SG11201402734XA - 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives - Google Patents
6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivativesInfo
- Publication number
- SG11201402734XA SG11201402734XA SG11201402734XA SG11201402734XA SG11201402734XA SG 11201402734X A SG11201402734X A SG 11201402734XA SG 11201402734X A SG11201402734X A SG 11201402734XA SG 11201402734X A SG11201402734X A SG 11201402734XA SG 11201402734X A SG11201402734X A SG 11201402734XA
- Authority
- SG
- Singapore
- Prior art keywords
- oxazin
- difluoromethyl
- dihydro
- amine derivatives
- amine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11191997 | 2011-12-05 | ||
| PCT/EP2012/074351 WO2013083557A1 (en) | 2011-12-05 | 2012-12-04 | 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201402734XA true SG11201402734XA (en) | 2014-06-27 |
Family
ID=47278317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201402734XA SG11201402734XA (en) | 2011-12-05 | 2012-12-04 | 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20140343048A1 (en) |
| EP (1) | EP2788346B1 (en) |
| JP (1) | JP6169095B2 (en) |
| KR (1) | KR102060379B1 (en) |
| CN (1) | CN103974951B (en) |
| AU (1) | AU2012347397B2 (en) |
| BR (1) | BR112014013310A2 (en) |
| CA (1) | CA2852366C (en) |
| EA (1) | EA023909B1 (en) |
| ES (1) | ES2558604T3 (en) |
| HK (1) | HK1198586A1 (en) |
| IL (1) | IL232916A (en) |
| MX (1) | MX357384B (en) |
| MY (1) | MY165209A (en) |
| PH (1) | PH12014501235A1 (en) |
| SG (1) | SG11201402734XA (en) |
| UA (1) | UA111749C2 (en) |
| WO (1) | WO2013083557A1 (en) |
| ZA (1) | ZA201404074B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009151098A1 (en) | 2008-06-13 | 2009-12-17 | 塩野義製薬株式会社 | SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING β-SECRETASE-INHIBITING ACTIVITY |
| RU2012129168A (en) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | OXASINE DERIVATIVES |
| EP2580200B1 (en) | 2010-06-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
| EP2655376B1 (en) | 2010-12-22 | 2017-08-23 | Janssen Pharmaceutica NV | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
| CN103415521B (en) | 2011-03-09 | 2016-01-06 | 詹森药业有限公司 | As 3,4-dihydro-pyrrole also [1,2-a] pyrazine-1-yl amine derivatives of beta-secretase (BACE) inhibitor |
| ES2582473T3 (en) * | 2011-12-06 | 2016-09-13 | Janssen Pharmaceutica, N.V. | 5- (3-Aminophenyl) -5-alkyl-5,6-dihydro-2H- [1,4] oxazin-3-amine derivatives for the treatment of disorders in which beta-secretase is involved |
| EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
| CN105452251B (en) | 2013-06-12 | 2017-12-26 | 詹森药业有限公司 | The glyoxalidine of 4 amino, 6 phenyl 5,6 as beta-secretase (BACE) inhibitor simultaneously [1,5 A] pyrazine 3 (2H) ketone derivatives |
| WO2014198853A1 (en) | 2013-06-12 | 2014-12-18 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
| US9751886B2 (en) | 2013-06-12 | 2017-09-05 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-A]pyrazine derivatives as inhibitors of beta-secretase (BACE) |
| KR20170095881A (en) | 2014-12-18 | 2017-08-23 | 얀센 파마슈티카 엔.브이. | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase |
| EP4096920A1 (en) * | 2020-01-27 | 2022-12-07 | Silcotek Corp. | Biopharmaceutical manufacturing process and product |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077328A1 (en) * | 2009-07-24 | 2011-08-17 | Novartis Ag | DERIVATIVES OF OXAZINE AND ITS USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS |
| US8188079B2 (en) | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
| UA103272C2 (en) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-amino-5,5-difluoro-5,6-dihydro-4h-[1,3]oxazines as bace1 and/or bace2 inhibitors |
| EP2580200B1 (en) * | 2010-06-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
| JP2014505688A (en) * | 2011-01-12 | 2014-03-06 | ノバルティス アーゲー | Oxazine derivatives and their use in the treatment of neurological disorders |
| JP2012147763A (en) * | 2011-01-17 | 2012-08-09 | Toshitaka Kobayashi | Dry food perforator |
| ES2582473T3 (en) * | 2011-12-06 | 2016-09-13 | Janssen Pharmaceutica, N.V. | 5- (3-Aminophenyl) -5-alkyl-5,6-dihydro-2H- [1,4] oxazin-3-amine derivatives for the treatment of disorders in which beta-secretase is involved |
-
2012
- 2012-04-12 UA UAA201403502A patent/UA111749C2/en unknown
- 2012-12-04 MX MX2014006689A patent/MX357384B/en active IP Right Grant
- 2012-12-04 JP JP2014543939A patent/JP6169095B2/en not_active Expired - Fee Related
- 2012-12-04 CN CN201280059719.1A patent/CN103974951B/en not_active Expired - Fee Related
- 2012-12-04 EP EP12794731.5A patent/EP2788346B1/en active Active
- 2012-12-04 MY MYPI2014700925A patent/MY165209A/en unknown
- 2012-12-04 CA CA2852366A patent/CA2852366C/en not_active Expired - Fee Related
- 2012-12-04 US US14/362,523 patent/US20140343048A1/en not_active Abandoned
- 2012-12-04 BR BR112014013310A patent/BR112014013310A2/en not_active Application Discontinuation
- 2012-12-04 ES ES12794731.5T patent/ES2558604T3/en active Active
- 2012-12-04 EA EA201491116A patent/EA023909B1/en not_active IP Right Cessation
- 2012-12-04 AU AU2012347397A patent/AU2012347397B2/en not_active Ceased
- 2012-12-04 WO PCT/EP2012/074351 patent/WO2013083557A1/en active Application Filing
- 2012-12-04 SG SG11201402734XA patent/SG11201402734XA/en unknown
- 2012-12-04 KR KR1020147013840A patent/KR102060379B1/en active IP Right Grant
-
2014
- 2014-06-02 PH PH12014501235A patent/PH12014501235A1/en unknown
- 2014-06-02 IL IL232916A patent/IL232916A/en active IP Right Grant
- 2014-06-04 ZA ZA2014/04074A patent/ZA201404074B/en unknown
- 2014-12-01 HK HK14112072A patent/HK1198586A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2852366A1 (en) | 2013-06-13 |
| ES2558604T3 (en) | 2016-02-05 |
| CA2852366C (en) | 2020-02-18 |
| JP2015500223A (en) | 2015-01-05 |
| IL232916A0 (en) | 2014-08-03 |
| UA111749C2 (en) | 2016-06-10 |
| BR112014013310A2 (en) | 2017-06-13 |
| MX357384B (en) | 2018-07-06 |
| EA023909B1 (en) | 2016-07-29 |
| HK1198586A1 (en) | 2015-04-30 |
| EP2788346B1 (en) | 2015-10-28 |
| CN103974951A (en) | 2014-08-06 |
| MX2014006689A (en) | 2014-09-04 |
| IL232916A (en) | 2016-07-31 |
| AU2012347397A1 (en) | 2014-04-24 |
| EP2788346A1 (en) | 2014-10-15 |
| AU2012347397B2 (en) | 2016-09-22 |
| PH12014501235B1 (en) | 2014-09-08 |
| ZA201404074B (en) | 2016-10-26 |
| KR102060379B1 (en) | 2019-12-30 |
| EA201491116A1 (en) | 2014-12-30 |
| US20140343048A1 (en) | 2014-11-20 |
| NZ626662A (en) | 2015-05-29 |
| CN103974951B (en) | 2016-04-13 |
| KR20140107209A (en) | 2014-09-04 |
| MY165209A (en) | 2018-03-05 |
| WO2013083557A1 (en) | 2013-06-13 |
| JP6169095B2 (en) | 2017-07-26 |
| PH12014501235A1 (en) | 2014-09-08 |
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