CN103610752A - Functional food with hypoglycemic effect and preparation method thereof - Google Patents
Functional food with hypoglycemic effect and preparation method thereof Download PDFInfo
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Abstract
The invention discloses functional food with the hypoglycemic effect and a preparation method thereof. The functional food with the hypoglycemic effect comprises gracilaria agar-agar, sodium alginate, an astragalus extract, a kudzuvine root extract and a mulberry leaf extract according to a certain proportion. The preparation method comprises the following steps: preparing the astragalus extract, the kudzuvine root extract and the mulberry leaf extract; uniformly mixing the gracilaria agar-agar, the sodium alginate, the astragalus extract, the kudzuvine root extract and the mulberry leaf extract in a certain ratio, sealing with capsules, and tabletting by a wet method or making into granules. The functional food disclosed by the invention is reasonable in formula, high in safety and capable of reducing blood glucose level, is used for the adjuvant therapy of diabetic patients and has the effect of improving diabetic complications.
Description
Technical field
The present invention relates to field of functional food, be specifically related to a kind of functional food with hypoglycemic activity, relate to a kind of preparation method with the functional food of hypoglycemic activity simultaneously.This functional food is applicable to diabetics and controls blood sugar level, can be used for the auxiliary treatment of diabetics.
Background technology
Along with improving constantly of people quality of life, the variation of diet style and dietary structure, diabetes just little by little become a kind of commonly encountered diseases and frequently-occurring disease, have greatly affected people's life quality.According to International Diabetes Federation's statistics, existing 3.71 hundred million diabeticss in the whole world, Chinese adult diabetics, up to 1.14 hundred million, this means that diabetes mellitus in China patient number accounts for 1/3 of global diabetics sum.
Diabetes are the interactions due to inherited genetic factors and environmental factors, cause islet function to weaken or peripheral tissues's insulin resistant etc. and the saccharide, protein, fat and the metabolic disturbance of electrolyte syndrome that cause.It is main feature that the blood glucose of take clinically significantly raises, and follows " three-many-one-little " symptom, i.e. polydipsia, polyuria, polyphagia and lose weight.Relevant expert points out, the hazardness of diabetes is not only diabetes itself, is more a series of complication that caused by diabetes.
Present stage, mainly with injection of insulin, oral sulphanylureas, non-sulphanylureas Insulin secretagogues, biguanides, Alpha-glucosidase inhibitor or its analog and insulin increase secreted agent class medicine for the treatment of diabetes.Prolonged application can cause hepatic and renal function damage in various degree, and has the risk of bringing out hypoglycemia and increasing cardiovascular and cerebrovascular disease, glomerular sclerosis disease.World medical circle generally believes, diet control therapy is prevention and the preferred embodiments for the treatment of diabetes.For diabetes patient's diet control, require to take in that heat is low, albumen is moderate and be rich in the food of dietary fiber.Therefore, the object of a series of functional foods of developing for diabetic diet feature is, improves diabetic symptom, prevention and delaying complications of diabetes.
Dietary fiber is that a class is difficult for digested dietary nutrient, comprises cellulose, hemicellulose, pectin and lignin etc., is called as " the 7th nutrient ", is keeping playing the part of important role on digestive system normal function.Dietary fiber can be alleviated many toxic actions that cause due to metabolism syndrome, comprises and controls diabetes blood sugar level, reduces blood fat and prophylaxis of tumours etc., especially more obvious with the effect of water soluble dietary fiber.
Gracilaria verrucosa agar gel be a kind of by D-galactose and 3,6-L-Anhydrogalactose. by β-Isosorbide-5-Nitrae and α-1, the complex polysaccharide that 3 glycosidic bonds are alternately formed by connecting; Algin is that β-guluronic acid and β-mannuronic acid are formed by connecting in three kinds of modes by α-Isosorbide-5-Nitrae glycosidic bond, and has multiple bioactive polysaccharide soluble-salt.Compare other source dietary fibers, agar and Algin all contain more hydrophilic group, have better retentiveness, belong to diet fiber of high soluble.Gracilaria verrucosa agar gel forms spawn at gastrointestinal, makes people produce satiety, postpones chyme and enters duodenal process, and the speed that sugar is absorbed slows down, thereby reduces blood glucose; In addition, can adsorbing the carcinogenic and noxious substance in food and accelerate Cholesterol Excretion, alleviating the toxic action that many metabolism syndromes cause, is the ideal material of development functionality food.The Radix Astragali has the effects such as benefiting QI for strengthening the superficies, inducing diuresis to remove edema, and astragalus polysaccharides is the main component that the Radix Astragali plays a role.Astragalus polysaccharides can be used as immunopotentiating agent or regulator, has the effects such as antiviral, antitumor, defying age, anti-stress, antioxidation simultaneously.Many bibliographical informations, astragalus polysaccharides has reduction alloxan mouse blood sugar and reduces the damaging action of alloxan to beta Cell of islet.Radix Puerariae sweet in the mouth cool in nature is pungent, and having induces sweat brings down a fever, and promotes the production of body fluid, the function such as yang invigorating, and contained Radix Puerariae flavone has multiple efficacies.Bibliographical information, Radix Puerariae flavone has the effects such as the blood glucose of reduction, cholesterol.Folium Mori have the effects such as blood pressure lowering, blood fat, antiinflammatory, are rich in multiple flavone, alkaloid and polysaccharide.Bibliographical information, flavones in mulberry leaves and alkaloid have the effect that reduces alloxan and Streptozotocin-induced mice blood glucose.The Radix Astragali, Radix Puerariae, Folium Mori, as integration of edible and medicinal herbs class medical material, all have application in different functional foods, but have no gracilaria verrucosa agar gel, Algin and the Radix Astragali, Radix Puerariae and Folium Mori compatibility for the report of function of blood sugar reduction food.
Summary of the invention
The object of the present invention is to provide a kind of functional food with hypoglycemic activity, its cost is lower, and compound recipe is reasonable, and blood sugar decreasing effect is obvious.
Another object of the present invention is to provide a kind of preparation method with the functional food of hypoglycemic activity.Its raw material source is abundant, and preparation technology is convenient, practical and can realize green production, free from environmental pollution.
To achieve these goals, the present invention adopts following technical scheme:
A functional food with hypoglycemic activity, formulated by 0～70wt% gracilaria verrucosa agar gel, 0～50wt% Algin, 5～40wt% Radix Astragali extract, 6～35wt% Radix Puerariae extract and 7～45wt% Folium Mori extract.
Described functional food is capsule, tablet or granule.
A preparation method with the functional food of hypoglycemic activity, comprises the following steps:
The preparation of A, the Radix Astragali, Radix Puerariae, Folium Mori extract
A. the Radix Astragali was pulverized to 30～60 mesh sieves, and usingd pure water as extracting solvent, 50～100 ℃ are extracted 1～5h, and 1～4 time, extracting solution merges filtration; Extracting solution is concentrated, first pre-freeze again lyophilization or extracting solution concentrated after spraying dry, obtain Radix Astragali extract;
B. Radix Puerariae was pulverized to 30～60 mesh sieves, the ethanol water that the concentration expressed in percentage by volume of usining is 30～70% is as extracting solvent, 50～95 ℃ of heating in water bath reflux, extract, 1～4h, and 1～4 time, extracting solution merges and filters; Extracting solution is concentrated, the lyophilization again of first pre-freeze, after extracting solution is concentrated, spraying is dried, and obtains Radix Puerariae extract;
C. Folium Mori remove impurity, the ethanol water that the concentration expressed in percentage by volume of usining is 30～70% is as extracting solvent, 50～95 ℃ of heating in water bath reflux, extract, 1～3h, 2～5 times, extracting solution merges and filters; Extracting solution is concentrated, first pre-freeze again lyophilization or extracting solution concentrated after spraying dry, obtain Folium Mori extract;
B, preparation
Gracilaria verrucosa agar gel, Algin and above-mentioned Radix Astragali extract, Radix Puerariae extract, Folium Mori extract is even according to following percentage mix, obtain having the functional food of hypoglycemic activity:
In above-mentioned steps B, adopt the preparation method of conventional capsule, by above-mentioned functions food take compacting method be sealed in the capsule that gelatin is material, make capsule.
In above-mentioned steps B, adopt wet granule compression tablet technique, by above-mentioned functions food, after wet granulation, single punch tablet machine tabletting, makes tablet.
In above-mentioned steps B, adopt wet granulation technology, above-mentioned functions food is operated to granulation agent through wet granular preparation, dry, granulate with stage unit.
In a substep of above-mentioned steps A, extracting solution merges after filtration, and extracting solution is concentrated, extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Radix Astragali extract.
In the b substep of above-mentioned steps A, extracting solution merges after filtration, and extracting solution is concentrated, extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Radix Puerariae extract.
In the c substep of above-mentioned steps A, extracting solution merges after filtration, and extracting solution is concentrated, extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Folium Mori extract.
Adopt such scheme, in the functional food with hypoglycemic activity of the present invention:
Gracilaria verrucosa agar gel and Algin can reduce blood sugar level effectively, and play the effect that improves carbohydrate tolerance.Gracilaria verrucosa agar gel and Algin all belong to highly-water-soluble dietary fiber, and gracilaria verrucosa agar gel can form the gel of suitable intensity in gastrointestinal, Algin can increase the viscosity of chyme, thereby extended the holdup time of food in gastrointestinal tract, reduce small intestinal glucose diffusion velocity, delay sugared absorption process.Secondly, highly-water-soluble dietary fiber can increase the sensitivity of peripheral tissues to insulin, effectively reduces post-prandial glycemia concentration and maintain blood sugar level stable.In addition, the food gel that gracilaria verrucosa agar gel and Algin form, can effectively reduce body for the absorption of lipid, reduces level of lipid.
Astragalus polysaccharides in Radix Astragali extract can improve the peroxidating stress state of intracellular plastochondria and endoplasmic reticulum generation, suppresses the apoptosis of peroxidating stress effect induction; Radix Puerariae flavone in astragalus polysaccharides and Radix Puerariae extract can also be removed the free radical in body effectively; reduce the content of malonaldehyde; increase the activity of superoxide dismutase; improve body total antioxidant capacity, significant to the protection of diabetics beta Cell of islet and reduction blood sugar level etc.
Puerarin in Radix Puerariae extract has the function of protection diabetics heart, kidney.Puerarin can effectively reduce the expression of tumor necrosis factor (TNF-α), thereby obviously improves the cardiac function of diabetics.Diabetic nephropathy is that diabetics is often disease accompanied, and its main feature is the expansion of glomerular mesangium district, and cellular matrix gathers, glomerular sclerosis.Experimentation proves, surperficial transferinggrowthingfactorβ (TGF-β) plays an important role in the pathogenic process of diabetes, and its level raises can cause glomerular sclerosis, thereby occurs together diabetic nephropathy.Puerarin can reduce TGF-β level, suppresses glomerular sclerosis, plays the effect of diabetes and nephropathy preventing.In addition, puerarin can also improve the clinical symptoms of diabetics " three-many-one-little ".
In sum, functional food of the present invention is comprised of gracilaria verrucosa agar gel, Algin and the integration of edible and medicinal herbs Chinese medicine extract of solubility, and edible safety is high.Gracilaria verrucosa agar gel and Algin soluble dietary fibre content are high, can form suitable intensity gel, and effectively the intestines and stomach coordinating environment, improves intestinal microbial population; Slow down the absorption of saccharide; The metabolism of absorbing fats, acceleration cholesterol.Astragalus polysaccharides can obviously reduce cellular oxidation stress state, removes free radical, stops superoxide ion for the damage of beta Cell of islet, thereby makes beta Cell of islet obtain repairing and regeneration.Flavones in mulberry leaves in Radix Puerariae flavone and Folium Mori extract, alkaloid component can effectively be controlled blood sugar level, effectively improve diabetics glucose homeostasis, diabetes-alleviating complication, reduce gradually diabetics for the dependency of sulphanylureas, biguanides, trypsin class medicine, play the effect of adjuvant therapy of diabetes.
Functional food of the present invention can obviously improve diabetes hyperglycemia state, maintains body glucose homeostasis, can be used for the auxiliary treatment of diabetics; The infringement to body of Lipid peroxidation that lipid metabolic disorder causes can be effectively alleviated simultaneously, the complication of diabetics can be obviously improved.
The specific embodiment
Listed embodiment describes content of the present invention below, and embodiment is only for the use that the present invention is further illustrated.
Embodiment 1:
A functional food with hypoglycemic activity, is comprised of following raw material:
| Form | Gracilaria verrucosa agar gel | Algin | Radix Astragali extract | Radix Puerariae extract | Folium Mori extract |
| wt% | 20 | 5 | 30 | 20 | 25 |
Embodiment 2:
A functional food with hypoglycemic activity, is comprised of following raw material:
| Form | Gracilaria verrucosa agar gel | Algin | Radix Astragali extract | Radix Puerariae extract | Folium Mori extract |
| wt% | 42 | 17 | 18 | 10 | 13 |
Embodiment 3:
A functional food with hypoglycemic activity, is comprised of following raw material:
| Form | Gracilaria verrucosa agar gel | Algin | Radix Astragali extract | Radix Puerariae extract | Folium Mori extract |
| wt% | 70 | 0 | 6 | 17 | 7 |
Embodiment 4:
A functional food with hypoglycemic activity, is comprised of following raw material:
| Form | Gracilaria verrucosa agar gel | Algin | Radix Astragali extract | Radix Puerariae extract | Folium Mori extract |
| wt% | 0 | 25 | 40 | 21 | 14 |
A kind of preparation method with the functional food of hypoglycemic activity of the embodiment of the present invention 1～4, realizes as follows:
The preparation of A, the Radix Astragali, Radix Puerariae, Folium Mori extract
A. the Radix Astragali was pulverized to 30～60 mesh sieves, and usingd pure water as extracting solvent, 50～100 ℃ are extracted 1～5h, and 1～4 time, extracting solution merges filtration.
Extracting solution concentrates, the lyophilization again of first pre-freeze, or the concentrated rear spraying of extracting solution is dry, obtains Radix Astragali extract.Specific practice is: extracting solution is concentrated, and extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Radix Astragali extract.
B. Radix Puerariae was pulverized to 30～60 mesh sieves, usingd 30～70% (v/v) ethanol water as extracting solvent, 50～95 ℃ of heating in water bath reflux, extract, 1～4h, 1～4 time, extracting solution merges filtration.
Extracting solution concentrates, the lyophilization again of first pre-freeze, or the concentrated rear spraying of extracting solution is dry, obtains Radix Puerariae extract; Specific practice is: extracting solution is concentrated, and extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Radix Puerariae extract.
C. Folium Mori remove impurity, usings 30～70% (v/v) ethanol water as extracting solvent, 50～95 ℃ of heating in water bath reflux, extract, 1～3h, and 2～5 times, extracting solution merges filtration.
Extracting solution concentrates, the lyophilization again of first pre-freeze, or the concentrated rear spraying of extracting solution is dry, obtains Folium Mori extract; Specific practice is: extracting solution is concentrated, and extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Folium Mori extract.
B, preparation
Gracilaria verrucosa agar gel, Algin and above-mentioned Radix Astragali extract, above-mentioned Radix Puerariae extract, above-mentioned Folium Mori extract is even according to the percentage mix of embodiment 1～4, obtain having the functional food of hypoglycemic activity.Adopt the preparation method of conventional capsule, by above-mentioned functions food take compacting method be sealed in the capsule that gelatin is material, make capsule; Or adopt wet granule compression tablet technique, by above-mentioned functions food, after wet granulation, single punch tablet machine tabletting, makes tablet; Or employing wet granulation technology, above-mentioned functions food is operated to granulation agent with stage unit through wet granular preparation, dry, granulate.
Animal functional experiment
1. material
1.1. animal SPF mice, male, 22 ± 2g.
1.2. medicine and reagent
For experiment sample, adopt embodiment 2 formulas; Alloxan (Alloxan Monohydrate): 10g/ Ping， U.S. Sigma company, lot number GA-21765; Positive drug: metformin hydrochloride, 0.5g/ Pian， Sino-U.S. Shanghai Shi Guibao pharmaceutical Co. Ltd, lot number H20023371; Glucose assays test kit (glucoseoxidase-hydrogen peroxide enzyme process), HDL-C test kit, low-density lipoprotein cholesterol test kit, T-CHOL test kit, Triglyceride Reagent box, the safe clinical reagent of Beijing Northization company limited.
1.3. instrument
Electronic balance: TE313S-DS, German Sai Duoli scientific instrument company limited; Ultra-violet and visible spectrophotometer, UV-1800, Chinese Shanghai Mei Nuoda Instrument Ltd.; Centrifuge, L-550, Hunan Xiang Yi centrifuge company limited.
2. method
2.1. mice is divided into 5 groups after alloxan modeling, and 10 every group, be respectively high dose group, middle dosage group, low dose group, model control group, positive controls, separately establish blank group.
2.2. respectively organize mice processing method
The high, medium and low dosage group of table 1 mouse stomach dosage (mg/kg)
| ? | Radix Puerariae extract | Radix Astragali extract | Folium Mori extract | Gracilaria verrucosa agar gel | Algin |
| High dose group | 100 | 186.6 | 140 | 400 | 240 |
| Middle dosage group | 50 | 93.3 | 70 | 200 | 120 |
| Low dose group | 25 | 46.6 | 35 | 100 | 60 |
High, medium and low dosage group mice is according to table 1 dosage gavage, the dosage normal saline such as model control group and blank group gavage, the metformin hydrochloride suspension of positive controls gavage 200mg/kg.Every day, gavage was 1 time, continuous 30d, and fasting 12h after last administration, detects corresponding index.
3. result
3.1. the impact of embodiment 2 on Mouse Weight and fasting glucose (FBG)
The impact of table 2 embodiment 2 on Mouse Weight and fasting glucose (FBG)
Note:
*compare significant difference (P < 0.05) with model group;
*compare with model group, difference is (P < 0.01) extremely significantly, and △ compares with Normal group, and difference is (P < 0.01) extremely significantly, lower same.
Table 2 result shows that embodiment 2 formulas have the effect of the hyperglycemia of reduction mouse blood sugar, improve the symptom of losing weight that diabetic mice causes because of carbohydrate metabolism disturbance.
3.2. the impact of embodiment 2 on mice oral glucose tolerance (OGTT)
The impact of table 3 embodiment 2 on mice oral glucose tolerance (OGTT)
| Group | Quantity | AUC |
| High dose group | 10 | 57.07±9.60 |
| Middle dosage group | 10 | 52.45±8.92 * |
| Low dose group | 10 | 60.92±5.38 |
| Positive controls | 10 | 42.03±10.04 ** |
| Model control group | 10 | 61.02±6.83 |
| Blank group | 10 | 20.16±1.73 |
Table 3 presentation of results, can effectively the slow down absorption rate of glucose of embodiment 2 formula, alleviates islets of langerhans burden, thereby improves diabetic mice impaired glucose tolerance, and maintain glucose homeostasis.
3.3. the impact of embodiment 2 on lipid of mice
The impact of table 4 embodiment 2 on lipid of mice
| Group | Quantity | TC(mmol/L) | HDL-C(mmol/L) | LDL-C(mmol/L) | TG(mmol/L) |
| High dose group | 10 | 5.74±0.58 | 2.56±0.24 ** | 2.71±0.34 * | 1.39±0.31 * |
| Middle dosage group | 10 | 6.01±0.67 | 2.51±0.36 * | 3.02±0.36 | 1.43±0.28 * |
| Low dose group | 10 | 6.20±0.91 | 2.24±0.44 | 3.10±0.59 | 1.62±0.45 |
| Positive controls | 10 | 5.59±0.44 * | 2.53±0.33 * | 2.80±0.52 | 1.22±0.27 ** |
| Model control group | 10 | 6.31±0.63 | 2.21±0.18 | 3.21±0.42 | 1.64±0.34 |
| Blank group | 10 | 5.06±0.53 ** | 2.65±0.14 ** | 2.56±0.40 ** | 1.03±0.39 ** |
The demonstration of table 4 result, embodiment 2 formulas can effectively reduce the blood lipid level of hyperglycemia diabetic mice, reduce the level of lipid of body.
4. conclusion
Alloxan induced hyperglycemia mice continuous (every day) is given after the 30d of the present invention of various dose, functional food of the present invention can effectively reduce the fasting blood glucose level of mice, improve carbohydrate tolerance, and the fasting blood glucose level of normal mouse and carbohydrate tolerance are had no significant effect.
Criterion judgement according to the check of Ministry of Public Health < < health food with assessment technique standard (2003 editions) > >, functional food of the present invention has the effect that reduces blood glucose and improve diabetic complication.
Claims (9)
1. a functional food with hypoglycemic activity, is characterized in that: formulated by 0～70wt% gracilaria verrucosa agar gel, 0～50wt% Algin, 5～40wt% Radix Astragali extract, 6～35wt% Radix Puerariae extract and 7～45wt% Folium Mori extract.
2. a kind of functional food with hypoglycemic activity according to claim 1, is characterized in that: described functional food is capsule, tablet or granule.
3. a preparation method with the functional food of hypoglycemic activity, is characterized in that: comprise the following steps:
The preparation of A, the Radix Astragali, Radix Puerariae, Folium Mori extract
A. the Radix Astragali was pulverized to 30～60 mesh sieves, and usingd pure water as extracting solvent, 50～100 ℃ are extracted 1～5h, and 1～4 time, extracting solution merges filtration; Extracting solution is concentrated, first pre-freeze again lyophilization or extracting solution concentrated after spraying dry, obtain Radix Astragali extract;
B. Radix Puerariae was pulverized to 30～60 mesh sieves, the ethanol water that the concentration expressed in percentage by volume of usining is 30～70% is as extracting solvent, 50～95 ℃ of heating in water bath reflux, extract, 1～4h, and 1～4 time, extracting solution merges and filters; Extracting solution is concentrated, first pre-freeze again lyophilization or extracting solution concentrated after spraying dry, obtain Radix Puerariae extract;
C. Folium Mori remove impurity, the ethanol water that the concentration expressed in percentage by volume of usining is 30～70% is as extracting solvent, 50～95 ℃ of heating in water bath reflux, extract, 1～3h, 2～5 times, extracting solution merges and filters; Extracting solution is concentrated, first pre-freeze again lyophilization or extracting solution concentrated after spraying dry, obtain Folium Mori extract;
B, preparation
Gracilaria verrucosa agar gel, Algin and above-mentioned Radix Astragali extract, Radix Puerariae extract, Folium Mori extract is even according to following percentage mix, obtain having the functional food of hypoglycemic activity:
4. a kind of preparation method with the functional food of hypoglycemic activity according to claim 3, it is characterized in that: in above-mentioned steps B, adopt the preparation method of conventional capsule, by above-mentioned functions food take compacting method be sealed in the capsule that gelatin is material, make capsule.
5. a kind of preparation method with the functional food of hypoglycemic activity according to claim 3, it is characterized in that: in above-mentioned steps B, adopt wet granule compression tablet technique, by above-mentioned functions food after wet granulation, single punch tablet machine tabletting, makes tablet.
6. a kind of preparation method with the functional food of hypoglycemic activity according to claim 3, it is characterized in that: in above-mentioned steps B, adopt wet granulation technology, above-mentioned functions food is operated to granulation agent through wet granular preparation, dry, granulate with stage unit.
7. a kind of preparation method with the functional food of hypoglycemic activity according to claim 3, it is characterized in that: in a substep of above-mentioned steps A, extracting solution merges after filtration, and extracting solution is concentrated, extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Radix Astragali extract.
8. a kind of preparation method with the functional food of hypoglycemic activity according to claim 3, it is characterized in that: in the b substep of above-mentioned steps A, extracting solution merges after filtration, and extracting solution is concentrated, extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Radix Puerariae extract.
9. a kind of preparation method with the functional food of hypoglycemic activity according to claim 3, it is characterized in that: in the c substep of above-mentioned steps A, extracting solution merges after filtration, and extracting solution is concentrated, extractum-20 ℃ pre-freeze 12～36h, lyophilization 12～72h; Or extracting solution is concentrated into relative density 1.02～1.25,120～190 ℃ of spray dryer inlet temperature, 60～85 ℃ of leaving air temps, spraying is dry, obtains Folium Mori extract.
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| CN105341950A (en) * | 2015-11-05 | 2016-02-24 | 江苏羚羊生物科技有限公司 | Oat dietary fibers capable of reducing blood sugar and preparation method of oat dietary fibers |
| CN106491965A (en) * | 2016-12-13 | 2017-03-15 | 四川天添生物科技应用有限公司 | Can repairing pancreas β cells secrete insulins function be applied to type ii diabetes patient natural plant composition |
| CN106605822A (en) * | 2016-12-19 | 2017-05-03 | 西安源森生物科技有限公司 | Composition facilitating reducing of blood sugar and preparation method of composition |
| CN107439946A (en) * | 2017-09-20 | 2017-12-08 | 南昌大学 | A kind of mulberry leaf noodles for reducing uric acid |
| CN109090604A (en) * | 2018-08-23 | 2018-12-28 | 辽宁兴海制药有限公司 | A kind of composition with auxiliary hyperglycemic function, health food and preparation method thereof |
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| CN104138418A (en) * | 2014-08-25 | 2014-11-12 | 济南康众医药科技开发有限公司 | Drying method for mulberry leaves |
| CN105341950A (en) * | 2015-11-05 | 2016-02-24 | 江苏羚羊生物科技有限公司 | Oat dietary fibers capable of reducing blood sugar and preparation method of oat dietary fibers |
| CN105341950B (en) * | 2015-11-05 | 2019-01-18 | 南京金陵红楼梦生物科技有限公司 | A kind of hypoglycemic Herba bromi japonici dietary fiber and preparation method thereof |
| CN106491965A (en) * | 2016-12-13 | 2017-03-15 | 四川天添生物科技应用有限公司 | Can repairing pancreas β cells secrete insulins function be applied to type ii diabetes patient natural plant composition |
| CN106605822A (en) * | 2016-12-19 | 2017-05-03 | 西安源森生物科技有限公司 | Composition facilitating reducing of blood sugar and preparation method of composition |
| CN107439946A (en) * | 2017-09-20 | 2017-12-08 | 南昌大学 | A kind of mulberry leaf noodles for reducing uric acid |
| CN109090604A (en) * | 2018-08-23 | 2018-12-28 | 辽宁兴海制药有限公司 | A kind of composition with auxiliary hyperglycemic function, health food and preparation method thereof |
| CN112205617A (en) * | 2019-07-11 | 2021-01-12 | 天赋能健康产业集团股份有限公司 | Diet suitable for people with diabetes and needing to control blood sugar |
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