) * 2002-09-20 2004-04-01 Stichting Katholieke Universiteit Method of treating rheumatoid arthritis by interfering with expression of dc-sign by macrophages and diagnosis thereof
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
EP2041299A4 (de) 2006-07-14 2010-01-13 Aviva Biosciences Corp Verfahren und zusammensetzungen für den nachweis seltener zellen aus einer biologischen probe
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
WO2010075579A2 (en) 2008-12-24 2010-07-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
GB201016864D0 (en) 2010-10-06 2010-11-17 Univ Aston Therapeutic methods
KR20210157418A (ko) 2013-03-27 2021-12-28 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
EP4105236A1 (de) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antikörper zur behandlung von entzündlichen darmerkrankungen
EP3430172A4 (de) 2016-03-17 2019-08-21 Cedars-Sinai Medical Center Verfahren zur diagnose einer entzündlichen darmerkrankung durch rnaset2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2011633C (en) * 1989-03-09 2007-05-15 Timothy A. Springer Intercellular adhesion molecule - 2 and its binding ligands

Also Published As

Publication number Publication date
BR9206142A (pt) 1994-12-27
BG98287A (bg) 1994-08-30
SK139593A3 (en) 1994-10-05
IE921893A1 (en) 1992-12-16
KR100333120B1 (ko) 2002-04-18
CN1188528C (zh) 2005-02-09
EP0590051A4 (de) 1994-10-12
AU2237692A (en) 1993-01-12
CN1069522A (zh) 1993-03-03
HU217176B (hu) 1999-12-28
AU670243B2 (en) 1996-07-11
IL102176A0 (en) 1993-01-14
UA27763C2 (uk) 2000-10-16
CZ270293A3 (en) 1994-08-17
ZA924276B (en) 1993-03-31
JPH06509706A (ja) 1994-11-02
BG61682B1 (bg) 1998-03-31
KR100291844B1 (ko) 2001-09-17
NO934491D0 (no) 1993-12-09
IL102176A (en) 2001-09-13
NO934491L (no) 1994-02-11
MX9202804A (es) 1992-12-01
NZ243114A (en) 1995-03-28
RU2130782C1 (ru) 1999-05-27
CA2110387A1 (en) 1992-12-23
WO1992022323A1 (en) 1992-12-23
HU9303529D0 (en) 1994-04-28
RO115415B1 (ro) 2000-02-28
SK279937B6 (sk) 1999-06-11
HUT66617A (en) 1994-12-28
FI935500A (fi) 1994-02-09
EP0590051A1 (de) 1994-04-06
FI935500A0 (fi) 1993-12-08
CZ283478B6 (cs) 1998-04-15
NO317658B1 (no) 2004-11-29

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