CN101264129A - Sugar-free heart-supplementing dracocephali moldavica granula - Google Patents
Sugar-free heart-supplementing dracocephali moldavica granula Download PDFInfo
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- CN101264129A CN101264129A CNA2008100147848A CN200810014784A CN101264129A CN 101264129 A CN101264129 A CN 101264129A CN A2008100147848 A CNA2008100147848 A CN A2008100147848A CN 200810014784 A CN200810014784 A CN 200810014784A CN 101264129 A CN101264129 A CN 101264129A
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Abstract
The invention discloses a sugar-free heart-supplementing dragonhead granule, which is produced by following raw material of weight proportion: dragonhead extraction 1 to 10, starch1 to 10, calcium carbonate 1 to 10, dextrine 1 to 10, xylo-oligosaccharide 0.5 to 3, xylose 1 to 10, polyvinyl pyrrolidone solution and fruit flavor; preparation technology is as below: dragonhead extraction, starch, calcium carbonate, dextrine, xylose and fruit flavor are measured according to proportion, mixed evenly and crushed and sifted out through 80 mesh sieve, moistened using 0.01% to 0.05% of PVP ethanol solution before non-slurry pelletized at granulation machine and then dried, thereby producing the granule in pharmacy. The sugar-free heart-supplementing dragonhead granule has the advantages of having good taste, improving increment environment of bifidobacteria for intestines and stomach, improving digestion and absorption function for intestines and stomach and being suitable for adjuvant therapy of diabetic patients with cardio-cerebrovascular disease caused by diabetes.
Description
1, technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, Sugarless type benefit heart Herba Dracocephali granule of specifically a kind of fruit taste and preparation method thereof.
2, background technology
Along with industrial expansion, the increase of the aggravation of atmospheric pollution level, population residential density, the quickening of rhythm of life, increasing people is perplexed by cardiovascular and cerebrovascular disease, the mortality rate height of cardiovascular and cerebrovascular disease, death toll is more and more, and cardiopulmonary are sick together often, simultaneously because the good result of Chinese medicine, increasing people begins to take Chinese medicine, but because the contained complex chemical composition of Chinese medicine, taste is relatively more bitter, traditional decoction or tablets and other formulations are not welcome by the patient more and more, wish that a kind of mouthfeel is convenient to the form of Chinese drug that diabetics is taken well.
3, summary of the invention
The purpose of this invention is to provide a kind of sugar-free heart-supplementing dracocephali moldavica granula and preparation method thereof.
In order to improve the bitterness of Herba Dracocephali, be suitable for diabetic to take simultaneously, we adopt the Herba Dracocephali extract to replace traditional former medicine, and adopt an amount of fruit flavor of interpolation and xylitol to replace conventional Chinese medicine correctives, adopt non-slurry pelletizing simultaneously, make Sugarless type Herba Dracocephali benefit heart granule with fruit taste.This product is compared with original beneficial heart Herba Dracocephali benefit heart granule and had: do not contain sucrose, the diabetes patient can take; Fruit taste mouthfeel is good, and patient is easy to accept; Adopt the non-slurry pelletizing of polyvinyl pyrrolidone (PVP) alcoholic solution, advantage such as it is simple to have technology, and drying time is short, and production cost is low.
Herba Dracocephali is the conventional Chinese medicine of Uygur's ethnic groups, has the beneficial heart and protects brain, diuresis, Zhichuan, strong liver and strengthening stomach; strengthen perceptibility, replenish protection, fill out the Fructus Alpiniae Oxyphyllae power of intelligence; open in the brain inaccessible, cardiopalmus is pained, dizziness, bradykinesia; sensation is low; thinking is unwise, and a little less than the insufficiency of stomach liver, the body natural agent descends, the Mental fatigue insomnia; vexed asthma, the treatment of commonly encountered diseases such as neurasthenia.
The present invention is a kind of sugar-free heart-supplementing dracocephali moldavica granula, and it has replaced traditional correctives sucrose with xylitol, is suitable for diabetic to take, and has added fruit essence, has the fruit taste, and mouthfeel is better.
Fruity sugar-free heart-supplementing dracocephali moldavica granula of the present invention is checked according to Chinese Pharmacopoeia version in 2005, particle drying, evenly, the color and luster unanimity, no moisture absorption caking deliquescence phenomenon, particulate granularity, melting, content uniformity, microbial limit is differentiated, assay is all up to specification.
Relevant requirements according to Chinese Pharmacopoeia version stability study in 2005, through acceleration test in 6 months and test in long-term 12 months to the fruity sugar-free heart-supplementing dracocephali moldavica granula, this product is being quickened under 6 months conditions particulate character, granularity, melting, content uniformity, microbial limit is differentiated, assay, comparing with 0 month does not have notable difference; This product under long-term 12 months conditions, particulate character, granularity, melting, content uniformity, microbial limit is differentiated, assay, comparing with 0 month does not have notable difference.The result shows: the quality of this product is more stable, and method is feasible.
By granule pharmacological experiment of the present invention is shown: 1, this product can obviously reduce the whole blood viscosity of mice, and low cutting and high shear rate and packed cell volume shows that the right lucky cloth submicron particle of beneficial heart Badische has the effect that improves with the conciliation hemorheological property; 2, this product can obviously reduce platelet aggregation rate, can improve reflection coronary heart disease platelet aggregation, is the objective indicator of state of an illness alleviation.
Excellent effect of the present invention is:
After using this product, patients with coronary heart disease blood plasma lipide peroxide reduces (P＜0.05) before the treatment, and free radical scavenging enzyme SOD is active to raise (P＜0.05), shows that this medicine improves the body activities of antioxidant enzymes, reduce body endoperoxides speed, vivo oxidation and antioxidative balance are reconciled in performance.
Continuous use after 10 days patient with angina pectoris angina pectoris pain degree alleviate, the persistent period reduces, frequency reduces.This product can reach 86.4% for anginal main clinic symptoms sign treatment total effective rate, can reach 50% to the electrocardiogram improvement rate of patient with angina pectoris.
Show by the double blind experiment to adjuvant sucrose in the fruity sugar-free heart-supplementing dracocephali moldavica granula and two kinds of compositions of dextrin: both do not have notable difference on therapeutic effect, but more acceptant this product of patient, the mouthfeel of this product is better, can improve the intestines and stomach bacillus bifidus increment environment well, improve the intestines and stomach digestive and absorptive functions, so be specially adapted to the auxiliary treatment of the cardiovascular and cerebrovascular disease that the diabetes patient causes because of diabetes.
4, the specific embodiment
Fruity sugar-free heart-supplementing dracocephali moldavica granula of the present invention, it is to be made by the raw material of following weight portion: 1～10 part of 1～10 part of Herba Dracocephali extract, 1～10 part of starch, 1～10 part of calcium carbonate, 1～10 part in dextrin, oligomeric xylose 0.5-3 part, xylitol; Fruit flavor is an amount of; Polyvinyl pyrrolidone (PVP) alcoholic solution is an amount of, wherein:
Fruit flavor: account for 0.1%～2% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose;
Concentration is 0.01%～0.05% polyvinyl pyrrolidone (PVP) alcoholic solution: consumption accounts for 1%～10% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose;
Preparation process is as follows:
Take by weighing Herba Dracocephali extract, starch, calcium carbonate, dextrin, oligomeric xylose, xylitol fruit flavor mix homogeneously in proportion; pulverize; cross 80 mesh sieves; PVP alcoholic solution moistening with 0.01%～0.05%; send the granulation machine non-slurry pelletizing; drying again, granulate are made the above granule of pharmaceutics.
It is to be made by the raw material of following weight portion:
3～7 parts of Herba Dracocephali extracts, 3～8 parts of starch, 2～7 parts of calcium carbonate, 4～8 parts in dextrin, oligomeric xylose 1-2 part, 3～7 parts of xylitol, fruit flavor are an amount of, polyvinyl pyrrolidone (PVP) alcoholic solution is an amount of;
Fruit flavor: account for 0.5%～1.5% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, oligomeric xylose, xylitol material total amount;
Concentration is 0.01%～0.05% polyvinyl pyrrolidone (PVP) alcoholic solution: consumption accounts for 3%～7% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose.
It is to be made by the raw material of following weight portion:
6 parts of Herba Dracocephali extracts, 5 parts of starch, 6 parts of calcium carbonate, dextrin: 7 parts, 4 parts of xylitol, 1.5 parts of oligomeric xyloses, fruit flavor are an amount of, polyvinyl pyrrolidone (PVP) alcoholic solution is an amount of;
Fruit flavor: account for 1.5% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, oligomeric xylose, the total inventory of xylitol;
Concentration is 0.01%～0.05% polyvinyl pyrrolidone (PVP) alcoholic solution: consumption accounts for 5% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose.
Fruit flavor is lemon essence, Fructus Ananadis comosi flavor essence, Fructus Mali pumilae flavor essence, Fructus Fragariae Ananssae flavor essence, orange flavor essence, Fructus Musae flavor essence, Citrullus vulgaris flavor essence, Fructus Crataegi flavor essence, pears flavor essence one or more a compositions wherein.
Embodiment 1:
Prescription: 1 part of Herba Dracocephali extract, 2 parts of starch, 1 part of calcium carbonate, 1 part in dextrin, 3 parts of xylitol, oligomeric xylose 2, fruit flavor accounts for 2% of total inventory.
Polyvinyl pyrrolidone (PVP) alcoholic solution, concentration 0.05%, consumption accounts for 5% of total inventory.
The preparation of granule:
Take by weighing Herba Dracocephali extract, starch, calcium carbonate, dextrin, oligomeric xylose, xylitol mix homogeneously in proportion, add fruit essence, pulverize, cross 80 mesh sieves, mix homogeneously is with the moistening of polyvinyl pyrrolidone (PVP) alcoholic solution, send the granulation machine non-slurry pelletizing, drying again, granulate is made the above granule of pharmaceutics;
Embodiment 2
Prescription: 1 part of Herba Dracocephali extract, 1 part of starch, 1 part of calcium carbonate, 2 parts in dextrin, oligomeric xylose, 1 part, 2 parts of xylitol, fruit flavor account for 1.5% of total inventory.
Polyvinyl pyrrolidone (PVP) alcoholic solution, concentration 0.05%, consumption accounts for 4% of total inventory.
Granule preparation: with embodiment 1.
Embodiment 3
Prescription: 1 part of Herba Dracocephali extract, 3 parts of starch, 1 part of calcium carbonate, 1 part in dextrin, 4 parts of xylitol, 3 parts of oligomeric xyloses, fruit flavor account for 1% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, oligomeric xylose, the total inventory of xylitol.
Polyvinyl pyrrolidone (PVP) alcoholic solution, concentration 0.05%, consumption accounts for 3.5% of total inventory.
Granule preparation: with embodiment 1
Embodiment 4
Prescription: 1 part of Herba Dracocephali extract, 3 parts of starch, 1 part of calcium carbonate, 1 part in dextrin, 5 parts of xylitol, 2.5 parts of oligomeric xyloses, fruit flavor accounts for 0.5% of total inventory.
Polyvinyl pyrrolidone (PVP) alcoholic solution, concentration 0.05%, consumption accounts for 3% of total inventory.
Granule preparation: with embodiment 1.
Embodiment 5
Prescription: 3 parts of Herba Dracocephali extracts, 5 parts of starch, 1 part of calcium carbonate, 1 part in dextrin, 3 parts of xylitol, 1 part of oligomeric xylose, fruit flavor accounts for 1.5% of total inventory.
Polyvinyl pyrrolidone (PVP) alcoholic solution, concentration 0.05%, consumption accounts for 5% of total inventory.The granule preparation is with embodiment 1.
Embodiment 6
Prescription: 4 parts of Herba Dracocephali extracts, 3 parts of starch, 2 parts of calcium carbonate, 2 parts in dextrin, 5 parts of xylitol, 0.5 part of oligomeric xylose, fruit flavor accounts for 1.2% of total inventory.
Polyvinyl pyrrolidone (PVP) alcoholic solution, concentration 0.05%, consumption accounts for 4% of total inventory.
The granule preparation is with embodiment 1.
Claims (4)
1, a kind of sugar-free heart-supplementing dracocephali moldavica granula is characterized in that it is to be made by following materials of weight proportions proportioning: 1～10 part of 1～10 part of Herba Dracocephali extract, 1～10 part of starch, 1～10 part of calcium carbonate, 1～10 part in dextrin, oligomeric xylose 0.5-3 part, xylitol; Fruit flavor is an amount of; Polyvinyl pyrrolidone PVP alcoholic solution is an amount of, wherein:
Fruit flavor: account for 0.1%～2% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose;
Concentration is 0.01%～0.05% polyvinyl pyrrolidone PVP alcoholic solution: consumption accounts for 1%～10% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose;
Preparation process is as follows:
Take by weighing Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, oligomeric xylose and fruit flavor mix homogeneously in proportion; pulverize; cross 80 mesh sieves; PVP alcoholic solution moistening with 0.01%～0.05%; send the granulation machine non-slurry pelletizing; drying again, granulate are made the above granule of pharmaceutics.
2, fruity sugar-free heart-supplementing dracocephali moldavica granula according to claim 1 is characterized in that it is to be made by following materials of weight proportions:
Herba Dracocephali extract: 3～7 parts, starch: 3～8 parts, calcium carbonate: 2～7 parts, dextrin: 4～8 parts, oligomeric xylose 1-2 part, xylitol: 3～7 parts, fruit flavor is an amount of, polyvinyl pyrrolidone PVP alcoholic solution is an amount of;
Fruit flavor: account for 0.5%～1.5% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose;
Concentration is 0.01%～0.05% polyvinyl pyrrolidone PVP alcoholic solution: consumption accounts for 3%～7% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose.
3, fruity sugar-free heart-supplementing dracocephali moldavica granula according to claim 1 is characterized in that it is to be made by following materials of weight proportions:
Herba Dracocephali extract: 6 parts, starch: 5 parts, calcium carbonate: 6 parts, dextrin: 7 parts, xylitol: 4 parts, 1.5 parts of oligomeric xyloses, fruit flavor: an amount of; Polyvinyl pyrrolidone PVP alcoholic solution is an amount of;
Fruit flavor: account for 1.5% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, the total inventory of xylitol;
Concentration is 0.01%～0.05% polyvinyl pyrrolidone PVP alcoholic solution: consumption accounts for 5% of Herba Dracocephali extract, starch, calcium carbonate, dextrin, xylitol, the total inventory of oligomeric xylose.
4, fruity sugar-free heart-supplementing dracocephali moldavica granula according to claim 1 is characterized in that fruit flavor is lemon essence, Fructus Ananadis comosi flavor essence, Fructus Mali pumilae flavor essence, Fructus Fragariae Ananssae flavor essence, orange flavor essence, Fructus Musae flavor essence, Citrullus vulgaris flavor essence, Fructus Crataegi flavor essence, pears flavor essence one or more a compositions wherein.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100147848A CN101264129A (en) | 2008-03-25 | 2008-03-25 | Sugar-free heart-supplementing dracocephali moldavica granula |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100147848A CN101264129A (en) | 2008-03-25 | 2008-03-25 | Sugar-free heart-supplementing dracocephali moldavica granula |
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| CN101264129A true CN101264129A (en) | 2008-09-17 |
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| CNA2008100147848A Pending CN101264129A (en) | 2008-03-25 | 2008-03-25 | Sugar-free heart-supplementing dracocephali moldavica granula |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230433A (en) * | 2013-05-09 | 2013-08-07 | 武汉市健恒药业有限公司 | Yixinbadiranjibuya granule and preparation method thereof |
| CN105902502A (en) * | 2016-05-30 | 2016-08-31 | 中国科学院西北高原生物研究所 | Dracocephalum heterophyllum granules and preparation method thereof |
| WO2018099493A1 (en) * | 2016-11-29 | 2018-06-07 | 广东大鹏医药科技有限公司 | Tropaeolum majus granules and preparation method therefor |
-
2008
- 2008-03-25 CN CNA2008100147848A patent/CN101264129A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230433A (en) * | 2013-05-09 | 2013-08-07 | 武汉市健恒药业有限公司 | Yixinbadiranjibuya granule and preparation method thereof |
| CN105902502A (en) * | 2016-05-30 | 2016-08-31 | 中国科学院西北高原生物研究所 | Dracocephalum heterophyllum granules and preparation method thereof |
| CN105902502B (en) * | 2016-05-30 | 2018-07-17 | 中国科学院西北高原生物研究所 | A kind of dracocephalum heterophyllum particle electuary and preparation method thereof |
| WO2018099493A1 (en) * | 2016-11-29 | 2018-06-07 | 广东大鹏医药科技有限公司 | Tropaeolum majus granules and preparation method therefor |
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Open date: 20080917 |