UA121476C2 - Поліморфна форма [5-фтор-3-({2-[(4-фторбензол)сульфоніл]піридин-3-іл}метил)-2-метиліндол-1-іл]-оцтової кислоти - Google Patents
Поліморфна форма [5-фтор-3-({2-[(4-фторбензол)сульфоніл]піридин-3-іл}метил)-2-метиліндол-1-іл]-оцтової кислоти Download PDFInfo
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- UA121476C2 UA121476C2 UAA201612235A UAA201612235A UA121476C2 UA 121476 C2 UA121476 C2 UA 121476C2 UA A201612235 A UAA201612235 A UA A201612235A UA A201612235 A UAA201612235 A UA A201612235A UA 121476 C2 UA121476 C2 UA 121476C2
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Landscapes
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| PCT/GB2015/051296 WO2015166280A1 (en) | 2014-05-02 | 2015-05-01 | Polymorphic form of [5-fluoro-3-({2-[(4-fluorobenzene) sulfonyl] pyridin-3-yl}methyl)-2-methylindol-1-yl]-acetic acid |
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| UA121476C2 true UA121476C2 (uk) | 2020-06-10 |
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| UAA201612235A UA121476C2 (uk) | 2014-05-02 | 2015-05-01 | Поліморфна форма [5-фтор-3-({2-[(4-фторбензол)сульфоніл]піридин-3-іл}метил)-2-метиліндол-1-іл]-оцтової кислоти |
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| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| CN108949699B (zh) * | 2018-08-03 | 2020-09-04 | 江南大学 | 一种分泌美洛昔康单克隆抗体的杂交瘤细胞株及其应用 |
| ES2991036T3 (es) * | 2019-03-25 | 2024-12-02 | Hoffmann La Roche | Formas sólidas de un compuesto del modificador alostérico de la proteína central del VHB |
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| US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| BE790679A (fr) | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
| DK151884C (da) | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
| US4363912A (en) | 1980-12-15 | 1982-12-14 | Pfizer Inc. | Indole thromboxane synthetase inhibitors |
| US4478842A (en) | 1981-11-19 | 1984-10-23 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
| GB8607294D0 (en) | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
| DE3514696A1 (de) | 1985-04-24 | 1986-11-06 | Bayer Ag, 5090 Leverkusen | N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung |
| US5214059A (en) | 1989-07-03 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Incorporated | 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders |
| GB9122590D0 (en) | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
| AU665690B2 (en) | 1992-05-08 | 1996-01-11 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
| IL109309A (en) | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| GB9317764D0 (en) | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
| US5641800A (en) | 1994-07-21 | 1997-06-24 | Eli Lilly And Company | 1H-indole-1-functional sPLA2 inhibitors |
| US5532237A (en) | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| US6040426A (en) | 1996-06-05 | 2000-03-21 | Bml, Inc. | Human Th2 specific protein |
| US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| KR100584650B1 (ko) | 1998-03-31 | 2006-05-30 | 디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 | 치환된 인돌알칸산 |
| PT1475377E (pt) | 1998-04-28 | 2006-11-30 | Elbion Ag | Derivados de indole e sua utilização como inibidores da fosfodiesterase 4 |
| EP0984012A3 (en) | 1998-08-31 | 2001-01-10 | Pfizer Products Inc. | Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties |
| TNSN99224A1 (fr) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| JP3486408B2 (ja) | 1999-08-23 | 2004-01-13 | 株式会社ビー・エム・エル | 物質のヒトプロスタグランジンｄ２受容体に対する性質の同定方法 |
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| WO2001064205A2 (en) | 2000-03-02 | 2001-09-07 | The Institutes For Pharmaceutical Discovery, Llc | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor |
| JP2001247570A (ja) | 2000-03-08 | 2001-09-11 | Japan Tobacco Inc | インドール酢酸化合物及びその製造方法 |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| US7534897B2 (en) | 2002-05-16 | 2009-05-19 | Shionogi & Co., Ltd. | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism |
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| ATE331708T1 (de) | 2002-12-10 | 2006-07-15 | Wyeth Corp | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren |
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| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| RU2006109108A (ru) | 2003-10-14 | 2007-11-20 | Оксаген Лимитед (GB) | Соединения, обладающие активностью антагонистов crth2 рецепторов |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| CN100509802C (zh) | 2003-11-05 | 2009-07-08 | 霍夫曼-拉罗奇有限公司 | 作为ppar激活剂的杂芳基衍生物 |
| SE0303180D0 (sv) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
| CA2563707A1 (en) | 2004-04-20 | 2005-11-03 | Pfizer Inc. | Method of treating neuropathic pain using a crth2 receptor antagonsit |
| US8673889B2 (en) | 2004-04-26 | 2014-03-18 | Ono Pharmaceutical Co., Ltd. | BLT2-mediated disease, BLT2 binding agent and the compound |
| GB0412914D0 (en) | 2004-06-10 | 2004-07-14 | Oxagen Ltd | Compounds |
| EA200700712A1 (ru) | 2004-09-21 | 2008-02-28 | Эсерсис, Инк. | Производные индолуксусной кислоты, способ получения таких производных (варианты), фармацевтическая композиция, набор на их основе, способ ингибирования связывания эндогенных лигандов и способ лечения заболеваний и расстройств, восприимчивых к ингибированию связывания эндогенных лигандов с рецептором crth-2 |
| GB2422830A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| GB2422829A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| GB2422831A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| GB0504150D0 (en) | 2005-03-01 | 2005-04-06 | Oxagen Ltd | Microcrystalline material |
| GB0505048D0 (en) | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
| JP5072594B2 (ja) | 2005-07-22 | 2012-11-14 | 塩野義製薬株式会社 | Ｐｇｄ２受容体アンタゴニスト活性を有するインドール誘導体 |
| EP1915372B1 (en) | 2005-08-12 | 2013-11-20 | Merck Canada Inc. | Indole derivatives as crth2 receptor antagonists |
| GB0518783D0 (en) | 2005-09-14 | 2005-10-26 | Argenta Discovery Ltd | Indolizine compounds |
| GB0605743D0 (en) | 2006-03-22 | 2006-05-03 | Oxagen Ltd | Salts with CRTH2 antagonist activity |
| GB0614068D0 (en) | 2006-07-14 | 2006-08-23 | Glaxo Group Ltd | Compounds |
| GB0614066D0 (en) | 2006-07-14 | 2006-08-23 | Glaxo Group Ltd | Compounds |
| EP2046740B1 (en) | 2006-07-22 | 2012-05-23 | Oxagen Limited | Compounds having crth2 antagonist activity |
| WO2009037503A2 (en) | 2007-09-18 | 2009-03-26 | Astrazeneca Ab | New combination - 012 for the treatment of respiratory diseases |
| GB0722216D0 (en) | 2007-11-13 | 2007-12-27 | Oxagen Ltd | Use of crth2 antagonist compounds |
| GB0722203D0 (en) | 2007-11-13 | 2007-12-19 | Oxagen Ltd | Use of CRTH2 antagonist compounds |
| ATE502920T1 (de) | 2007-12-14 | 2011-04-15 | Pulmagen Therapeutics Asthma Ltd | Indole und ihre therapeutische verwendung |
| MX2010007833A (es) | 2008-01-18 | 2010-08-11 | Oxagen Ltd | Compuestos que tienen actividad antagonista de crth2. |
| US20110060026A1 (en) | 2008-01-18 | 2011-03-10 | George Hynd | Indoles Active on CRTH2 Receptor |
| US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| JP2011509990A (ja) | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Ｃｒｔｈ２アンタゴニスト活性を有する化合物 |
| EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
| EP2300425A4 (en) | 2008-06-24 | 2012-03-21 | Panmira Pharmaceuticals Llc | PROSTAGLANDIN D2 RECEPTOR CYCLOALCANEÝBINDLUCK ANTAGONISTS |
| GB201103837D0 (en) | 2011-03-07 | 2011-04-20 | Oxagen Ltd | Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid |
| GB201121557D0 (en) | 2011-12-15 | 2012-01-25 | Oxagen Ltd | Process |
| JP2015500326A (ja) | 2011-12-16 | 2015-01-05 | アトピックス テラピューティクス リミテッド | 好酸球性食道炎の治療のためのｃｒｔｈ２拮抗薬およびプロトンポンプ阻害薬の組み合わせ |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| GB201407813D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407807D0 (en) * | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
-
2014
- 2014-05-02 GB GBGB1407820.8A patent/GB201407820D0/en not_active Ceased
-
2015
- 2015-05-01 JP JP2016565442A patent/JP2017514841A/ja active Pending
- 2015-05-01 TR TR2019/07568T patent/TR201907568T4/tr unknown
- 2015-05-01 RU RU2016142519A patent/RU2702343C2/ru active
- 2015-05-01 UA UAA201612235A patent/UA121476C2/uk unknown
- 2015-05-01 WO PCT/GB2015/051296 patent/WO2015166280A1/en not_active Ceased
- 2015-05-01 US US15/308,290 patent/US9951042B2/en active Active
- 2015-05-01 EP EP15721032.9A patent/EP3137453B8/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| RU2016142519A3 (OSRAM) | 2018-11-02 |
| US20170121306A1 (en) | 2017-05-04 |
| TR201907568T4 (tr) | 2019-06-21 |
| US9951042B2 (en) | 2018-04-24 |
| JP2017514841A (ja) | 2017-06-08 |
| RU2702343C2 (ru) | 2019-10-08 |
| EP3137453B1 (en) | 2019-02-27 |
| RU2016142519A (ru) | 2018-06-05 |
| GB201407820D0 (en) | 2014-06-18 |
| WO2015166280A1 (en) | 2015-11-05 |
| EP3137453A1 (en) | 2017-03-08 |
| EP3137453B8 (en) | 2019-05-15 |
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