TWM478489U - Antrodia cinnamomea powder capsule structure for suppressing hepatitis B virus - Google Patents

Antrodia cinnamomea powder capsule structure for suppressing hepatitis B virus Download PDF

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TWM478489U
TWM478489U TW102220997U TW102220997U TWM478489U TW M478489 U TWM478489 U TW M478489U TW 102220997 U TW102220997 U TW 102220997U TW 102220997 U TW102220997 U TW 102220997U TW M478489 U TWM478489 U TW M478489U
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capsule
hepatitis
virus
protective layer
core
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TW102220997U
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Chin-Yuan Chan
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Miyuan Biotech Co Ltd
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Description

一種用於抑制B型肝炎病毒之牛樟芝粉末膠囊結構A capsule structure of Antrodia camphorata for inhibiting hepatitis B virus

本創作係關於一種可包埋粉末之膠囊結構的技術領域。This creation relates to the technical field of a capsule structure that can embed powder.

牛樟芝(Antrodia camphorata),又稱樟芝或牛樟菇等,於分類學上屬於真菌界(Fungi)、擔子菌門(Basidiomycota)、擔子菌亞門(Basidiomycotina)、同擔子菌綱(Homobasidiomycetes)、無褶菌目(Aphyllophorales)、多孔菌科(Polyporaceae)、薄孔菌屬(Antrodia)。牛樟芝生長於海拔450~2000公尺之深山,又名牛樟菇、紅樟、樟菇、樟窟內菇,僅生長於臺灣特有之牛樟樹幹的腐朽心材內壁。牛樟芝目前已知具有多種的活性成分,使得牛樟芝具有護肝、提昇免疫力、抑制B行肝炎病毒活性等,具有「森林中的紅寶石」之美稱。Antrodia camphorata, also known as Antrodia camphorata or Burdock mushroom, belongs to the fungi community (Fungi), Basidiomycota, Basidiomycotina, Homobasidiomycetes, and taxonomy. Aphyllophorales, Polyporaceae, Antrodia. Antrodia camphorata grows in the deep mountains of 450~2000 meters above sea level, also known as burdock mushroom, red peony, oyster mushroom, and oyster mushroom. It grows only on the inner wall of the decaying heartwood of Taiwan's unique burdock trunk. Niobium lucidum is known to have a variety of active ingredients, which makes the Antrodia camphorata have the reputation of "protecting the liver, enhancing immunity, inhibiting hepatitis B virus activity, etc." and has the reputation of "ruby in the forest".

牛樟芝子實體為多年生,無柄且為木栓質至木質,具有濃厚的樟樹香氣,形態多變,有板狀、鐘狀、馬蹄狀或塔狀,緊貼於木材表面,菇體表面孔狀,初生時鮮紅色,隨著生長逐變為乳白色、淡紅褐色、淡褐色或淡黃褐色,週邊常呈放射狀,並往四週擴展生長,呈半圓狀或不規則形。The body of Ox sylvestris is perennial, sessile and cork-to-wood. It has a strong aroma of eucalyptus and has a variety of shapes. It has a plate shape, a bell shape, a horseshoe shape or a tower shape. It is close to the surface of the wood and has a pore shape on the surface of the mushroom. It is bright red at the beginning of life, and becomes milky white, reddish brown, light brown or yellowish brown as the growth progresses. The periphery is often radial and spreads to the periphery, showing a semicircular or irregular shape.

植物化學研究顯示,牛樟芝子實體包含多醣(30-50%)、三萜 類(30%)、類固醇類、超氧化物歧化酶和氨基酸類。在台灣民俗醫學療法上,牛樟芝子實體被認為具有某些醫藥功效,將該子實體細磨成乾燥粉末或以熬煮方式口服,為民間流傳具療效的食藥菇類,具有抗B型肝炎病毒及治療肝臟疾病等活性。Phytochemical studies have shown that the fruit body of A. angustifolia contains polysaccharides (30-50%), three 萜 Classes (30%), steroids, superoxide dismutase and amino acids. In Taiwan's folk medicine therapy, the body of A. sylvestris is considered to have certain medical effects. The fruiting body is finely ground into a dry powder or taken orally in a boiled way. It is a food-borne mushroom with a curative effect and has anti-hepatitis B. Virus and treatment of liver disease and other activities.

B型肝炎是因為B型肝炎病毒感染造成的疾病,在台灣地區和大陸東南地區有很高的盛行率。一般都是經由血液或者體液(例如精液,組織液)所傳染,正常的皮膚因為有保護外來病菌侵犯的功能,所以即使是接觸到病人的體液,只要接觸者的皮膚沒有傷口,被傳染的機會是很小的,另外由唾液傳染的機會比起血液或體液來的低,所以和B型肝炎的病人一起用餐,並不需要特別擔心。但是如果是黏膜部分接觸到B型肝炎病人的體液(例如眼睛,生殖器黏膜,口腔黏膜),被感染的機會就比較大了,在感染B型肝炎之後,病毒主要會造成肝臟的發炎,因此可能引發急性肝炎,造成疲倦,黃疸,食慾不振等等現象。另外有一群病人會跟病毒長期相處,成為慢性肝炎患者或者B型肝炎帶原者。Hepatitis B is a disease caused by hepatitis B virus infection and has a high prevalence rate in Taiwan and the southeastern part of the mainland. It is usually transmitted through blood or body fluids (such as semen, tissue fluid). Normal skin has the function of protecting foreign bacteria. Therefore, even if it comes into contact with the patient's body fluid, as long as the contact's skin has no wound, the chance of being infected is Very small, and the chance of being infected by saliva is lower than that of blood or body fluids, so it is not necessary to worry about eating with patients with hepatitis B. However, if the mucous membrane is partially exposed to the body fluids of patients with hepatitis B (such as the eyes, genital mucosa, oral mucosa), the chance of being infected is relatively large. After infection with hepatitis B, the virus mainly causes inflammation of the liver, so it is possible Causes acute hepatitis, causing fatigue, jaundice, loss of appetite and so on. In addition, a group of patients will get along with the virus for a long time, becoming a chronic hepatitis patient or a hepatitis B carrier.

慢性化B型肝炎帶原者的這群病人,常常是沒有症狀的,但是如果病毒的數目急遽增加的時候,這群病患也可能變成急性肝炎發作。在多次的急性肝炎發作之後,有一部份的病患會有肝硬化的現象,一部份的人也會造成肝癌。少數的病患會有肝外表徵(extrahepatic manifestations)一般相信是由因為病毒引發人體的一些免疫反應,造成循環中的免疫復合體造成關節炎,皮疹,血管炎,冷凝球蛋白血症,或腎絲球腎炎和再生不良性貧血等。This group of patients with chronic hepatitis B carriers is often asymptomatic, but if the number of viruses increases rapidly, this group of patients may also become acute hepatitis attacks. After many episodes of acute hepatitis, some patients will have cirrhosis, and some people will also develop liver cancer. A small number of patients with extrarahepatic manifestations are generally believed to be caused by the virus's immune response, causing the immune complex in the circulation to cause arthritis, rash, vasculitis, condensed globulinemia, or kidney. Silk glomerulonephritis and aplastic anemia.

根據B型肝炎醫療策進會統計,全台約有三百萬名B型肝炎 帶原者,相當於成人中每五人就有一人。而肝基會認為,民國七十三年以前出生的每五人至六人中就有一位血清中有B型肝炎病毒的表面抗原存在。台灣並已自1984年7月1日開始全面推行B型肝炎疫苗接種,雖然可能斷絕B型肝炎之持續傳播,然而全台已近四百萬民眾成為B型肝炎的帶原者。According to the statistics of the Hepatitis B Medical Policy Association, there are about 3 million hepatitis B in Taiwan. With the original, it is equivalent to one in five people in an adult. The liver-based association believes that one out of every five to six people born before the Republic of China seventy-three years ago has a surface antigen of hepatitis B virus. Taiwan has been fully vaccinated against hepatitis B since July 1, 1984. Although it may sever the continued spread of hepatitis B, nearly four million people in Taiwan have become the carriers of hepatitis B.

大多數急性B型肝炎病患都可以自癒,所以對於沒有併發症之急性B型肝炎,大多採取支持療法即可。至於某些病患因食慾欠佳或嚴重嘔吐導致脫水者,才需給予靜脈輸液治療。Most patients with acute hepatitis B can heal themselves, so most patients with acute hepatitis B without complications can take supportive care. In some patients, intravenous infusion is required for dehydration due to poor appetite or severe vomiting.

B型肝炎與肝硬化、肝癌等病變相關性極高,B型肝炎帶原者罹患肝癌的機率比一般人高很多倍。依台灣地區十大死亡原因統計資料,自民國七十一年以來,癌症即躍居首位,其中肝癌居男性癌症死亡率第一位,亦居女性癌症死亡率第二位,而肝癌初期幾乎沒有症狀,肝癌若發現得晚,很難治療,但若及早發現,治療效果好。目前防治的方法只有從「早期診斷,早期治療」及服用保健食品預防開始著手。Hepatitis B is highly correlated with liver cirrhosis and liver cancer, and the probability of hepatitis B with the liver is many times higher than that of the average person. According to the statistics of the top ten causes of death in Taiwan, since the Republic of China, cancer has leapt to the top in the past seventy-one years. Among them, liver cancer ranks first in male cancer mortality, and it also ranks second in female cancer mortality. Symptoms, if the liver cancer is found late, it is difficult to treat, but if it is discovered early, the treatment effect is good. The current method of prevention and treatment begins with "early diagnosis, early treatment" and taking health food prevention.

目前諸多之實驗可得知牛樟芝子實體具有抑制B型肝炎病毒之效果,且其所含成分亦陸續被分析出。因此,若能提供該等患者一更佳之治療或預防B型肝炎之方法,是一迫切亟需解決之課題。At present, many experiments have revealed that the body of A. angustifolia has the effect of inhibiting hepatitis B virus, and its components are also analyzed. Therefore, providing a better treatment or prevention of hepatitis B in these patients is an urgent problem to be solved.

由此,本案創作人鑑於上述衍生之缺失,乃亟思加以改良創新,除了研發一牛樟芝粉末,其中之活性成分具有抑制B型肝炎病毒;此外,搭配本創作之膠囊結構,可供使用者易於攝取足夠之牛樟芝粉末,並藉此抑制B型肝炎病毒。是故,提出本件『一種用於抑制B型肝炎病毒之牛樟芝粉末膠囊結構』。Therefore, the creators of this case, in view of the above-mentioned lack of derivative, are thinking and improving and innovating, in addition to the development of a burdock powder, the active ingredient of which inhibits hepatitis B virus; in addition, with the capsule structure of the creation, it is easy for the user to use. Ingest enough of the Antrodia camphorata powder to inhibit the hepatitis B virus. Therefore, this article "a structure of a capsule of Astragalus membranaceus for inhibiting hepatitis B virus" is proposed.

本創作之目的即在於提供一種用於抑制B型肝炎病毒之牛樟芝粉末膠囊結構。The purpose of the present invention is to provide a capsule structure of Antrodia camphorata for inhibiting hepatitis B virus.

本創作之次一目的在於提供一種膠囊結構,以使其中之牛樟芝粉末之活性成分得以於服用者體內發揮其抑制B型肝炎病毒之效用。A second object of the present invention is to provide a capsule structure in which the active ingredient of the Antrodia camphorata powder can exert its effect of inhibiting hepatitis B virus in a user.

可達成上述創作目的之一種用於抑制B型肝炎病毒之牛樟芝粉末膠囊結構,包括:一囊殼、一保護層、及一核心;該核心係被該保護層所披覆,該保護層再以一囊殼包覆之。The invention relates to a structure of an Antrodia camphorata powder capsule for inhibiting hepatitis B virus, comprising: a capsule shell, a protective layer, and a core; the core layer is covered by the protective layer, and the protective layer is further Covered by a capsule.

本創作所提供之牛樟芝粉末膠囊結構,除了可供內含之牛樟芝粉末(及其活性成分)得以被長時間保存外;此外,其核心所含之牛樟芝粉末(及其活性成分)亦可抑制B型肝炎病毒。本創作提供之膠囊結構可易於使使用者服用,因此,除可用於日常保健外,亦可搭配其他療程一併使用之。The structure of the Antrodia camphorata powder capsule provided by the present invention can be preserved for a long time in addition to the contained Antrodia camphorata powder (and its active ingredient); in addition, the core of the Antrodia camphorata powder (and its active ingredient) can also inhibit B Hepatitis virus. The capsule structure provided by this creation can be easily taken by the user, so that it can be used in combination with other treatments in addition to daily health care.

1‧‧‧膠囊結構1‧‧‧Capsule structure

11‧‧‧囊殼11‧‧‧ capsule

12‧‧‧保護層12‧‧‧Protective layer

13‧‧‧核心13‧‧‧ core

圖一為一種用於抑制B型肝炎病毒之牛樟芝粉末膠囊結構的剖面圖。Figure 1 is a cross-sectional view showing the structure of an Antrodia camphorata powder capsule for inhibiting hepatitis B virus.

本創作係提供一種用於抑制B型肝炎病毒之牛樟芝粉末膠囊結構,根據本創作詳細說明之,並請參閱第一圖說明。The present invention provides a structure of an Antrodia camphorata powder capsule for inhibiting hepatitis B virus, which is described in detail in accordance with the present creation, and is described in the first figure.

本創作之一種用於抑制B型肝炎病毒之牛樟芝粉末膠囊結 構1,由外至內依序包括:一囊殼11、一保護層12、及一核心13;該核心13係被該保護層12所披覆,除了可用以阻隔外界環境與該核心13之間的氧化作用外,亦可用以保護核心13中之牛樟芝活性成分不受胃酸等因素所破壞。另,該保護層12再以一囊殼11包覆,以保護核心13及保護層12免於受物理性因子(如:重壓、尖刺等)之破壞。One of the creations of the Antrodia camphorata powder capsule for inhibiting hepatitis B virus The structure 1 includes, from the outside to the inside, a capsule 11, a protective layer 12, and a core 13; the core 13 is covered by the protective layer 12, except that it can be used to block the external environment and the core 13 In addition to the oxidation, it can also be used to protect the active constituents of the Antrodia camphorata in the core 13 from diseases such as gastric acid. In addition, the protective layer 12 is further covered by a capsule 11 to protect the core 13 and the protective layer 12 from physical factors such as heavy pressure, spikes, and the like.

其中該囊殼11所用之成分包含但不限於:明膠(吉利丁(Gelatin))、甲基纖維素(Methyl cellulose)、羥丙基甲基纖維素(Hydroxymethyl propyl cellulose)、羥丙基纖維素(Hydroxymethyl propyl cellulose)、聚乙烯醇(Polyvinyl alcohol)、聚乙烯吡咯酮(Polyvinyl pyrrolidone)、鄰苯二甲酸醋酸纖維素(Cellulose acetate phthalate)、鄰苯二甲酸羥丙基纖維素(Hydroxypropyl methylcellulose phthalate)或其它適用於本創作的材料;其中該明膠可包含動物性明膠(由魚皮、豬皮等動物性來源所製成)及植物性明膠(如:羥丙基甲基纖維素(HPMC))。The components used in the capsule 11 include, but are not limited to, gelatin (Gelatin), Methyl cellulose, Hydroxymethyl propyl cellulose, Hydroxypropyl cellulose ( Hydroxymethyl propyl cellulose), polyvinyl alcohol, polyvinyl pyrrolidone, Cellulose acetate phthalate, Hydroxypropyl methyl phthalate or Other materials suitable for use in the present invention; wherein the gelatin may comprise animal gelatin (made from animal sources such as fish skin, pig skin, etc.) and vegetable gelatin (eg, hydroxypropyl methylcellulose (HPMC)).

其中該保護層12之可包含但不限於:賦形劑、崩解劑、腸溶衣、黏合劑、稀釋劑、包覆劑、潤脹劑、潤滑劑、調味劑、甜味劑、增溶劑、或其之任意組合。The protective layer 12 may include, but is not limited to, an excipient, a disintegrant, an enteric coating, a binder, a diluent, a coating agent, a swelling agent, a lubricant, a flavoring agent, a sweetener, a solubilizing agent. Or any combination thereof.

其中,如賦形劑可為糖類,包括乳糖、蔗糖、甘露醇、山梨醇;纖維素製備物像是,例如,玉米澱粉、小麥澱粉、稻米澱粉、馬鈴薯澱粉、明膠、黃蓍膠等或其他適用本創作之材料;其可用以增加口感、支撐整體之結構、及保護核心13。Wherein, the excipient may be a sugar, including lactose, sucrose, mannitol, sorbitol; the cellulose preparation is, for example, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, etc. or other Materials suitable for this creation; they can be used to increase the mouthfeel, support the overall structure, and protect the core 13.

其中該核心13中包含牛樟芝粉末(活性物質),其可用以抑制B型肝炎病毒。該牛樟芝粉末可從牛樟芝子實體中製成。The core 13 contains an antrodia arsenic powder (active substance) which can be used to inhibit the hepatitis B virus. The Antrodia camphorata powder can be made from the fruit body of Antrodia camphorata.

上述膠囊結構1亦可視需要適宜地添加一或多種以上該領域通常會使用的保存劑、著色劑、香料及風味劑或其它適用於本創作的添加物,以使其賦形、保存、上色、增添風味。The above-mentioned capsule structure 1 may also be suitably added with one or more kinds of preservatives, colorants, flavors and flavors or other additives suitable for the present invention which are commonly used in the field, so as to shape, preserve and color. Add flavor.

上述粉末膠囊結構可藉由製備於膠囊內以供口服外,亦可直接服用、或藉由其他適用本創作之形式服用。The above powder capsule structure can be prepared by taking it in a capsule for oral administration, or by taking it directly or by other forms suitable for the present invention.

上列詳細說明係針對本創作之一可行實施方式之具體說明,惟該實施例並非用以限制本創作之專利範圍,凡未脫離本創作技藝精神所為之等效實施或變更,均應包含於本案之專利範圍中。The detailed description above is a detailed description of one of the possible implementations of the present invention, but the embodiment is not intended to limit the scope of the patents of the present invention, and equivalent implementations or modifications that are not departing from the spirit of the present invention should be included in The patent scope of this case.

綜上所述,本案所揭露之技術特徵已充分符合新穎性、進步性及產業利用性之法定專利要件,爰依法提出申請,懇請 貴局核准本件新型專利申請案,以勵發明,至感德便。In summary, the technical features disclosed in this case have fully met the statutory patent requirements for novelty, advancement and industrial applicability. If you apply in accordance with the law, you are requested to approve the new patent application for your invention. Will.

1‧‧‧膠囊結構1‧‧‧Capsule structure

11‧‧‧囊殼11‧‧‧ capsule

12‧‧‧保護層12‧‧‧Protective layer

13‧‧‧核心13‧‧‧ core

Claims (5)

一種用於抑制B型肝炎病毒之牛樟芝粉末膠囊結構,由外至內依序包含:一囊殼、一保護層、及一核心;該核心係被該保護層所披覆,該保護層再以一囊殼包覆之。 A structure of an Antrodia camphorata powder capsule for inhibiting hepatitis B virus, comprising: a capsule shell, a protective layer, and a core from the outside to the inside; the core layer is covered by the protective layer, and the protective layer is further Covered by a capsule. 如申請專利範圍第1項所述之膠囊結構,其中該囊殼之成分包含明膠、甲基纖維素、羥丙基甲基纖維素、羥丙基纖維素、聚乙烯醇、聚乙烯吡咯酮、鄰苯二甲酸醋酸纖維素、鄰苯二甲酸羥丙基纖維素。 The capsule structure according to claim 1, wherein the composition of the capsule comprises gelatin, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, Cellulose acetate phthalate, hydroxypropyl cellulose phthalate. 如申請專利範圍第1項所述之膠囊結構,其中該保護層之成分包含賦形劑、崩解劑、腸溶衣、黏合劑、稀釋劑、包覆劑、潤脹劑、潤滑劑、調味劑、甜味劑、增溶劑。 The capsule structure according to claim 1, wherein the protective layer component comprises an excipient, a disintegrating agent, an enteric coating, a binder, a diluent, a coating agent, a swelling agent, a lubricant, and a seasoning. Agent, sweetener, solubilizer. 如申請專利範圍第3項所述之膠囊結構,其中該賦形劑之成分包含乳糖、蔗糖、甘露醇、山梨醇、玉米澱粉、小麥澱粉、稻米澱粉、馬鈴薯澱粉、明膠、黃蓍膠。 The capsule structure of claim 3, wherein the component of the excipient comprises lactose, sucrose, mannitol, sorbitol, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth. 如申請專利範圍第1項所述之膠囊結構,其中該核心包含從牛樟芝子實體中製成之牛樟芝粉末。 The capsule structure of claim 1, wherein the core comprises anthraquinone powder prepared from a body of A. nigra.
TW102220997U 2013-11-08 2013-11-08 Antrodia cinnamomea powder capsule structure for suppressing hepatitis B virus TWM478489U (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113795258A (en) * 2019-02-25 2021-12-14 吉亚生技控股股份有限公司 Methods and compositions for inhibiting viral infection

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113795258A (en) * 2019-02-25 2021-12-14 吉亚生技控股股份有限公司 Methods and compositions for inhibiting viral infection
CN113795258B (en) * 2019-02-25 2024-04-16 吉亚生技控股股份有限公司 Methods and compositions for inhibiting viral infection

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