CN105902502A - Dracocephalum heterophyllum granules and preparation method thereof - Google Patents
Dracocephalum heterophyllum granules and preparation method thereof Download PDFInfo
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- CN105902502A CN105902502A CN201610370094.0A CN201610370094A CN105902502A CN 105902502 A CN105902502 A CN 105902502A CN 201610370094 A CN201610370094 A CN 201610370094A CN 105902502 A CN105902502 A CN 105902502A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention relates to dracocephalum heterophyllum granules and a preparation method thereof. The dracocephalum heterophyllum granules are prepared from the following raw materials in parts by weight: 5-25 parts of dracocephalum heterophyllum, 10-30 parts of inulin, 15-45 parts of dextrin, 1-10 parts of carboxymethyl cellulose and 5-35 parts of sucrose. The dracocephalum heterophyllum granules have the effects of clearing liver heat and protecting liver.
Description
Technical field
The invention belongs to Chinese herbal medicine manufacture field, particularly relate to a kind of dracocephalum heterophyllum dissolved granule and preparation side thereof
Method.
Background technology
Liver is human body most important removing toxic substances internal organs, has irreplaceable to the normal activities maintaining people
Effect.It has powerful defence function of detoxification, so to the toxin produced from external and body own metabolism
And excessive drinking, Drug abuse, toxic chemical substance etc. all can increase the weight of the burden of liver and then cause various liver
Damage.Hepatic disease has become as " assailant " of serious harm health.Owing to hepatopathy does not has in early days
Especially significant symptom, once finds that the state of an illness has belonged to late period, and modern medicine there is no in terms of the treatment of hepatic injury
Specific medicament, so in daily life, hepatoprotective is particularly important for modern.
Dracocephalum heterophyllum is Labiatae dragonhead, has effect of clear eliminating pathogen in the liver heat.Among the people for treating jaundice
Property hepatitis, liver-fire rise gingival swelling and pain, hemorrhage, oral ulcer etc..Dracocephalum heterophyllum dissolved granule can suppress
Glutamate pyruvate transaminase that various hepatic injury cause and the rising of glutamic oxaloacetic transaminase, GOT, can be obviously improved liver's discomfort disease
Shape.And dissolved granule is easy to carry, with drink with punching, the multiple demand of people's hepatoprotective can be met.
Summary of the invention
It is contemplated that one of technical problem solved the most to a certain extent in correlation technique.
To this end, it is an object of the present invention to propose a kind of have clear eliminating pathogen in the liver heat, hepatoprotective effect different
Herba Dracocephali Integrifolii dissolved granule.
A kind of dracocephalum heterophyllum dissolved granule according to embodiments of the present invention, including the raw material of following parts by weight:
Dracocephalum heterophyllum 5 parts～25 parts, inulin 10 parts～30 parts, 15 parts～45 parts of dextrin, carboxymethyl cellulose 1
Part～10 parts and sucrose 5 parts～35 parts.
A kind of dracocephalum heterophyllum dissolved granule according to embodiments of the present invention, easy to carry, be easy to take, the inside
Contained dracocephalum heterophyllum composition has effect of hepatoprotective to all kinds of hepatopaths.
It addition, a kind of dracocephalum heterophyllum dissolved granule according to the above embodiment of the present invention, it is also possible to have as follows
Additional technical characteristic:
Further, the present invention proposes a kind of dracocephalum heterophyllum dissolved granule, former including following parts by weight
Material: dracocephalum heterophyllum 10 parts～20 parts, inulin 15 parts～25 parts, 25 parts～35 parts of dextrin, carboxymethyl cellulose
Element 3 parts～8 parts and sucrose 15 parts～25 parts.
Further, the present invention proposes a kind of dracocephalum heterophyllum dissolved granule, former including following parts by weight
Material: dracocephalum heterophyllum 5 parts, inulin 10 parts, 15 parts of dextrin, carboxymethyl cellulose 1 part and sucrose 5 parts.
Further, the present invention proposes a kind of dracocephalum heterophyllum dissolved granule, former including following parts by weight
Material: dracocephalum heterophyllum 5 parts, inulin 6 parts, 9 parts of dextrin, carboxymethyl cellulose 2 parts and sucrose 7 parts.
Further, the present invention proposes a kind of dracocephalum heterophyllum dissolved granule, former including following parts by weight
Material: dracocephalum heterophyllum 5 parts, inulin 7 parts, 10 parts of dextrin, carboxymethyl cellulose 1.8 parts and sucrose 7 parts.
Further, the present invention proposes a kind of dracocephalum heterophyllum dissolved granule, former including following parts by weight
Material: dracocephalum heterophyllum 13 parts, inulin 18 parts, 28 parts of dextrin, carboxymethyl cellulose 5 parts and sucrose 18
Part.
Further, the present invention proposes a kind of dracocephalum heterophyllum dissolved granule, former including following parts by weight
Material: dracocephalum heterophyllum 17 parts, inulin 22 parts, 32 parts of dextrin, carboxymethyl cellulose 7 parts and sucrose 32
Part.
Further object is that a kind of method preparing dracocephalum heterophyllum dissolved granule of proposition.
A kind of method preparing dracocephalum heterophyllum dissolved granule proposed according to the present invention, comprises the steps: to carry
Take: after dracocephalum heterophyllum is pulverized, with alcohol solution dipping, alcohol solution dipping liquid is heated to reflux and filters,
Take filter liquor.Concentrate: by filter liquor concentrating under reduced pressure, take concentrated solution.Dispensing: be mixed in concentrated solution inulin,
Dextrin, carboxymethyl cellulose and sucrose, to obtain dracocephalum heterophyllum soft material.Dry: dracocephalum heterophyllum soft material is dried
Dry become granule, and by pellet through sieves, i.e. obtain dracocephalum heterophyllum dissolved granule.
Further, in extraction step, the volumetric concentration of ethanol solution is 92%～98%, ethanol solution
Parts by weight be 8 parts～20 parts, the time of alcohol solution dipping is 10h～15h, is heated to reflux temperature and is
45 DEG C～85 DEG C, the time of being heated to reflux is 2h～4h.
Further, in concentration step, the temperature of concentrating under reduced pressure is 50 DEG C～65 DEG C；In baking step,
Drying temperature is 50 DEG C～65 DEG C.
The additional aspect of the present invention and advantage will part be given in the following description, and part will be retouched from following
Become obvious in stating, or recognized by the practice of the present invention.
Accompanying drawing explanation
Fig. 1 is the dracocephalum heterophyllum dissolved granule of the present invention treatment to the hepatic injury that self property immunoreation causes
Effect.
Fig. 2 is the dracocephalum heterophyllum dissolved granule of the present invention response to treatment to acute hepatitis.
Detailed description of the invention
Embodiments of the invention are described below in detail.The embodiment described below with reference to accompanying drawing is exemplary
, it is intended to it is used for explaining the present invention, and is not considered as limiting the invention.
Embodiment 1
A kind of dracocephalum heterophyllum dissolved granule, including the raw material of following parts by weight: dracocephalum heterophyllum 5 parts～25 parts,
Inulin 10 parts～30 parts, 15 parts～45 parts of dextrin, carboxymethyl cellulose 1 part～10 parts and sucrose 5 parts～35
Part.
Its preparation method, comprises the following steps:
(1) dracocephalum heterophyllum weighing 5 kilograms～25 kilograms pulverizes sample, with 50 kilograms～250 kilograms, body
Volume concentrations is the edible ethanol solution soaking 11 hours of 92%, heating and refluxing extraction 3 times at a temperature of 55 DEG C,
Each 2 hours, filter, take filter liquor.
(2) being 0.07MPa by above-mentioned filter liquor in vacuum, temperature is evaporated under the conditions of being 65 DEG C
The paste thing of proportion 1 times.
(3) add in paste thing 10 kilograms～30 kilograms of inulin, 15 kilograms～45 kilograms of dextrin, 1
Kilogram～10 kilograms of carboxymethyl celluloses, 5 kilograms～35 kilograms of sucrose, make soft material after mixing.
(4) soft material is dried at 55 DEG C dry granule, granulate, sieves, i.e. obtain dracocephalum heterophyllum granule
Electuary.
Embodiment 2
The dissolved granule of a kind of dracocephalum heterophyllum hepatoprotective, including the raw material of following parts by weight: dracocephalum heterophyllum
10 parts～20 parts, inulin 15 parts～25 parts, 25 parts～35 parts of dextrin, carboxymethyl cellulose 3 parts～8 parts and
Sucrose 15 parts～25 parts.
Its preparation method, comprises the following steps:
(1) weigh 10 kilograms～20 kilograms dracocephalum heterophyllum pulverize sample, with 130 kilograms～260 kilograms,
Volumetric concentration is the edible ethanol solution soaking 12 hours of 94%, heating and refluxing extraction 1 at a temperature of 65 DEG C
Secondary, extract 4 hours, filter, take filter liquor.
(2) being 0.08MPa by filter liquor in vacuum, temperature is evaporated to proportion under the conditions of being 58 DEG C
The paste thing of 3 times.
(3) add in above-mentioned paste thing 15 kilograms～25 kilograms of inulin, 25 kilograms～35 kilograms of dextrin,
3 kilograms～8 kilograms of carboxymethyl celluloses, 15 kilograms～25 kilograms of sucrose, make soft material after mixing；
(4) above-mentioned soft material is dried at 58 DEG C dry granule, granulate, sieves, i.e. obtain dracocephalum heterophyllum
Dissolved granule.
Embodiment 3
The dissolved granule of a kind of dracocephalum heterophyllum hepatoprotective, including the raw material of following parts by weight: dracocephalum heterophyllum
5 parts, inulin 10 parts, 15 parts of dextrin, carboxymethyl cellulose 1 part and sucrose 5 parts.
Its preparation method, comprises the following steps:
(1) weigh 5 kilograms dracocephalum heterophyllum pulverize sample, with 40 kilograms, volumetric concentration be the food of 95%
With alcohol solution dipping 10 hours, heating and refluxing extraction 3 times at a temperature of 45 DEG C, each 3 hours, mistake
Filter, takes filter liquor.
(2) being 0.06MPa by above-mentioned filter liquor in vacuum, temperature is evaporated under the conditions of being 65 DEG C
The paste thing of proportion 1 times.
(3) in above-mentioned paste thing, 10 kilograms of inulin, 15 kilograms of dextrin, 1 kilogram of carboxymethyl are added
Cellulose, 5 kilograms of sucrose, make soft material after mixing.
(4) above-mentioned soft material is dried at 60 DEG C dry granule, granulate, sieves, i.e. obtain dracocephalum heterophyllum
Dissolved granule.
Embodiment 4
The dissolved granule of a kind of dracocephalum heterophyllum hepatoprotective, including the raw material of following parts by weight: dracocephalum heterophyllum
5 parts, inulin 6 parts, 9 parts of dextrin, carboxymethyl cellulose 2 parts and sucrose 7 parts.
Its preparation method, comprises the following steps:
(1) weigh 5 kilograms of dracocephalum heterophyllums and pulverize samples, with 100 kilograms, volumetric concentration be the food of 95%
With alcohol solution dipping 15 hours, heating and refluxing extraction 1 time at a temperature of 45 DEG C, extract 3 hours, mistake
Filter, takes filter liquor.
(2) being 0.09MPa by above-mentioned filter liquor in vacuum, temperature is evaporated under the conditions of being 50 DEG C
The paste thing of proportion 3 times；
(3) in above-mentioned paste thing, 6 kilograms of inulin, 9 kilograms of dextrin, 2 kilograms of carboxymethyl fibres are added
Dimension element, 7 kilograms of sucrose, make soft material after mixing.
(4) above-mentioned soft material is dried at 60 DEG C dry granule, granulate, sieves, i.e. obtain dracocephalum heterophyllum
Dissolved granule.
Embodiment 5
The dissolved granule of a kind of dracocephalum heterophyllum hepatoprotective, including the raw material of following parts by weight: dracocephalum heterophyllum
5 parts, inulin 7 parts, 10 parts of dextrin, carboxymethyl cellulose 1.8 parts and sucrose 7 parts.
Its preparation method, comprises the following steps:
(1) weigh 5 kilograms of dracocephalum heterophyllums and pulverize samples, with 100 kilograms, volumetric concentration be the food of 95%
With alcohol solution dipping 15 hours, heating and refluxing extraction 1 time at a temperature of 45 DEG C, extract 3 hours, mistake
Filter, takes filter liquor.
(2) being 0.09MPa by above-mentioned filter liquor in vacuum, temperature is evaporated under the conditions of being 50 DEG C
The paste thing of proportion 3 times.
(3) in above-mentioned paste thing, 7 kilograms of inulin, 10 kilograms of dextrin, 1.8 kilograms of carboxylic first are added
Base cellulose, 7 kilograms of sucrose, make soft material after mixing.
(4) above-mentioned soft material is dried at 60 DEG C dry granule, granulate, sieves, i.e. obtain dracocephalum heterophyllum
Dissolved granule.
Embodiment 6
The dissolved granule of a kind of dracocephalum heterophyllum hepatoprotective, including the raw material of following parts by weight: dracocephalum heterophyllum
13 parts, inulin 18 parts, 28 parts of dextrin, carboxymethyl cellulose 5 parts and sucrose 18 parts.
Its preparation method, comprises the following steps:
(1) weigh 13 kilograms of dracocephalum heterophyllums and pulverize samples, with 208 kilograms, volumetric concentration be the food of 96%
With alcohol solution dipping 13 hours, heating and refluxing extraction 2 times at a temperature of 75 DEG C, extract 2 hours every time,
Filter, take filter liquor.
(2) being 0.07MPa by above-mentioned filter liquor in vacuum, temperature is evaporated under the conditions of being 61 DEG C
The paste thing of proportion 2 times.
(3) in above-mentioned paste thing, 18 kilograms of inulin, 28 kilograms of dextrin, 5 kilograms of carboxymethyls are added
Cellulose, 18 kilograms of sucrose, make soft material after mixing.
(4) above-mentioned soft material is dried at 61 DEG C dry granule, granulate, sieves, i.e. obtain dracocephalum heterophyllum
Dissolved granule.
Embodiment 7
The dissolved granule of a kind of dracocephalum heterophyllum hepatoprotective, including the raw material of following parts by weight: dracocephalum heterophyllum
17 parts, inulin 22 parts, 32 parts of dextrin, carboxymethyl cellulose 7 parts and sucrose 32 parts.
Its preparation method, comprises the following steps:
(1) weigh 17 kilograms of dracocephalum heterophyllums and pulverize samples, with 306 kilograms, volumetric concentration be the food of 98%
With alcohol solution dipping 14 hours, heating and refluxing extraction 1 time at a temperature of 85 DEG C, extract 4 hours, mistake
Filter, takes filter liquor.
(2) being 0.08MPa by above-mentioned filter liquor in vacuum, temperature is evaporated under the conditions of being 64 DEG C
The paste thing of proportion 3 times.
(3) in above-mentioned paste thing, 22 kilograms of inulin, 32 kilograms of dextrin, 7 kilograms of carboxymethyls are added
Cellulose, 32 kilograms of sucrose, make soft material after mixing.
(4) above-mentioned soft material is dried at 64 DEG C dry granule, granulate, sieves, i.e. obtain dracocephalum heterophyllum
Dissolved granule.
As it is shown in figure 1, utilize canavaline enzyme to cause Liver immunity system that liver self excessive immune is reacted
Liver organization damage is caused to carry out the liver that in simulated virus hepatitis, the viral Autoimmune Disorders caused causes thin
Born of the same parents' necrosis pathology.In this pathological model, by detection concanavalin A (Con A) induction hepatitis
Group and the change of dracocephalum heterophyllum dissolved granule group albino lab mouse (balb/c mice) transaminase values index
Judge the drug influence of this dissolved granule, find that dracocephalum heterophyllum dissolved granule can treat body self property significantly
The hepatic injury that immunoreation causes.
Number with " * " represents that the significant level of difference, i.e. " * " represent variant, but the most notable
(P < 0.1), " * * " represents significant difference (P < 0.05), and " * * * " represents that difference is extremely notable (P < 0.01).
Glutamate pyruvate transaminase (ALT) and glutamic oxaloacetic transaminase, GOT between blank group and dracocephalum heterophyllum dissolved granule treatment group
(AST) there is extremely significantly difference (P < 0.01) in level.Wherein, blank group is blue or green without adding different leaf
Blue dissolved granule.
Test establishes the autoimmunity liver injury model of Con A induction, little by comparing administration 16
Time, ALT and AST in comparative example mice and dracocephalum heterophyllum grains electuary group mice serum after 24 hours
Level, evaluate the ethanol extraction therapeutical effect to autoimmune Liver Injury in Mice.Found that it is blank
In the mice serum of group and dracocephalum heterophyllum dissolved granule treatment group the level of ALT and AST at 16 hours and
24 little the most all exist extremely significantly difference (P < 0.01), it may be assumed that the ALT of dracocephalum heterophyllum dissolved granule treatment group
ALT and AST level with AST level pole is significantly lower than naive mice, illustrates dracocephalum heterophyllum
Grain electuary has good therapeutic effect to the hepatic injury that mice Autoimmune Disorders causes.
As in figure 2 it is shown, in Shi Yan by balb/c mice joint injection poly cytidine (Poly I:C) with
D type galactose ammonia (D-GalN), inducing mouse generation acute hepatitis.Blue or green with different leaf by relatively blank group
In blue dissolved granule treatment group mice serum, the level of ALT judges the ethanol extraction medicine to acute hepatitis
Thing effect, finds that the ALT level of dracocephalum heterophyllum dissolved granule group is substantially less than the ALT water of naive mice
Flat, illustrate that dracocephalum heterophyllum dissolved granule has significant inhibitory action to acute hepatitis.
According to the dissolved granule of the present invention a kind of dracocephalum heterophyllum hepatoprotective, its feed distribution is wide, it is easy in batches
Get the raw materials ready.Solvent for use of the present invention is ethanol, cheap, and can use with regeneration cycle, safe noresidue,
It is prone to scale.Present invention process is simple, repeatability is preferable, obtained dissolved granule steady quality, can
Long-term preservation, directly eats, it is simple to carry.
In the description of this specification, reference term " embodiment ", " some embodiments ", " example ",
It is concrete that the description of " concrete example " or " some examples " etc. means to combine this embodiment or example describes
Feature, structure, material or feature are contained at least one embodiment or the example of the present invention.In this theory
In bright book, the schematic representation of above-mentioned term is necessarily directed to identical embodiment or example.And,
Describe specific features, structure, material or feature can with in one or more embodiments in office or example with
Suitably mode combines.Additionally, in the case of the most conflicting, those skilled in the art can be by this
The feature of different embodiments described in description or example and different embodiment or example be combined and
Combination.
Although above it has been shown and described that embodiments of the invention, it is to be understood that above-described embodiment
It is exemplary, it is impossible to being interpreted as limitation of the present invention, those of ordinary skill in the art is the present invention's
In the range of above-described embodiment can be changed, revise, replace and modification.
Claims (10)
1. a dracocephalum heterophyllum dissolved granule, it is characterised in that include the raw material of following parts by weight: different leaf
Dracocephalum moldabium 5 parts～25 parts, inulin 10 parts～30 parts, 15 parts～45 parts of dextrin, carboxymethyl cellulose 1 part～10
Part and sucrose 5 parts～35 parts.
Dracocephalum heterophyllum dissolved granule the most according to claim 1, it is characterised in that include following weight
The raw material of number: dracocephalum heterophyllum 10 parts～20 parts, inulin 15 parts～25 parts, 25 parts～35 parts of dextrin, carboxylic
Methylcellulose 3 parts～8 parts and sucrose 15 parts～25 parts.
Dracocephalum heterophyllum dissolved granule the most according to claim 1, it is characterised in that include following weight
The raw material of number: dracocephalum heterophyllum 5 parts, inulin 10 parts, 15 parts of dextrin, carboxymethyl cellulose 1 part and sugarcane
Sugar 5 parts.
Dracocephalum heterophyllum dissolved granule the most according to claim 1, it is characterised in that include following weight
The raw material of number: dracocephalum heterophyllum 5 parts, inulin 6 parts, 9 parts of dextrin, carboxymethyl cellulose 2 parts and sucrose
7 parts.
Dracocephalum heterophyllum dissolved granule the most according to claim 1, it is characterised in that include following weight
The raw material of number: dracocephalum heterophyllum 5 parts, inulin 7 parts, 10 parts of dextrin, carboxymethyl cellulose 1.8 parts and sugarcane
Sugar 7 parts.
Dracocephalum heterophyllum dissolved granule the most according to claim 1 and 2, it is characterised in that include as follows
The raw material of parts by weight: dracocephalum heterophyllum 13 parts, inulin 18 parts, 28 parts of dextrin, carboxymethyl cellulose 5
Part and sucrose 18 parts.
Dracocephalum heterophyllum dissolved granule the most according to claim 1 and 2, it is characterised in that include as follows
The raw material of parts by weight: dracocephalum heterophyllum 17 parts, inulin 22 parts, 32 parts of dextrin, carboxymethyl cellulose 7
Part and sucrose 32 parts.
8. the method preparing dracocephalum heterophyllum dissolved granule as described in any one of claim 1-7, it is special
Levy and be, comprise the steps:
Extract: after dracocephalum heterophyllum is pulverized, with alcohol solution dipping, described alcohol solution dipping liquid is heated
Reflux and filter, taking filter liquor；
Concentrate: by described filter liquor concentrating under reduced pressure, take concentrated solution；
Dispensing: be mixed into inulin, dextrin, carboxymethyl cellulose and sucrose in described concentrated solution, different to obtain
Herba Dracocephali Integrifolii soft material；
Dry: described dracocephalum heterophyllum soft material is dried into granule, and by described pellet through sieves, i.e. obtains different leaf
Dracocephalum moldabium dissolved granule.
A kind of method preparing dracocephalum heterophyllum dissolved granule the most according to claim 8, it is characterised in that
In described extraction step, the volumetric concentration of described ethanol solution is 92%～98%, the weight of described ethanol solution
Amount number be 8 parts～20 parts, the time of described alcohol solution dipping is 10h～15h, described in be heated to reflux temperature
Degree is 45 DEG C～85 DEG C, described in be heated to reflux the time be 2h～4h.
A kind of method preparing dracocephalum heterophyllum dissolved granule the most according to claim 8, its feature exists
In, in described concentration step, the temperature of described concentrating under reduced pressure is 50 DEG C～65 DEG C；At described baking step
In, described drying temperature is 50 DEG C～65 DEG C.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109043030A (en) * | 2018-08-06 | 2018-12-21 | 中国科学院西北高原生物研究所 | A kind of health-care tea for fat-reducing liver-fortifying and preparation method thereof |
| CN114634536A (en) * | 2022-02-28 | 2022-06-17 | 中国科学院西北高原生物研究所 | Separation process and application of phenol natural free radical scavenger in dracocephalum heterophyllum benth |
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