TWM555211U - Bone/tooth tissue filling membrane net containing highly-biocompatible micro scaffold used in minimally invasive orthopedic and dental surgery - Google Patents

Description

Minimally invasive bone-toothed tissue filling membrane network with high biocompatibility micro-scaffold

This creative department relates to a bone-tooth tissue filling membrane network for minimally invasive micro-invasive micro-stents. In particular, the bone filling material of the present invention comprises a micro-bio-supporting micro-scaffold structure, which can be used for dental, orthopedics, medical beauty, face-to-face modification, orthopedic reconstruction, repair and degradation of tissue to fill the omentum.

This creation refers to a bone-tooth tissue filling membrane network for minimally invasive micro-invasive micro-stents, especially one that can be used for dental, orthopedics, medical facial modification, orthopedic reconstruction and postponement. The degraded bone tooth tissue fills the membrane network. In orthopedic surgery, it is often necessary to repair bone defects, but the limited source of autologous transplantation, while allogeneic and xenotransplantation have a high risk of infection. Therefore, more and more different organic, inorganic and metallic materials are used in bone tissue engineering today. In addition, in order to avoid secondary surgery, it is necessary to use biodegradable materials. The different materials currently used have their advantages and disadvantages. In order to solve different medical problems, the development of new functional composite materials is still one of the research priorities. Tissue engineering is an interdisciplinary field that connects engineering and biology. Tissue engineering develops biological substrates that can repair, restore or improve the function of tissues. among them Tissue engineering involves three main strategies: the use of in vitro cells or cell substitutes to replace limited tissue functions; the induction of tissue production, such as the utilization of growth factors; the development of biological scaffolds for tissue repair and regeneration. Therefore, the key factor in the development of scaffolds is the growth environment designed by mimicking the physical and biological functions of extracellular matrix (ECM), which is an important development technique in cell culture media. In the application of orthopedic surgery, different forms of defects are differently repaired, and it is necessary to develop different functional stents for surgical use. On the other hand, in the past, when the teeth of the patient were unable to maintain the original function due to external force fracture, tooth decay, periodontal disease or lesions around the root tip, the tooth was removed and the fibrous wound area caused by the tooth extraction was made of sterile fiber gauze. Stop bleeding and repair wounds. However, the disadvantage of using fiber gauze is that it can only stop bleeding, is not absorbed by the patient, and easily bury the food residue, so it is easy to cause wound infection, and the wound needs a longer repair time. In recent years, collagen tooth filling products have emerged. These collagen tooth filling materials are composed only of collagen, which can be completely absorbed by the organism and have a stereoscopic porous structure, which can provide support and cell growth space and absorb blood. Although such products are also helpful for alveolar bone regeneration, such products are completely absorbed by the patient within two weeks or even less after implantation in the affected area of the alveolar defect. However, in such a short period of time, the bone cells in the patient's alveolar can not grow enough bone tissue, so that the new alveolar bone can not return to the original intact state, and because there is no need for support around the new alveolar bone tissue. Teeth, so these tissues will be absorbed by the patient's body over time, the so-called alveolar bone atrophy, so that the height or width of the alveolar bone is more insufficient, which may cause the normal teeth around the missing teeth to be skewed. Adequate orbital bone in the defect area after tooth extraction, in addition to affecting the normal tooth stability of the missing tooth, is now the key to the success of artificial implant surgery. Since the artificial implants need to be fixed by sufficient alveolar bone, the regeneration of the alveolar bone becomes a necessary measure before the artificial dental implant surgery. Also known in the art of learning Over-linked products, but there is a risk of cross-linking agent residues on such products. Therefore, there is an urgent need for a biodegradable filling for the repair of alveolar bone, which allows bone cells to adhere and grow when implanted in a hole in a patient's missing tooth, and the rate of filling degradation is close to that in the alveolar bone. The rate of cell growth, thus allowing the new alveolar bone to approach the original intact state, reducing atrophy of the alveolar bone while avoiding skewing of the surrounding normal teeth. In view of this, the applicant has been engaged in the biomedical engineering and materials for many years of experience, through continuous research and experimentation, research and development of a bone tooth tissue filling membrane network for the minimally invasive micro-invasive bioscaffolds with high biocompatibility. And its materials, imperfect supply for clinical use in orthopedics.

The present invention provides a bone-tooth tissue filling membrane network for minimally invasive micro-invasive micro-stents. In particular, the present invention relates to a medical device and a biomedical material comprising a highly biocompatible micro-scaffold structure, wherein the bone-toothed tissue-filled membrane network comprises a plurality of bone-toothed tissue-connected membrane fibers which are interconnected into a network, wherein the bone The tooth tissue-filling membrane mesh fiber comprises a filling membrane mesh structure body and a high biocompatible micro-scaffold coating layer; wherein the high biocompatibility micro-scaffold coating layer comprises a plurality of high biocompatibility micro-scaffolds, The high biocompatibility micro-scaffold is evenly distributed on the high biocompatible micro-scaffold coating layer, and the high-biocompatible micro-scaffold has a void space for filling function. Sexual structure.

Preferably, the filler body structure has a flexible structure.

Preferably, the filler body structure is an integrally formed structure.

Preferably, the highly biocompatible microscaffold is composed of an organism selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. It can be composed of decomposable polymers.

Preferably, the highly biocompatible microscaffold consists of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof.

Preferably, the highly biocompatible micro-scaffold is a collagen structure obtained by enzymatically treating the dermis of the animal and the supercritical carbon dioxide degreasing by hydrophilic vibration.

Preferably, the filler body structure is biodegradable high from a selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactic acid and combinations thereof. Made up of molecules.

The first embodiment - a bone tooth tissue filling membrane network for minimally invasive micro-invasive micro-stent

The first embodiment of the bone tooth tissue filling membrane network for minimally invasive bone-containing tissue containing a highly biocompatible micro-scaffold is described with reference to FIG. 1 . The invention is used for the minimally invasive bone-tooth tissue of the bone-toothed tissue with high biocompatibility micro-scaffold filling the membrane network 1, wherein a plurality of bone-toothed tissues connected to each other are filled into the membrane fiber 5, wherein the bone tooth tissue is filled The membrane mesh fiber 5 comprises a filled membrane mesh structure body 30 and a highly biocompatible micro-scaffold coating layer 20; wherein the high biocompatible micro-scaffold 10 coating layer 20 comprises a plurality of high biocompatibility micro- The stent 10 is uniformly distributed on the highly biocompatible micro-scaffold coating layer 20, and the filled membrane-network structure body 30 is coated. The highly biocompatible micro-frame has a gap. Space, can be used to fill the machine Energy structure. Preferably, the filler body structure is selected from the group consisting of a flexible structure, a flexible structure, a viscoelastic structure, and combinations thereof. The shape may be flexed according to clinical needs, and preferably, the filler body structure is an integrally formed structure. Preferably, the highly biocompatible microscaffold 10 is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. Biodegradable polymer. Preferably, the highly biocompatible microscaffold consists of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof. Preferably, the high biocompatibility micro-scaffold is a collagen structure obtained by using hydrophilic vibration to cut animal dermis and supercritical carbon dioxide degreasing and enzymatic treatment, which can provide clinical application, space for cell growth, and exchangeable nutrients. . Preferably, the filler body structure is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate, bioceramic, titanium, titanium. Alloy, alloy and combination thereof.

The above description is only a preferred embodiment of the present invention. When it is not possible to limit the scope of the creation of the present invention, the equivalent changes and modifications made by the applicant in accordance with the scope of the patent application and the contents of the new manual should remain This creative patent covers the scope. Looking at the above, the structural features of this creation do have practical value and progressiveness. In terms of its overall structure, Cheng has already complied with the statutory requirements of the Patent Law and has filed a new type of patent application according to law.

1‧‧‧ bone tooth tissue filling membrane network

5‧‧‧ bone tooth tissue filling membrane fiber

10‧‧‧High biocompatible micro scaffold

20‧‧‧High biocompatible micro-scaffold coating

30‧‧‧ Filling the main body of the membrane network structure

The first figure is a schematic diagram of the whole structure of the bone tooth tissue filling membrane network (A) for the minimally invasive micro-invasive micro-stent containing bone implants and (B) the fiber diagram of the membrane mesh.

1‧‧‧ bone tooth tissue filling membrane network

5‧‧‧ bone tooth tissue filling membrane fiber

10‧‧‧High biocompatible micro scaffold

20‧‧‧High biocompatible micro-scaffold coating

30‧‧‧ Filling the main body of the membrane network structure

Claims (9)

A bone tooth tissue filling membrane network for minimally invasive biocompatible microscaffolds for bone dental implants comprises a plurality of bone tooth tissues which are interconnected into a network to fill the membrane fiber, wherein the bone tooth tissue fills the membrane network fiber Filling the membrane network structure body and a highly biocompatible micro-scaffold coating layer; wherein the high biocompatibility micro-scaffold coating layer comprises a plurality of highly biocompatible micro-scaffolds, and the high biocompatibility The micro-scaffold is evenly distributed on the high biocompatible micro-scaffold coating layer, and the filling membrane network structure main body is coated. The high biocompatibility micro-scaffold has a void space and can be used for filling the functional structure. The bone tooth tissue filling membrane network according to claim 1, wherein the filler body structure is selected from the group consisting of a flexible structure, a flexible structure, a viscoelastic structure, and combinations thereof. The bone tooth tissue filling membrane network according to claim 1, wherein the filler body structure is an integrally formed structure. The bone tooth tissue filling membrane network according to claim 1, wherein the high biocompatibility microscaffold is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, It is composed of chitin, polylactic acid, polylactic acid ester and a combination of biodegradable polymers. The bone tooth tissue filling membrane network according to claim 4, wherein the high biocompatibility microscaffold is composed of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof. . The bone tooth tissue filling membrane network according to claim 5, wherein the high biocompatibility micro-scaffold is a collagen structure obtained by hydrolyzing animal dermis and supercritical carbon dioxide degreasing and enzymatic treatment. The bone tooth tissue filling membrane network according to claim 1, wherein the high biocompatible micro-scaffold coating layer is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, It is composed of a biodegradable polymer of polysaccharide, chitin, polylactic acid, polylactic acid ester and combinations thereof. The bone tooth tissue filling membrane network according to claim 1, wherein the filler body structure is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, Polylactic acid, polylactic acid ester and a combination thereof are composed of biodegradable polymers. The bone tooth tissue filling membrane network according to claim 1, wherein the filler body structure is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, Polylactic acid, polylactic acid ester, bioceramic, titanium metal, titanium alloy, alloy and combination thereof.