UA110343C2 - Spiro heterocyclic compounds as antagonists mglur5 - Google Patents
Spiro heterocyclic compounds as antagonists mglur5Info
- Publication number
- UA110343C2 UA110343C2 UAA201301071A UAA201301071A UA110343C2 UA 110343 C2 UA110343 C2 UA 110343C2 UA A201301071 A UAA201301071 A UA A201301071A UA A201301071 A UAA201301071 A UA A201301071A UA 110343 C2 UA110343 C2 UA 110343C2
- Authority
- UA
- Ukraine
- Prior art keywords
- treatment
- compounds
- carbon atom
- urinary tract
- lower urinary
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36294410P | 2010-07-09 | 2010-07-09 | |
| PCT/EP2011/061690 WO2012004400A1 (en) | 2010-07-09 | 2011-07-08 | Novel spiroheterocyclic compounds as mglu5 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA110343C2 true UA110343C2 (en) | 2015-12-25 |
Family
ID=44503767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201301071A UA110343C2 (en) | 2010-07-09 | 2011-08-07 | Spiro heterocyclic compounds as antagonists mglur5 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8580962B2 (ru) |
| EP (1) | EP2590985B1 (ru) |
| JP (1) | JP2013529673A (ru) |
| KR (1) | KR101862626B1 (ru) |
| CN (1) | CN103097391B (ru) |
| AU (1) | AU2011275696B2 (ru) |
| BR (1) | BR112013000529B1 (ru) |
| CA (1) | CA2800930C (ru) |
| EA (1) | EA023020B1 (ru) |
| ES (1) | ES2492694T3 (ru) |
| HK (1) | HK1179248A1 (ru) |
| IL (1) | IL223330A (ru) |
| MX (1) | MX2013000300A (ru) |
| NZ (1) | NZ603868A (ru) |
| SG (1) | SG186107A1 (ru) |
| UA (1) | UA110343C2 (ru) |
| WO (1) | WO2012004400A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| US9593127B2 (en) * | 2014-12-29 | 2017-03-14 | Recordati Ireland Ltd. | Heterocyclylalkyne derivatives and their use as modulators of mGluR5 receptors |
| KR102035048B1 (ko) | 2015-06-03 | 2019-10-22 | 에프. 호프만-라 로슈 아게 | 에틴일 유도체 |
| CN107903265A (zh) * | 2017-11-21 | 2018-04-13 | 毛琳琳 | 一种新型螺环类杀虫剂的制备方法及应用 |
| CN116351472A (zh) * | 2023-02-22 | 2023-06-30 | 万华化学集团股份有限公司 | 一种催化精馏生产异氰酸酯的制备方法和系统 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW593241B (en) | 1999-04-20 | 2004-06-21 | Hoffmann La Roche | Carbamic acid derivatives |
| US6548522B1 (en) * | 1999-10-12 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for treating conditions related to the glutamate receptor using carboxylic acid amide derivatives |
| SV2002000205A (es) | 1999-11-01 | 2002-06-07 | Lilly Co Eli | Compuestos farmaceuticos ref. x-01095 |
| PT1294358E (pt) | 2000-06-28 | 2004-12-31 | Smithkline Beecham Plc | Processo de moagem por via humida |
| US6369222B1 (en) | 2000-07-18 | 2002-04-09 | Hoffmann-La Roche Inc. | mGluR antagonists and a method for their synthesis |
| GB0322612D0 (en) * | 2003-09-26 | 2003-10-29 | Novartis Ag | Organic compounds |
| GB0508318D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| WO2008032191A2 (en) * | 2006-09-13 | 2008-03-20 | Astrazeneca Ab | Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators |
-
2011
- 2011-07-08 KR KR1020137003488A patent/KR101862626B1/ko active IP Right Grant
- 2011-07-08 CA CA2800930A patent/CA2800930C/en not_active Expired - Fee Related
- 2011-07-08 SG SG2012087912A patent/SG186107A1/en unknown
- 2011-07-08 CN CN201180043746.5A patent/CN103097391B/zh not_active Expired - Fee Related
- 2011-07-08 BR BR112013000529-7A patent/BR112013000529B1/pt not_active IP Right Cessation
- 2011-07-08 AU AU2011275696A patent/AU2011275696B2/en not_active Ceased
- 2011-07-08 EA EA201270799A patent/EA023020B1/ru not_active IP Right Cessation
- 2011-07-08 ES ES11746494.1T patent/ES2492694T3/es active Active
- 2011-07-08 NZ NZ603868A patent/NZ603868A/en not_active IP Right Cessation
- 2011-07-08 WO PCT/EP2011/061690 patent/WO2012004400A1/en active Application Filing
- 2011-07-08 JP JP2013517409A patent/JP2013529673A/ja not_active Withdrawn
- 2011-07-08 MX MX2013000300A patent/MX2013000300A/es active IP Right Grant
- 2011-07-08 EP EP11746494.1A patent/EP2590985B1/en active Active
- 2011-07-11 US US13/180,166 patent/US8580962B2/en not_active Expired - Fee Related
- 2011-08-07 UA UAA201301071A patent/UA110343C2/ru unknown
-
2012
- 2012-11-28 IL IL223330A patent/IL223330A/en active IP Right Grant
-
2013
- 2013-05-23 HK HK13106089.4A patent/HK1179248A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013529673A (ja) | 2013-07-22 |
| EA201270799A1 (ru) | 2013-05-30 |
| MX2013000300A (es) | 2013-02-27 |
| SG186107A1 (en) | 2013-01-30 |
| CN103097391B (zh) | 2015-04-08 |
| NZ603868A (en) | 2014-08-29 |
| EA023020B1 (ru) | 2016-04-29 |
| CA2800930C (en) | 2018-08-21 |
| US8580962B2 (en) | 2013-11-12 |
| IL223330A (en) | 2015-09-24 |
| AU2011275696B2 (en) | 2016-02-11 |
| CA2800930A1 (en) | 2012-01-12 |
| US20120059015A1 (en) | 2012-03-08 |
| BR112013000529A2 (pt) | 2016-05-24 |
| ES2492694T3 (es) | 2014-09-10 |
| CN103097391A (zh) | 2013-05-08 |
| WO2012004400A1 (en) | 2012-01-12 |
| KR101862626B1 (ko) | 2018-05-31 |
| EP2590985A1 (en) | 2013-05-15 |
| BR112013000529B1 (pt) | 2019-11-19 |
| KR20130097153A (ko) | 2013-09-02 |
| HK1179248A1 (en) | 2013-09-27 |
| EP2590985B1 (en) | 2014-05-14 |
| IL223330A0 (en) | 2013-02-03 |
| AU2011275696A1 (en) | 2012-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2009237649B2 (en) | Indole modulators of the alpha 7 nicotinic acetylcholine receptor | |
| AU2018282336A1 (en) | Trk-inhibiting compound | |
| CY1121601T1 (el) | Ενωσεις διαμιδιου που εχουν δραστικοτητα ανταγωνιστη μουσκαρινικου υποδοχεα και αγωνιστη βητα 2 αδρενεργικου υποδοχεα | |
| MX2012003499A (es) | Inhibidores de demetilasa-1 especificos de lisina y su uso. | |
| EA201400553A1 (ru) | Производные 2-(1,2,3-триазол-2-ил)бензамида и 3-(1,2,3-триазол-2-ил)пиколинамида | |
| JP2014506599A5 (ru) | ||
| UA110343C2 (en) | Spiro heterocyclic compounds as antagonists mglur5 | |
| MY148694A (en) | Substituted benzimidazoles and methods of preparation | |
| BR122019017036B8 (pt) | compostos de arilamidas substituídas por tetrazol, usos dos referidos compostos e composição farmacêutica | |
| NO20075624L (no) | Nye histamin H3-reseptorligander og deres terapeutiske anvendelser | |
| CY1110952T1 (el) | Παραγωγα κινουκλιδινης και η χρηση αυτων ως μουσκαρινικοι ανταγωνιστες υποδοχεων μ3 | |
| MX2013005535A (es) | Compuesto de 3- (amino-aril) -piridina. | |
| PE20121050A1 (es) | Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog | |
| CA2825134A1 (en) | Indole derivative, and pharmacologically acceptable salt thereof | |
| MX2016006685A (es) | Compuestos heterociclicos de n-acilimino. | |
| EA200800540A1 (ru) | Карбоксамидные производные в качестве антагонистов мускариновых рецепторов | |
| NO20076424L (no) | N-koblete heterocykliske antagonister av P2Y1 reseptoren nyttige for behandling av tromboseforstyrrelser | |
| EP3390394A1 (en) | Hydantoin modulators of kv3 channels | |
| MX2009013115A (es) | Derivados de prolinamida como antagonistas de nk3. | |
| MY157481A (en) | Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors | |
| EA201001645A1 (ru) | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора | |
| AR104837A1 (es) | Compuestos heterocíclicos de 3,3-difluorpiperidina carbamato como antagonistas del receptor de nmda nr2b | |
| ES2380165T3 (es) | Nuevos compuestos heterocíclicos como antagonistas mGlu5 | |
| MX2012001799A (es) | Derivados de pirrolidina como antagonistas del receptor de neuroquinona 3 (nk3). | |
| BR112013000253A2 (pt) | derivados de (3-metilpirrolidin-3-il) metil piridinil éter e seu uso como antagonistas do receptor nk-3 |