UA114706C2 - Композиція для лікування нервових розладів - Google Patents
Композиція для лікування нервових розладівInfo
- Publication number
- UA114706C2 UA114706C2 UAA201312638A UAA201312638A UA114706C2 UA 114706 C2 UA114706 C2 UA 114706C2 UA A201312638 A UAA201312638 A UA A201312638A UA A201312638 A UAA201312638 A UA A201312638A UA 114706 C2 UA114706 C2 UA 114706C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compositions
- treatment
- neurologic disorders
- vitamin
- mufas
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 208000012902 Nervous system disease Diseases 0.000 title abstract 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 2
- 201000006417 multiple sclerosis Diseases 0.000 abstract 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract 1
- 229930003427 Vitamin E Natural products 0.000 abstract 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract 1
- 235000010382 gamma-tocopherol Nutrition 0.000 abstract 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 235000021391 short chain fatty acids Nutrition 0.000 abstract 1
- 235000019155 vitamin A Nutrition 0.000 abstract 1
- 239000011719 vitamin A Substances 0.000 abstract 1
- 235000019165 vitamin E Nutrition 0.000 abstract 1
- 239000011709 vitamin E Substances 0.000 abstract 1
- 229940046009 vitamin E Drugs 0.000 abstract 1
- 229940045997 vitamin a Drugs 0.000 abstract 1
- 239000002478 γ-tocopherol Substances 0.000 abstract 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Abstract
Винахід стосується рідкої пероральної фармацевтичної композиції, що містить довголанцюжкову фракцію поліненасиченої жирної кислоти (PUFA), яка містить ейкозапентаєнову кислоту (EPA), докозагексаєнову кислоту (DHA), лінолеву кислоту (LA) і гамму-ліноленову кислоту (GLA), де співвідношення DHA:EPA складає від приблизно 2:1 до приблизно 5:1 (мас./мас.), одну або декілька інших PUFA омега-3 і одну або декілька мононенасичених жирних кислот (MUFA) і терапевтично ефективну кількість гамма-токоферолу, де гамма-токоферол присутній в кількості від 100 до 3000 мг з розрахунку на щоденну дозу композиції і де введення терапевтично ефективної кількості композиції пацієнту, який страждає на нейродегенеративне захворювання, приводить до зниження тяжкості захворювання.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161469081P | 2011-03-29 | 2011-03-29 | |
PCT/IB2012/000824 WO2012131493A1 (en) | 2011-03-29 | 2012-03-28 | Compositions for the treatment of neurologic disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
UA114706C2 true UA114706C2 (uk) | 2017-07-25 |
Family
ID=46275907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201312638A UA114706C2 (uk) | 2011-03-29 | 2012-03-28 | Композиція для лікування нервових розладів |
Country Status (21)
Country | Link |
---|---|
US (2) | US20120252888A1 (uk) |
EP (1) | EP2691086B1 (uk) |
JP (1) | JP6092843B2 (uk) |
CN (1) | CN104010634B (uk) |
AU (1) | AU2012235869B2 (uk) |
BR (1) | BR112013025088B1 (uk) |
CA (1) | CA2831506C (uk) |
CY (1) | CY1117828T1 (uk) |
DK (1) | DK2691086T3 (uk) |
EA (1) | EA025232B1 (uk) |
ES (1) | ES2585066T3 (uk) |
GE (1) | GEP201606568B (uk) |
HK (1) | HK1194665A1 (uk) |
HR (1) | HRP20160939T1 (uk) |
HU (1) | HUE028065T2 (uk) |
IL (1) | IL228541A (uk) |
MX (1) | MX2013011295A (uk) |
PL (1) | PL2691086T3 (uk) |
UA (1) | UA114706C2 (uk) |
WO (1) | WO2012131493A1 (uk) |
ZA (1) | ZA201307256B (uk) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10709680B2 (en) * | 2011-07-18 | 2020-07-14 | Physicians Recommended Nutriceuticals, Llc | Methods for treating dry eye |
ITMI20130354A1 (it) * | 2013-03-08 | 2014-09-09 | Again Life Italia Srl | Miscela di acidi grassi (f.a.g. fatty acids group) per uso nel trattamento di patologie infiammatorie. |
WO2015073515A1 (en) * | 2013-11-12 | 2015-05-21 | Abbott Laboratories | Uses of nutritional compositions including natural vitamin e, and polyunsaturated fatty acid |
CN106687113B (zh) | 2014-06-06 | 2021-09-03 | 海洋原料公司 | ω-3组合物、剂型及使用方法 |
BR112017009678A2 (pt) * | 2014-11-07 | 2018-01-23 | Kocheri Paul Thomson | composição optimizada de nutrientes de ácidos graxos e método de preparação da mesma |
DE102015109352A1 (de) * | 2015-06-12 | 2016-12-15 | K. D. Pharma Bexbach Gmbh | Anwendung von Omega-3- und/oder Omega-6-Fettsäure(n) |
AR102008A1 (es) * | 2015-09-24 | 2017-01-25 | Brix S R L | Ingrediente farmacéutico activo (ifa) oleoso para el tratamiento de afecciones de la piel, composiciones que lo comprenden y su uso para prepararlas |
CA3042592A1 (en) * | 2016-11-04 | 2018-05-11 | Immd Sp. Zo.O | Inteligent delivery of ingested and absorbed molecules |
CN109125311A (zh) * | 2018-06-26 | 2019-01-04 | 东南大学 | 预防或治疗阿尔茨海默症的药物组合物及其应用 |
JP7075869B2 (ja) | 2018-10-29 | 2022-05-26 | 昭和電工株式会社 | ヒートシンクの製造方法 |
EP4384157A1 (en) * | 2021-08-09 | 2024-06-19 | Kentucky Equine Research, Inc. | Compositions and methods for modulating equine fatty acid profiles |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8601399D0 (en) * | 1986-01-21 | 1986-02-26 | Delta Iota Ltd | Information transmission/processing |
GB8601915D0 (en) * | 1986-01-27 | 1986-03-05 | Efamol Ltd | Pharmaceutical compositions |
GB8813766D0 (en) | 1988-06-10 | 1988-07-13 | Efamol Holdings | Essential fatty acid compositions |
GB9001121D0 (en) * | 1990-01-18 | 1990-03-21 | Efamol Holdings | Efa compositions and therapy |
PH31403A (en) * | 1991-03-01 | 1998-10-29 | Warner Lambert Co | Therapeutic compositions to protect and recuscitate mammalian cells and methods for preparing same. |
GB9111900D0 (en) * | 1991-06-03 | 1991-07-24 | Efamol Holdings | Fatty acid compositions |
JP3283274B2 (ja) * | 1991-06-15 | 2002-05-20 | サントリー株式会社 | 新規組成物 |
GB9506837D0 (en) * | 1995-04-03 | 1995-05-24 | Scotia Holdings Plc | Triglycerides |
DE19757414A1 (de) * | 1997-12-23 | 1999-07-01 | Nutricia Nv | Fettmischung |
US6048891A (en) * | 1998-12-17 | 2000-04-11 | Loma Linda University Medical Center | Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease |
GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
US6677321B1 (en) * | 1999-12-09 | 2004-01-13 | Bruce Levin | Methods and compositions for treatment of inflammatory disease |
US7045683B2 (en) | 2001-05-04 | 2006-05-16 | Abbott Laboratories | Δ4-desaturase genes and uses thereof |
PT1390025E (pt) * | 2001-05-30 | 2005-08-31 | Laxdale Ltd | Utilizacao de coenzima q (ubiquinona) e acido eicosapentaenoico (epa) para o tratamento de linfoma nao de hodgkin e de distubios psiquiatricos ou neurologicos |
DE60220415T2 (de) | 2001-07-27 | 2008-02-14 | Neptune Technologies & Bioressources Inc., Laval | Flavonoide und mehrfach ungesättigte fettsäuren enthaltende natürliche phospholipide maritimen ursprungs sowie deren anwendungen |
US20030144219A1 (en) * | 2001-11-15 | 2003-07-31 | Phinney Stephen Dodge | Formulations and methods for treatment or amelioration of inflammatory conditions |
US20050080109A1 (en) | 2003-10-09 | 2005-04-14 | Papas Andreas M. | Gamma-tocopherol and gamma-tocotrienol therapy for multiple sclerosis |
CN101346138B (zh) * | 2005-12-21 | 2013-03-13 | 布鲁迪科技有限公司 | Dha、epa或dha衍生的epa用于治疗细胞氧化损伤相关疾病的用途 |
US20090196862A1 (en) * | 2008-01-22 | 2009-08-06 | William Davis | High dosage Vitamin D |
JP2010155799A (ja) * | 2008-12-26 | 2010-07-15 | Fujifilm Corp | 粉末組成物及びそれを含む食品 |
JP5872453B2 (ja) * | 2009-04-17 | 2016-03-01 | ナタク ファルマ エセ.エレ. | フィタン酸含量が低く、ω−3脂肪酸に富む組成物 |
-
2012
- 2012-03-27 US US13/431,429 patent/US20120252888A1/en not_active Abandoned
- 2012-03-28 PL PL12727411.6T patent/PL2691086T3/pl unknown
- 2012-03-28 HU HUE12727411A patent/HUE028065T2/en unknown
- 2012-03-28 MX MX2013011295A patent/MX2013011295A/es not_active Application Discontinuation
- 2012-03-28 ES ES12727411.6T patent/ES2585066T3/es active Active
- 2012-03-28 EP EP12727411.6A patent/EP2691086B1/en not_active Revoked
- 2012-03-28 DK DK12727411.6T patent/DK2691086T3/en active
- 2012-03-28 UA UAA201312638A patent/UA114706C2/uk unknown
- 2012-03-28 CN CN201280026514.3A patent/CN104010634B/zh not_active Expired - Fee Related
- 2012-03-28 GE GEAP201213272A patent/GEP201606568B/en unknown
- 2012-03-28 JP JP2014501739A patent/JP6092843B2/ja not_active Expired - Fee Related
- 2012-03-28 EA EA201391407A patent/EA025232B1/ru not_active IP Right Cessation
- 2012-03-28 WO PCT/IB2012/000824 patent/WO2012131493A1/en active Application Filing
- 2012-03-28 AU AU2012235869A patent/AU2012235869B2/en not_active Ceased
- 2012-03-28 BR BR112013025088-7A patent/BR112013025088B1/pt not_active IP Right Cessation
- 2012-03-28 CA CA2831506A patent/CA2831506C/en not_active Expired - Fee Related
-
2013
- 2013-09-27 ZA ZA2013/07256A patent/ZA201307256B/en unknown
- 2013-09-29 IL IL228541A patent/IL228541A/en active IP Right Grant
-
2014
- 2014-08-05 HK HK14108018.5A patent/HK1194665A1/zh not_active IP Right Cessation
-
2016
- 2016-07-25 HR HRP20160939TT patent/HRP20160939T1/hr unknown
- 2016-07-26 CY CY20161100730T patent/CY1117828T1/el unknown
-
2019
- 2019-05-22 US US16/419,213 patent/US20190343774A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HK1194665A1 (zh) | 2014-10-24 |
EP2691086A1 (en) | 2014-02-05 |
CN104010634A (zh) | 2014-08-27 |
EA201391407A1 (ru) | 2014-03-31 |
AU2012235869A1 (en) | 2013-10-17 |
AU2012235869B2 (en) | 2017-04-20 |
NZ616554A (en) | 2015-10-30 |
CY1117828T1 (el) | 2017-05-17 |
EA025232B1 (ru) | 2016-12-30 |
CA2831506C (en) | 2019-07-09 |
BR112013025088B1 (pt) | 2021-12-14 |
GEP201606568B (en) | 2016-11-10 |
WO2012131493A1 (en) | 2012-10-04 |
PL2691086T3 (pl) | 2016-12-30 |
BR112013025088A2 (pt) | 2017-02-14 |
EP2691086B1 (en) | 2016-04-27 |
US20190343774A1 (en) | 2019-11-14 |
CN104010634B (zh) | 2017-06-09 |
JP2014512351A (ja) | 2014-05-22 |
ZA201307256B (en) | 2014-12-23 |
US20120252888A1 (en) | 2012-10-04 |
IL228541A (en) | 2017-11-30 |
DK2691086T3 (en) | 2016-08-15 |
IL228541A0 (en) | 2013-12-31 |
HRP20160939T1 (hr) | 2016-10-07 |
HUE028065T2 (en) | 2016-11-28 |
ES2585066T3 (es) | 2016-10-03 |
JP6092843B2 (ja) | 2017-03-08 |
CA2831506A1 (en) | 2012-10-04 |
MX2013011295A (es) | 2014-11-10 |
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