TWM563250U - Composite skin separation membrane with high biocompatibility micro-stent - Google Patents

Abstract

The present invention discloses a skin composite barrier film containing a highly biocompatible microscaffold for minimally invasive clinical use of the skin, comprising a barrier support layer and a highly biocompatible microscaffold coating layer, wherein the high organism The compatible micro-scaffold coating layer comprises a plurality of highly biocompatible micro-scaffolds attached to a surface of the support layer of the separator, and the high biocompatibility The micro-stent is evenly disposed on the high biocompatible micro-scaffold coating layer, and the high bio-compatible micro-stent includes a void space that can be used to accommodate the functional structure.

Description

Skin composite separator with high biocompatibility micro-stent

This creation is a skin composite barrier containing a highly biocompatible microstent for the minimally invasive clinical use of the skin. In particular, the skin composite barrier film of the present invention comprises a high biocompatibility micro-scaffold structure, which can be used for skin, dental, orthopedics, medical beauty, facial modification, orthopedic reconstruction and repair.

This creation refers to a skin composite barrier film for skin minimally invasive biocompatible micro-stent, especially one that can be used in dermatology, dentistry, orthopedics, medical beauty, facial modification, orthopedic reconstruction, delayed degradation Skin composite barrier film. In clinical surgery, it is often necessary to repair tissue defects, but the limited source of autologous transplantation, while allogeneic and xenotransplantation have a high risk of infection. Therefore, more and more different organic, inorganic, and metallic materials are used in tissue engineering today. In addition, in order to avoid secondary surgery, it is necessary to use biodegradable materials. The different materials currently used have their advantages and disadvantages. In order to solve different medical problems, the development of new functional composite materials is still one of the research priorities. Tissue engineering is an interdisciplinary field that connects engineering and biology. Tissue engineering develops biological substrates that can repair, restore or improve the function of tissues. Organization Engineering involves three main strategies: the use of in vitro cells or cell substitutes to replace limited tissue functions; the induction of tissue production, such as the utilization of growth factors; the development of biological scaffolds for tissue repair and regeneration. Therefore, the key factor in the development of scaffolds is the growth environment designed by mimicking the physical and biological functions of extracellular matrix (ECM), which is an important development technique in cell culture media. In minimally invasive surgery, different forms of defects are differently repaired, and it is necessary to develop different functional stents for clinical application. In view of this, the applicant has been engaged in biomedical engineering and materials for many years of experience, through continuous research and experimentation, and has developed a medical device and biomedical materials for reconstruction and repair of highly biocompatible micro-scaffold structures. Supplied for clinical use.

This creation provides a skin composite barrier. In particular, the present invention relates to medical devices and biomedical materials containing a highly biocompatible micro-scaffold structure, wherein the skin composite barrier film for minimally invasive skin containing high biocompatible micro-stent comprises

a barrier support layer and a highly biocompatible micro-scaffold coating layer, wherein the highly biocompatible micro-scaffold coating layer comprises a plurality of highly biocompatible micro-scaffolds, the highly biocompatible micro-scaffold a coating layer is attached to a surface of the separator support layer, and the highly biocompatible micro-scaffold is uniformly disposed on the high biocompatible micro-scaffold coating layer, and the high biocompatibility micro-scaffold comprises There is a void space that can be used to accommodate the functional structure. Preferably, the highly biocompatible microscaffold is composed of an organism selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. It can be composed of decomposable polymers.

Preferably, the highly biocompatible microscaffold consists of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof.

Preferably, the highly biocompatible micro-scaffold is a collagen structure obtained by enzymatically treating the dermis of the animal and the supercritical carbon dioxide degreasing by hydrophilic vibration.

Preferably, the separator support layer is selected from the group consisting of silicone, rubber, polyethylene, polypropylene, polymethyl methacrylate, polyurethane, polyvinyl alcohol, nylon, polytetrafluoroethylene, collagen, It is composed of collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and a combination thereof. Most preferably, the barrier film support layer is comprised of a polymer selected from the group consisting of silicone, polyethylene, polylactic acid, polylactate, and combinations thereof.

First Embodiment - a skin composite separator containing a highly biocompatible microscaffold

The first embodiment of the skin composite barrier film for minimally invasive skin containing high biocompatibility microscaffolds will be described with reference to Fig. 1. The present invention is applied to a skin micro-invasive skin composite separator 1 containing a highly biocompatible micro-stent, wherein the skin composite separator 1 comprises a separator support layer 20 and a highly biocompatible micro-scaffold coating layer 30, Wherein the high biocompatible micro-scaffold coating layer 30 comprises a plurality of highly biocompatible micro-scaffolds 10 attached to a surface of the separator support layer 20 And the high biocompatibility micro-scaffold is uniformly disposed on the high biocompatible micro-scaffold coating layer 30, and the high bio-compatible micro-scaffold 10 includes a void space 15 that can be used to accommodate Install a functional structure. Preferably, the highly biocompatible microscaffold 10 is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. Biodegradable high score The composition of the child. Preferably, the highly biocompatible microscaffold 10 is comprised of a biodegradable polymer selected from the group consisting of collagen, collagen peptides, gelatin, and combinations thereof. Preferably, the highly biocompatible microscaffold 10 is a collagen structure obtained by hydrolyzing animal dermis and supercritical carbon dioxide degreasing and enzymatic treatment. Preferably, the separator support layer is selected from the group consisting of silicone, rubber, polyethylene, polypropylene, polymethyl methacrylate, polyurethane, polyvinyl alcohol, nylon, polytetrafluoroethylene, collagen, It is composed of collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin, polylactic acid, polylactate and a combination thereof. Most preferably, the separator support layer is composed of a polymer selected from the group consisting of silicone, polyethylene, polylactic acid, polylactic acid ester and combinations thereof, and the most important feature is low adhesion or water repellency for isolating the lesion. Avoid infection, specifically using a film made of silicone or polylactate for complete isolation, or selectively provide a waterproof and moisture permeable film, such as polyurethane, according to clinical requirements. The clinical application diagram of the skin composite separator for skin minimally invasive micro-stent containing high biocompatibility is shown in FIG. 2, and the high biocompatible micro-scaffold coating layer 30 is on the same side as the lesion 1000. The highly biocompatible microscaffold 10 is in direct contact with the lesion 1000, which is irritating, cytotoxic and sensitizing due to its high biocompatibility, which can be used to accommodate functional structures such as tissue healing. Cell structure or other secretory material.

The above description is only a preferred embodiment of the present invention. When it is not possible to limit the scope of the creation of the present invention, the equivalent changes and modifications made by the applicant in accordance with the scope of the patent application and the contents of the new manual should remain This creative patent covers the scope. Looking at the above, the structural features of this creation do have practical value and progressiveness. In terms of its overall structure, Cheng has already complied with the statutory requirements of the Patent Law and has filed a new type of patent application according to law.

1‧‧‧Skin composite separator

10‧‧‧High biocompatible micro scaffold

15‧‧‧ void space

20‧‧‧Separator support layer

30‧‧‧High biocompatible micro-scaffold coating

1000‧‧‧ lesions

Figure 1 is a schematic diagram of a skin composite barrier film containing a highly biocompatible microscaffold.

The second picture is a schematic diagram of the clinical application of the skin composite barrier film with high biocompatibility micro-stent.

Claims (6)

A skin composite separator comprising a highly biocompatible microscaffold comprising a barrier support layer and a highly biocompatible microscaffold coating layer, wherein the high biocompatible micro stent coating layer comprises a plurality of a highly biocompatible micro-scaffold coated on a surface of the support layer of the separator, and the highly biocompatible micro-scaffold is uniformly disposed on the high biocompatibility The micro-scaffold coating layer and the high biocompatibility micro-stent includes a void space that can be used to accommodate the functional structure. The skin composite separator according to claim 1, wherein the high biocompatibility microscaffold is selected from the group consisting of collagen, collagen peptide, gelatin, sodium alginate, cellulose, polysaccharide, chitin. Polylactic acid, polylactic acid ester and a combination thereof are composed of biodegradable polymers. The skin composite barrier film of claim 2, wherein the highly biocompatible microscaffold is composed of a biodegradable polymer selected from the group consisting of collagen, collagen peptide, gelatin and combinations thereof. The skin composite separator according to claim 3, wherein the high biocompatibility microscaffold is a collagen structure obtained by hydrolyzing animal dermis and supercritical carbon dioxide degreasing and enzymatic treatment. The skin composite separator according to claim 1, wherein the separator support layer is selected from the group consisting of silicone rubber, rubber, polyethylene, polypropylene, polymethyl methacrylate, and polyurethane. It consists of sodium, cellulose, polysaccharide, chitin, polylactic acid, polylactate and combinations thereof. The skin composite barrier film of claim 5, wherein the barrier film support layer is composed of a polymer selected from the group consisting of silicone, polyethylene, polylactic acid, polylactic acid ester, and combinations thereof.