UA126882C2 - Застосування ly3154207 при лікуванні дофамінергічних порушень цнс - Google Patents
Застосування ly3154207 при лікуванні дофамінергічних порушень цнс Download PDFInfo
- Publication number
- UA126882C2 UA126882C2 UAA202103923A UAA202103923A UA126882C2 UA 126882 C2 UA126882 C2 UA 126882C2 UA A202103923 A UAA202103923 A UA A202103923A UA A202103923 A UAA202103923 A UA A202103923A UA 126882 C2 UA126882 C2 UA 126882C2
- Authority
- UA
- Ukraine
- Prior art keywords
- dose
- pharmaceutical composition
- per day
- patient
- administration
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 170
- 230000003291 dopaminomimetic effect Effects 0.000 title claims abstract description 133
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 255
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 170
- 208000035475 disorder Diseases 0.000 claims abstract description 151
- 238000000034 method Methods 0.000 claims abstract description 81
- 208000018737 Parkinson disease Diseases 0.000 claims abstract description 63
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 34
- 208000010877 cognitive disease Diseases 0.000 claims abstract description 34
- 208000028698 Cognitive impairment Diseases 0.000 claims abstract description 31
- 208000009829 Lewy Body Disease Diseases 0.000 claims abstract description 29
- 206010041349 Somnolence Diseases 0.000 claims abstract description 26
- 206010002942 Apathy Diseases 0.000 claims abstract description 23
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims abstract description 22
- 208000019116 sleep disease Diseases 0.000 claims abstract description 22
- 208000008589 Obesity Diseases 0.000 claims abstract description 21
- 235000020824 obesity Nutrition 0.000 claims abstract description 21
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims abstract description 20
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims abstract description 20
- 206010003805 Autism Diseases 0.000 claims abstract description 19
- 208000020706 Autistic disease Diseases 0.000 claims abstract description 19
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims abstract description 19
- 208000001640 Fibromyalgia Diseases 0.000 claims abstract description 19
- 206010024264 Lethargy Diseases 0.000 claims abstract description 19
- 208000019022 Mood disease Diseases 0.000 claims abstract description 19
- 201000004810 Vascular dementia Diseases 0.000 claims abstract description 19
- 230000001684 chronic effect Effects 0.000 claims abstract description 19
- 208000017004 dementia pugilistica Diseases 0.000 claims abstract description 19
- 201000003631 narcolepsy Diseases 0.000 claims abstract description 19
- 201000000980 schizophrenia Diseases 0.000 claims abstract description 19
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims abstract description 17
- 210000003169 central nervous system Anatomy 0.000 claims description 121
- 239000013256 coordination polymer Substances 0.000 claims description 66
- 230000003920 cognitive function Effects 0.000 claims description 48
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 31
- 230000007774 longterm Effects 0.000 claims description 31
- 206010012289 Dementia Diseases 0.000 claims description 30
- 235000019789 appetite Nutrition 0.000 claims description 22
- 230000036528 appetite Effects 0.000 claims description 21
- 230000007423 decrease Effects 0.000 claims description 19
- 230000008482 dysregulation Effects 0.000 claims description 18
- 208000022925 sleep disturbance Diseases 0.000 claims description 17
- 208000029028 brain injury Diseases 0.000 claims description 11
- 241001112258 Moca Species 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 244000005894 Albizia lebbeck Species 0.000 claims 1
- 101500021173 Aplysia californica Myomodulin-E Proteins 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 244000178993 Brassica juncea Species 0.000 claims 1
- 108010016766 KK 3 Proteins 0.000 claims 1
- 241001026509 Kata Species 0.000 claims 1
- 240000005546 Piper methysticum Species 0.000 claims 1
- 235000016787 Piper methysticum Nutrition 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 abstract description 12
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract description 8
- 230000009529 traumatic brain injury Effects 0.000 abstract description 8
- 201000002832 Lewy body dementia Diseases 0.000 abstract description 6
- XHCSBQBBGNQINS-DOTOQJQBSA-N 2-(2,6-dichlorophenyl)-1-[(1s,3r)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydro-1h-isoquinolin-2-yl]ethanone Chemical compound N1([C@H](C2=CC=CC(CCC(C)(C)O)=C2C[C@@H]1CO)C)C(=O)CC1=C(Cl)C=CC=C1Cl XHCSBQBBGNQINS-DOTOQJQBSA-N 0.000 abstract description 3
- 235000021229 appetite regulation Nutrition 0.000 abstract description 2
- 206010012335 Dependence Diseases 0.000 abstract 1
- 208000033914 shift work type circadian rhythm sleep disease Diseases 0.000 abstract 1
- 230000002354 daily effect Effects 0.000 description 62
- 230000000694 effects Effects 0.000 description 60
- 229940126601 medicinal product Drugs 0.000 description 38
- 238000004519 manufacturing process Methods 0.000 description 36
- 239000000902 placebo Substances 0.000 description 36
- 229940068196 placebo Drugs 0.000 description 36
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 32
- 241001465754 Metazoa Species 0.000 description 25
- 230000006872 improvement Effects 0.000 description 23
- 208000024891 symptom Diseases 0.000 description 23
- 208000016285 Movement disease Diseases 0.000 description 19
- 201000010099 disease Diseases 0.000 description 19
- 238000004458 analytical method Methods 0.000 description 18
- 230000036772 blood pressure Effects 0.000 description 17
- 229960003638 dopamine Drugs 0.000 description 16
- 231100000673 dose–response relationship Toxicity 0.000 description 16
- 229940079593 drug Drugs 0.000 description 16
- 239000003814 drug Substances 0.000 description 16
- 230000035488 systolic blood pressure Effects 0.000 description 16
- 238000012360 testing method Methods 0.000 description 15
- 230000008859 change Effects 0.000 description 14
- 229940126027 positive allosteric modulator Drugs 0.000 description 14
- 230000007596 spatial working memory Effects 0.000 description 14
- 230000004580 weight loss Effects 0.000 description 14
- 230000002411 adverse Effects 0.000 description 13
- 108020003175 receptors Proteins 0.000 description 13
- 102000005962 receptors Human genes 0.000 description 13
- 230000004044 response Effects 0.000 description 12
- 206010062519 Poor quality sleep Diseases 0.000 description 11
- 230000008901 benefit Effects 0.000 description 11
- 230000006735 deficit Effects 0.000 description 11
- 230000007958 sleep Effects 0.000 description 11
- 241000282560 Macaca mulatta Species 0.000 description 10
- 102100039087 Peptidyl-alpha-hydroxyglycine alpha-amidating lyase Human genes 0.000 description 10
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- 230000004936 stimulating effect Effects 0.000 description 10
- 230000003111 delayed effect Effects 0.000 description 9
- 238000013461 design Methods 0.000 description 9
- 230000001965 increasing effect Effects 0.000 description 9
- 210000002381 plasma Anatomy 0.000 description 9
- 230000004620 sleep latency Effects 0.000 description 9
- 230000001149 cognitive effect Effects 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 239000000945 filler Substances 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 230000011664 signaling Effects 0.000 description 8
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 7
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 206010022437 insomnia Diseases 0.000 description 7
- 230000003414 procognitive effect Effects 0.000 description 7
- 238000012216 screening Methods 0.000 description 7
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 6
- 230000004913 activation Effects 0.000 description 6
- 239000000556 agonist Substances 0.000 description 6
- 238000013459 approach Methods 0.000 description 6
- 230000006399 behavior Effects 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 230000002526 effect on cardiovascular system Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 230000002459 sustained effect Effects 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- -1 3,4-dihydroisoquinolin-2(1H)-yl compounds Chemical class 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- 241000288906 Primates Species 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 230000008092 positive effect Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 208000019901 Anxiety disease Diseases 0.000 description 4
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 description 4
- 108050004812 Dopamine receptor Proteins 0.000 description 4
- 102000015554 Dopamine receptor Human genes 0.000 description 4
- 206010028813 Nausea Diseases 0.000 description 4
- 208000032140 Sleepiness Diseases 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 230000036506 anxiety Effects 0.000 description 4
- 230000035487 diastolic blood pressure Effects 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 4
- 238000001647 drug administration Methods 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 230000036651 mood Effects 0.000 description 4
- 230000008693 nausea Effects 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 230000037321 sleepiness Effects 0.000 description 4
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 3
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 3
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 3
- 208000012902 Nervous system disease Diseases 0.000 description 3
- 208000001431 Psychomotor Agitation Diseases 0.000 description 3
- 206010038743 Restlessness Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 102000003802 alpha-Synuclein Human genes 0.000 description 3
- 108090000185 alpha-Synuclein Proteins 0.000 description 3
- 230000002146 bilateral effect Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000009760 functional impairment Effects 0.000 description 3
- 229960004502 levodopa Drugs 0.000 description 3
- 210000004558 lewy body Anatomy 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000037023 motor activity Effects 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 210000002442 prefrontal cortex Anatomy 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 description 2
- 238000010207 Bayesian analysis Methods 0.000 description 2
- 206010006100 Bradykinesia Diseases 0.000 description 2
- 206010013710 Drug interaction Diseases 0.000 description 2
- 208000004547 Hallucinations Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000006083 Hypokinesia Diseases 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- 208000027089 Parkinsonian disease Diseases 0.000 description 2
- 206010034010 Parkinsonism Diseases 0.000 description 2
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- 101100107923 Vitis labrusca AMAT gene Proteins 0.000 description 2
- 230000004308 accommodation Effects 0.000 description 2
- 230000036626 alertness Effects 0.000 description 2
- 230000003281 allosteric effect Effects 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000544 cholinesterase inhibitor Substances 0.000 description 2
- 210000003618 cortical neuron Anatomy 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 2
- 210000005064 dopaminergic neuron Anatomy 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000000366 juvenile effect Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229960001165 modafinil Drugs 0.000 description 2
- 230000007659 motor function Effects 0.000 description 2
- 208000013465 muscle pain Diseases 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 238000009520 phase I clinical trial Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 208000020016 psychiatric disease Diseases 0.000 description 2
- 239000000018 receptor agonist Substances 0.000 description 2
- 229940044601 receptor agonist Drugs 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 229960004136 rivastigmine Drugs 0.000 description 2
- 231100000279 safety data Toxicity 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000002027 skeletal muscle Anatomy 0.000 description 2
- 208000020685 sleep-wake disease Diseases 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 230000001755 vocal effect Effects 0.000 description 2
- 230000003936 working memory Effects 0.000 description 2
- GFXQUCWFEPCALC-UHFFFAOYSA-N 1-(4-isothiocyanato-2-nitrophenyl)imidazole Chemical compound [O-][N+](=O)C1=CC(N=C=S)=CC=C1N1C=NC=C1 GFXQUCWFEPCALC-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 206010001541 Akinesia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 206010002653 Anosmia Diseases 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 206010005746 Blood pressure fluctuation Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 description 1
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010054089 Depressive symptom Diseases 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 101710107143 Dopamine receptor 1 Proteins 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 241001539473 Euphoria Species 0.000 description 1
- 206010015535 Euphoric mood Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000004547 Glucosylceramidase Human genes 0.000 description 1
- 108010017544 Glucosylceramidase Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010019075 Hallucination, visual Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000282566 Macaca arctoides Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000489861 Maximus Species 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010029216 Nervousness Diseases 0.000 description 1
- 208000027626 Neurocognitive disease Diseases 0.000 description 1
- 241000283965 Ochotona princeps Species 0.000 description 1
- 208000037048 Prodromal Symptoms Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010071390 Resting tremor Diseases 0.000 description 1
- 241000408490 Sovia Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000008484 agonism Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 229960004046 apomorphine Drugs 0.000 description 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 230000037007 arousal Effects 0.000 description 1
- 230000003935 attention Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229960002130 benzoin Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 229960002802 bromocriptine Drugs 0.000 description 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
- 229960004596 cabergoline Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- 229960003340 calcium silicate Drugs 0.000 description 1
- 235000012241 calcium silicate Nutrition 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000037410 cognitive enhancement Effects 0.000 description 1
- 230000007370 cognitive improvement Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000003520 dendritic spine Anatomy 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 229940052760 dopamine agonists Drugs 0.000 description 1
- 230000006744 dopaminergic deficit Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 235000019564 dysgeusia Nutrition 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003971 excitatory amino acid agent Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000010326 executive functioning Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 239000003445 gaba agent Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000000848 glutamatergic effect Effects 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000009532 heart rate measurement Methods 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000011545 laboratory measurement Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000008449 language Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229960001794 melevodopa Drugs 0.000 description 1
- XBBDACCLCFWBSI-ZETCQYMHSA-N melevodopa Chemical compound COC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 XBBDACCLCFWBSI-ZETCQYMHSA-N 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 230000006993 memory improvement Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 229940095102 methyl benzoate Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000001095 motoneuron effect Effects 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000000626 neurodegenerative effect Effects 0.000 description 1
- 239000003176 neuroleptic agent Substances 0.000 description 1
- 230000000701 neuroleptic effect Effects 0.000 description 1
- 230000001962 neuropharmacologic effect Effects 0.000 description 1
- 238000010855 neuropsychological testing Methods 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000000181 nicotinic agonist Substances 0.000 description 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940052740 other dopaminergic agent in atc Drugs 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000001936 parietal effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229960004851 pergolide Drugs 0.000 description 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 238000009521 phase II clinical trial Methods 0.000 description 1
- XAMUDJHXFNRLCY-UHFFFAOYSA-N phenthoate Chemical compound CCOC(=O)C(SP(=S)(OC)OC)C1=CC=CC=C1 XAMUDJHXFNRLCY-UHFFFAOYSA-N 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000001144 postural effect Effects 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960003089 pramipexole Drugs 0.000 description 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000036385 rapid eye movement (rem) sleep Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003893 regulation of appetite Effects 0.000 description 1
- 230000015355 regulation of circadian sleep/wake cycle, sleep Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229960001879 ropinirole Drugs 0.000 description 1
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 description 1
- 229960003179 rotigotine Drugs 0.000 description 1
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 235000000891 standard diet Nutrition 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 239000012058 sterile packaged powder Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000003523 substantia nigra Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000003956 synaptic plasticity Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000004260 weight control Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862781251P | 2018-12-18 | 2018-12-18 | |
US201962904048P | 2019-09-23 | 2019-09-23 | |
PCT/US2019/066465 WO2020131671A1 (en) | 2018-12-18 | 2019-12-16 | Dose regimens for use of ly3154207 in the treatment of dopaminergic cns disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
UA126882C2 true UA126882C2 (uk) | 2023-02-15 |
Family
ID=69167914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA202103923A UA126882C2 (uk) | 2018-12-18 | 2019-12-16 | Застосування ly3154207 при лікуванні дофамінергічних порушень цнс |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220062265A1 (ja) |
EP (2) | EP4417258A2 (ja) |
JP (2) | JP2022514659A (ja) |
KR (1) | KR20210111783A (ja) |
CN (1) | CN113347961A (ja) |
AU (1) | AU2019402087B2 (ja) |
BR (1) | BR112021012102A2 (ja) |
CA (1) | CA3124416C (ja) |
IL (1) | IL284175A (ja) |
MA (1) | MA54530A (ja) |
MX (1) | MX2021007442A (ja) |
SG (1) | SG11202106595VA (ja) |
TW (2) | TW202423437A (ja) |
UA (1) | UA126882C2 (ja) |
WO (1) | WO2020131671A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20240299375A1 (en) * | 2021-03-08 | 2024-09-12 | Eli Lilly And Company | Use of mevidalen and other d1 positive allosteric modulators in the treatment of hallucinations and dementia-related psychosis |
WO2022192255A1 (en) * | 2021-03-09 | 2022-09-15 | Eli Lilly And Company | Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3316B1 (ar) | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
AR106332A1 (es) | 2015-10-23 | 2018-01-03 | Lilly Co Eli | Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona |
-
2019
- 2019-12-16 US US17/416,320 patent/US20220062265A1/en active Pending
- 2019-12-16 WO PCT/US2019/066465 patent/WO2020131671A1/en unknown
- 2019-12-16 UA UAA202103923A patent/UA126882C2/uk unknown
- 2019-12-16 CA CA3124416A patent/CA3124416C/en active Active
- 2019-12-16 EP EP24180893.0A patent/EP4417258A2/en active Pending
- 2019-12-16 EP EP19836884.7A patent/EP3897578A1/en active Pending
- 2019-12-16 MX MX2021007442A patent/MX2021007442A/es unknown
- 2019-12-16 CN CN201980089891.3A patent/CN113347961A/zh active Pending
- 2019-12-16 JP JP2021535892A patent/JP2022514659A/ja active Pending
- 2019-12-16 MA MA054530A patent/MA54530A/fr unknown
- 2019-12-16 TW TW112133925A patent/TW202423437A/zh unknown
- 2019-12-16 TW TW108146071A patent/TWI831896B/zh active
- 2019-12-16 KR KR1020217022499A patent/KR20210111783A/ko not_active Application Discontinuation
- 2019-12-16 AU AU2019402087A patent/AU2019402087B2/en active Active
- 2019-12-16 SG SG11202106595VA patent/SG11202106595VA/en unknown
- 2019-12-16 BR BR112021012102-1A patent/BR112021012102A2/pt unknown
-
2021
- 2021-06-18 IL IL284175A patent/IL284175A/en unknown
-
2023
- 2023-01-24 JP JP2023008488A patent/JP2023055770A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112021012102A2 (pt) | 2021-09-08 |
IL284175A (en) | 2021-08-31 |
TWI831896B (zh) | 2024-02-11 |
MA54530A (fr) | 2021-10-27 |
SG11202106595VA (en) | 2021-07-29 |
JP2022514659A (ja) | 2022-02-14 |
CA3124416C (en) | 2023-05-23 |
MX2021007442A (es) | 2021-10-01 |
TW202038955A (zh) | 2020-11-01 |
US20220062265A1 (en) | 2022-03-03 |
EP3897578A1 (en) | 2021-10-27 |
WO2020131671A1 (en) | 2020-06-25 |
TW202423437A (zh) | 2024-06-16 |
AU2019402087A1 (en) | 2021-07-15 |
KR20210111783A (ko) | 2021-09-13 |
AU2019402087B2 (en) | 2023-04-06 |
JP2023055770A (ja) | 2023-04-18 |
CN113347961A (zh) | 2021-09-03 |
EP4417258A2 (en) | 2024-08-21 |
CA3124416A1 (en) | 2020-06-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR102413756B1 (ko) | 신경퇴행성 질병을 위한 치료제 | |
JP2023055770A (ja) | ドーパミン作動性cns障害の治療におけるly3154207の使用のための用量レジメン | |
JPH0227327B2 (ja) | ||
KR102413754B1 (ko) | 이동성 및 인지 기능을 개선시키기 위한 아세틸-류신 또는 이의 약제학적으로 허용되는 염 | |
JP2020500165A (ja) | アルツハイマー病を治療するための抗aベータプロトフィブリル抗体及びベータ−セクレターゼbace1阻害剤を含む組成物 | |
US20220387396A1 (en) | Methods of treating the symptoms of autism spectrum disorder | |
Micarelli et al. | Changes in sleep performance and chronotype behaviour after vestibular rehabilitation in unilateral vestibular hypofunction | |
US20240299375A1 (en) | Use of mevidalen and other d1 positive allosteric modulators in the treatment of hallucinations and dementia-related psychosis | |
Afreen | Treatment options of Parkinson’s disease: How far we are from the cure? | |
Gannon et al. | The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms | |
CN111032048B (zh) | 丁螺环酮用于治疗功能性头晕的用途 | |
US20240165101A1 (en) | Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression | |
US20220323426A1 (en) | Cholinergic potentiation of binocular vision | |
Brémová | Niemann-Pick type C disease: Effects of a therapy with acetyl-DL-leucine and vestibular function | |
Miron | Optimizing Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder | |
Reetz | Efficacy of the long chain alcohol metabolite octanoic acid as an adjunct to standard first line therapy of classical essential tremor | |
Merrison et al. | EP. 109Establishing a new psychology service for people living with amyotrophic lateral sclerosis | |
CN116234579A (zh) | 用于治疗神经退行性疾病的包含罗替戈汀和乙酰胆碱酯酶抑制剂的组合药物制剂 | |
Harch et al. | Hyperbaric Oxygen Therapy in in Neurodegenerative Disease with Case Presentations of Alzheimer's Disease | |
Macerollo | The role of somatosensory afferences in Parkinson's disease | |
Cooper | Psychopharmacology and physical treatments | |
RU2450822C1 (ru) | Применение гептапептида для лечения болезни паркинсона и способ лечения такой болезни | |
Lehr Jr | Therapy, neuroplasticity, and rehabilitation | |
Paik | Applications of Neuromodulation in Neurology and Neurorehabilitation | |
WO2003101391A2 (en) | Therapeutic methods |