TWM559719U - Skin composite regeneration film containing highly bio-compatible micro-scaffolds for minimally invasive skin incision - Google Patents

Abstract

The present invention discloses a skin composite regenerative membrane for skin minimally invasive biocompatible microscaffold comprising a regenerative membrane support layer and a highly biocompatible microscaffold coating layer, wherein the regenerative membrane support layer is disposed a plurality of support layer diffusion channels, and a plurality of diffusion channel external through holes corresponding to the support layer diffusion channels for communicating with the external environment; the high biocompatibility micro-scaffold coating layer comprises a plurality of high biocompatible a micro-stent, the highly biocompatible micro-scaffold coating is attached to a surface of the regenerative membrane support layer, and the highly biocompatible micro-scaffold is uniformly disposed on the high biocompatible micro-stent coating The layer, and the highly biocompatible microscaffold includes a void space that can be used to accommodate the functional structure.

Description

Skin composite regenerative membrane for minimally invasive skin with high biocompatibility microscaffold

The present invention relates to a skin composite regenerative membrane for minimally invasive skin containing high biocompatibility microscaffolds. In particular, the skin composite barrier film of the present invention comprises a high biocompatibility micro-scaffold structure, which can be used for skin, dental, orthopedics, medical beauty, facial modification, orthopedic reconstruction and repair.

This creation refers to a skin composite regenerative membrane for skin minimally invasive biocompatible microscaffolds, especially one that can be used in dermatology, dentistry, orthopedics, medical beauty, facial modification, orthopedic reconstruction, delayed degradation Skin composite barrier film. In clinical surgery, it is often necessary to repair tissue defects, but the limited source of autologous transplantation, while allogeneic and xenotransplantation have a high risk of infection. Therefore, more and more different organic, inorganic, and metallic materials are used in tissue engineering today. In addition, in order to avoid secondary surgery, it is necessary to use biodegradable materials. The different materials currently used have their advantages and disadvantages. In order to solve different medical problems, the development of new functional composite materials is still one of the research priorities. Tissue engineering is an interdisciplinary field that connects engineering and biology. Tissue engineering develops biological substrates that can repair, restore or improve the function of tissues. Among them, tissue engineering involves three main strategies: using in vitro cells or cell substitutes to replace limited tissue work. Ability to induce tissue production, such as the utilization of growth factors; development of biological scaffolds facilitate tissue repair and regeneration. Therefore, the key factor in the development of scaffolds is the growth environment designed by mimicking the physical and biological functions of extracellular matrix (ECM), which is an important development technique in cell culture media. In minimally invasive surgery, different forms of defects are differently repaired, and it is necessary to develop different functional stents for clinical application. In view of this, the applicant has been engaged in biomedical engineering and materials for many years of experience, through continuous research and experimentation, and has developed a medical device and biomedical materials for reconstruction and repair of highly biocompatible micro-scaffold structures. Supplied for clinical use.

This creation provides a skin composite regeneration film. In particular, the present invention relates to a medical device and a biomedical material containing a highly biocompatible micro-scaffold structure, wherein the skin composite regeneration film for skin minimally invasive biocompatible micro-stent comprises a regenerative film support layer and a high a biocompatible micro-scaffold coating layer, wherein the regenerated film support layer is provided with a plurality of support layer diffusion channels, and a plurality of diffusion channel external through holes corresponding to the support layer diffusion channels for circulating with the external environment; The highly biocompatible micro-scaffold coating layer comprises a plurality of highly biocompatible micro-scaffolds attached to a surface of the regenerative membrane support layer, and the high bio-phase The capacitive micro-scaffold is uniformly disposed on the high biocompatible micro-scaffold coating layer, and the high bio-compatible micro-stent includes a void space that can be used to accommodate the functional structure.

Preferably, the highly biocompatible microscaffold is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactic acid and combinations thereof. The biodegradable polymer is composed of.

Preferably, the highly biocompatible microscaffold consists of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof.

Preferably, the highly biocompatible micro-scaffold is a collagen structure obtained by enzymatically treating the dermis of the animal and the supercritical carbon dioxide degreasing by hydrophilic vibration.

Preferably, the regenerative membrane supporting layer is composed of a polymer selected from the group consisting of polyurethane, polyvinyl alcohol, collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin and combinations thereof. Composed of.

1‧‧‧ Skin composite regeneration film

10‧‧‧High biocompatible micro scaffold

15‧‧‧ void space

20‧‧‧Regeneration membrane support layer

25‧‧‧Support layer diffusion channel

27‧‧‧Driving channel external through hole

30‧‧‧High biocompatible micro-scaffold coating

1000‧‧‧ lesions

The first figure is a schematic diagram of the skin composite regenerative membrane for the minimally invasive skin containing high biocompatibility microscaffold.

The second figure is a schematic diagram of the clinical application of the skin composite regenerative membrane for skin minimally invasive micro-stent with high biocompatibility.

The first embodiment - a skin composite regeneration membrane for minimally invasive skin containing high biocompatibility microscaffold

The first embodiment of the skin composite reconstituted film for minimally invasive skin containing a highly biocompatible microscaffold is described with reference to Fig. 1. The present invention is applied to a skin micro-invasive skin composite regenerated film 1 containing a highly biocompatible micro-scaffold, wherein the skin composite regenerative film 1 comprises a regenerated film supporting layer 20 and a highly biocompatible micro-scaffold coating layer 30, Wherein the regenerative film supporting layer 20 is provided with a plurality of supporting layer diffusion channels 25, and a plurality of diffusion channels corresponding to the supporting layer diffusion channels 25 a through hole 27 for communicating with the external environment; and the highly biocompatible micro-scaffold coating layer 30 comprises a plurality of highly biocompatible micro-scaffolds 10, the highly biocompatible micro-scaffold coating layer 30 Attached to a surface of the regenerative membrane support layer 20, the highly biocompatible micro-scaffold is uniformly disposed on the high biocompatible micro-scaffold coating layer 30, and the highly biocompatible micro-scaffold 10 comprises There is a void space 15 which can be used to accommodate the functional structure. Preferably, the highly biocompatible microscaffold 10 is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. Biodegradable polymer. Preferably, the highly biocompatible microscaffold 10 is comprised of a biodegradable polymer selected from the group consisting of collagen, collagen peptides, gelatin, and combinations thereof. Preferably, the highly biocompatible microscaffold 10 is a collagen structure obtained by hydrolyzing animal dermis and supercritical carbon dioxide degreasing and enzymatic treatment. Preferably, the regenerated film support layer is selected from the group consisting of silicone, rubber, polyethylene, polypropylene, polymethyl methacrylate, polyurethane, polyvinyl alcohol, nylon, polytetrafluoroethylene, collagen, It is composed of collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and a combination thereof. The regenerated film support layer is composed of a polymer selected from the group consisting of polyurethane, polyvinyl alcohol, collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin and combinations thereof. The most important feature is the selective moisturizing and venting environment that provides tissue healing, such as polyurethane, according to clinical needs. The clinical application diagram of the skin composite regenerative membrane for minimally invasive skin containing high biocompatibility microscaffold is shown in FIG. 2, and the high biocompatibility microscaffold coating layer 30 is on the same side as the lesion 1000. The highly biocompatible microscaffold 10 can directly contact the lesion 1000, and the void space 15 can be used to accommodate the functional structure because its high biocompatibility does not cause irritation, cytotoxicity and sensitization. For example, tissue healing cells or other secretory substances.

The above description is only a preferred embodiment of the present invention. When it is not possible to limit the scope of the creation of the present invention, the equivalent changes and modifications made by the applicant in accordance with the scope of the patent application and the contents of the new manual should remain This creative patent covers the scope. Looking at the above, the structural features of this creation do have practical value and progressiveness. In terms of its overall structure, Cheng has already complied with the statutory requirements of the Patent Law and has filed a new type of patent application according to law.

Claims (6)

A skin composite regeneration film for skin minimally invasive biocompatible microscaffold comprising a regenerative membrane support layer and a highly biocompatible micro-scaffold coating layer, wherein the regenerative membrane support layer is provided with a plurality of supports a layer diffusion channel, and a plurality of diffusion channel external through holes corresponding to the support layer diffusion channel for circulating with the external environment; and the high biocompatibility micro-scaffold coating layer comprises a plurality of highly biocompatible micro-stents The highly biocompatible micro-scaffold coating layer is attached to a surface of the regenerative film support layer, and the highly biocompatible micro-scaffold is uniformly disposed on the high biocompatible micro-scaffold coating layer, and The highly biocompatible microscaffold includes a void space that can be used to accommodate a functional structure. The skin composite regenerative film according to claim 1, wherein the high biocompatibility microscaffold is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin. Polylactic acid, polylactic acid ester and a combination thereof are composed of biodegradable polymers. The skin composite regenerative film according to claim 2, wherein the highly biocompatible microscaffold is composed of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof. The skin composite regenerative film according to claim 3, wherein the high biocompatibility microscaffold is a collagen structure obtained by hydrolyzing animal dermis and supercritical carbon dioxide degreasing and enzymatic treatment. The skin composite regenerative film according to claim 1, wherein the regenerated film support layer is selected from the group consisting of silicone rubber, rubber, polyethylene, polypropylene, polymethyl methacrylate, polyurethane, and poly It is composed of vinyl alcohol, nylon, polytetrafluoroethylene, collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and a combination thereof. The skin composite regenerative film according to claim 5, wherein the regenerated film support layer is selected from the group consisting of polyurethane, polyvinyl alcohol, collagen, collagen peptide, gelatin, sodium alginate, fiber. It consists of a polymer of polysaccharides, polysaccharides, chitin and combinations thereof.