UA108092C2 - Синтетическое промежуточное соединение производного оксазола и способ ее получения - Google Patents

Синтетическое промежуточное соединение производного оксазола и способ ее получения

Info

Publication number
UA108092C2
UA108092C2 UAA201210058A UAA201210058A UA108092C2 UA 108092 C2 UA108092 C2 UA 108092C2 UA A201210058 A UAA201210058 A UA A201210058A UA A201210058 A UAA201210058 A UA A201210058A UA 108092 C2 UA108092 C2 UA 108092C2
Authority
UA
Ukraine
Prior art keywords
substituted
halogen
phenyl
substituted lower
alkyl group
Prior art date
Application number
UAA201210058A
Other languages
English (en)
Ukrainian (uk)
Inventor
Акіхіро Ямамото
Коіті Сінхама
Нобухіса Фудзіта
Сіндзі Акі
Сін Огасавара
Наото Уцумі
Original Assignee
Оцука Фармасьютікал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оцука Фармасьютікал Ко., Лтд. filed Critical Оцука Фармасьютікал Ко., Лтд.
Publication of UA108092C2 publication Critical patent/UA108092C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Задачей данного изобретения является разработка способа получения соединения оксазола с высоким выходом. Данная задача может быть достигнута использованием соединения, представленной формулой (11): EMBED ISISServer , (11) где R1 представляет атом водорода или низшую алкильную группу; R2 представляет 1-пиперидильную группу, замещенную в положении 4 заместителем, выбранным из (A1a) феноксигруппы, замещенной на фенильной части одной или более замещенными галогеном группами низшего алкокси, (A1b) замещенной феноксигруппы низшего алкила, замещенной на фенильной части одной или более замещенными галогеном низшими алкильными группами, (А1с) замещенной фенилом низшей алкокси низшей алкильной группы, замещенной на фенильной части галогеном, (A1d) замещенной фенилом низшей алкильной группы, замещенной на фенильной части одной или более замещенными галогеном низшими алкоксигруппами, (A1e) аминогруппы, замещенной фенильной группой, замещенной одной или более замещенными галогеном низшими алкоксигруппами, и низшей алкильной группой, и (A1f) замещенной фенилом низшей алкоксигруппы, замещенной на фенильной части одной или более замещенными галогеном низшими алкоксигруппами; n представляет целое число от 1 до 6, и X3 представляет органическую сульфонилоксигруппу.
UAA201210058A 2010-01-29 2011-01-28 Синтетическое промежуточное соединение производного оксазола и способ ее получения UA108092C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010019289 2010-01-29
PCT/JP2011/052307 WO2011093529A1 (en) 2010-01-29 2011-01-28 Synthetic intermediate of oxazole compound and method for producing the same

Publications (1)

Publication Number Publication Date
UA108092C2 true UA108092C2 (ru) 2015-03-25

Family

ID=43759747

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201210058A UA108092C2 (ru) 2010-01-29 2011-01-28 Синтетическое промежуточное соединение производного оксазола и способ ее получения

Country Status (28)

Country Link
US (1) US8598358B2 (ru)
EP (1) EP2528896B1 (ru)
JP (1) JP5818802B2 (ru)
KR (1) KR101839160B1 (ru)
CN (1) CN102725269B (ru)
AR (1) AR080287A1 (ru)
AU (1) AU2011211311A1 (ru)
BR (1) BR112012018069A2 (ru)
CA (1) CA2787246A1 (ru)
CY (1) CY1115654T1 (ru)
DK (1) DK2528896T3 (ru)
EA (1) EA201290681A1 (ru)
EG (1) EG26595A (ru)
ES (1) ES2509946T3 (ru)
HK (1) HK1174031A1 (ru)
HR (1) HRP20141087T1 (ru)
IL (1) IL220754A (ru)
MX (1) MX2012008501A (ru)
MY (1) MY156360A (ru)
NZ (1) NZ601239A (ru)
PL (1) PL2528896T3 (ru)
PT (1) PT2528896E (ru)
SG (1) SG181990A1 (ru)
SI (1) SI2528896T1 (ru)
TW (1) TW201200523A (ru)
UA (1) UA108092C2 (ru)
WO (1) WO2011093529A1 (ru)
ZA (1) ZA201204802B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201632533A (zh) 2015-01-29 2016-09-16 南京明德新藥研發股份有限公司 抗肺結核病的硝基咪唑衍生物
JP6776226B2 (ja) * 2015-03-27 2020-10-28 大塚製薬株式会社 １−（４−ヒドロキシフェニル）−４−（４−トリフルオロメトキシフェノキシ）ピペリジン又はその塩の製造方法
WO2020202205A1 (en) * 2019-04-01 2020-10-08 Council Of Scientific And Industrial Research Process for the preparation of derivatives of 1,1-dialkylethane-1,2-diols as useful intermediates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2871063B2 (ja) 1990-10-26 1999-03-17 日本たばこ産業株式会社 （ｒ，ｚ）―５―テトラデセン―４―オリドの製造方法
TWI347946B (en) * 2002-10-11 2011-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
TWI331607B (en) 2002-10-15 2010-10-11 Otsuka Pharma Co Ltd 1-substituted-4-nitroimidazole compound
UA88925C2 (en) * 2002-10-15 2009-12-10 Оцука Фармасьютикал Ко., Лтд. 4-nitroimidazole derivatives
DK1906926T3 (da) * 2005-07-28 2011-01-31 Otsuka Pharma Co Ltd Farmaceutisk sammensætning omfattende 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolderivater
JP5105818B2 (ja) * 2005-10-05 2012-12-26 大塚製薬株式会社 医薬組成物
AR070301A1 (es) 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
JP2009269859A (ja) * 2008-05-08 2009-11-19 Otsuka Pharmaceut Co Ltd Ｎ−含有複素環化合物
EP2323990B1 (en) * 2008-08-21 2014-06-18 Dynamit Nobel GmbH Explosivstoff- und Systemtechnik Methods for the production of 2-halo-4-nitroimidazole and intermediates thereof

Also Published As

Publication number Publication date
AR080287A1 (es) 2012-03-28
CN102725269A (zh) 2012-10-10
MX2012008501A (es) 2012-08-17
HRP20141087T1 (hr) 2015-01-16
KR101839160B1 (ko) 2018-03-15
PL2528896T3 (pl) 2015-01-30
EA201290681A1 (ru) 2013-02-28
HK1174031A1 (en) 2013-05-31
KR20120130326A (ko) 2012-11-30
TW201200523A (en) 2012-01-01
NZ601239A (en) 2014-10-31
SI2528896T1 (sl) 2014-12-31
EP2528896A1 (en) 2012-12-05
SG181990A1 (en) 2012-08-30
WO2011093529A1 (en) 2011-08-04
MY156360A (en) 2016-02-15
JP2013518033A (ja) 2013-05-20
ES2509946T3 (es) 2014-10-20
EG26595A (en) 2014-03-20
IL220754A (en) 2015-10-29
PT2528896E (pt) 2014-10-09
US8598358B2 (en) 2013-12-03
EP2528896B1 (en) 2014-08-27
DK2528896T3 (da) 2014-11-10
JP5818802B2 (ja) 2015-11-18
CN102725269B (zh) 2015-03-25
US20120302757A1 (en) 2012-11-29
AU2011211311A1 (en) 2012-07-26
ZA201204802B (en) 2013-09-25
BR112012018069A2 (pt) 2016-02-23
CY1115654T1 (el) 2017-01-25
CA2787246A1 (en) 2011-08-04

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