TWM563272U - Skin repair film for minimally invasive skin with high biocompatibility micro scaffold - Google Patents

Abstract

The present invention relates to a skin repair film for minimally invasive skin containing a highly biocompatible microscaffold comprising a structural body and a plurality of highly biocompatible micro-stents, wherein the structural body is provided with a plurality of diffusion channels, and a plurality of diffusion passage outer through holes corresponding to the diffusion passages for circulating with the external environment; and the high biocompatibility micro-scaffold distribution is evenly disposed inside the structural body, and the high biocompatibility micro-stent includes A void space that can be used to accommodate a functional structure and communicate with the outside environment through a plurality of micro-bracket through-holes.

Description

Minimally invasive skin repair film containing high biocompatibility microscaffold

This creation is about a skin repair film for minimally invasive skin-containing microbiostains. In particular, the skin repair film of the present invention comprises a highly biocompatible micro-scaffold structure, which can be used for skin, dental, orthopedics, medical beauty, facial modification, orthopedic reconstruction and repair.

This creation refers to a skin repairing membrane for skin minimally invasive micro-stents with high biocompatibility, especially one that can be used in dermatology, dentistry, orthopedics, medical beauty, facial modification, orthopedic reconstruction, delayed degradation. Skin repair film. In clinical surgery, it is often necessary to repair tissue defects, but the limited source of autologous transplantation, while allogeneic and xenotransplantation have a high risk of infection. Therefore, more and more different organic, inorganic, and metallic materials are used in tissue engineering today. In addition, in order to avoid secondary surgery, it is necessary to use biodegradable materials. The different materials currently used have their advantages and disadvantages. In order to solve different medical problems, the development of new functional composite materials is still one of the research priorities. Tissue engineering is an interdisciplinary field that connects engineering and biology. Tissue engineering develops biological substrates that can repair, restore or improve the function of tissues. Among them, tissue engineering involves three main strategies: using in vitro cells or cell substitutes to replace limited tissue functions; inducing tissue production, such as the utilization of growth factors; developing biological scaffolds for tissue repair With regeneration. Therefore, the key factor in the development of scaffolds is the growth environment designed by mimicking the physical and biological functions of extracellular matrix (ECM), which is an important development technique in cell culture media. In minimally invasive surgery, different forms of defects are differently repaired, and it is necessary to develop different functional stents for clinical application. In view of this, the applicant has been engaged in biomedical engineering and materials for many years of experience, through continuous research and experimentation, and has developed a medical device and biomedical materials for reconstruction and repair of highly biocompatible micro-scaffold structures. Supplied for clinical use.

This creation provides a skin repair film. In particular, the present invention relates to medical devices and biomedical materials containing a highly biocompatible microscaffold structure, wherein the skin repair membrane for minimally invasive skin containing high biocompatibility microscaffolds comprises a structural body and a plurality of high biological phases. a capacitive micro-stent, wherein the structural body is provided with a plurality of diffusion channels, and a plurality of diffusion channel external through holes corresponding to the diffusion channels for circulating with the external environment; and the highly biocompatible micro-bracket is evenly distributed Inside the structural body, the highly biocompatible micro-bracket includes a void space for receiving the functional structure and communicating with the outer environment through a plurality of micro-bracket through holes.

Preferably, the highly biocompatible microscaffold is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, acellular dermal collagen, decellularized animal tissue collagen, and decellularized cartilage collagen. Protein, acellular small intestinal membrane collagen, acellular corneal collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, fish collagen peptide, porcine collagen peptide, bovine collagen Peptide, collagen polypeptide and combinations thereof Collagen structure. More preferably, the highly biocompatible microscaffold is obtained by hydrophilic vibration cutting animal tissue and supercritical carbon dioxide degreasing clean treatment.

Preferably, the main structure of the structure consists of a polymer selected from the group consisting of polyurethane, polyvinyl alcohol, collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin and combinations thereof. .

First embodiment

The first embodiment of the present invention for skin minimally invasive skin repair film containing a highly biocompatible microscaffold will be described with reference to Fig. 1. The present invention is applied to a skin minimally invasive skin repair membrane 1 containing a highly biocompatible microscaffold comprising a structural body 20 and a plurality of highly biocompatible micro-scaffolds 10, wherein the structural body is provided with a plurality of diffusion channels 21 And a plurality of diffusion channel outer through holes 25 corresponding to the diffusion channel 21 for circulating with the external environment; and the highly biocompatible micro-frame 10 is uniformly disposed inside the structure body 20, and the high biological phase The capacitive microcage 10 includes a void space 11 for receiving a functional structure and communicating with the outer environment through a plurality of micro-bracket through-holes 15. Preferably, the highly biocompatible microscaffold is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, acellular dermal collagen, decellularized animal tissue collagen, and decellularized cartilage collagen. Protein, acellular small intestinal membrane collagen, acellular corneal collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, fish collagen peptide, porcine collagen peptide, bovine collagen Collagen structure of peptide, collagen peptide and combinations thereof. Most preferably, the high biocompatibility The micro-scaffold is obtained by hydrophilic vibration cutting animal tissue and supercritical carbon dioxide degreasing clean treatment. Optionally, the main structure of the structure consists of a polymer selected from the group consisting of polyurethane, polyvinyl alcohol, collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharides, chitin and combinations thereof. composition. The clinical application diagram of the skin repairing membrane for minimally invasive skin containing high biocompatibility microscaffold is shown in Fig. 2. In clinical operation, the skin repair membrane 1 is adjacent to the lesion 1000, and the high biological phase The capacitive microscaffold 10 thus directly contacts the lesion 1000, and because of its high biocompatibility, it does not produce irritation, cytotoxicity and sensitization, and the void space 11 can be used to accommodate functional structures such as tissue healing tissue structures. Body or other secretory substances. Further, through the design of the artificial diffusion channel 21, the circulation of the cell structure or other secretory substances which can heal the tissue can be assisted and circulated in the skin repair film 1. Specifically, the skin repair film 1 uses the human body decomposable material. When the tissue heals, it can be absorbed by the body.

The above description is only a preferred embodiment of the present invention. When it is not possible to limit the scope of the creation of the present invention, the equivalent changes and modifications made by the applicant in accordance with the scope of the patent application and the contents of the new manual should remain This creative patent covers the scope. Looking at the above, the structural features of this creation do have practical value and progressiveness. In terms of its overall structure, Cheng has already complied with the statutory requirements of the Patent Law and has filed a new type of patent application according to law.

1‧‧‧Skin repair film

10‧‧‧High biocompatible micro scaffold

11‧‧‧ void space

15‧‧‧Micro-bracket through-hole

20‧‧‧Structural subject

21‧‧‧Diffuse channel

25‧‧‧Driving channel external through hole

1000‧‧‧ lesions

The first figure is a schematic diagram of the skin repairing membrane for the minimally invasive skin containing high biocompatibility microscaffold.

The second picture is the skin repair film for the skin minimally invasive micro-stent with high biocompatibility. A schematic diagram of the bed application.

Claims (4)

A skin repairing membrane for skin minimally invasive biocompatible microscaffold comprising a structural body and a plurality of highly biocompatible micro-scaffolds, wherein the structural body is provided with a plurality of diffusion channels, and corresponding diffusion channels a plurality of diffusion passage outer through holes for circulating with the external environment; and the high biocompatible micro-bracket is uniformly disposed inside the structural body, and the high biocompatibility micro-support comprises a void space, The void space can be used to accommodate the functional structure and communicate with the outside environment through a plurality of micro-bracket through holes. The skin repairing film according to claim 1, wherein the highly biocompatible microscaffold is selected from the group consisting of porous collagen, coated collagen, artificial biomimetic reticular collagen, and acellular dermal collagen. , acellular animal tissue collagen, acellular cartilage collagen, acellular small intestinal membrane collagen, acellular corneal collagen, fish collagen, porcine collagen, bovine collagen, collagen polypeptide, type II collagen, The collagen structure of fish collagen peptide, porcine collagen peptide, bovine collagen peptide, collagen peptide and their combination. The skin repair film according to claim 2, wherein the high biocompatibility microscaffold is obtained by hydrophilic vibration cutting animal tissue and supercritical carbon dioxide degreasing clean treatment. The skin repairing film according to claim 1, wherein the main structure of the structure is selected from the group consisting of polyurethane, polyvinyl alcohol, collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide. The composition of the body, chitin and its combination of polymers.