CN101456918B - Sealwort polysaccharide and preparation method thereof, and its application in preparing hypoglycemic and reducing blood lipid drugs - Google Patents
Sealwort polysaccharide and preparation method thereof, and its application in preparing hypoglycemic and reducing blood lipid drugs Download PDFInfo
- Publication number
- CN101456918B CN101456918B CN2009100005339A CN200910000533A CN101456918B CN 101456918 B CN101456918 B CN 101456918B CN 2009100005339 A CN2009100005339 A CN 2009100005339A CN 200910000533 A CN200910000533 A CN 200910000533A CN 101456918 B CN101456918 B CN 101456918B
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- Prior art keywords
- filtrate
- polygonatum polysaccharide
- suction filtration
- centrifugal
- ethanol
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- 150000004676 glycans Chemical class 0.000 title claims abstract description 58
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 56
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 210000004369 blood Anatomy 0.000 title claims abstract description 15
- 239000008280 blood Substances 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 title claims abstract description 10
- 230000002218 hypoglycaemic effect Effects 0.000 title claims description 6
- 229940079593 drug Drugs 0.000 title abstract description 3
- 150000002632 lipids Chemical class 0.000 title 1
- 241000756042 Polygonatum Species 0.000 claims abstract description 56
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 10
- 241000234280 Liliaceae Species 0.000 claims abstract description 4
- 241000196324 Embryophyta Species 0.000 claims abstract description 3
- 239000000706 filtrate Substances 0.000 claims description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 238000001556 precipitation Methods 0.000 claims description 20
- 238000000967 suction filtration Methods 0.000 claims description 18
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000012043 crude product Substances 0.000 claims description 11
- AZHSSKPUVBVXLK-UHFFFAOYSA-N ethane-1,1-diol Chemical compound CC(O)O AZHSSKPUVBVXLK-UHFFFAOYSA-N 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 7
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
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- 238000001914 filtration Methods 0.000 claims description 4
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- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 150000003214 pyranose derivatives Chemical group 0.000 claims description 4
- AISMNBXOJRHCIA-UHFFFAOYSA-N trimethylazanium;bromide Chemical compound Br.CN(C)C AISMNBXOJRHCIA-UHFFFAOYSA-N 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 3
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 3
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 2
- 229920002101 Chitin Polymers 0.000 claims description 2
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 2
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 2
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 2
- 239000002585 base Substances 0.000 claims description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 2
- 239000000920 calcium hydroxide Substances 0.000 claims description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 2
- 235000011116 calcium hydroxide Nutrition 0.000 claims description 2
- NEUSVAOJNUQRTM-UHFFFAOYSA-N cetylpyridinium Chemical compound CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NEUSVAOJNUQRTM-UHFFFAOYSA-N 0.000 claims description 2
- 229960004830 cetylpyridinium Drugs 0.000 claims description 2
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 235000011118 potassium hydroxide Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- UUNIOFWUJYBVGQ-UHFFFAOYSA-N 2-amino-4-(3,4-dimethoxyphenyl)-10-fluoro-4,5,6,7-tetrahydrobenzo[1,2]cyclohepta[6,7-d]pyran-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C1C(C#N)=C(N)OC2=C1CCCC1=CC=C(F)C=C12 UUNIOFWUJYBVGQ-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 abstract 1
- 238000003912 environmental pollution Methods 0.000 abstract 1
- 150000002772 monosaccharides Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 15
- 241000699666 Mus <mouse, genus> Species 0.000 description 9
- 230000002265 prevention Effects 0.000 description 5
- 239000008103 glucose Substances 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 150000004804 polysaccharides Polymers 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
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- 238000004519 manufacturing process Methods 0.000 description 2
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- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 2
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- 239000000047 product Substances 0.000 description 2
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical group C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 2
- 229960002855 simvastatin Drugs 0.000 description 2
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- 238000012360 testing method Methods 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 244000291564 Allium cepa Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
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- 206010068676 Pneumoretroperitoneum Diseases 0.000 description 1
- 235000008737 Polygonatum biflorum Nutrition 0.000 description 1
- 208000005727 Retropneumoperitoneum Diseases 0.000 description 1
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- 238000004108 freeze drying Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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CN2009100005339A CN101456918B (en) | 2009-01-16 | 2009-01-16 | Sealwort polysaccharide and preparation method thereof, and its application in preparing hypoglycemic and reducing blood lipid drugs |
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CN2009100005339A CN101456918B (en) | 2009-01-16 | 2009-01-16 | Sealwort polysaccharide and preparation method thereof, and its application in preparing hypoglycemic and reducing blood lipid drugs |
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CN101456918A CN101456918A (en) | 2009-06-17 |
CN101456918B true CN101456918B (en) | 2011-05-11 |
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Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102351960B (en) * | 2011-11-15 | 2013-07-10 | 重庆市秀山红星中药材开发有限公司 | Method for extracting rhizoma polygonati polysaccharide |
CN102351961A (en) * | 2011-11-15 | 2012-02-15 | 重庆市秀山红星中药材开发有限公司 | Method for extracting rhizoma polygonati polysaccharide from stems and leaves of rhizoma polygonati |
CN102491999A (en) * | 2011-11-15 | 2012-06-13 | 重庆市秀山红星中药材开发有限公司 | Method for extracting polygonatum rhizome oligosaccharide |
CN105218692B (en) * | 2014-06-05 | 2018-01-30 | 上海家化联合股份有限公司 | A kind of sealwort β galactans and preparation method thereof and the application for suppressing Apoptosis |
CN107586343A (en) * | 2016-07-08 | 2018-01-16 | 玉溪众欣农业科技有限公司 | A kind of Siberian solomonseal rhizome polysaccharide extraction process |
CN107259429A (en) * | 2017-06-18 | 2017-10-20 | 合肥睿联生物科技有限公司 | A kind of wonderful taste longan of Siberian solomonseal rhizome polysaccharide and preparation method thereof |
CN107279917A (en) * | 2017-06-18 | 2017-10-24 | 合肥睿联生物科技有限公司 | A kind of tasty bar denier wood of Siberian solomonseal rhizome polysaccharide and preparation method thereof |
CN107319464A (en) * | 2017-06-18 | 2017-11-07 | 合肥睿联生物科技有限公司 | A kind of wonderful taste Chinese chestnut of Siberian solomonseal rhizome polysaccharide and preparation method thereof |
CN107242511A (en) * | 2017-06-18 | 2017-10-13 | 合肥睿联生物科技有限公司 | A kind of tasty melon seeds of Siberian solomonseal rhizome polysaccharide and preparation method thereof |
CN110845639A (en) * | 2019-12-31 | 2020-02-28 | 山东省分析测试中心 | Method for extracting polygonatum polysaccharide |
CN113004433A (en) * | 2021-03-09 | 2021-06-22 | 成都中医药大学 | Rhizoma polygonati fructan and preparation method and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1796418A (en) * | 2004-12-30 | 2006-07-05 | 中国科学院上海药物研究所 | Immune polysaccharide of rhizome of manyflower solomonseal, composition and application |
CN101255199A (en) * | 2008-03-25 | 2008-09-03 | 西安交通大学 | Method for extracting Siberian solomonseal rhizome polysaccharide from siberian solomonseal rhizome |
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2009
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1796418A (en) * | 2004-12-30 | 2006-07-05 | 中国科学院上海药物研究所 | Immune polysaccharide of rhizome of manyflower solomonseal, composition and application |
CN101255199A (en) * | 2008-03-25 | 2008-09-03 | 西安交通大学 | Method for extracting Siberian solomonseal rhizome polysaccharide from siberian solomonseal rhizome |
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