TWM478447U - Antrodia cinnamomea powder capsule structure having assisting anticancer drug - Google Patents

Antrodia cinnamomea powder capsule structure having assisting anticancer drug Download PDF

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TWM478447U
TWM478447U TW102220963U TW102220963U TWM478447U TW M478447 U TWM478447 U TW M478447U TW 102220963 U TW102220963 U TW 102220963U TW 102220963 U TW102220963 U TW 102220963U TW M478447 U TWM478447 U TW M478447U
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capsule
capsule structure
protective layer
core
anticancer drug
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TW102220963U
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Chinese (zh)
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Chin-Yuan Chan
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Miyuan Biotech Co Ltd
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Description

一種具有輔助抗癌藥物之牛樟芝粉末膠囊結構A capsule structure of Antrodia camphorata with auxiliary anticancer drugs

本創作係關於一種可包埋粉末之膠囊結構的技術領域。This creation relates to the technical field of a capsule structure that can embed powder.

牛樟芝(Antrodia camphorata),又稱樟芝或牛樟菇等,於分類學上屬於真菌界(Fungi)、擔子菌門(Basidiomycota)、擔子菌亞門(Basidiomycotina)、同擔子菌綱(Homobasidiomycetes)、無褶菌目(Aphyllophorales)、多孔菌科(Polyporaceae)、薄孔菌屬(Antrodia)。牛樟芝子實體生長於台灣保育類牛樟樹(Cinnamoum kanehirai Hay)之心材內壁,週邊向內彎曲,能分解木材之纖維素而造成木頭腐朽,為木頭腐朽菌。野生牛樟芝生長環境均屬於幽暗、潮濕且溫度較低之中海拔地區,特別是野生牛樟芝生長緩慢,因此產生子實體需要相當長的時間。由於牛樟樹為保育類樹種且分布數量極為稀少,再加上人為的盜採,使得野生牛樟芝數量相當稀少,使得牛樟芝價格昂貴,所以具有「森林中的紅寶石」之美稱。Antrodia camphorata, also known as Antrodia camphorata or Burdock mushroom, belongs to the fungi community (Fungi), Basidiomycota, Basidiomycotina, Homobasidiomycetes, and taxonomy. Aphyllophorales, Polyporaceae, Antrodia. The body of the burdock is grown on the inner wall of the heartwood of the Cinnamoum kanehirai Hay in Taiwan. The periphery is curved inward and can decompose the cellulose of the wood and cause the wood to decay. It is a decaying wood. The growth environment of wild Antrodia camphorata belongs to the dark, humid and low temperature middle altitude areas, especially the wild Antrodia camphora grows slowly, so it takes a long time to produce fruiting bodies. Because burdock is a kind of conservation tree species and the distribution is extremely rare, coupled with artificial piracy, the number of wild burdock is quite rare, making the burdock an expensive price, so it has the reputation of "the ruby in the forest".

牛樟芝子實體為多年生,無柄且為木栓質至木質,具有濃厚的樟樹香氣,形態多變,有板狀、鐘狀、馬蹄狀或塔狀,緊貼於木材表面,菇體表面孔狀,初生時鮮紅色,隨著生長逐變為乳白色、淡紅褐色、淡褐色或淡黃褐色,週邊常呈放射狀,並往四週擴展生長,呈半圓狀或不規則 形。The body of Ox sylvestris is perennial, sessile and cork-to-wood. It has a strong aroma of eucalyptus and has a variety of shapes. It has a plate shape, a bell shape, a horseshoe shape or a tower shape. It is close to the surface of the wood and has a pore shape on the surface of the mushroom. It is bright red at birth, and becomes milky white, reddish brown, light brown or yellowish brown with growth. The periphery is often radial and grows to the periphery, showing a semicircular or irregular shape. shape.

有些牛樟芝的種類被發現具有藥理活性,在台灣民俗醫學療法上,牛樟芝子實體被認為具有某些醫藥功效,將該子實體細磨成乾燥粉末或以熬煮方式口服,為民間流傳具療效的食藥菇類,可通過調節免疫功能,抑制腫瘤的浸潤和轉移,並具輔助抗癌藥物之作用等活性。Some species of Antrodia camphorata have been found to have pharmacological activity. In Taiwan folk medicine therapy, the body of A. sylvestris is considered to have certain medical effects. The fruiting body is finely ground into a dry powder or taken orally in a boiled way, which is effective for folk circulation. The edible mushroom can inhibit the infiltration and metastasis of the tumor by regulating the immune function, and has the activity of assisting the anticancer drug.

營養支持對於接受癌症治療的病人非常重要。透過營養素與臨床抗癌藥物的交互作用,營養素可能具有輔助或抑制藥物的效用,可能提高或降低癌症病人的治療效率,因此營養素的建議攝取對於藥物治療的效果有重要的角色。Nutritional support is very important for patients receiving cancer treatment. Through the interaction of nutrients with clinical anticancer drugs, nutrients may have the effect of assisting or inhibiting drugs, which may increase or decrease the therapeutic efficiency of cancer patients. Therefore, the recommended intake of nutrients plays an important role in the effect of drug treatment.

癌症在治療方法上除手術外,還有化學治療與放射線治療。化學治療藥物中包含鉑金屬化合物,如:cisplatin、carboplatin與oxaliplatin等。但化學治療藥物容易產生副作用,如:腎毒性、神經毒性、噁心嘔吐等,造成病患身體不適。為解決目前抗癌用藥抗藥性及副作用的困境,藉由牛樟芝的輔助去降低新穎化合物或臨床藥物的使用劑量,進而解決困境。In addition to surgery, cancer has chemotherapy and radiation therapy. Platinum metal compounds such as cisplatin, carboplatin and oxaliplatin are included in the chemotherapeutic drugs. However, chemotherapeutic drugs are prone to side effects such as nephrotoxicity, neurotoxicity, nausea and vomiting, which cause the patient to feel unwell. In order to solve the current predicament of anti-cancer drug resistance and side effects, the use of Niobium Oxide to reduce the dosage of novel compounds or clinical drugs, thereby solving the dilemma.

一個好的化學治療計劃是根據癌症的特性、病患的身心狀況以及癌症治療的既往史,配合適當的抗癌藥物組合之選擇來治療癌症。這些藥物可以經由口服、肌肉注射,或者由靜脈點滴注射等方式給予,來達到治療癌症的目的。A good chemotherapeutic plan is to treat cancer based on the characteristics of the cancer, the physical and mental condition of the patient, and the history of cancer treatment, combined with the appropriate combination of anticancer drugs. These drugs can be administered orally, intramuscularly, or by intravenous drip injection to achieve the purpose of treating cancer.

而抗癌藥物有如刀的兩面,同樣會影響體內正常組織,所以也會作用於體內中任何正常生長的細胞,例如體內的骨髓、腸胃道、生殖系統和毛囊等器官均會受到影響,不過這些組織在治療結束後很快就會恢復正常了。Anticancer drugs, like the two sides of the knife, also affect the normal tissues in the body, so they also act on any normal growing cells in the body, such as the bone marrow, gastrointestinal tract, reproductive system and hair follicles in the body will be affected, but these The tissue will return to normal soon after the treatment is over.

牛樟芝富含之多醣體可以促進補體(由蛋白質所構成的系統,這些蛋白質中許多是酵素的前身),活化補體,讓補體蛋白的功能變強,然後直接去攻擊癌細胞,進而達到輔助抗癌藥物的功效,對於癌症患者無非是一大幫助。The polysaccharide rich in burdock can promote complement (a system composed of proteins, many of which are the precursors of enzymes), activate complement, make the function of complement protein stronger, and then directly attack cancer cells to achieve anti-cancer. The efficacy of the drug is nothing but a help for cancer patients.

由此,本案創作人鑑於上述衍生之缺失,乃亟思加以改良創新,除了研發一牛樟芝粉末,其中之活性成分具有輔助抗癌藥物作用;此外,搭配本創作之膠囊結構,可供使用者易於攝取足夠之牛樟芝粉末,並藉此輔助抗癌藥物。是故,提出本件『一種具有輔助抗癌藥物之牛樟芝粉末膠囊結構』。Therefore, in view of the above-mentioned lack of the above-mentioned derivatives, the creators of this case have improved and innovated, in addition to the development of a burdock powder, the active ingredients of which have the function of assisting anticancer drugs; in addition, with the capsule structure of the creation, it is easy for the user to use. Ingest enough of Antrodia camphorata powder to supplement anticancer drugs. Therefore, this article "a structure of an anthraquinone powder capsule with an auxiliary anticancer drug" is proposed.

本創作之目的即在於提供一種具有輔助抗癌藥物之牛樟芝粉末膠囊結構。The purpose of the present invention is to provide a structure of an Antrodia camphora powder capsule having an auxiliary anticancer drug.

本創作之次一目的在於提供一種膠囊結構,以使其中之牛樟芝粉末之活性成分得以於服用者體內發揮其輔助抗癌藥物之效用。A second objective of the present invention is to provide a capsule structure in which the active ingredient of the Antrodia camphorata powder can exert its anti-cancer effect in the body of the user.

可達成上述創作目的之一種具有輔助抗癌藥物之牛樟芝粉末膠囊結構,包括:一囊殼、一保護層、及一核心;該核心係被該保護層所披覆,該保護層再以一囊殼包覆之。The invention relates to a structure of an Antrodia camphora powder capsule having an auxiliary anticancer drug, comprising: a capsule shell, a protective layer, and a core; the core layer is covered by the protective layer, and the protective layer is further a capsule Covered with shells.

本創作所提供之牛樟芝粉末膠囊結構,除了可供內含之樟芝粉末(及其活性成分)得以被長時間保存外;此外,其核心所含之牛樟芝粉末(及其活性成分)亦可輔助抗癌藥物。本創作提供之膠囊結構可易於使使用者服用,因此,除可用於日常保健外,亦可搭配其他療程一併使用 之。The structure of the Antrodia camphorata powder capsule provided by the present invention can be preserved for a long time in addition to the contained Antrodia camphorata powder (and its active ingredient); in addition, the core of the Antrodia camphorata powder (and its active ingredient) can also be assisted. Anti-cancer drugs. The capsule structure provided by this creation can be easily taken by the user, so that it can be used in combination with other treatments in addition to daily health care. It.

1‧‧‧膠囊結構1‧‧‧Capsule structure

11‧‧‧囊殼11‧‧‧ capsule

12‧‧‧保護層12‧‧‧Protective layer

13‧‧‧核心13‧‧‧ core

圖一為一種具有輔助抗癌藥物之牛樟芝粉末膠囊結構的剖面圖。Figure 1 is a cross-sectional view showing the structure of an Antrodia camphora powder capsule having an auxiliary anticancer drug.

本創作係提供一種具有輔助抗癌藥物之牛樟芝粉末膠囊結構,根據本創作詳細說明之,並請參閱第一圖說明。This creation provides a structure of an Antrodia camphora powder capsule with an auxiliary anticancer drug, which is described in detail in accordance with this creation, and please refer to the first figure.

本創作之輔助抗癌藥物之牛樟芝粉末膠囊結構1,由外至內依序包括:一囊殼11、一保護層12、及一核心13;該核心13係被該保護層12所披覆,除了可用以阻隔外界環境與該核心13之間的氧化作用外,亦可用以保護核心13中之牛樟芝活性成分不受胃酸等因素所破壞。另,該保護層12再以一囊殼11包覆,以保護核心13及保護層12免於受物理性因子(如:重壓、尖刺等)之破壞。The auxiliary anticancer drug of the present invention comprises a capsule 1 structure comprising, from the outside to the inside, a capsule 11, a protective layer 12, and a core 13; the core 13 is covered by the protective layer 12. In addition to being used to block the oxidation between the external environment and the core 13, it can also be used to protect the active ingredient of the Antrodia camphorata in the core 13 from being damaged by factors such as gastric acid. In addition, the protective layer 12 is further covered by a capsule 11 to protect the core 13 and the protective layer 12 from physical factors such as heavy pressure, spikes, and the like.

其中該囊殼11所用之成分包含但不限於:明膠(吉利丁(Gelatin))、甲基纖維素(Methyl cellulose)、羥丙基甲基纖維素(Hydroxymethyl propyl cellulose)、羥丙基纖維素(Hydroxymethyl propyl cellulose)、聚乙烯醇(Polyvinyl alcohol)、聚乙烯吡咯酮(Polyvinyl pyrrolidone)、鄰苯二甲酸醋酸纖維素(Cellulose acetate phthalate)、鄰苯二甲酸羥丙基纖維素(Hydroxypropyl methylcellulose phthalate)或其它適用於本創作的材料;其中該明膠可包含動物性明膠(由魚皮、豬皮等動物性來源所製成)及植物性明膠(如:羥丙 基甲基纖維素(HPMC))。The components used in the capsule 11 include, but are not limited to, gelatin (Gelatin), Methyl cellulose, Hydroxymethyl propyl cellulose, Hydroxypropyl cellulose ( Hydroxymethyl propyl cellulose), polyvinyl alcohol, polyvinyl pyrrolidone, Cellulose acetate phthalate, Hydroxypropyl methyl phthalate or Other materials suitable for the present invention; wherein the gelatin may comprise animal gelatin (made from animal sources such as fish skin, pig skin, etc.) and vegetable gelatin (eg: hydroxypropyl) Methyl cellulose (HPMC)).

其中該保護層12之可包含但不限於:賦形劑、崩解劑、腸溶衣、黏合劑、稀釋劑、包覆劑、潤脹劑、潤滑劑、調味劑、甜味劑、增溶劑、或其之任意組合。The protective layer 12 may include, but is not limited to, an excipient, a disintegrant, an enteric coating, a binder, a diluent, a coating agent, a swelling agent, a lubricant, a flavoring agent, a sweetener, a solubilizing agent. Or any combination thereof.

其中,如賦形劑可為糖類,包括乳糖、蔗糖、甘露醇、山梨醇;纖維素製備物像是,例如,玉米澱粉、小麥澱粉、稻米澱粉、馬鈴薯澱粉、明膠、黃蓍膠等或其他適用本創作之材料;其可用以增加口感、支撐整體之結構、及保護核心13。Wherein, the excipient may be a sugar, including lactose, sucrose, mannitol, sorbitol; the cellulose preparation is, for example, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, etc. or other Materials suitable for this creation; they can be used to increase the mouthfeel, support the overall structure, and protect the core 13.

其中該核心13中包含牛樟芝粉末(活性物質),其可用以輔助抗癌藥物。該牛樟芝粉末可從牛樟芝子實體中製成。The core 13 contains an Antrodia camphora powder (active substance) which can be used to assist an anticancer drug. The Antrodia camphorata powder can be made from the fruit body of Antrodia camphorata.

上述膠囊結構1亦可視需要適宜地添加一或多種以上該領域通常會使用的保存劑、著色劑、香料及風味劑或其它適用於本創作的添加物,以使其賦形、保存、上色、增添風味。The above-mentioned capsule structure 1 may also be suitably added with one or more kinds of preservatives, colorants, flavors and flavors or other additives suitable for the present invention which are commonly used in the field, so as to shape, preserve and color. Add flavor.

上述粉末膠囊結構可藉由製備於膠囊內以供口服外,亦可直接服用、或藉由其他適用本創作之形式服用。The above powder capsule structure can be prepared by taking it in a capsule for oral administration, or by taking it directly or by other forms suitable for the present invention.

上列詳細說明係針對本創作之一可行實施方式之具體說明,惟該實施例並非用以限制本創作之專利範圍,凡未脫離本創作技藝精神所為之等效實施或變更,均應包含於本案之專利範圍中。The detailed description above is a detailed description of one of the possible implementations of the present invention, but the embodiment is not intended to limit the scope of the patents of the present invention, and equivalent implementations or modifications that are not departing from the spirit of the present invention should be included in The patent scope of this case.

綜上所述,本案所揭露之技術特徵已充分符合新穎性、進步性及產業利用性之法定專利要件,爰依法提出申請,懇請 貴局核准本件新型專利申請案,以勵發明,至感德便。In summary, the technical features disclosed in this case have fully met the statutory patent requirements for novelty, advancement and industrial applicability. If you apply in accordance with the law, you are requested to approve the new patent application for your invention. Will.

1‧‧‧膠囊結構1‧‧‧Capsule structure

11‧‧‧囊殼11‧‧‧ capsule

12‧‧‧保護層12‧‧‧Protective layer

13‧‧‧核心13‧‧‧ core

Claims (5)

一種具有輔助抗癌藥物之牛樟芝粉末膠囊結構,由外至內依序包含:一囊殼、一保護層、及一核心;該核心係被該保護層所披覆,該保護層再以一囊殼包覆之。 An Anthocyanin powder capsule structure having an auxiliary anticancer drug, comprising: a capsule shell, a protective layer, and a core from the outside to the inside; the core layer is covered by the protective layer, and the protective layer is further a capsule Covered with shells. 如申請專利範圍第1項所述之膠囊結構,其中該囊殼之成分包含明膠、甲基纖維素、羥丙基甲基纖維素、羥丙基纖維素、聚乙烯醇、聚乙烯吡咯酮、鄰苯二甲酸醋酸纖維素、鄰苯二甲酸羥丙基纖維素。 The capsule structure according to claim 1, wherein the composition of the capsule comprises gelatin, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, Cellulose acetate phthalate, hydroxypropyl cellulose phthalate. 如申請專利範圍第1項所述之膠囊結構,其中該保護層之成分包含賦形劑、崩解劑、腸溶衣、黏合劑、稀釋劑、包覆劑、潤脹劑、潤滑劑、調味劑、甜味劑、增溶劑。 The capsule structure according to claim 1, wherein the protective layer component comprises an excipient, a disintegrating agent, an enteric coating, a binder, a diluent, a coating agent, a swelling agent, a lubricant, and a seasoning. Agent, sweetener, solubilizer. 如申請專利範圍第3項所述之膠囊結構,其中該賦形劑之成分包含乳糖、蔗糖、甘露醇、山梨醇、玉米澱粉、小麥澱粉、稻米澱粉、馬鈴薯澱粉、明膠、黃蓍膠。 The capsule structure of claim 3, wherein the component of the excipient comprises lactose, sucrose, mannitol, sorbitol, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth. 如申請專利範圍第1項所述之膠囊結構,其中該核心包含從牛樟芝子實體中製成之牛樟芝粉末。 The capsule structure of claim 1, wherein the core comprises anthraquinone powder prepared from a body of A. nigra.
TW102220963U 2013-11-08 2013-11-08 Antrodia cinnamomea powder capsule structure having assisting anticancer drug TWM478447U (en)

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