CN105902502B - A kind of dracocephalum heterophyllum particle electuary and preparation method thereof - Google Patents
A kind of dracocephalum heterophyllum particle electuary and preparation method thereof Download PDFInfo
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to a kind of dracocephalum heterophyllum particle electuaries and preparation method thereof.The dracocephalum heterophyllum particle electuary includes the raw material of following parts by weight：5 parts~35 parts of 5 parts~25 parts of dracocephalum heterophyllum, 10 parts~30 parts of inulin, 15 parts~45 parts of dextrin, 1 part~10 parts of carboxymethyl cellulose and sucrose.A kind of dracocephalum heterophyllum particle electuary according to the present invention has effects that clear purging the liver of pathogenic fire heat, liver protecting.
Description
Technical field
The invention belongs to Chinese herbal medicine manufacture fields more particularly to a kind of dracocephalum heterophyllum particle electuary and preparation method thereof.
Background technology
Liver is the most important removing toxic substances internal organs of human body, to maintaining the normal activities of people to have irreplaceable role.
It has a powerful defence function of detoxification to the toxin from the generation of external and body own metabolism, however excessive drinking, abuse
Drug, toxic chemical substance etc. can all aggravate the burden of liver and then cause various hepatic injuries.Liver diseases have become seriously
" assailant " being detrimental to health.Since hepatopathy is in early stage no especially significant symptom, once find that the state of an illness has belonged to late period, it is existing
Specific medicament is had no in terms of the treatment of hepatic injury for medicine, so liver protecting seems outstanding in daily life for modern
It is important.
Dracocephalum heterophyllum is Labiatae dragonhead, has effects that clear purging the liver of pathogenic fire heat.It is civil to be used to treat icterepatitis,
The swelling and aching of gum that irascibility rises, bleeding, canker sore etc..Dracocephalum heterophyllum particle electuary can inhibit paddy third caused by various hepatic injuries
The raising of transaminase and glutamic-oxalacetic transaminease can be obviously improved liver's malaise symptoms.And particle electuary is easy to carry, with drink with
Punching, can meet a variety of demands of people's liver protecting.
Invention content
The present invention is directed to solve at least some of the technical problems in related technologies.
For this purpose, an object of the present invention is to provide it is a kind of have effects that clear purging the liver of pathogenic fire heat, liver protecting dracocephalum heterophyllum
Particle electuary.
A kind of dracocephalum heterophyllum particle electuary according to the ... of the embodiment of the present invention, includes the raw material of following parts by weight：Different leaf is green
5 parts~25 parts blue, 10 parts~30 parts of inulin, 15 parts~45 parts of dextrin, 1 part~10 parts of carboxymethyl cellulose and sucrose 5 parts~35
Part.
A kind of dracocephalum heterophyllum particle electuary according to the ... of the embodiment of the present invention, it is easy to carry, convenient for taking, contained by the inside
Dracocephalum heterophyllum ingredient has effects that liver protecting to all kinds of hepatopaths.
In addition, a kind of dracocephalum heterophyllum particle electuary according to the above embodiment of the present invention, can also have following additional
Technical characteristic：
Further, the present invention proposes a kind of dracocephalum heterophyllum particle electuary, includes the raw material of following parts by weight：Different leaf
15 parts of green 10 parts~20 parts blue, 15 parts~25 parts of inulin, 25 parts~35 parts of dextrin, 3 parts~8 parts of carboxymethyl cellulose and sucrose~
25 parts.
Further, the present invention proposes a kind of dracocephalum heterophyllum particle electuary, includes the raw material of following parts by weight：Different leaf
5 parts of green 5 parts blue, 10 parts of inulin, 15 parts of dextrin, 1 part of carboxymethyl cellulose and sucrose.
Further, the present invention proposes a kind of dracocephalum heterophyllum particle electuary, includes the raw material of following parts by weight：Different leaf
7 parts of green 5 parts blue, 6 parts of inulin, 9 parts of dextrin, 2 parts of carboxymethyl cellulose and sucrose.
Further, the present invention proposes a kind of dracocephalum heterophyllum particle electuary, includes the raw material of following parts by weight：Different leaf
7 parts of green 5 parts blue, 7 parts of inulin, 10 parts of dextrin, 1.8 parts of carboxymethyl cellulose and sucrose.
Further, the present invention proposes a kind of dracocephalum heterophyllum particle electuary, includes the raw material of following parts by weight：Different leaf
18 parts of green 13 parts blue, 18 parts of inulin, 28 parts of dextrin, 5 parts of carboxymethyl cellulose and sucrose.
Further, the present invention proposes a kind of dracocephalum heterophyllum particle electuary, includes the raw material of following parts by weight：Different leaf
32 parts of green 17 parts blue, 22 parts of inulin, 32 parts of dextrin, 7 parts of carboxymethyl cellulose and sucrose.
It is another object of the present invention to propose a kind of method preparing dracocephalum heterophyllum particle electuary.
According to a kind of method preparing dracocephalum heterophyllum particle electuary proposed by the present invention, include the following steps：Extraction：It will be different
After Herba Dracocephali Integrifolii crushes, with alcohol solution dipping, alcohol solution dipping liquid is heated to reflux and is filtered, filter liquor is taken.Concentration：It will filter
Go out liquid reduced pressure, takes concentrate.Dispensing：Inulin, dextrin, carboxymethyl cellulose and sucrose are mixed into concentrate, to obtain
Dracocephalum heterophyllum softwood.Drying：Dracocephalum heterophyllum softwood is dried into particle, and pellet through sieves are rushed to get to dracocephalum heterophyllum particle
Agent.
Further, in extraction step, the volumetric concentration of ethanol solution is 92%~98%, the parts by weight of ethanol solution
Number is 8 parts~20 parts, and the time of alcohol solution dipping is 10h~15h, and it is 45 DEG C~85 DEG C to be heated to reflux temperature, is heated to reflux
Time is 2h~4h.
Further, in concentration step, the temperature of reduced pressure is 50 DEG C~65 DEG C；In baking step, drying temperature
Degree is 50 DEG C~65 DEG C.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Description of the drawings
Fig. 1 is response to treatment of the dracocephalum heterophyllum particle electuary of the present invention to hepatic injury caused by itself property immune response.
Fig. 2 is response to treatment of the dracocephalum heterophyllum particle electuary of the present invention to oxyhepatitis.
Specific implementation mode
The embodiment of the present invention is described below in detail.The embodiments described below with reference to the accompanying drawings are exemplary, purport
For explaining the present invention, and it is not considered as limiting the invention.
Embodiment 1
A kind of dracocephalum heterophyllum particle electuary, includes the raw material of following parts by weight：5 parts~25 parts of dracocephalum heterophyllum, inulin 10
5 parts~35 parts of part~30 parts, 15 parts~45 parts of dextrin, 1 part~10 parts of carboxymethyl cellulose and sucrose.
Preparation method includes the following steps：
(1) it weighs 5 kilograms~25 kilograms of dracocephalum heterophyllum and crushes sample, be with 50 kilograms~250 kilograms, volumetric concentration
92% edible ethanol solution impregnates 11 hours, the heating and refluxing extraction 3 times at a temperature of 55 DEG C, 2 hours every time, and filtering takes filter
Go out liquid.
(2) it is 0.07MPa in vacuum degree by above-mentioned filter liquor, temperature is concentrated under reduced pressure into 1 times of proportion under the conditions of being 65 DEG C
Paste object.
(3) 10 kilograms~30 kilograms inulin, 15 kilograms~45 kilograms dextrin, 1 kilogram~10 public affairs are added in paste object
Jin carboxymethyl cellulose, 5 kilograms~35 kilograms sucrose, softwood is made after mixing.
(4) softwood is dried into dry particl at 55 DEG C, whole grain, sieving is to get to dracocephalum heterophyllum particle electuary.
Embodiment 2
A kind of particle electuary of dracocephalum heterophyllum liver protecting, includes the raw material of following parts by weight：10 parts of dracocephalum heterophyllum~
15 parts~25 parts of 20 parts, 15 parts~25 parts of inulin, 25 parts~35 parts of dextrin, 3 parts~8 parts of carboxymethyl cellulose and sucrose.
Preparation method includes the following steps：
(1) it weighs 10 kilograms~20 kilograms of dracocephalum heterophyllum and crushes sample, be with 130 kilograms~260 kilograms, volumetric concentration
94% edible ethanol solution impregnates 12 hours, the heating and refluxing extraction 1 time at a temperature of 65 DEG C, extracts 4 hours, and filtering takes filter
Go out liquid.
(2) it is 0.08MPa in vacuum degree by filter liquor, temperature is concentrated under reduced pressure into the thick paste of 3 times of proportion under the conditions of being 58 DEG C
Shape object.
(3) 15 kilograms~25 kilograms inulin, 25 kilograms~35 kilograms dextrin, 3 kilograms~8 are added in above-mentioned paste object
Kilogram carboxymethyl cellulose, 15 kilograms~25 kilograms sucrose, softwood is made after mixing；
(4) above-mentioned softwood is dried into dry particl at 58 DEG C, whole grain, sieving is to get to dracocephalum heterophyllum particle electuary.
Embodiment 3
A kind of particle electuary of dracocephalum heterophyllum liver protecting, includes the raw material of following parts by weight：5 parts of dracocephalum heterophyllum, chrysanthemum
5 parts of 10 parts of powder, 15 parts of dextrin, 1 part of carboxymethyl cellulose and sucrose.
Preparation method includes the following steps：
(1) it weighs 5 kilograms of dracocephalum heterophyllum and crushes sample, with 40 kilograms, the edible ethanol solution that volumetric concentration is 95%
It impregnates 10 hours, the heating and refluxing extraction 3 times at a temperature of 45 DEG C, 3 hours every time, filtering takes filter liquor.
(2) it is 0.06MPa in vacuum degree by above-mentioned filter liquor, temperature is concentrated under reduced pressure into 1 times of proportion under the conditions of being 65 DEG C
Paste object.
(3) 10 kilograms of inulin, 15 kilograms of dextrin, 1 kilogram of carboxymethyl cellulose, 5 public affairs are added in above-mentioned paste object
Jin sucrose, softwood is made after mixing.
(4) above-mentioned softwood is dried into dry particl at 60 DEG C, whole grain, sieving is to get to dracocephalum heterophyllum particle electuary.
Embodiment 4
A kind of particle electuary of dracocephalum heterophyllum liver protecting, includes the raw material of following parts by weight：5 parts of dracocephalum heterophyllum, chrysanthemum
7 parts of 6 parts of powder, 9 parts of dextrin, 2 parts of carboxymethyl cellulose and sucrose.
Preparation method includes the following steps：
(1) 5 kilograms of dracocephalum heterophyllums are weighed and crush sample, are soaked with 100 kilograms, the edible ethanol solution that volumetric concentration is 95%
Bubble 15 hours, the heating and refluxing extraction 1 time at a temperature of 45 DEG C are extracted 3 hours, and filtering takes filter liquor.
(2) it is 0.09MPa in vacuum degree by above-mentioned filter liquor, temperature is concentrated under reduced pressure into 3 times of proportion under the conditions of being 50 DEG C
Paste object；
(3) in above-mentioned paste object be added 6 kilograms of inulin, 9 kilograms of dextrin, 2 kilograms of carboxymethyl celluloses, 7 kilograms
Softwood is made after mixing in sucrose.
(4) above-mentioned softwood is dried into dry particl at 60 DEG C, whole grain, sieving is to get to dracocephalum heterophyllum particle electuary.
Embodiment 5
A kind of particle electuary of dracocephalum heterophyllum liver protecting, includes the raw material of following parts by weight：5 parts of dracocephalum heterophyllum, chrysanthemum
7 parts of 7 parts of powder, 10 parts of dextrin, 1.8 parts of carboxymethyl cellulose and sucrose.
Preparation method includes the following steps：
(1) 5 kilograms of dracocephalum heterophyllums are weighed and crush sample, are soaked with 100 kilograms, the edible ethanol solution that volumetric concentration is 95%
Bubble 15 hours, the heating and refluxing extraction 1 time at a temperature of 45 DEG C are extracted 3 hours, and filtering takes filter liquor.
(2) it is 0.09MPa in vacuum degree by above-mentioned filter liquor, temperature is concentrated under reduced pressure into 3 times of proportion under the conditions of being 50 DEG C
Paste object.
(3) 7 kilograms of inulin, 10 kilograms of dextrin, 1.8 kilograms of carboxymethyl celluloses, 7 public affairs are added in above-mentioned paste object
Jin sucrose, softwood is made after mixing.
(4) above-mentioned softwood is dried into dry particl at 60 DEG C, whole grain, sieving is to get to dracocephalum heterophyllum particle electuary.
Embodiment 6
A kind of particle electuary of dracocephalum heterophyllum liver protecting, includes the raw material of following parts by weight：13 parts of dracocephalum heterophyllum, chrysanthemum
18 parts of 18 parts of powder, 28 parts of dextrin, 5 parts of carboxymethyl cellulose and sucrose.
Preparation method includes the following steps：
(1) 13 kilograms of dracocephalum heterophyllums are weighed and crush sample, with 208 kilograms, the edible ethanol solution that volumetric concentration is 96%
It impregnates 13 hours, the heating and refluxing extraction 2 times at a temperature of 75 DEG C, every time extraction 2 hours, filtering takes filter liquor.
(2) it is 0.07MPa in vacuum degree by above-mentioned filter liquor, temperature is concentrated under reduced pressure into 2 times of proportion under the conditions of being 61 DEG C
Paste object.
(3) 18 kilograms of inulin, 28 kilograms of dextrin, 5 kilograms of carboxymethyl celluloses, 18 public affairs are added in above-mentioned paste object
Jin sucrose, softwood is made after mixing.
(4) above-mentioned softwood is dried into dry particl at 61 DEG C, whole grain, sieving is to get to dracocephalum heterophyllum particle electuary.
Embodiment 7
A kind of particle electuary of dracocephalum heterophyllum liver protecting, includes the raw material of following parts by weight：17 parts of dracocephalum heterophyllum, chrysanthemum
32 parts of 22 parts of powder, 32 parts of dextrin, 7 parts of carboxymethyl cellulose and sucrose.
Preparation method includes the following steps：
(1) 17 kilograms of dracocephalum heterophyllums are weighed and crush sample, with 306 kilograms, the edible ethanol solution that volumetric concentration is 98%
It impregnates 14 hours, the heating and refluxing extraction 1 time at a temperature of 85 DEG C, extracts 4 hours, filtering takes filter liquor.
(2) it is 0.08MPa in vacuum degree by above-mentioned filter liquor, temperature is concentrated under reduced pressure into 3 times of proportion under the conditions of being 64 DEG C
Paste object.
(3) 22 kilograms of inulin, 32 kilograms of dextrin, 7 kilograms of carboxymethyl celluloses, 32 public affairs are added in above-mentioned paste object
Jin sucrose, softwood is made after mixing.
(4) above-mentioned softwood is dried into dry particl at 64 DEG C, whole grain, sieving is to get to dracocephalum heterophyllum particle electuary.
As shown in Figure 1, causing Liver immunity system to cause liver to the reaction of liver itself excessive immune using canavaline enzyme
Dirty tissue damage carrys out necrosis of liver cells pathology caused by Autoimmune Disorders caused by virus in simulated virus hepatitis.In the disease
It manages in model, induces hepatitis group and dracocephalum heterophyllum particle electuary group albino to test by detecting concanavalin A (Con A)
The variation of room mouse (balb/c mouse) transaminase values index judges the drug effect of the particle electuary, finds the punching of dracocephalum heterophyllum particle
Agent can significantly treat hepatic injury caused by body itself property immune response.
With " * " number indicate the level of signifiance of difference, i.e., " * " is indicated variant, but not significantly (P<0.1), " * * "
Indicate significant difference (P<0.05), " * * * " indicates difference extremely significantly (P<0.01).Blank group and the treatment of dracocephalum heterophyllum particle electuary
Between group there is extremely significant difference (P in glutamic-pyruvic transaminase (ALT) and the horizontal of glutamic-oxalacetic transaminease (AST)<0.01).Wherein, empty
White group is not added plus dracocephalum heterophyllum particle electuary.
The autoimmune liver injury model that Con A inductions are established in experiment, by comparing administration 16 hours, 24 hours
Afterwards in comparative example mouse and dracocephalum heterophyllum grains electuary group mice serum ALT and AST level, evaluate ethanol extract pair
The therapeutic effect of autoimmunity Liver Injury in Mice.As a result, it has been found that the mouse blood of blank group and dracocephalum heterophyllum particle electuary treatment group
In clear there is extremely significant difference (P at 16 hours and 24 hours in the level of ALT and AST<0.01), i.e.,：Dracocephalum heterophyllum
The ALT and AST that the horizontal pole ALT and AST of grain Chongji for Treatment group is significantly lower than naive mice are horizontal, illustrate dracocephalum heterophyllum
Grain electuary hepatic injury caused by mouse Autoimmune Disorders has good therapeutic effect.
As shown in Fig. 2, by giving balb/c mouse joint injection poly cytidines (Poly I in experiment：C) with D type galactolipins
Oxyhepatitis occurs for ammonia (D-GalN), inducing mouse.By comparing blank group and dracocephalum heterophyllum particle electuary treatment group mouse blood
The level of ALT judges drug effect of the ethanol extract to oxyhepatitis in clear, finds the ALT of dracocephalum heterophyllum particle electuary group
The ALT that level is substantially less than naive mice is horizontal, illustrates that dracocephalum heterophyllum particle electuary has significant inhibition to make oxyhepatitis
With.
According to a kind of particle electuary of dracocephalum heterophyllum liver protecting of the present invention, feed distribution is wide, is easy to batch and stocks up.This
Invention solvent for use is ethyl alcohol, cheap, and can be used with regeneration cycle, and safe noresidue is easy to scale.Work of the present invention
Skill is simple, repeatability preferably, obtained particle electuary stable quality, can long-term preservation, directly eat, it is easy to carry.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiments or example.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changes, replacing and modification.
Claims (10)
1. a kind of dracocephalum heterophyllum particle electuary, which is characterized in that include the raw material of following parts by weight：Dracocephalum heterophyllum 5 parts~25
Part, 10 parts~30 parts of inulin, 15 parts~45 parts of dextrin, 1 part~10 parts of carboxymethyl cellulose and 5 parts~35 parts of sucrose.
2. dracocephalum heterophyllum particle electuary according to claim 1, which is characterized in that include the raw material of following parts by weight：
10 parts~20 parts of dracocephalum heterophyllum, 15 parts~25 parts of inulin, 25 parts~35 parts of dextrin, 3 parts~8 parts of carboxymethyl cellulose and sucrose 15
Part~25 parts.
3. dracocephalum heterophyllum particle electuary according to claim 1, which is characterized in that include the raw material of following parts by weight：
5 parts of 5 parts of dracocephalum heterophyllum, 10 parts of inulin, 15 parts of dextrin, 1 part of carboxymethyl cellulose and sucrose.
4. dracocephalum heterophyllum particle electuary according to claim 1, which is characterized in that include the raw material of following parts by weight：
7 parts of 5 parts of dracocephalum heterophyllum, 6 parts of inulin, 9 parts of dextrin, 2 parts of carboxymethyl cellulose and sucrose.
5. dracocephalum heterophyllum particle electuary according to claim 1, which is characterized in that include the raw material of following parts by weight：
7 parts of 5 parts of dracocephalum heterophyllum, 7 parts of inulin, 10 parts of dextrin, 1.8 parts of carboxymethyl cellulose and sucrose.
6. dracocephalum heterophyllum particle electuary according to claim 1 or 2, which is characterized in that include the original of following parts by weight
Material：18 parts of 13 parts of dracocephalum heterophyllum, 18 parts of inulin, 28 parts of dextrin, 5 parts of carboxymethyl cellulose and sucrose.
7. dracocephalum heterophyllum particle electuary according to claim 1 or 2, which is characterized in that include the original of following parts by weight
Material：32 parts of 17 parts of dracocephalum heterophyllum, 22 parts of inulin, 32 parts of dextrin, 7 parts of carboxymethyl cellulose and sucrose.
8. a kind of preparing the method such as claim 1-7 any one of them dracocephalum heterophyllum particle electuaries, which is characterized in that including
Following steps：
Extraction：After dracocephalum heterophyllum is crushed, with alcohol solution dipping, the alcohol solution dipping liquid is heated to reflux and is filtered,
Take filter liquor；
Concentration：The filter liquor is concentrated under reduced pressure, concentrate is taken；
Dispensing：Inulin, dextrin, carboxymethyl cellulose and sucrose are mixed into the concentrate, to obtain dracocephalum heterophyllum softwood；
Drying：The dracocephalum heterophyllum softwood is dried into particle, and the pellet through sieves are rushed to get to dracocephalum heterophyllum particle
Agent.
9. a kind of method preparing dracocephalum heterophyllum particle electuary according to claim 8, which is characterized in that in the extraction
In step, the volumetric concentration of the ethanol solution is 92%~98%, and the parts by weight of the ethanol solution are 8 parts~20 parts,
The time of the alcohol solution dipping is 10h~15h, and the temperature that is heated to reflux is 45 DEG C~85 DEG C, described when being heated to reflux
Between be 2h~4h.
10. a kind of method preparing dracocephalum heterophyllum particle electuary according to claim 8, which is characterized in that described dense
In contracting step, the temperature of the reduced pressure is 50 DEG C~65 DEG C；In the baking step, the drying temperature be 50 DEG C~
65℃。
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| CN109043030A (en) * | 2018-08-06 | 2018-12-21 | 中国科学院西北高原生物研究所 | A kind of health-care tea for fat-reducing liver-fortifying and preparation method thereof |
| CN114634536B (en) * | 2022-02-28 | 2023-04-21 | 中国科学院西北高原生物研究所 | Separation process and application of phenolic natural free radical scavenger in dracocephalum heterophyllum |
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