UA100229U - METHOD OF CORRECTION OF THE IMMUNE RESISTANCE OF THE ORGANISM OF PATIENTS WITH CHRONIC SALPINGOPHORITES - Google Patents

Abstract

A method of correcting the immune resistance of the body to patients with chronic salpingoophoritis, which includes complex therapy using immunomodulatory physical factors. The patient is prescribed hyperbaric oxygenation in the isopression mode of 0.3-0.5 atmospheres, exposure 30 minutes, compression 10 minutes, decompression 10 minutes at t ° 20-23 ° C, relative humidity 65-85%, the number of sessions 10; local vaginal hypothermia with tip temperature + 7 ° - +, session duration 20 minutes, daily for 10 days. Infrared radiation 850-890 nm, lasting 5 minutes, daily, course of treatment 10 days and simultaneously neohemodesis 200.0 ml intravenously, drip, after 2 days, 5 times; chlorophyllpt 0.25% alcohol solution of 2.0 ml, diluted in 38.0 ml of 0.9% sodium chloride, intravenously, daily, 15 days. Sodium thiosulphate 30% solution of 10.0 ml, intravenously, daily, 12 days; proserin 0.05% 1.0 ml, subcutaneously, daily, 10 days; Novo-Pasit for 5 ml, 3 times a day, 10 days. Chamomile broth 200.0 ml, internally, 2 times a day, 20 days.

Description

The useful model belongs to medicine, namely to gynecology, and can be used to correct the immune resistance of the body in patients with chronic salpingo-oophoritis.

Treatment of chronic salpingo-oophoritis in the stage of remission is carried out, as a rule, without prescribing antibacterial agents, with the use of immunocorrectors, biostimulants, non-steroidal anti-inflammatory drugs, vitamins, enzymes. Widely used local absorption therapy, phytotherapy, action of physical factors, etc.

So, for example, the use of immunocorrective drugs hepon and longidase in the complex pharmacotherapy of patients with chronic salpingo-oophoritis is known. The use of longidase in the form of suppositories has a corrective and normalizing effect on disturbed indicators of the immunometabolic status in patients with chronic salpingo-oophoritis, mainly at the local level, while the injection form of this drug normalizes the parameters of the immune and oxidant status at the systemic level (Efficacy of immunomodulators in the treatment of chronic salpingo-oophoritis in the exacerbation stage / S.N. Abramova, G.A. Lazareva,

A.A. Konoplya, Zh. Po. Omasharifa // System analysis and control in biomedical systems.-2013. - T. 12, Mo. 4.-S. 972-975).

In the complex treatment of chronic salpingo-oophoritis, the clinical and immunological effectiveness of the use of immunomodulators (ridostin, derinat, ferovir, immunofan, polyoxidonium and longidase) was determined. Konoplya A.A. The use of immunomodulators in the complex treatment of chronic salpingo-oophoritis / A.A. Konoplya, M.G. Gazazyan, A.V. Karaulov //

Obstetrics and gynecology.-2010. - Mo 4. - P. 75-78.

There is a well-known method of treatment of chronic salpingo-oophoritis, which includes performing balneoprocedures on the reflexogenic points of information-wave therapy for 10 minutes every day, changing the points of influence every other day. There are 10 procedures per course. Iodine-bromine balneotherapy in the form of vaginal irrigation and general baths is carried out one or two days in a row with a day off, a course of 8 procedures. The method makes it possible to shorten the duration of treatment and prolong remission due to the activation of adaptive capabilities of the body, improvement of blood supply to the pelvic organs, normalization of indicators of cellular and humoral immunity, indicators of lipid peroxidation and antioxidant protection (Pat. Mo 2238098, Russia, IPC

AbIKZ35/08, Ab1NZ35/00, Ab1NZ3/00, Ab1H39/00, Ab1M5/02. The method of chronic treatment

From salpingo-oophoritis / Kurtaev O.Sh., Melnikova T.V., Karaeva D.R., Gordon K.V.; Scientific Research Center of Spa Resorts and Rehabilitation of the Black Sea Zonal Administration of Specialized Sanatoriums.-3. Mo 2002113949/14; statement 05/28/2002; published 20.10.2004).

This method of correcting the immune resistance of the body of patients with chronic salpingo-oophoritis is the closest to what is claimed, in terms of technical essence and the result that can be

C5 is achievable, so it was chosen as a prototype.

The basis of the useful model is the task of expanding the arsenal of methods for correcting the body's immunoresistance in patients with chronic salpingo-oophoritis.

The task is solved by the fact that in the well-known method of correcting the immune resistance of the body of patients with chronic salpingo-oophoritis, which includes complex therapy with the use of immunomodulating physical factors, according to a useful model, the patient is prescribed hyperbaric oxygenation in the isopressure mode of 0.3-0.5 atmospheres, exposure 30 minutes, compression 10 minutes, decompression 10 minutes, at C 20-23" C, relative humidity 65-85,905, number of sessions 10; local vaginal hypothermia with tip temperature -77--10 C, session duration 20 minutes, daily, during 10 days; infrared radiation 850-890 nm, lasting 5 minutes, daily, a course of treatment of 10 days, and at the same time neohemodesis 200.0 ml intravenously, drip, after 2 days, 5 times; chlorophyllipt 0.25 95 alcohol solution for 2, 0 ml, diluted to 38.0 ml of sodium chloride 0.9 95, intravenously, daily, 15 days; sodium thiosulfate 30 U5-solution 10.0 ml, intravenously, daily, 12 days; proserin 0.05 95 per 1, 0 ml, pi daily, 10 days; Novo-Pasyt 5 ml, 3 times a day, 10 days; broth

BO chamomile 200.0 ml, internally, 2 times a day, 20 days.

The technical effect of the useful model, namely the expansion of the arsenal of methods for correcting the immune resistance of the body of patients with chronic salpingo-oophoritis, is due to the synergism of the measures that are applied and the means that were used.

The method is performed as follows: the patient is prescribed hyperbaric oxygenation in the isopressure mode of 0.3-0.5 atmospheres, exposure for 30 minutes, compression for 10 minutes, decompression for 10 minutes at 20-23" C, relative humidity of 65-85,905, number of sessions 10; local vaginal hypothermia with a tip temperature of 77--10 "C, session duration 20 minutes, daily, for 10 days; infrared radiation of 850-890 nm, lasting 5 minutes, daily, a course of treatment of 10 days and at the same time neohemodesis of 200.0 ml intravenously, drip, after 2 60 days, 5 times; chlorophyllipt 0.25 96 alcoholic solution of 2.0 ml, diluted with 38.0 ml of 0.9 95 sodium chloride, intravenously, daily, 15 days; sodium thiosulfate 30 95-solution of 10.0 ml, intravenously, daily, 12 days; Proserin 0.05 95 per 1.0 ml, subcutaneously, daily, 10 days;

Novo-Pasyt 5 ml, 3 times a day, 10 days; decoction of chamomile 200.0 ml, internally, 2 times a day, 20 days.

The effectiveness of the method has been proven by clinical studies.

125 patients with salpingo-oophoritis participated in the study. Depending on the treatment methods, the patients were divided into 4 clinical groups: the first group consisted of patients (31) who received traditional therapy; the second group consisted of women (31), who received only physiotherapy treatment (hyperbaric oxygenation, local hypothermia and vaginal laser therapy); the third group of women (31) received combined treatment (physiotherapy combined with phytotherapy); The fourth group of women (32) received drug treatment according to the scheme developed by us, which includes neohemodesis, 30 96 sodium thiosulfate solution, 0.25 956 alcohol solution of chlorophyllipt, 0.05 95 proserin, chamomile decoction, Novo-Pasit in combination with physical therapy - hyperbaric oxygenation, local hypothermia, vaginal laser therapy.

Hyperbaric oxygenation of patients with chronic non-specific salpingo-oophoritis was performed on a BLKO-3-01 single-seat apparatus. Isopressure mode 0.3-0.5 atmospheres, exposure 30 minutes, compression 10 minutes, decompression 10 minutes at a temperature of 20-23 "C and relative humidity 65-85 95, number of sessions - 10.

Local vaginal hypothermia was performed using the "Sever-01" device, with a tip temperature of 7 - 410 "C. The duration of the session was 20 minutes, daily, for 10 days.

The effect on the uterine appendages was carried out with the help of a semiconductor infrared laser probe "BARVA" with a radiation wavelength of 850-890 nm. The influence of the beam on the walls of the vagina lasted for 5 minutes daily. The course of treatment is 10 days.

The effectiveness of complex therapy compared to traditional treatment was evaluated by the integral indicators of the state of non-specific immunoresistance and the completion of phagocytosis.

In women treated with the traditional method, compared to the period before treatment, the leukogram of peripheral blood showed a decrease in the total number of leukocytes, a decrease

From the percentage of eosinophils, rod-shaped and segmented neutrophils with a simultaneous increase in the number of lymphocytes and monocytes. All noted shifts in leukogram indicators were within the physiological norm, which characterizes the recovery period in the hematopoietic system.

In the system of non-specific resistance, activation of the protective function of cells and reduction of the tension of humoral factors was observed after the treatment. However, the level of these changes did not characterize the restoration of their protective properties within the limits of physiological standards. This caused a decrease in the level of phagocytosis and elimination of autoantigens. The content of circulating immune complexes was reduced.

All noted changes in the immune system contributed to a decrease in the level of the integral indicator of non-specific resistance (NIR) and an increase in the tension of immunogenesis - an integral indicator of the tension level of the process of modulation of the protective reaction (PN) when modulating the antigen-antibody reaction.

Taking into account the correlation dependence of the specified factors that make up the immune reaction, it can be considered that traditional therapy does not contribute to the full formation of the reparative stage of the disease, but causes an increase in the intensity of the antigen-antibody reaction, which ultimately causes autoallergization (a low level of PZ is an integral indicator of the completion of the immune reaction during the formation of the final reparative stage of recovery) of the body.

In the women of the 2nd and 3rd groups, who received only physiotherapy in combination with phytotherapy, compared to the period before treatment, a decrease in the total number of leukocytes, a decrease in the percentage of eosinophils, rod-nuclear and segmented neutrophils with a simultaneous increase in the number of lymphocytes and monocytes was noted in the leukogram of peripheral blood .

In the system of non-specific resistance, after the treatment, a high level of activity of the processes of phagocytosis and elimination of decay products from the body was observed (normal level of PNR).

The conducted combined therapy caused a stress of immunogenesis, an increase in the number of immunoglobulins of class M and thereby increased the level of formation of the antigen-antibody reaction (a sufficiently high content of circulating immune complexes), which caused autoallergization of the body (reduced level of PZ) in the final stage of the formation of the immune reaction.

In patients with chronic nonspecific salpingo-oophoritis of the 4th main group, who underwent complex treatment: hyperbaric oxygenation, local hypothermia, vaginal laser therapy, neohemodesis, 30 95 sodium thiosulfate solution, 0.25 95 chlorophyllipt solution, 0.05 95 proserin, chamomile decoction compared with the period before treatment (Table 1), the leukogram of peripheral blood showed a decrease in the total number of leukocytes, a decrease in the percentage of eosinophils, rod- and segmented neutrophils with a simultaneous increase in the number of lymphocytes and monocytes. All noted shifts in leukogram parameters were within physiological limits, which is characteristic of the recovery period in the hematopoietic system.

Table 1

Indicators of non-specific resistance of women of the 4th main group (complex therapy: physiotherapy, phytotherapy, drug therapy) before and after treatment (Mat)

Humor, link - Leikoformula, 90 non-specialists.

Mo Group Leukots resistant those | F.Ch., | F.I., examined by Mr. n/p Act. Fo |abs.h. nya g/l Lim |Mono| Title |.

Eosin | Ph.D. | S/ya.n. lysots., photos. | quote | aglut vu 4 4th primary 32 8.2 6.0 5.0 690 | 18.0 | 20 | 6190 | 41.0 | 390 | 1.3 before treatment 0.08 | -0.22| 0.4 | 0.21 | 40.96 |30.08| 35.0 | -0.75| 52.4 | 30.8? fall of the ram to 868) 40) 30 | 580) 300 | Because | 256.0) 789) 820 | 28 - 0.26 | 30.08 | 70.08 | 40.25 | 340.24 |30.09| 12.0 | -0.5 | 2.55 | 40.06 treatment of tva P rovovovv| department oh | 5 here is his | Ltd. Geo

Continuation of table 1

Me | Groups of obste- Immunoglobulins pl| 1.94) 12.7 540 26.8 922 87.0 0.68 0.080 0.02 -0.141 |-0.30| 0.9 | -0.7 | -0.04 | 3.0 | 48.90 | 30.04 | 0.002 ? pad new until 08) AB) 14 scrap |629| 340 543 |148 .4 | 049 | 0.050 . 0.005) 10.31 | 140.0881 | 30.283 | 42.8 | 40.69 | 340.46 | жз7.4 | 0.003) -0.004 treatment of EE in Gev| in oov| 25 days оот| ов ов 05.

In the system of non-specific resistance, after the treatment, activation of the protective function of cellular and humoral factors was observed, which led to a high level of activity of the processes of phagocytosis and elimination of decay products from the body (normal level

Poland).

The noted changes characterizing the phagocytic ability of leukocytes-phagocytes contributed to the restoration and normalization of the process of antibody formation in the immune system (normal level

PN) and, in addition, they removed the overvoltage of the processes of immunogenesis (the level of class M immunoglobulin decreased to normal). Confirmation of all the above is a stable integral indicator of the completion of the immune reaction (13) during the formation of the final reparative stage of recovery.

After a comprehensive course of treatment of patients with chronic salpingo-oophoritis according to our scheme, no relapses of the disease were observed for 6 months.

A statistical comparison of the levels of integral indicators and the state of immunoresistance (table 2) made it possible to establish that in women who received traditional treatment, compared to complex therapy, there was a reduced level of activity of the general non-specific resistance (PN), intensity of modulation of the immune response (high level of PN) and active reaction of autoallergization (low level of PZ).

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Table 2

The effectiveness of complex therapy compared to traditional treatment according to integral indicators of the state of non-specific immunoresistance (MAM)

Indicators -8y- t - Probability criteria 101.3-26.3 148.47 4 Р«0.05 0.86:0.02 0.49ж0.03 Р«0.05 0.012520.005 0.050-0.004 Р "0.05

With complex treatment, all the above-mentioned integral indicators were within the physiological norm.

The indicator of the completion of the immune reaction (IP) in the reparative stage characterized the recovery of the patient.

Thus, the most effective method of treating patients with chronic non-specific salpingo-oophoritis with pain syndrome compared to the traditional one is the complex therapy developed by us.

Claims (1)

USEFUL MODEL FORMULA A method of correcting the immune resistance of patients with chronic salpingo-oophoritis, which includes complex therapy using immunomodulating physical factors, which differs in that the patient is prescribed hyperbaric oxygenation in the isopressure mode of 0.3-0.5 atmospheres, exposure for 30 minutes, compression for 10 minutes , decompression for 10 minutes at 20-23 C, relative humidity 65-85 905, number of sessions 10; local vaginal hypothermia with a tip temperature of -77--107C, session duration 20 minutes, daily, for 10 days; infrared radiation of 850-890 nm, lasting 5 minutes, daily, a course of treatment of 10 days, and at the same time neohemodesis of 200.0 ml intravenously, drip, after 2 days, 5 times; Chlorophyllipt 0.25 95 alcohol solution of 2.0 ml, diluted with 38.0 ml of 0.9 95 sodium chloride, intravenously, daily, 15 days; sodium thiosulfate 30 U5-solution 10.0 ml, intravenously, daily, 12 days; Proserin 0.05 95 per 1.0 ml, subcutaneously, daily, 10 days; Novo-Pasyt 5 ml, 3 times a day, 10 days; decoction of chamomile 200.0 ml, internally, 2 times a day, 20 days.