TWM481015U - Antrodia cinnamomea powder capsule structure for inhibiting cancer cell proliferation - Google Patents

Antrodia cinnamomea powder capsule structure for inhibiting cancer cell proliferation Download PDF

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TWM481015U
TWM481015U TW102220995U TW102220995U TWM481015U TW M481015 U TWM481015 U TW M481015U TW 102220995 U TW102220995 U TW 102220995U TW 102220995 U TW102220995 U TW 102220995U TW M481015 U TWM481015 U TW M481015U
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capsule
protective layer
cancer cells
core
capsule structure
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TW102220995U
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Chin-Yuan Chan
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Miyuan Biotech Co Ltd
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Description

一種抑制癌細胞擴散之牛樟芝粉末膠囊結構A capsule structure of Antrodia camphorata inhibiting the spread of cancer cells

本創作係關於一種可包埋粉末之膠囊結構的技術領域。This creation relates to the technical field of a capsule structure that can embed powder.

牛樟芝(Antrodia camphorata),又稱樟芝或牛樟菇等,於分類學上屬於真菌界(Fungi)、擔子菌門(Basidiomycota)、擔子菌亞門(Basidiomycotina)、同擔子菌綱(Homobasidiomycetes)、無褶菌目(Aphyllophorales)、多孔菌科(Polyporaceae)、薄孔菌屬(Antrodia)。牛樟芝生長於海拔450~2000公尺之深山,又名牛樟菇、紅樟、樟菇、樟窟內菇,僅生長於臺灣特有之牛樟樹幹的腐朽心材內壁。牛樟芝目前已知具有多種的活性成分,使得牛樟芝具有護肝、提昇免疫力、抗氧化與抑制癌細胞擴散等作用,為臺灣著名且珍貴之藥用真菌,具有「森林中的紅寶石」之美稱。Antrodia camphorata, also known as Antrodia camphorata or Burdock mushroom, belongs to the fungi community (Fungi), Basidiomycota, Basidiomycotina, Homobasidiomycetes, and taxonomy. Aphyllophorales, Polyporaceae, Antrodia. Antrodia camphorata grows in the deep mountains of 450~2000 meters above sea level, also known as burdock mushroom, red peony, oyster mushroom, and oyster mushroom. It grows only on the inner wall of the decaying heartwood of Taiwan's unique burdock trunk. Niobium lucidum is known to have a variety of active ingredients, which makes the Antrodia camphorata have the functions of protecting the liver, enhancing immunity, resisting oxidation and inhibiting the spread of cancer cells. It is a famous and precious medicinal fungus in Taiwan and has the reputation of "the ruby in the forest".

牛樟芝子實體為多年生,無柄且為木栓質至木質,具有濃厚的樟樹香氣,形態多變,有板狀、鐘狀、馬蹄狀或塔狀,緊貼於木材表面,菇體表面孔狀,初生時鮮紅色,隨著生長逐變為乳白色、淡紅褐色、淡褐色或淡黃褐色,週邊常呈放射狀,並往四週擴展生長,呈半圓狀或不規則形。The body of Ox sylvestris is perennial, sessile and cork-to-wood. It has a strong aroma of eucalyptus and has a variety of shapes. It has a plate shape, a bell shape, a horseshoe shape or a tower shape. It is close to the surface of the wood and has a pore shape on the surface of the mushroom. It is bright red at the beginning of life, and becomes milky white, reddish brown, light brown or yellowish brown as the growth progresses. The periphery is often radial and spreads to the periphery, showing a semicircular or irregular shape.

植物化學研究顯示,牛樟芝子實體包含多醣(30-50%)、三萜類(30%)、類固醇類、超氧化物歧化酶和氨基酸類。在台灣民俗醫學療法上,牛樟芝子實體被認為具有某些醫藥功效,將該子實體細磨成乾燥粉末或以熬煮方式口服,為民間流傳具療效的食藥菇類,具有抑制癌細胞擴散的活性。Phytochemical studies have shown that the body complex of Antrodia camphorata contains polysaccharides (30-50%), triterpenoids (30%), steroids, superoxide dismutase and amino acids. In Taiwan's folk medicine therapy, the burdock fruit body is considered to have certain medicinal effects, and the fruit body is finely ground into a dry powder or taken orally in a boiled manner, which is a curative effect on the spread of cancer cells. Activity.

絕大多數的癌細胞起源於基因突變。基因突變原因有非常多種,第一種是所謂染色體轉位(translocation):通常發生在細胞分裂時,染色體的分配發生錯誤,例如慢性白血症就是染色體9與22發生轉位。如果細胞的染色體發生這種轉移,此細胞未來成為癌症的機會非常高。這表示染色體裡重要的基因發生了根本的結構性改變。The vast majority of cancer cells originate from genetic mutations. There are many reasons for gene mutations. The first one is called translocation: usually occurs when cells divide, and chromosome assignments are wrong. For example, chronic white blood is the translocation of chromosomes 9 and 22. If this shift occurs in the chromosomes of the cells, the chances of this cells becoming cancer in the future are very high. This indicates that a fundamental structural change has occurred in important genes in the chromosome.

第二是環境中的致癌物質或突變劑造成的突變,包括化學物質、放射線、病毒等。最有名的致癌物質是真菌分泌的黃麴毒素,人吃入體內後,肝臟代謝成為aflatoxin-2,3-cpoxide,會去攻擊DNA,修飾DNA上頭的鹼基,使得DNA上的遺傳訊息發生錯誤,而失去正常的調控功能。The second is a mutation caused by carcinogens or mutants in the environment, including chemicals, radiation, viruses, and the like. The most famous carcinogen is the xanthine toxin secreted by the fungus. After eating into the body, the liver metabolizes to aflatoxin-2,3-cpoxide, which attacks the DNA and modifies the base on the DNA, causing genetic information on the DNA to occur. Error, and lose normal regulatory functions.

第三是遺傳上的疾病,病人本身負責修補基因的基因受損,他們便很可能得到癌症:例如「著色性乾皮病」(xeroderma pigmentosum)這種皮膚癌。The third is a genetic disease in which the patient's own gene responsible for repairing the gene is damaged, and they are likely to get cancer: for example, xeroderma pigmentosum.

細胞的特性就是能夠不停地分裂生長,一旦指揮正常細胞的指令發生一些錯誤,使細胞無法正常進入分化、休眠或死亡,此時細胞唯一能做的就是持續生長分裂,也就是癌細胞最重要的特色。正常細胞必須與其他細胞有某種程度的接觸,才能調控彼此的生長,但癌細胞喪失了這種調控能力,所以不受細胞間的生長指令所控制。The characteristic of cells is that they can continue to divide and grow. Once the instructions commanding normal cells make some mistakes, the cells can not enter the differentiation, dormancy or death normally. At this time, the only thing the cell can do is to continue to grow and divide, that is, the most important cancer cells. Features. Normal cells must have some degree of contact with other cells in order to regulate each other's growth, but cancer cells lose this ability to regulate, so they are not controlled by intercellular growth instructions.

在癌細胞的擴散過程中,它會由原本的腫瘤擴散到別的器官上。但為什麼這些擴散的癌細胞只在特定器官或部位生根繁殖呢?像肺和肝臟就是就是癌細胞最常擴散的目標器官。有些研究顯示這種『偏好』是因為當癌細胞藉著血液擴散到別的器官時,血管變得十分狹窄,而癌細胞就這樣『卡』在適當的血管上。也有另一種說法是某種蛋白質會對特定組織的血管壁作用造成癌細胞的停留繁殖。During the spread of cancer cells, it spreads from the original tumor to other organs. But why do these diffuse cancer cells only multiply in specific organs or parts? Like the lungs and liver, it is the target organ that cancer cells spread most often. Some studies have shown that this "preference" is because when cancer cells spread through blood to other organs, the blood vessels become very narrow, and the cancer cells are "snapped" on the appropriate blood vessels. There is also another saying that a certain protein acts on the blood vessel wall of a specific tissue to cause the cancer cells to stay and multiply.

癌細胞擴散是一個連續的過程:癌細胞從原本的腫瘤上剝落,藉由血管傳播到適當的位置生根繁殖。它會在新的地方建立血管系來支持自己的生長,而能長大到會威脅生命的量。癌細胞同時具有刺激和抑制此種過程的物質,而癌細胞和宿主細胞之間的關係也非常值得深究。最好的例子就是骨癌的惡性循環,癌細胞分泌和副甲狀腺功能相似的蛋白質,用來活化正常骨髓細胞,骨髓細胞分解骨頭的基質,這種分解作用會導致生長激素被釋放出來,造成癌細胞的增生,且分泌更多的副甲狀腺功能相似的蛋白質。The spread of cancer cells is a continuous process: cancer cells are exfoliated from the original tumor and propagated to the proper location by the blood vessels to multiply. It will build a vascular system in a new place to support its own growth, and grow up to the amount that will threaten life. Cancer cells also have substances that stimulate and inhibit this process, and the relationship between cancer cells and host cells is also worthy of further investigation. The best example is the vicious circle of bone cancer. The cancer cells secrete proteins similar to the parathyroid function. They are used to activate normal bone marrow cells. The bone marrow cells break down the matrix of bones. This decomposition causes the growth hormone to be released and cause cancer. The cells proliferate and secrete more proteins with similar parathyroid function.

目前諸多之實驗可得知牛樟芝萃取物具有抑制癌細胞擴散的活性,且其所含成分亦陸續被分析出。因此,若能提供該等患者一更佳之抑制癌細胞擴散的方法,是一迫切亟需解決之課題。At present, many experiments have revealed that the extract of Antrodia camphorata has the activity of inhibiting the spread of cancer cells, and the components thereof are also analyzed one after another. Therefore, providing a better way for these patients to inhibit the spread of cancer cells is an urgent problem to be solved.

由此,本案創作人鑑於上述衍生之缺失,乃亟思加以改良創新,除了研發一牛樟芝粉末,其中之活性成分具有抑制癌細胞擴散之效用;此外,搭配本創作之膠囊結構,可供使用者易於攝取足夠之牛樟芝粉末,並藉此抑制癌細胞擴散。是故,提出本件『一種抑制癌細胞擴散之牛樟芝粉末膠囊結構』。Therefore, in view of the above-mentioned lack of the above-mentioned derivatives, the creators of this case have improved and innovated, in addition to the development of a burdock powder, the active ingredient of which has the effect of inhibiting the spread of cancer cells; It is easy to ingest enough of Antrodia camphorata powder to inhibit the spread of cancer cells. Therefore, this article "a structure of a capsule of Astragalus membranaceus that inhibits the spread of cancer cells" is proposed.

本創作之目的即在於提供一種抑制癌細胞擴散之牛樟芝粉末膠囊結構。The purpose of this creation is to provide a capsule structure of Antrodia camphorata which inhibits the spread of cancer cells.

本創作之次一目的在於提供一種膠囊結構,以使其中之牛樟芝粉末之活性成分得以於服用者體內發揮其抑制癌細胞擴散之效用。A second object of the present invention is to provide a capsule structure in which the active ingredient of the Antrodia camphorata powder is exerted in the user's body to inhibit the spread of cancer cells.

可達成上述創作目的之一種用於抑制癌細胞擴散之牛樟芝粉末膠囊結構,包括:一囊殼、一保護層、及一核心;該核心係被該保護層所披覆,該保護層再以一囊殼包覆之。The invention relates to a structure of an Antrodia camphorata powder capsule for inhibiting the spread of cancer cells, comprising: a capsule shell, a protective layer, and a core; the core layer is covered by the protective layer, and the protective layer is further Covered by a capsule.

本創作所提供之牛樟芝粉末膠囊結構,除了可供內含之牛樟芝粉末(及其活性成分)得以被長時間保存外;此外,其核心所含之牛樟芝粉末(及其活性成分)亦可抑制癌細胞擴散。本創作提供之膠囊結構可易於使使用者服用,因此,除可用於日常保健外,亦可搭配其他療程一併使用之。The structure of the Antrodia camphorata powder capsule provided by the present invention can be preserved for a long time in addition to the contained Antrodia camphorata powder (and its active ingredient); in addition, the core of the Antrodia camphorata powder (and its active ingredient) can also inhibit cancer. The cells spread. The capsule structure provided by this creation can be easily taken by the user, so that it can be used in combination with other treatments in addition to daily health care.

1‧‧‧膠囊結構1‧‧‧Capsule structure

11‧‧‧囊殼11‧‧‧ capsule

12‧‧‧保護層12‧‧‧Protective layer

13‧‧‧核心13‧‧‧ core

圖一為一種抑制癌細胞擴散之牛樟芝粉末膠囊結構的剖面圖。Figure 1 is a cross-sectional view showing the structure of an Antrodia camphorata powder capsule which inhibits the spread of cancer cells.

本創作係提供一種抑制癌細胞擴散之牛樟芝粉末膠囊結構,根據本創作詳細說明之,並請參閱第一圖說明。This creation provides a structure of an Antrodia camphorata powder capsule that inhibits the spread of cancer cells, as described in detail in this creation, and is described in the first figure.

本創作之一種抑制癌細胞擴散之牛樟芝粉末膠囊結構1,由外至內依序包括:一囊殼11、一保護層12、及一核心13;該核心13係被該保護層12所披覆,除了可用以阻隔外界環境與該核心13之間的氧化作用外,亦可用以保護核心13中之牛樟芝活性成分不受胃酸等因素所破壞。另,該保護層12再以一囊殼11包覆,以保護核心13及保護層12免於受物理性因子(如:重壓、尖刺等)之破壞。The invention relates to a structure 1 for the growth of cancer cells, which comprises a capsule shell 11, a protective layer 12 and a core 13; the core 13 is covered by the protective layer 12; In addition to being used to block the oxidation between the external environment and the core 13, it can also be used to protect the active ingredient of the Antrodia camphorata in the core 13 from being damaged by factors such as gastric acid. In addition, the protective layer 12 is further covered by a capsule 11 to protect the core 13 and the protective layer 12 from physical factors such as heavy pressure, spikes, and the like.

其中該囊殼11所用之成分包含但不限於:明膠(吉利丁(Gelatin))、甲基纖維素(Methyl cellulose)、羥丙基甲基纖維素(Hydroxymethyl propyl cellulose)、羥丙基纖維素(Hydroxymethyl propyl cellulose)、聚乙烯醇(Polyvinyl alcohol)、聚乙烯吡咯酮(Polyvinyl pyrrolidone)、鄰苯二甲酸醋酸纖維素(Cellulose acetate phthalate)、鄰苯二甲酸羥丙基纖維素(Hydroxypropyl methylcellulose phthalate)或其它適用於本創作的材料;其中該明膠可包含動物性明膠(由魚皮、豬皮等動物性來源所製成)及植物性明膠(如:羥丙基甲基纖維素(HPMC))。The components used in the capsule 11 include, but are not limited to, gelatin (Gelatin), Methyl cellulose, Hydroxymethyl propyl cellulose, Hydroxypropyl cellulose ( Hydroxymethyl propyl cellulose), polyvinyl alcohol, polyvinyl pyrrolidone, Cellulose acetate phthalate, Hydroxypropyl methyl phthalate or Other materials suitable for use in the present invention; wherein the gelatin may comprise animal gelatin (made from animal sources such as fish skin, pig skin, etc.) and vegetable gelatin (eg, hydroxypropyl methylcellulose (HPMC)).

其中該保護層12之可包含但不限於:賦形劑、崩解劑、腸溶衣、黏合劑、稀釋劑、包覆劑、潤脹劑、潤滑劑、調味劑、甜味劑、增溶劑、或其之任意組合。The protective layer 12 may include, but is not limited to, an excipient, a disintegrant, an enteric coating, a binder, a diluent, a coating agent, a swelling agent, a lubricant, a flavoring agent, a sweetener, a solubilizing agent. Or any combination thereof.

其中,如賦形劑可為糖類,包括乳糖、蔗糖、甘露醇、山梨醇;纖維素製備物像是,例如,玉米澱粉、小麥澱粉、稻米澱粉、馬鈴薯澱粉、明膠、黃蓍膠等或其他適用本創作之材料;其可用以增加口感、支撐整體之結構、及保護核心13。Wherein, the excipient may be a sugar, including lactose, sucrose, mannitol, sorbitol; the cellulose preparation is, for example, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, etc. or other Materials suitable for this creation; they can be used to increase the mouthfeel, support the overall structure, and protect the core 13.

其中該核心13中包含牛樟芝粉末(活性物質),其可用以抑 制癌細胞擴散。該牛樟芝粉末可從牛樟芝子實體中製成。Wherein the core 13 comprises anthraquinone powder (active substance), which can be used to inhibit The cancer cells spread. The Antrodia camphorata powder can be made from the fruit body of Antrodia camphorata.

上述膠囊結構1亦可視需要適宜地添加一或多種以上該領域通常會使用的保存劑、著色劑、香料及風味劑或其它適用於本創作的添加物,以使其賦形、保存、上色、增添風味。The above-mentioned capsule structure 1 may also be suitably added with one or more kinds of preservatives, colorants, flavors and flavors or other additives suitable for the present invention which are commonly used in the field, so as to shape, preserve and color. Add flavor.

上述粉末膠囊結構可藉由製備於膠囊內以供口服外,亦可直接服用、或藉由其他適用本創作之形式服用。The above powder capsule structure can be prepared by taking it in a capsule for oral administration, or by taking it directly or by other forms suitable for the present invention.

上列詳細說明係針對本創作之一可行實施方式之具體說明,惟該實施例並非用以限制本創作之專利範圍,凡未脫離本創作技藝精神所為之等效實施或變更,均應包含於本案之專利範圍中。The detailed description above is a detailed description of one of the possible implementations of the present invention, but the embodiment is not intended to limit the scope of the patents of the present invention, and equivalent implementations or modifications that are not departing from the spirit of the present invention should be included in The patent scope of this case.

綜上所述,本案所揭露之技術特徵已充分符合新穎性、進步性及產業利用性之法定專利要件,爰依法提出申請,懇請 貴局核准本件新型專利申請案,以勵發明,至感德便。In summary, the technical features disclosed in this case have fully met the statutory patent requirements for novelty, advancement and industrial applicability. If you apply in accordance with the law, you are requested to approve the new patent application for your invention. Will.

1‧‧‧膠囊結構1‧‧‧Capsule structure

11‧‧‧囊殼11‧‧‧ capsule

12‧‧‧保護層12‧‧‧Protective layer

13‧‧‧核心13‧‧‧ core

Claims (5)

一種抑制癌細胞擴散之牛樟芝粉末膠囊結構,由外至內依序包含:一囊殼、一保護層、及一核心;該核心係被該保護層所披覆,該保護層再以一囊殼包覆之。 The structure of an Antrodia camphorata powder capsule for inhibiting the spread of cancer cells comprises, in order from the outside to the inside: a capsule shell, a protective layer, and a core; the core layer is covered by the protective layer, and the protective layer is further a capsule shell Covered. 如申請專利範圍第1項所述之膠囊結構,其中該囊殼之成分包含明膠、甲基纖維素、羥丙基甲基纖維素、羥丙基纖維素、聚乙烯醇、聚乙烯吡咯酮、鄰苯二甲酸醋酸纖維素、鄰苯二甲酸羥丙基纖維素。 The capsule structure according to claim 1, wherein the composition of the capsule comprises gelatin, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, Cellulose acetate phthalate, hydroxypropyl cellulose phthalate. 如申請專利範圍第1項所述之膠囊結構,其中該保護層之成分包含賦形劑、崩解劑、腸溶衣、黏合劑、稀釋劑、包覆劑、潤脹劑、潤滑劑、調味劑、甜味劑、增溶劑。 The capsule structure according to claim 1, wherein the protective layer component comprises an excipient, a disintegrating agent, an enteric coating, a binder, a diluent, a coating agent, a swelling agent, a lubricant, and a seasoning. Agent, sweetener, solubilizer. 如申請專利範圍第3項所述之膠囊結構,其中該賦形劑之成分包含乳糖、蔗糖、甘露醇、山梨醇、玉米澱粉、小麥澱粉、稻米澱粉、馬鈴薯澱粉、明膠、黃蓍膠。 The capsule structure of claim 3, wherein the component of the excipient comprises lactose, sucrose, mannitol, sorbitol, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth. 如申請專利範圍第1項所述之膠囊結構,其中該核心包含從牛樟芝子實體中製成之牛樟芝粉末。 The capsule structure of claim 1, wherein the core comprises anthraquinone powder prepared from a body of A. nigra.
TW102220995U 2013-11-08 2013-11-08 Antrodia cinnamomea powder capsule structure for inhibiting cancer cell proliferation TWM481015U (en)

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