TWM597140U - Astmgali radix polysaccharide crystal grain structure with enhanced dissolving capability and absorption rate - Google Patents

Abstract

This creation provides a crystal structure of Huangqi polysaccharide crystals that enhances the dissolution and absorption rate. It contains Huangqi polysaccharide particles and mannose particles linked together by a water chain structure, so that Huangqi polysaccharide particles will be dispersed in water vapor and dispersed. The granule structure of Huangqi polysaccharide and water vapor form small particles, the larger particles have larger body surface area, and the crystal structure of Huangqi polysaccharide crystal does not contain colloidal components, so it can improve the dissolution and absorption in the body after eating Rate, improve product efficacy.

Description

The crystal structure of Huangqi polysaccharide crystals with enhanced dissolving power and absorption rate

This creation provides a structure of Huangqi polysaccharide crystal particles that enhances the dissolution and absorption rate. It contains Huangqi polysaccharide particles and mannose particles linked together by a water chain structure, so that Huangqi polysaccharide crystal particles will be uniformly dispersed in the solution. , Evenly dispersed Astragalus polysaccharide crystal particle structure, small particles, larger particles have a larger body surface area, improve the dissolution and absorption rate in the body after consumption, and improve product efficacy.

According to several medical reports "cancer may be a metabolic disease", long-term stress will produce a large amount of "cytokines", this inflammatory protein will increase the possibility of inflammation, thereby impairing immune function and promoting cancer cell growth . The National Science Journal reported a study that unravels the metabolic mechanism of cancer cells and confirms that cancer cells are caused by mutations in normal cell metabolism pathways.

In the process of cell metabolism, food enters the body and is converted into glucose. After normal cells decompose glucose, they produce "pyruvate" and enter the mitochondria (bioenergy factories) to produce the energy needed by the cells and allow the cells to function normally. But the metabolic pathway of cancer cells is that only a small amount of pyruvate enters the mitochondria, and most pyruvate produces a large amount of lactic acid, which in turn promotes tumor growth.

Among them, PMK2 enzymes such as "gatekeepers", most of the glucose will be converted into energy and carbon dioxide by PMK2, but when the oncogenic factor JMJD5 appears, PMK2 and JMJD5 The combination will make the PMK2 enzyme go to the gatekeeping function. Researchers say that there are dietary guidelines that restrict sugar intake early in the treatment of cancer patients. Some drugs that control diabetes and blood sugar have also been shown to inhibit tumor growth, indicating that the normal operation of metabolism is indeed related to cancer prevention.

Current cancer drugs mostly block the growth of cancer cells or destroy the genes and growth mechanisms of cancer cells, but these practices often harm normal cells.

Huang Qi is classified as a qi-invigorating medicine in Chinese medicine. Some studies indicate that Huang Qi has a normalizing effect on the metabolic pathway. By normalizing the metabolic pathway of cancerous cells, you can have the opportunity to successfully slow down the proliferation of cancer cells. It will not affect normal cells, nor will there be side effects. It has been pointed out in many scientific reports that the extract of Huangqi has the functions of dilating blood vessels, improving blood oxygen, energizing spirit, and lowering blood sugar, so that the body will not be in a state of low temperature, high sugar, and hypoxia, and the cells will use normal granules. The body energy pathway (without using anaerobic respiration), there will not be a lot of pyruvate production, so that cancer cells can not use pyruvate to proliferate. It has the function of reducing the production of lactic acid in the body, which can further reduce the proliferation of cancer cells using lactic acid.

Among the various types of Astragalus membranaceus, the Astragalus membranaceus, which is produced in northern Mongolia, is also known as the North Astragalus. It contains the best Astragalus polysaccharides and has the effects of improving immunity, anti-cancer and anti-aging.

The extract of Huangqi can improve the activity of superoxide dismutase and anti-oxidation substances, and it can remove the active oxygen produced by superoxide anion free radical, hydroxyl free radical and polymorphonuclear leukocyte respiratory burst. Anti-aging effect that can enhance the physiological metabolism of cells and extend the life of cells. Huang Qi also has anti-stress effect, including anti-fatigue effect, low temperature and high temperature resistance, anti-radiation effect, anti-hypoxia effect. Astragalus alcohol extract and Astragalus saponin can enhance the contractility of the isolated animal heart. Astragalus polysaccharides have a protective effect on myocardial ischemia, and have anti-arrhythmic effects, dilation of blood vessels, dilation of coronary arteries and blood pressure.

It can be known from the above that Huangqi extract as a health food has a considerable effect on the prevention of cancer. Although currently there are Huangqi decoction pieces on the market, there are fewer Huangqi extracts, but are these health foods of Huangqi extract It can be effectively absorbed by the body Question, because the extract of Astragalus membranaceus is in the state of moist powder, and its fluidity is extremely poor, so it is impossible to carry out the process of product packaging. Moreover, the extract of Huangqi contains high concentration of polysaccharides, but because the polysaccharides have the characteristics of easy absorption of moisture, high viscosity and high gelation, after a period of time, they will stick to a large water-insoluble hard block, which not only affects the product Safe quality, greatly reduce the absorption rate of products in the body.

Therefore, a suitable crystal structure of Astragalus polysaccharides has been developed, so that the extracts of Astragalus membranaceus can maintain a stable structure during the manufacturing process and storage process, and can be effectively absorbed after entering the human body to reduce stress, improve and prevent cancer The efficacy of this is the most important problem that needs to be solved urgently at this stage.

Unless otherwise defined, all technical terms used herein have the same meaning as those of ordinary skill in the art to which this creation belongs. Unless the context clearly indicates otherwise, the singular forms "a" and "an" used in this specification and the appended claims include plural references. Unless otherwise stated, any reference to "or" in this document is intended to cover "and/or".

The following will provide an explanation of some aspects of the creation. These explanations present the selected concepts of the creation in a simplified form as an introduction to the more detailed description presented below.

In order to solve the above-mentioned problems, this creation developed a crystal structure of Huangqi polysaccharide crystals composed of a Huangqi polysaccharide particle and a mannose particle, and through the water chain structure, the Huangqi extract can be used in the manufacturing process and preservation process. Maintain a stable structure.

The structure of Huangqi polysaccharide crystal particles is further added with mannose as a structural matching component. Through the structural design, the problem of agglomeration caused by the characteristics of both Huangqi and mannose are extremely hygroscopic.

Among them, mannose has been experimentally confirmed that mannose can inhibit the metabolism of glucose in the cells of cancer-bearing mice, and can also reduce the production of pyruvate.

The invention provides a yellow agaric polysaccharide crystal particle structure, comprising: a yellow agaric polysaccharide particle; a mannose particle; and a water chain structure, one end of the yellow agaric polysaccharide particle is linked to one end and the mannose particle.

In one embodiment of the present invention, the water chain structure is formed by water molecule links.

In one embodiment of the present invention, the water chain structure has a spherical shape or a round shape.

In an embodiment of the present invention, the Huangqi polysaccharide particles and the mannose particles form a dumbbell-shaped structure by the water chain structure.

In one embodiment of the present invention, the Huangqi polysaccharide particles and the mannose particles are combined 1:2.

In one embodiment of the present invention, the Huangqi polysaccharide particles and the mannose particles are combined 1:3.

In one embodiment of the present invention, the water chain structure will reduce the stickiness during the manufacturing process.

In one embodiment of the present invention, the crystal structure of Astragalus polysaccharides has the effect of interfering with and reducing the proliferation of cancer cells.

In one embodiment of the present invention, the Astragalus polysaccharide crystal particle structure has the ability to inhibit abnormal metabolism of glucose by cancer cells.

In one embodiment of the present invention, the agaric polysaccharide crystal particle structure has improved solubility and absorption rate in the body after consumption.

In one embodiment of the present invention, the crystal structure of the polysaccharide crystals of Astragalus can be manufactured in the form of powder packets, drinks, capsules or lozenges for users to choose according to their needs.

10: mannose granules

20: Water chain structure

30: Huangqi polysaccharide particles

The first picture is the monomer type of Huangqi polysaccharide crystal particle structure.

The second picture is another monomer type of the Huangqi polysaccharide crystal particle structure.

The third picture shows that the crystal structure of the polysaccharide crystals of Astragalus mongholicus was evenly dispersed in the solution.

In order to provide a more complete and clear disclosure of the technical content used in this creation, the purpose of the creation and the effect achieved, please refer to the detailed description below, and please refer to the drawings and figures.

Example 1: Preparation method of polysaccharide extract of Astragalus membranaceus

Huang Qi itself is a botanical medicinal material, and the efficacy characteristics of botanical medicinal materials are very different from chemical drugs. Chemical drugs use a series of chemical reactions to produce "single compounds", which are then made into medicines. But plant-based medicinal materials are different. Plant-based medicinal materials themselves are complex, and as many as hundreds of functional ingredients may exist in the plant at the same time, so specialization must be used, especially for the separation and purification process specially developed for such medicinal materials.

The process of separation and purification of raw materials of Huangqi uses the main active functional components of Huangqi, polysaccharides, amino acids, isoflavones, saponins and other functional components. It achieves the separation of the components of Astragalus polysaccharides, amino acids, isoflavones, and saponins, and achieves the purpose of specific purification, and then obtains the polysaccharides of Astragalus polysaccharides.

Example 2: Preparation method and structure of Huangqi polysaccharide crystal particle structure

The extract of Huangqi is in a moist powder state, and its fluidity is very poor, so it is impossible to carry out the process of product packaging. Moreover, the extract of Astragalus membranaceus contains a high concentration of polysaccharides, but because the polysaccharides have the characteristics of easily absorbing moisture, high viscosity and high gelation, after a period of time, they will stick to a large water-insoluble hard block.

Therefore, the extracted Huangqi polysaccharide particles are further passed through a special multi-crystal granulation process to manufacture the new creation of Huangqi polysaccharide crystal particle structure, so that the Huangqi polysaccharide particles (30) and mannose particles (10) through the water chain structure ( 20) Form the crystal structure of Huangqi polysaccharide crystal particles as shown in the first picture. The monomer structure of Huangqi polysaccharide crystal particle structure may be a dumbbell-shaped structure, or it may be due to the formation of various forms during the manufacturing process of the water chain structure (20). It will form the knot polysaccharide crystal particles as shown in the second picture To construct another monomer type, it can be combined with 2 Huangqi polysaccharide particles (30) and 2 mannose particles (10) at a time.

In the production process of this product, the spray granulation process is specially used. In addition to the hardware, mixing, granulation, drying or cooling are completed at one time to avoid external pollution. At the same time, it uses a specific wind speed, powder volume and extremely low The proportion of water mist is made into small particles with high uniformity, in addition to avoiding the product quickly gelling and forming clumps over time.

Special multi-crystal granulation process to solve the problem of agglomeration caused by the characteristics of Huangqi polysaccharide particles (30) and mannose particles (10), which are extremely hygroscopic. The water chain structure (20) can be used to link the two. It has a certain distance and creates gaps in the easy, so that the Huangqi polysaccharide particles (30) and mannose particles (10) quickly gelatinize to form clumps.

At the same time increase the body absorption rate of the product and enhance the product's efficacy. The Huangqi polysaccharide particles (30) and mannose particles (10) and the water chain structure (20) will be evenly dispersed in the solution as shown in the third figure, followed by the granulation process In the step, the water chain structure (20) is dried and removed, and after drying, it can become a homogeneously distributed product of polysaccharide particles (30) and mannose particles (10). Although the water chain structure (20) was finally removed, the particles of Huangqi polysaccharides were very viscous, so the particles did not fall apart, mainly because the viscosity of the Huangqi polysaccharide particles (30) adhered to the mannose particles (10).

Example 3: Clinical effect of Huangqi polysaccharide crystal particle structure

Huangqi polysaccharide particles (30) and mannose particles (10) and water chain structure (20) will be uniformly dispersed in the solution. As shown in the third figure, the uniformly dispersed Huangqi polysaccharide crystal particle structure small particles can be more than large particles Larger body surface area enhances the dissolving power and absorption rate in the body after consumption, and enhances the efficacy of the product.

In the process of slowly developing cancer, due to stress or tight emotions, the body's stress hormones are secreted in large amounts (adrenaline), causing blood vessels to contract, which in turn places the body in an hypoxic state with low body temperature and high blood sugar. Cells will tend to anaerobic breathing to obtain a large amount of energy in a short time to overcome difficulties, but this energy reaction path will leave a lot of pyruvate, which in turn becomes lactic acid, which will promote tumor growth. According to research, tumor cells will abandon the path of normal aerobic respiration capacity of mitochondria (pyruvate will be metabolized, there is no remaining), and the use of anaerobic respiration of cells, the purpose is to leave pyruvate to For its rapid proliferation.

The significance of the special combination of Huangqi polysaccharide crystal particle structure products is that, looking at the entire process of cancer generation and growth, using the efficacy characteristics of different ingredients, one reverses the physical condition (aerobic/hypoxic state), and one inhibits the cancer cells' glucose for glucose. Abnormal metabolism. By transforming different important mutation points in the process of cancer cell generation and hyperplasia separately, supplemented by small particles of high purity and good absorption, in order to achieve the purpose of interfering with and reducing the proliferation of cancer cells.

10: mannose granules

20: Water chain structure

30: Huangqi polysaccharide particles

Claims (10)

A crystal structure of Astragalus polysaccharide crystals for improving dissolution and absorption rate, including: One yellow agaric polysaccharide particles; 1 mannose granule; and A water chain structure, one end links the yellow agaric polysaccharide particles and one end links the mannose particles. The crystal structure of the polysaccharide crystal of Astragalus polysaccharides as described in item 1 of the patent application scope, wherein the water chain structure is formed by water molecule chains. The crystal structure of the polysaccharide crystal of Astragalus polysaccharides as described in item 1 of the patent application, wherein the water chain structure is columnar or spherical. The yellow agaric polysaccharide crystal particle structure as described in item 1 of the patent application scope, wherein the yellow agar polysaccharide particles and the mannose particles form a dumbbell-shaped structure by the water chain structure. The crystal structure of Huangqi polysaccharide crystals as described in item 1 of the patent application scope, wherein the Huangqi polysaccharide particles and the mannose particles are combined in a 1:2 ratio. The crystal structure of Huangqi polysaccharide as described in item 1 of the patent application scope, wherein the Huangqi polysaccharide particles and the mannose particles are combined in a 1:3 ratio. As described in the first paragraph of the patent application, the polysaccharide crystal particle structure of Astragalus membranaceus, wherein the water chain structure will reduce the stickiness of the polysaccharide during the manufacturing process. The Huangqi polysaccharide crystal particle structure as described in item 1 of the patent application scope, wherein the Huangqi polycrystalline particle structure has interference and reduces the proliferation of cancer cells. The Huangqi polysaccharide crystal particle structure as described in Item 1 of the patent application range, wherein the Huangqi polycrystalline particle structure has the ability to inhibit the abnormal metabolism of glucose by cancer cells. The Huangqi polysaccharide crystal particle structure as described in Item 1 of the patent application scope, wherein the Huangqi polycrystalline particle structure has improved dissolution power and absorption rate in the body after consumption.

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