UA100937C2 - Фармацевтична композиція, що містить проліки інгібітора полімерази hcv - Google Patents

Фармацевтична композиція, що містить проліки інгібітора полімерази hcv

Info

Publication number
UA100937C2
UA100937C2 UAA201110008A UAA201110008A UA100937C2 UA 100937 C2 UA100937 C2 UA 100937C2 UA A201110008 A UAA201110008 A UA A201110008A UA A201110008 A UAA201110008 A UA A201110008A UA 100937 C2 UA100937 C2 UA 100937C2
Authority
UA
Ukraine
Prior art keywords
prodrugs
pharmaceutical composition
polymerase inhibitor
hcv polymerase
compression
Prior art date
Application number
UAA201110008A
Other languages
English (en)
Russian (ru)
Inventor
Ашіш Чаттерджі
Діпен Десаі
Харпріт К. Сандху
Навніт Харговіндас Шах
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of UA100937C2 publication Critical patent/UA100937C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

У заявці описані нові композиції (2R,3R,4R,5R)-5-(4-aмінo-2-оксo-2H-піримідин-1-іл)-4-фтор-2-ізобутирилоксиметил-4-метилтетрагідрофуран-3-ілового ефіру ізомасляної кислоти й гідроксипропілцелюлози, які забезпечують високу насипну щільність, малий розмір гранул, більше придатні для поліпшеної пресувальності й плинності, більш ефективного пресування й поліпшених профілів розчинення.
UAA201110008A 2009-01-21 2010-01-11 Фармацевтична композиція, що містить проліки інгібітора полімерази hcv UA100937C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14599909P 2009-01-21 2009-01-21
PCT/EP2010/050182 WO2010084041A2 (en) 2009-01-21 2010-01-11 Pharmaceutical compositions with superior product performance and patient compliance

Publications (1)

Publication Number Publication Date
UA100937C2 true UA100937C2 (uk) 2013-02-11

Family

ID=42026386

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201110008A UA100937C2 (uk) 2009-01-21 2010-01-11 Фармацевтична композиція, що містить проліки інгібітора полімерази hcv

Country Status (28)

Country Link
US (1) US8222230B2 (uk)
EP (1) EP2389164B1 (uk)
JP (1) JP5415561B2 (uk)
KR (1) KR101331723B1 (uk)
CN (1) CN102292075B (uk)
AR (1) AR075037A1 (uk)
AU (1) AU2010206224B2 (uk)
BR (1) BRPI1006924A2 (uk)
CA (1) CA2748895C (uk)
CL (1) CL2011001764A1 (uk)
CO (1) CO6440558A2 (uk)
DK (1) DK2389164T3 (uk)
EC (1) ECSP11011191A (uk)
ES (1) ES2513415T3 (uk)
HK (1) HK1164742A1 (uk)
IL (1) IL213804A0 (uk)
MA (1) MA32969B1 (uk)
MX (1) MX2011007771A (uk)
NZ (1) NZ593795A (uk)
PE (1) PE20120020A1 (uk)
PL (1) PL2389164T3 (uk)
RU (1) RU2489153C2 (uk)
SG (1) SG173001A1 (uk)
SI (1) SI2389164T1 (uk)
TW (1) TWI414295B (uk)
UA (1) UA100937C2 (uk)
WO (1) WO2010084041A2 (uk)
ZA (1) ZA201104882B (uk)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012062691A1 (en) * 2010-11-09 2012-05-18 F. Hoffmann-La Roche Ag Pharmaceutical compositions for treating hcv infections
EP2919903B1 (en) 2012-11-14 2020-07-22 W.R. Grace & CO. - CONN. Compositions containing a biologically active material and a non-ordered inorganic oxide
DE102013215831A1 (de) * 2013-08-09 2015-02-12 Beiersdorf Ag Gelförmiges, alkoholisches Sonnenschutzmittel
WO2016121925A1 (ja) * 2015-01-30 2016-08-04 協和発酵バイオ株式会社 機能性物質を高含有する錠剤及びその製造方法
RU2749135C2 (ru) * 2016-02-19 2021-06-04 Цзянсу Хэнжуй Медицин Ко., Лтд. Фармацевтическая композиция, включающая производное имидазолина
JP6323846B2 (ja) * 2016-04-07 2018-05-16 塩野義製薬株式会社 オピオイドを含有する乱用防止製剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2434386C (en) * 2001-01-22 2006-12-05 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
JP4408340B2 (ja) * 2002-03-22 2010-02-03 武田薬品工業株式会社 速崩壊性固形製剤
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
ES2366381T3 (es) * 2005-06-22 2011-10-19 Takeda Pharmaceutical Company Limited Comprimido que contiene un ingrediente activo difícilmente soluble.
JP2008230967A (ja) * 2005-06-23 2008-10-02 Kowa Co 医薬組成物
EP1957510A1 (en) * 2005-12-09 2008-08-20 F.Hoffmann-La Roche Ag Antiviral nucleosides
PL1962808T3 (pl) 2005-12-14 2011-03-31 Hoffmann La Roche Preparat proleku przeciw HCV

Also Published As

Publication number Publication date
AU2010206224B2 (en) 2012-12-13
EP2389164B1 (en) 2014-08-13
CO6440558A2 (es) 2012-05-15
CL2011001764A1 (es) 2012-01-20
PL2389164T3 (pl) 2015-01-30
CA2748895A1 (en) 2010-07-29
CN102292075B (zh) 2013-04-17
IL213804A0 (en) 2011-07-31
PE20120020A1 (es) 2012-02-02
EP2389164A2 (en) 2011-11-30
KR20110117683A (ko) 2011-10-27
ECSP11011191A (es) 2011-10-31
AR075037A1 (es) 2011-03-02
DK2389164T3 (da) 2014-09-15
US20100184716A1 (en) 2010-07-22
JP2012515739A (ja) 2012-07-12
BRPI1006924A2 (pt) 2016-02-16
HK1164742A1 (en) 2012-09-28
SI2389164T1 (sl) 2014-12-31
TW201031410A (en) 2010-09-01
US8222230B2 (en) 2012-07-17
KR101331723B1 (ko) 2013-11-26
CA2748895C (en) 2014-05-13
RU2489153C2 (ru) 2013-08-10
WO2010084041A3 (en) 2011-08-18
ZA201104882B (en) 2012-03-28
MX2011007771A (es) 2011-08-12
RU2011134713A (ru) 2013-03-10
SG173001A1 (en) 2011-08-29
NZ593795A (en) 2013-02-22
MA32969B1 (fr) 2012-01-02
JP5415561B2 (ja) 2014-02-12
WO2010084041A2 (en) 2010-07-29
CN102292075A (zh) 2011-12-21
TWI414295B (zh) 2013-11-11
ES2513415T3 (es) 2014-10-27
AU2010206224A1 (en) 2011-08-25

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