TWM567616U - High biocompatible microscaffold-containing composite regenerative filling caplet structure used in orthopedic or dental minimal invasiveness - Google Patents

Abstract

The present invention discloses a composite regeneration-filled ingot-like structure for minimally invasive biocompatible micro-scaffolds comprising a filling ingot-like structure body; and a plurality of discretely disposed in the body of the filling ingot-shaped structure a microporous sphere, a plurality of highly biocompatible microscaffolds and a plurality of non-directional microchannels; wherein the microporous spheres comprise a plurality of microporous spherical pores; and the non-directional microchannels connect the microporous spheres and the high organism a compatible micro-scaffold and communicating with an external environment, the non-directional microchannel, the micro-porous sphere and the highly biocompatible micro-framelet being connected to each other through the non-directional microchannel to form inside the filling ingot-shaped structure body An accommodating space is provided for accommodating a plurality of functional structures in the accommodating space.

Description

For the minimally invasive bioreactive microscaffold of bone dental implants to fill the ingot structure

The present invention relates to a composite regeneration filling ingot-like structure for minimally invasive micro-invasive bioscaffolds with high biocompatibility. In particular, the composite regenerative filling ingot structure comprises a multi-layer growth promoting functional layer micro-cavity structure, which can be used for dental, orthopedics, medical beauty facial modification, orthopedic reconstruction, delayed degradation, composite regeneration filling. Ingot structure.

This creation refers to a composite regeneration-filled ingot-like structure for minimally invasive micro-invasive micro-stents, especially for orthopedics, orthopedics, medical beauty and facial modification. The composite regeneration that delays degradation fills the ingot structure. In orthopedic surgery, it is often necessary to repair bone defects, but the limited source of autologous transplantation, while allogeneic and xenotransplantation have a high risk of infection. Therefore, more and more different organic, inorganic and metallic materials are used in bone tissue engineering today. In addition, in order to avoid secondary surgery, it is necessary to use biodegradable materials. The different materials currently used have their advantages and disadvantages. In order to solve different medical problems, the development of new functional composite materials is still one of the research priorities. Tissue engineering is an interdisciplinary field that connects engineering and biology. Tissue engineering develops biological substrates that can repair, restore or improve tissue Features. Among them, tissue engineering involves three main strategies: the use of in vitro cells or cell substitutes to replace limited tissue functions; the induction of tissue production, such as the utilization of growth factors; the development of biological scaffolds for tissue repair and regeneration. Therefore, the key factor in the development of scaffolds is the growth environment designed by mimicking the physical and biological functions of extracellular matrix (ECM), which is an important development technique in cell culture media. In the application of orthopedic surgery, different forms of defects are differently repaired, and it is necessary to develop different functional stents for surgical use. On the other hand, in the past, when the teeth of the patient were unable to maintain the original function due to external force fracture, tooth decay, periodontal disease or lesions around the root tip, the tooth was removed and the fibrous wound area caused by the tooth extraction was made of sterile fiber gauze. Stop bleeding and repair wounds. However, the disadvantage of using fiber gauze is that it can only stop bleeding, is not absorbed by the patient, and easily bury the food residue, so it is easy to cause wound infection, and the wound needs a longer repair time. In recent years, collagen tooth filling products have emerged. These collagen tooth filling materials are composed only of collagen, which can be completely absorbed by the organism and have a stereoscopic porous structure, which can provide support and cell growth space and absorb blood. Although such products are also helpful for alveolar bone regeneration, such products are completely absorbed by the patient within two weeks or even less after implantation in the affected area of the alveolar defect. However, in such a short period of time, the bone cells in the patient's alveolar can not grow enough bone tissue, so that the new alveolar bone can not return to the original intact state, and because there is no need for support around the new alveolar bone tissue. Teeth, so these tissues will be absorbed by the patient's body over time, the so-called alveolar bone atrophy, so that the height or width of the alveolar bone is more insufficient, which may cause the normal teeth around the missing teeth to be skewed. Adequate orbital bone in the defect area after tooth extraction, in addition to affecting the normal tooth stability of the missing tooth, is now the key to the success of artificial implant surgery. Since the artificial implants need to be fixed by sufficient alveolar bone, the regeneration of the alveolar bone becomes a necessary measure before the artificial dental implant surgery. Traditional technology Art also has products that are cross-linked, but there is a risk of cross-linking agent residue on such products. Therefore, there is an urgent need for a biodegradable filling for the repair of alveolar bone, which allows bone cells to adhere and grow when implanted in a hole in a patient's missing tooth, and the rate of filling degradation is close to that in the alveolar bone. The rate of cell growth, thus allowing the new alveolar bone to approach the original intact state, reducing atrophy of the alveolar bone while avoiding skewing of the surrounding normal teeth. In view of this, the applicant has been engaged in biomedical engineering and materials for many years of experience. Through continuous research and experimentation, he has developed a composite regeneration filling ingot structure for minimally invasive micro-invasive bioscaffolds with high biocompatibility. Body and its materials, pray for supply for clinical use.

The present invention provides a composite regeneration filled ingot structure for reconstruction and repair. In particular, the present invention relates to a composite regenerative filled ingot structure for minimally invasive microbiocide containing microbioscaffolds, wherein the composite regenerative filled ingot structure comprises a body that fills the ingot structure; And a plurality of micro-biospheres on the body of the ingot-shaped structure, a plurality of highly biocompatible micro-frames and a plurality of non-directional microchannels; wherein the micro-pore ball comprises a plurality of micro-pore ball holes; and the non-directional micro-hole Channels are connected in series with the microporous sphere and the high biocompatible micro-frame and fixed in the body of the filling ingot structure, and communicate with the external environment through a plurality of non-directional microchannel outer through holes, the non-directional microchannel, The microporous ball and the highly biocompatible micro-stent are connected to each other through the non-directional microchannel to form an accommodating space inside the filling ingot structure body, and the accommodating space can be used for accommodating a plurality of functions. Structure. That is, the present invention relates to a composite regeneration filling ingot structure for a minimally invasive microbiocide containing a highly biocompatible microscaffold, wherein the composite regenerative filling ingot structure comprises a plurality of microporous spheres; a biocompatible microscaffold; and a non-directional microchannel, wherein the non-directional microchannel is used to concatenate the microporous sphere and the highly biocompatible microscaffold, and to make the micropore sphere compatible with the biocompatibility The micro-stent mixing and the non-directional micro-channel together form a filling ingot-shaped structure body, wherein the filling ingot-shaped structure body comprises a top surface, a bottom surface and a bottom surface and a bottom surface, and is connected to the top surface and the bottom surface The circumference of the ring, and the inside is a solid entity.

Preferably, the microporous sphere is composed of a biomedical ceramic selected from the group consisting of calcium phosphate, calcium phosphate, dicalcium phosphate, tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, hydroxyapatite. One of the group of β-tricalcium phosphate, hydroxyapatite/β-tricalcium phosphate composite and combinations thereof.

Preferably, the hydroxyapatite has a particle size ranging from 0.075 to 0.150 mm; the β-tricalcium phosphate has a particle size ranging from 0.5 to 2.0 mm; and the hydroxyapatite/β-phosphate The particle size of the tricalcium composite is in the range of 0.5 to 1.0 mm.

Preferably, the main system for filling the ingot structure is selected from the group consisting of biodegradable polymers of collagen, collagen peptide, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactic acid ester and combinations thereof. .

Preferably, the highly biocompatible microscaffold is composed of an organism selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. It can be composed of decomposable polymers.

Preferably, the highly biocompatible microscaffold consists of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof.

More preferably, the highly biocompatible microscaffold is a collagen structure obtained by hydrolyzing animal dermis and supercritical carbon dioxide degreasing and enzymatic treatment.

1‧‧‧Composite regeneration to fill the ingot structure

10‧‧‧High biocompatible micro scaffold

20‧‧‧Micropore ball

25‧‧‧Microporous Ball Holes

30‧‧‧ Filling the main body of the ingot

35‧‧‧Non-directional microchannels

37‧‧‧Non-directional microchannel outer through hole

301‧‧‧ top surface

303‧‧‧ bottom

305‧‧‧ Around the circumference

1000‧‧‧ lesions

The first picture is a transparent schematic diagram of the composite regeneration filling ingot-shaped structure (A) for the minimally invasive micro-invasive micro-scaffold of the orthopedics, and (B) a schematic view of the incision section.

The second figure is a schematic diagram of the clinical application of the composite regenerative filling ingot structure for the minimally invasive micro-invasive micro-stent with bone biopsy.

First Embodiment - A composite regeneration filling ingot structure for minimally invasive microbiosynthesis containing microbiota

The present invention is described in detail with reference to Fig. 1 for a preferred embodiment of a composite regeneration-filled ingot-like structure 1 for minimally invasive hyperplastic invasive micro-stents. The present invention provides a composite regeneration-filled ingot-like structure 1 for reconstruction and repair, wherein the composite regeneration-filled ingot-shaped structure 1 comprises a plurality of micro-pore spheres 20; a plurality of highly biocompatible micro-scaffolds 10; a non-directional microchannel 35, wherein the non-directional microchannel is used to serially connect the micropore ball 20 and the high biocompatible micro-scaffold 10, and mix the micro-pore ball 20 with the high biocompatibility micro-scaffold 10 The non-directional microchannels 35 collectively form a filled ingot-like structure body 30, wherein the filling ingot-shaped structure body comprises a top surface 301, a bottom surface 303 and a top surface 301 A circumferential surface 305 connected to the bottom surface 303 and connected to the top surface 301 and the bottom surface 303, and the inside thereof is a solid body. . In particular, the present invention relates to a composite regenerated pad-shaped structure 1 derived from a highly biocompatible microscaffold 10, wherein the composite regenerated pad-shaped structure 1 comprises a filled ingot-like structure body 30; The plurality of microporous spheres 20 in the ingot-like structure body 30, the plurality of highly biocompatible micro-frames and the plurality of non-directional microchannels; wherein the micro-pore ball 20 has a plurality of micro-pore ball holes 25, the non-directional The microchannel 35 connects the micropore ball 20 and the high biocompatibility micro-stent 10, and communicates with the external environment through a plurality of non-directional microchannel outer through holes 37, the non-directional microchannel 35, the micropore ball 20 The accommodating space can be used to accommodate a plurality of functional structures in the accommodating space 30. body. Preferably, the microporous ball 20 is composed of a biomedical ceramic selected from the group consisting of calcium phosphate, calcium phosphate, dicalcium phosphate, tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, hydroxyapatite. One of the group of stone, β-tricalcium phosphate, hydroxyapatite/β-tricalcium phosphate composite and combinations thereof. Preferably, the hydroxyapatite has a particle size ranging from 0.075 to 0.150 mm; the β-tricalcium phosphate has a particle size ranging from 0.5 to 2.0 mm; and the hydroxyapatite/β-phosphate The particle size of the tricalcium composite is in the range of 0.5 to 1.0 mm. Preferably, the filling ingot-like structure body 30 is selected from the group consisting of collagen, collagen peptide, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. composition. Preferably, the highly biocompatible microscaffold 10 is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. Biodegradable polymer. Preferably, the highly biocompatible microscaffold consists of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof. More preferably, the highly biocompatible microscaffold is a collagen structure obtained by enzymatically treating the dermis of the animal and the supercritical carbon dioxide degreasing by hydrophilic vibration. body. The present invention is a clinical application diagram of a composite regeneration filling ingot-shaped structure 1 for minimally invasive micro-invasive micro-stents of bone dental implants. As shown in Fig. 2, the non-directional microchannel outer through-hole 37 can directly contact the lesion 1000. Connected, the highly biocompatible microscaffold 10 does not produce irritation, cytotoxicity and sensitization due to high biocompatibility, the non-directional microchannel 35, the micropore 20 and the highly biocompatible microscaffold The accommodating space formed inside the filling ingot-like structure body 30 through the non-directional microchannels 35 can be used to accommodate a functional structure such as a tissue healing cell structure or other secretory material.

The above description is only a preferred embodiment of the present invention. When it is not possible to limit the scope of the creation of the present invention, the equivalent changes and modifications made by the applicant in accordance with the scope of the patent application and the contents of the new manual should remain This creative patent covers the scope. Looking at the above, the structural features of this creation do have practical value and progressiveness. In terms of its overall structure, Cheng has already complied with the statutory requirements of the Patent Law and has filed a new type of patent application according to law.

Claims (7)

A composite regeneration filling ingot structure for minimally invasive biocompatible micro-scaffolds, wherein the composite regeneration filling ingot structure comprises a plurality of microporous spheres; and a plurality of high biocompatibility micro-scaffolds And concatenating the microporous sphere and one of the highly biocompatible micro-stent non-directional microchannels, and mixing the micro-pore sphere with the high biocompatibility micro-stent to form a filled ingot with the non-directional microchannel The body of the structural body, wherein the body of the filling ingot structure comprises a top surface, a bottom surface and a circumferential surface connected between the top surface and the bottom surface, and connected to the top surface and the bottom surface, and the interior thereof is a solid entity . The composite regenerated filling ingot structure according to claim 1, wherein the microporous sphere is composed of a biomedical ceramic selected from the group consisting of calcium phosphate, calcium phosphate, and dicalcium phosphate. One of the group consisting of tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, hydroxyapatite, β-tricalcium phosphate, hydroxyapatite/β-tricalcium phosphate composite and combinations thereof. The composite regenerated filling ingot structure according to claim 2, wherein the hydroxyapatite has a particle size ranging from 0.075 to 0.150 mm; and the β-tricalcium phosphate has a particle diameter of 0.5 To a range of 2.0 mm; and the particle size of the hydroxyapatite/β-tricalcium phosphate composite is in the range of 0.5 to 1.0 mm. The composite regeneration filling ingot structure according to claim 1, wherein the main system for filling the ingot structure is selected from the group consisting of collagen, collagen peptide, sodium alginate, cellulose, polysaccharide, and It is composed of a biodegradable polymer of chitin, polylactic acid, polylactic acid ester and combinations thereof. The composite regeneration filling ingot structure according to claim 1, wherein the high biocompatibility microscaffold is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, and polysaccharide. , a composition of biodegradable polymers of chitin, polylactic acid, polylactic acid ester and combinations thereof. The composite regenerative filling ingot structure according to claim 5, wherein the highly biocompatible microscaffold is composed of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof. composition. The composite regeneration filling ingot structure according to claim 6, wherein the high biocompatibility micro-scaffold is a collagen structure obtained by enzymatically treating animal dermis and supercritical carbon dioxide degreasing by hydrophilic vibration. .