UA111749C2 - Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну - Google Patents
Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну Download PDFInfo
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- UA111749C2 UA111749C2 UAA201403502A UAA201403502A UA111749C2 UA 111749 C2 UA111749 C2 UA 111749C2 UA A201403502 A UAA201403502 A UA A201403502A UA A201403502 A UAA201403502 A UA A201403502A UA 111749 C2 UA111749 C2 UA 111749C2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11191997 | 2011-12-05 | ||
| PCT/EP2012/074351 WO2013083557A1 (en) | 2011-12-05 | 2012-12-04 | 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA111749C2 true UA111749C2 (uk) | 2016-06-10 |
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| US (1) | US20140343048A1 (enExample) |
| EP (1) | EP2788346B1 (enExample) |
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| AU (1) | AU2012347397B2 (enExample) |
| BR (1) | BR112014013310A2 (enExample) |
| CA (1) | CA2852366C (enExample) |
| EA (1) | EA023909B1 (enExample) |
| ES (1) | ES2558604T3 (enExample) |
| IL (1) | IL232916A (enExample) |
| MX (1) | MX357384B (enExample) |
| MY (1) | MY165209A (enExample) |
| PH (1) | PH12014501235B1 (enExample) |
| SG (1) | SG11201402734XA (enExample) |
| UA (1) | UA111749C2 (enExample) |
| WO (1) | WO2013083557A1 (enExample) |
| ZA (1) | ZA201404074B (enExample) |
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| NZ589590A (en) | 2008-06-13 | 2012-05-25 | Shionogi & Co | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
| WO2011071135A1 (ja) | 2009-12-11 | 2011-06-16 | 塩野義製薬株式会社 | オキサジン誘導体 |
| WO2011154431A1 (en) | 2010-06-09 | 2011-12-15 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
| BR112013015430A2 (pt) | 2010-12-22 | 2016-09-20 | Janssen Pharmaceutica Nv | derivados de 5,6-diidro-imidazo[1,2-a]pirazin-8-ilamina úteis como inibidores de beta-secretase (bace) |
| JP5853035B2 (ja) | 2011-03-09 | 2016-02-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な３，４−ジヒドロ−ピロロ［１，２−ａ］ピラジン−１−イルアミン誘導体 |
| JP5989130B2 (ja) * | 2011-12-06 | 2016-09-07 | ヤンセン ファーマシューティカ エヌ．ベー． | ５−（３−アミノフェニル）−５−アルキル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン−３−アミン誘導体 |
| US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
| MX368326B (es) | 2013-06-12 | 2019-09-27 | Janssen Pharmaceutica Nv | Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5-a]pirazin-3(2h )-ona como inhibidores de beta-secretasa (bace). |
| CN105283457B (zh) | 2013-06-12 | 2018-09-18 | 詹森药业有限公司 | 作为β-分泌酶(BACE)抑制剂的4-氨基-6-苯基-5,6-二氢咪唑并[1,5-A]吡嗪衍生物 |
| WO2014198854A1 (en) | 2013-06-12 | 2014-12-18 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
| CN107108582B (zh) | 2014-12-18 | 2019-10-18 | 詹森药业有限公司 | β-分泌酶的2，3，4，5-四氢吡啶-6-胺化合物抑制剂 |
| EP4096920A1 (en) * | 2020-01-27 | 2022-12-07 | Silcotek Corp. | Biopharmaceutical manufacturing process and product |
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| AR077328A1 (es) * | 2009-07-24 | 2011-08-17 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos |
| US8188079B2 (en) * | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| WO2011154431A1 (en) * | 2010-06-09 | 2011-12-15 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
| US20130281449A1 (en) * | 2011-01-12 | 2013-10-24 | Novartis Ag | Oxazine Derivatives and their Use in the Treatment of Neurological Disorders |
| JPWO2012147763A1 (ja) * | 2011-04-26 | 2014-07-28 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤 |
| JP5989130B2 (ja) * | 2011-12-06 | 2016-09-07 | ヤンセン ファーマシューティカ エヌ．ベー． | ５−（３−アミノフェニル）−５−アルキル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン−３−アミン誘導体 |
-
2012
- 2012-04-12 UA UAA201403502A patent/UA111749C2/uk unknown
- 2012-12-04 MX MX2014006689A patent/MX357384B/es active IP Right Grant
- 2012-12-04 WO PCT/EP2012/074351 patent/WO2013083557A1/en not_active Ceased
- 2012-12-04 SG SG11201402734XA patent/SG11201402734XA/en unknown
- 2012-12-04 BR BR112014013310A patent/BR112014013310A2/pt not_active Application Discontinuation
- 2012-12-04 KR KR1020147013840A patent/KR102060379B1/ko not_active Expired - Fee Related
- 2012-12-04 MY MYPI2014700925A patent/MY165209A/en unknown
- 2012-12-04 AU AU2012347397A patent/AU2012347397B2/en not_active Ceased
- 2012-12-04 CN CN201280059719.1A patent/CN103974951B/zh not_active Expired - Fee Related
- 2012-12-04 EA EA201491116A patent/EA023909B1/ru not_active IP Right Cessation
- 2012-12-04 JP JP2014543939A patent/JP6169095B2/ja not_active Expired - Fee Related
- 2012-12-04 EP EP12794731.5A patent/EP2788346B1/en active Active
- 2012-12-04 CA CA2852366A patent/CA2852366C/en not_active Expired - Fee Related
- 2012-12-04 US US14/362,523 patent/US20140343048A1/en not_active Abandoned
- 2012-12-04 ES ES12794731.5T patent/ES2558604T3/es active Active
-
2014
- 2014-06-02 PH PH12014501235A patent/PH12014501235B1/en unknown
- 2014-06-02 IL IL232916A patent/IL232916A/en active IP Right Grant
- 2014-06-04 ZA ZA2014/04074A patent/ZA201404074B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103974951B (zh) | 2016-04-13 |
| NZ626662A (en) | 2015-05-29 |
| IL232916A0 (en) | 2014-08-03 |
| JP2015500223A (ja) | 2015-01-05 |
| EP2788346B1 (en) | 2015-10-28 |
| CA2852366C (en) | 2020-02-18 |
| CN103974951A (zh) | 2014-08-06 |
| AU2012347397A1 (en) | 2014-04-24 |
| SG11201402734XA (en) | 2014-06-27 |
| ES2558604T3 (es) | 2016-02-05 |
| MX357384B (es) | 2018-07-06 |
| EA023909B1 (ru) | 2016-07-29 |
| KR102060379B1 (ko) | 2019-12-30 |
| MY165209A (en) | 2018-03-05 |
| US20140343048A1 (en) | 2014-11-20 |
| BR112014013310A2 (pt) | 2017-06-13 |
| PH12014501235A1 (en) | 2014-09-08 |
| MX2014006689A (es) | 2014-09-04 |
| AU2012347397B2 (en) | 2016-09-22 |
| WO2013083557A1 (en) | 2013-06-13 |
| EA201491116A1 (ru) | 2014-12-30 |
| EP2788346A1 (en) | 2014-10-15 |
| ZA201404074B (en) | 2016-10-26 |
| IL232916A (en) | 2016-07-31 |
| PH12014501235B1 (en) | 2014-09-08 |
| JP6169095B2 (ja) | 2017-07-26 |
| CA2852366A1 (en) | 2013-06-13 |
| HK1198586A1 (zh) | 2015-04-30 |
| KR20140107209A (ko) | 2014-09-04 |
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