TWM555211U - Bone/tooth tissue filling membrane net containing highly-biocompatible micro scaffold used in minimally invasive orthopedic and dental surgery - Google Patents
Bone/tooth tissue filling membrane net containing highly-biocompatible micro scaffold used in minimally invasive orthopedic and dental surgery Download PDFInfo
- Publication number
- TWM555211U TWM555211U TW106215388U TW106215388U TWM555211U TW M555211 U TWM555211 U TW M555211U TW 106215388 U TW106215388 U TW 106215388U TW 106215388 U TW106215388 U TW 106215388U TW M555211 U TWM555211 U TW M555211U
- Authority
- TW
- Taiwan
- Prior art keywords
- bone
- micro
- tooth tissue
- collagen
- tissue filling
- Prior art date
Links
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Description
本創作係有關於一種用於骨齒科微創含高生物相容性微支架之骨齒組織填補膜網。特別是本創作骨填補物包含有一種含高生物相容性微支架結構,可以用於齒科、骨科、醫美顏面整型修飾整形外科重建修復延緩降解之組織填補網膜。 This creative department relates to a bone-tooth tissue filling membrane network for minimally invasive micro-invasive micro-stents. In particular, the bone filling material of the present invention comprises a micro-bio-supporting micro-scaffold structure, which can be used for dental, orthopedics, medical beauty, face-to-face modification, orthopedic reconstruction, repair and degradation of tissue to fill the omentum.
本創作係指一種用於骨齒科微創含高生物相容性微支架之骨齒組織填補膜網,尤指一種可以用於齒科、骨科、醫美顏面整型修飾整形外科重建修復延緩降解之骨齒組織填補膜網。在骨科臨床手術中,常需對骨缺損進行修補,然而自體移植的有限來源,而異體與異種移植則具高傳染風險。因此,現今有越來越多不同的有機、無機、金屬材料應用於骨組織工程。此外為了避免二次手術,使用生物可降解材料有其必要性。目前所使用之不同材料皆有其優缺點,為了解決醫療上不同問題,開發新的功能性複合材料仍是研究重點之一。組織工程是連接工程和生物學的一個跨學科領域。組織工程發展生物基材,它可以修復,恢復或改善組織之功能。其中 組織工程涉及三個主要策略:利用體外細胞或細胞替代物,取代有限的組織功能;誘導組織生成,例如生長因子(growth factors)的利用;發展生物支架(scaffold)有利於組織修補與再生。因此,支架的發展關鍵因素是模仿細胞外基質(ECM)的物理和生物功能設計而成之生長環境,是在細胞培養基材重要發展技術。應用於骨外科手術中,不同形式的缺損以不同修補方式,開發不同功能性支架應用於外科臨床是必要的。另一方面,以往患者牙齒因外力斷裂、蛀牙、牙周病或牙根尖周圍病變等造成牙齒無法維持原有功用時,則拔除該牙齒並針對拔牙後所造成的空洞創傷區域,以無菌纖維紗布進行止血與修復傷口。不過,使用纖維紗布的缺點在於僅能止血、不被患者所吸收、容易包埋食物殘渣,故容易造成傷口感染,使傷口需更長的修復時間。近幾年來,出現膠原蛋白牙填補材產品,此類膠原蛋白牙填補材僅由膠原蛋白所組成,其可被生物體完全吸收而且具有立體多孔結構,可提供支撐與細胞生長空間與吸收血液。雖然此類產品對於齒槽骨再生也有幫助,但此類產品植入齒槽缺損患處後會於兩星期甚至更短的時間內完全被患者吸收。然而,在如此短暫的時間內,患者齒槽中的骨細胞無法生長出足夠的骨頭組織,致使新生的齒槽骨無法恢復至原始完整狀態,且因為新生的齒槽骨組織周圍已無需支持的牙齒,故這些組織會隨著時間而被患者體內自行吸收,即所謂的齒槽骨萎縮,如此則更加劇齒槽骨高度或寬度不足,可能造成缺損牙齒周圍的正常牙齒歪斜。拔牙後缺損區域的齒槽骨充足與否,除了影響缺損牙旁的正常牙齒穩定性外,現在也成為人工植牙手術成功與否的關鍵。由於人工植牙駐體需藉由充足的齒槽骨來固定,所以齒槽骨的再生即成為人工植牙手術前必要的措施。習知技藝中也有透 過交鏈的產品,但此類產品上有交鏈劑殘留的風險。因此,現在急需一種可供齒槽骨修復用之生物可分解性填補物,使其在植入患者缺損牙齒的孔洞時,可供骨細胞附著生長,且填補物降解速率接近齒槽中的骨細胞生長的速率,因此可讓新生的齒槽骨接近原始完整狀態,減少齒槽骨萎縮同時避免周圍的正常牙齒發生歪斜。申請人有鑑於此,乃秉持從事生物醫學工程及材料之多年經驗,經不斷研究、實驗,遂研發創作一種用於骨齒科微創含高生物相容性微支架之骨齒組織填補膜網及其材料,祈使供應用於骨外科臨床使用。 This creation refers to a bone-tooth tissue filling membrane network for minimally invasive micro-invasive micro-stents, especially one that can be used for dental, orthopedics, medical facial modification, orthopedic reconstruction and postponement. The degraded bone tooth tissue fills the membrane network. In orthopedic surgery, it is often necessary to repair bone defects, but the limited source of autologous transplantation, while allogeneic and xenotransplantation have a high risk of infection. Therefore, more and more different organic, inorganic and metallic materials are used in bone tissue engineering today. In addition, in order to avoid secondary surgery, it is necessary to use biodegradable materials. The different materials currently used have their advantages and disadvantages. In order to solve different medical problems, the development of new functional composite materials is still one of the research priorities. Tissue engineering is an interdisciplinary field that connects engineering and biology. Tissue engineering develops biological substrates that can repair, restore or improve the function of tissues. among them Tissue engineering involves three main strategies: the use of in vitro cells or cell substitutes to replace limited tissue functions; the induction of tissue production, such as the utilization of growth factors; the development of biological scaffolds for tissue repair and regeneration. Therefore, the key factor in the development of scaffolds is the growth environment designed by mimicking the physical and biological functions of extracellular matrix (ECM), which is an important development technique in cell culture media. In the application of orthopedic surgery, different forms of defects are differently repaired, and it is necessary to develop different functional stents for surgical use. On the other hand, in the past, when the teeth of the patient were unable to maintain the original function due to external force fracture, tooth decay, periodontal disease or lesions around the root tip, the tooth was removed and the fibrous wound area caused by the tooth extraction was made of sterile fiber gauze. Stop bleeding and repair wounds. However, the disadvantage of using fiber gauze is that it can only stop bleeding, is not absorbed by the patient, and easily bury the food residue, so it is easy to cause wound infection, and the wound needs a longer repair time. In recent years, collagen tooth filling products have emerged. These collagen tooth filling materials are composed only of collagen, which can be completely absorbed by the organism and have a stereoscopic porous structure, which can provide support and cell growth space and absorb blood. Although such products are also helpful for alveolar bone regeneration, such products are completely absorbed by the patient within two weeks or even less after implantation in the affected area of the alveolar defect. However, in such a short period of time, the bone cells in the patient's alveolar can not grow enough bone tissue, so that the new alveolar bone can not return to the original intact state, and because there is no need for support around the new alveolar bone tissue. Teeth, so these tissues will be absorbed by the patient's body over time, the so-called alveolar bone atrophy, so that the height or width of the alveolar bone is more insufficient, which may cause the normal teeth around the missing teeth to be skewed. Adequate orbital bone in the defect area after tooth extraction, in addition to affecting the normal tooth stability of the missing tooth, is now the key to the success of artificial implant surgery. Since the artificial implants need to be fixed by sufficient alveolar bone, the regeneration of the alveolar bone becomes a necessary measure before the artificial dental implant surgery. Also known in the art of learning Over-linked products, but there is a risk of cross-linking agent residues on such products. Therefore, there is an urgent need for a biodegradable filling for the repair of alveolar bone, which allows bone cells to adhere and grow when implanted in a hole in a patient's missing tooth, and the rate of filling degradation is close to that in the alveolar bone. The rate of cell growth, thus allowing the new alveolar bone to approach the original intact state, reducing atrophy of the alveolar bone while avoiding skewing of the surrounding normal teeth. In view of this, the applicant has been engaged in the biomedical engineering and materials for many years of experience, through continuous research and experimentation, research and development of a bone tooth tissue filling membrane network for the minimally invasive micro-invasive bioscaffolds with high biocompatibility. And its materials, imperfect supply for clinical use in orthopedics.
本創作係提供一種用於骨齒科微創含高生物相容性微支架之骨齒組織填補膜網。特別是本創作涉及含高生物相容性微支架結構之醫療器材及生物醫學材料,其中該骨齒組織填補膜網包含複數個相互連接成網狀之骨齒組織填補膜網纖維,其中該骨齒組織填補膜網纖維包含一填補膜網結構主體及一高生物相容性微支架塗覆層;其中該高生物相容性微支架塗覆層包含有複數個高生物相容性微支架,而該高生物相容性微支架均勻分布於高生物相容性微支架塗覆層,將該填補膜網結構主體包覆,該高生物相容性微支架具有一空隙空間,可用來填充機能性結構。 The present invention provides a bone-tooth tissue filling membrane network for minimally invasive micro-invasive micro-stents. In particular, the present invention relates to a medical device and a biomedical material comprising a highly biocompatible micro-scaffold structure, wherein the bone-toothed tissue-filled membrane network comprises a plurality of bone-toothed tissue-connected membrane fibers which are interconnected into a network, wherein the bone The tooth tissue-filling membrane mesh fiber comprises a filling membrane mesh structure body and a high biocompatible micro-scaffold coating layer; wherein the high biocompatibility micro-scaffold coating layer comprises a plurality of high biocompatibility micro-scaffolds, The high biocompatibility micro-scaffold is evenly distributed on the high biocompatible micro-scaffold coating layer, and the high-biocompatible micro-scaffold has a void space for filling function. Sexual structure.
優選地,該填補物主體結構具有可撓性結構體。 Preferably, the filler body structure has a flexible structure.
優選地,該填補物主體結構為一體成型結構體。 Preferably, the filler body structure is an integrally formed structure.
優選地,該高生物相容性微支架係由一選自由膠原蛋白,膠原胜肽,明膠,海藻酸鈉,纖維素,多醣體,甲殼素,聚乳酸,聚乳酸酯及其組合之生物可分解高分子所組成。 Preferably, the highly biocompatible microscaffold is composed of an organism selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. It can be composed of decomposable polymers.
優選地,該高生物相容性微支架係由一選自由膠原蛋白,膠原胜肽,明膠及其組合之生物可分解高分子所組成。 Preferably, the highly biocompatible microscaffold consists of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof.
優選地,該高生物相容性微支架為一種利用親水性震動切削動物真皮及超臨界二氧化碳脫脂,酶處理所得的膠原蛋白結構體。 Preferably, the highly biocompatible micro-scaffold is a collagen structure obtained by enzymatically treating the dermis of the animal and the supercritical carbon dioxide degreasing by hydrophilic vibration.
優選地,該填補物主體結構係由一選自由膠原蛋白,膠原胜肽,明膠,海藻酸鈉,纖維素,多醣體,甲殼素,聚乳酸,聚乳酸酯及其組合之生物可分解高分子所組成。 Preferably, the filler body structure is biodegradable high from a selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactic acid and combinations thereof. Made up of molecules.
本創作用於骨齒科微創含高生物相容性微支架之骨齒組織填補膜網之第1實施例將參閱第1圖加以說明。本創作用於骨齒科微創含高生物相容性微支架之骨齒組織填補膜網1,其中複數個相互連接成網狀之骨齒組織填補膜網纖維5,其中該骨齒組織填補膜網纖維5包含一填補膜網結構主體30及一高生物相容性微支架塗覆層20;其中該高生物相容性微支架10塗覆層20包含有複數個高生物相容性微支架10,而該高生物相容性微支架10均勻分布於高生物相容性微支架塗覆層20,將該填補膜網結構主體30包覆,該高生物相容性微支架具有一空隙空間,可用來填充機 能性結構。優選地,該填補物主體結構係選自由可撓性結構體,折曲性結構體,黏彈性結構體及其組合。可依據臨床需求折曲形狀,優選地,該填補物主體結構為一體成型結構體。優選地,該高生物相容性微支架10係由一選自由膠原蛋白,膠原胜肽,明膠,海藻酸鈉,纖維素,多醣體,甲殼素,聚乳酸,聚乳酸酯及其組合之生物可分解高分子所組成。優選地,該高生物相容性微支架係由一選自由膠原蛋白,膠原胜肽,明膠及其組合之生物可分解高分子所組成。優選地,該高生物相容性微支架為一種利用親水性震動切削動物真皮及超臨界二氧化碳脫脂,酶處理所得的膠原蛋白結構體,可以提供臨床應用,細胞成長的支架空間,並且可交換養分。優選地,該填補物主體結構係由一選自由膠原蛋白,膠原胜肽,明膠,海藻酸鈉,纖維素,多醣體,甲殼素,聚乳酸,聚乳酸酯,生物陶瓷,鈦金屬,鈦合金,合金及其組合所組成。 The first embodiment of the bone tooth tissue filling membrane network for minimally invasive bone-containing tissue containing a highly biocompatible micro-scaffold is described with reference to FIG. 1 . The invention is used for the minimally invasive bone-tooth tissue of the bone-toothed tissue with high biocompatibility micro-scaffold filling the membrane network 1, wherein a plurality of bone-toothed tissues connected to each other are filled into the membrane fiber 5, wherein the bone tooth tissue is filled The membrane mesh fiber 5 comprises a filled membrane mesh structure body 30 and a highly biocompatible micro-scaffold coating layer 20; wherein the high biocompatible micro-scaffold 10 coating layer 20 comprises a plurality of high biocompatibility micro- The stent 10 is uniformly distributed on the highly biocompatible micro-scaffold coating layer 20, and the filled membrane-network structure body 30 is coated. The highly biocompatible micro-frame has a gap. Space, can be used to fill the machine Energy structure. Preferably, the filler body structure is selected from the group consisting of a flexible structure, a flexible structure, a viscoelastic structure, and combinations thereof. The shape may be flexed according to clinical needs, and preferably, the filler body structure is an integrally formed structure. Preferably, the highly biocompatible microscaffold 10 is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. Biodegradable polymer. Preferably, the highly biocompatible microscaffold consists of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof. Preferably, the high biocompatibility micro-scaffold is a collagen structure obtained by using hydrophilic vibration to cut animal dermis and supercritical carbon dioxide degreasing and enzymatic treatment, which can provide clinical application, space for cell growth, and exchangeable nutrients. . Preferably, the filler body structure is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate, bioceramic, titanium, titanium. Alloy, alloy and combination thereof.
上所述者,僅為本創作之較佳實施例,當不能以此限定本創作實施之範圍,即大凡依本創作申請專利範圍及新型說明書內容所作之等效變化與修飾,皆應仍屬本創作專利涵蓋之範圍內。綜觀上述,本創作之構造特徵確實具有實用價值及進步性,以其整體結構而言,誠已符合專利法之法定要件,爰依法提出新型專利申請。 The above description is only a preferred embodiment of the present invention. When it is not possible to limit the scope of the creation of the present invention, the equivalent changes and modifications made by the applicant in accordance with the scope of the patent application and the contents of the new manual should remain This creative patent covers the scope. Looking at the above, the structural features of this creation do have practical value and progressiveness. In terms of its overall structure, Cheng has already complied with the statutory requirements of the Patent Law and has filed a new type of patent application according to law.
1‧‧‧骨齒組織填補膜網 1‧‧‧ bone tooth tissue filling membrane network
5‧‧‧骨齒組織填補膜網纖維 5‧‧‧ bone tooth tissue filling membrane fiber
10‧‧‧高生物相容性微支架 10‧‧‧High biocompatible micro scaffold
20‧‧‧高生物相容性微支架塗覆層 20‧‧‧High biocompatible micro-scaffold coating
30‧‧‧填補膜網結構主體 30‧‧‧ Filling the main body of the membrane network structure
第1圖係為本創作之用於骨齒科微創含高生物相容性微支架之骨齒組織填補膜網(A)全結構示意圖及(B)膜網纖維示意圖。 The first figure is a schematic diagram of the whole structure of the bone tooth tissue filling membrane network (A) for the minimally invasive micro-invasive micro-stent containing bone implants and (B) the fiber diagram of the membrane mesh.
1‧‧‧骨齒組織填補膜網 1‧‧‧ bone tooth tissue filling membrane network
5‧‧‧骨齒組織填補膜網纖維 5‧‧‧ bone tooth tissue filling membrane fiber
10‧‧‧高生物相容性微支架 10‧‧‧High biocompatible micro scaffold
20‧‧‧高生物相容性微支架塗覆層 20‧‧‧High biocompatible micro-scaffold coating
30‧‧‧填補膜網結構主體 30‧‧‧ Filling the main body of the membrane network structure
Claims (9)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW106215388U TWM555211U (en) | 2017-10-19 | 2017-10-19 | Bone/tooth tissue filling membrane net containing highly-biocompatible micro scaffold used in minimally invasive orthopedic and dental surgery |
CN201820896617.XU CN208989771U (en) | 2017-10-19 | 2018-06-11 | Bone and tooth tissue filling membrane net containing high-biocompatibility micro-scaffold for minimally invasive orthopedics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW106215388U TWM555211U (en) | 2017-10-19 | 2017-10-19 | Bone/tooth tissue filling membrane net containing highly-biocompatible micro scaffold used in minimally invasive orthopedic and dental surgery |
Publications (1)
Publication Number | Publication Date |
---|---|
TWM555211U true TWM555211U (en) | 2018-02-11 |
Family
ID=62015932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW106215388U TWM555211U (en) | 2017-10-19 | 2017-10-19 | Bone/tooth tissue filling membrane net containing highly-biocompatible micro scaffold used in minimally invasive orthopedic and dental surgery |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN208989771U (en) |
TW (1) | TWM555211U (en) |
-
2017
- 2017-10-19 TW TW106215388U patent/TWM555211U/en unknown
-
2018
- 2018-06-11 CN CN201820896617.XU patent/CN208989771U/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN208989771U (en) | 2019-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Maas et al. | Implants in rhinoplasty | |
US8353967B2 (en) | Self-supporting collagen tunnel for guided tissue regeneration and method of using same | |
Colombo et al. | Regenerative medicine: clinical applications and future perspectives | |
Grecchi et al. | Reconstruction of the zygomatic bone with smartbone®: Case report | |
TWI400100B (en) | Medical equipment and manufacturing methods thereof | |
CN103007358A (en) | Cartilage tissue engineering fiber scaffold material and preparation method thereof | |
CN113349988A (en) | Tissue engineering bone for repairing jaw cleft palate defect and preparation method thereof | |
JP4279233B2 (en) | Sheet for inducing mesenchymal tissue regeneration and method for producing the same | |
Kesharwani et al. | Tissue Engineering: Applications and Advancements | |
TWM555211U (en) | Bone/tooth tissue filling membrane net containing highly-biocompatible micro scaffold used in minimally invasive orthopedic and dental surgery | |
Nidagundi et al. | 3D printed scaffolds in bone tissue engineering and their application in periodontology | |
CN209519145U (en) | Needle holder being applied to surgery Minimally nerve trachea | |
US9833544B2 (en) | Biphasic collagen membrane or capsule for guided tissue regeneration | |
Varghese et al. | Biomaterials in Medical Applications | |
RU157799U1 (en) | IMPLANT FOR SUBSTITUTION AND PLASTY OF BONE AND CARTILAGE TISSUES | |
TWM516973U (en) | Bone filler for reconstructing and repairing microporous structure provided with bioceramic surface activation layer | |
TWM567616U (en) | High biocompatible microscaffold-containing composite regenerative filling caplet structure used in orthopedic or dental minimal invasiveness | |
TWM514853U (en) | Active bone fillings for repairment/reconstruction of nuclear structure having growth promoting function | |
TWM559152U (en) | Breast sculpture filling containing high biocompatible micro-stents for minimally invasive medical cosmetic surgery | |
JP2020523165A (en) | Injured nerve tissue prosthesis implant, surgical treatment of injured nerve tissue, and use of porous polytetrafluoroethylene | |
CN209884427U (en) | Corneal repair membrane containing high-biocompatibility micro-scaffold for ophthalmic minimally invasive treatment | |
TWI472350B (en) | Medical equipment and manufacturing methods thereof | |
Hixon et al. | Scaffolds for cleft lip and cleft palate reconstruction | |
Said Rücker et al. | Functional Approaches to Oral-Maxillo-facial Restoration | |
Tayebi et al. | Application of 3D Printing in Reconstruction of Oral and Maxillofacial Multi-and Interfacial Tissue Defects |