TWM478485U - Antrodia camphorate powder capsule structure for inducing reversion and apoptosis of cancer cells - Google Patents

Antrodia camphorate powder capsule structure for inducing reversion and apoptosis of cancer cells Download PDF

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TWM478485U
TWM478485U TW102220986U TW102220986U TWM478485U TW M478485 U TWM478485 U TW M478485U TW 102220986 U TW102220986 U TW 102220986U TW 102220986 U TW102220986 U TW 102220986U TW M478485 U TWM478485 U TW M478485U
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capsule
apoptosis
protective layer
cancer cells
core
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TW102220986U
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Chinese (zh)
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Chin-Yuan Chan
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Miyuan Biotech Co Ltd
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一種誘導癌細胞逆轉及凋亡之牛樟芝粉末膠囊結構A capsule structure of Antrodia camphorata which induces the reversal and apoptosis of cancer cells

本創作係關於一種可包埋粉末之膠囊結構的技術領域。This creation relates to the technical field of a capsule structure that can embed powder.

牛樟芝(Antrodia camphorata),又稱樟芝或牛樟菇等,於分類學上屬於真菌界(Fungi)、擔子菌門(Basidiomycota)、擔子菌亞門(Basidiomycotina)、同擔子菌綱(Homobasidiomycetes)、無褶菌目(Aphyllophorales)、多孔菌科(Polyporaceae)、薄孔菌屬(Antrodia)。牛樟芝子實體生長於台灣保育類牛樟樹(Cinnamoum kanehirai Hay)之心材內壁,週邊向內彎曲,能分解木材之纖維素而造成木頭腐朽,為木頭腐朽菌。野生牛樟芝生長環境均屬於幽暗、潮濕且溫度較低之中海拔地區,特別是野生牛樟芝生長緩慢,因此產生子實體需要相當長的時間。由於牛樟樹為保育類樹種且分布數量極為稀少,再加上人為的盜採,使得野生牛樟芝數量相當稀少,使得牛樟芝價格昂貴,所以具有「森林中的紅寶石」之美稱。Antrodia camphorata, also known as Antrodia camphorata or Burdock mushroom, belongs to the fungi community (Fungi), Basidiomycota, Basidiomycotina, Homobasidiomycetes, and taxonomy. Aphyllophorales, Polyporaceae, Antrodia. The body of the burdock is grown on the inner wall of the heartwood of the Cinnamoum kanehirai Hay in Taiwan. The periphery is curved inward and can decompose the cellulose of the wood and cause the wood to decay. It is a decaying wood. The growth environment of wild Antrodia camphorata belongs to the dark, humid and low temperature middle altitude areas, especially the wild Antrodia camphora grows slowly, so it takes a long time to produce fruiting bodies. Because burdock is a kind of conservation tree species and the distribution is extremely rare, coupled with artificial piracy, the number of wild burdock is quite rare, making the burdock an expensive price, so it has the reputation of "the ruby in the forest".

牛樟芝子實體為多年生,無柄且為木栓質至木質,具有濃厚的樟樹香氣,形態多變,有板狀、鐘狀、馬蹄狀或塔狀,緊貼於木材表面,菇體表面孔狀,初生時鮮紅色,隨著生長逐變為乳白色、淡紅褐色、淡褐色或淡黃褐色,週邊常呈放射狀,並往四週擴展生長,呈半圓狀或不規則 形。The body of Ox sylvestris is perennial, sessile and cork-to-wood. It has a strong aroma of eucalyptus and has a variety of shapes. It has a plate shape, a bell shape, a horseshoe shape or a tower shape. It is close to the surface of the wood and has a pore shape on the surface of the mushroom. It is bright red at birth, and becomes milky white, reddish brown, light brown or yellowish brown with growth. The periphery is often radial and grows to the periphery, showing a semicircular or irregular shape. shape.

有些牛樟芝的種類被發現具有藥理活性,在台灣民俗醫學療法上,牛樟芝子實體被認為具有某些醫藥功效,將該子實體細磨成乾燥粉末或以熬煮方式口服,為民間流傳具療效的食藥菇類,可通過調節免疫功能,抑制腫瘤的浸潤和轉移,且具有誘導癌細胞逆轉及凋亡的活性。Some species of Antrodia camphorata have been found to have pharmacological activity. In Taiwan folk medicine therapy, the body of A. sylvestris is considered to have certain medical effects. The fruiting body is finely ground into a dry powder or taken orally in a boiled way, which is effective for folk circulation. The edible mushroom can inhibit the invasion and metastasis of the tumor by regulating the immune function, and has the activity of inducing the reversal and apoptosis of the cancer cells.

儘管醫學發達日新月異,但是癌症的治療一直到現在還是以化學治療、放射治療及手術治療為主。化療及放療以「殲滅癌細胞」為唯一目標;手術則以「把癌細胞拿乾淨」為目的。這些治療往往令病人苦不堪言。Despite the rapid development of medicine, the treatment of cancer has been dominated by chemotherapy, radiation therapy and surgery. Chemotherapy and radiotherapy are the only targets for "killing cancer cells"; the surgery is aimed at "cleaning cancer cells." These treatments often make patients miserable.

報廢淘汰受傷害的細胞的確是生物體內一個重要功能。細胞凋亡(Apoptosis)是指細胞在一定的生理或病理條件下啟動內在程序,主動結束自己生命自我毀滅的過程。健康的細胞有在「出問題的時候自我毀滅」的功能,但癌細胞沒有這項功能,所以最後發展成惡性腫瘤。The elimination of damaged cells is indeed an important function in the body. Apoptosis refers to the process by which a cell initiates an internal procedure under certain physiological or pathological conditions and actively ends its own life and self-destruction. Healthy cells have the function of "self-destruction when problems occur," but cancer cells do not have this function, so they eventually develop into malignant tumors.

癌細胞經由使凋亡機制失調,而讓自己能在惡劣環境中存活下來。有些癌症對化學治療、放射治療、內分泌療法無效,常是因為其凋亡機制的異常使得臨牀療效不彰。若能在目前傳統治療方式加上誘導癌細胞凋亡的治療,通過修復這種缺陷,重建凋亡通路,使癌細胞是在分化誘導劑作用下發生逆轉而演變成正常細胞的。這種癌細胞的逆轉不產生任何毒副作用,是腫瘤生物治療學的一個新領域。Cancer cells allow themselves to survive in harsh environments by dysregulating the mechanisms of apoptosis. Some cancers are ineffective for chemotherapy, radiation therapy, and endocrine therapy, often because of the abnormal mechanism of apoptosis that makes clinical efficacy less. If the current treatment is combined with the treatment of inducing apoptosis of cancer cells, by repairing this defect, the apoptotic pathway is reconstituted, and the cancer cells are reversed by the differentiation inducer and evolve into normal cells. This reversal of cancer cells does not produce any toxic side effects and is a new field of tumor biotherapeutics.

細胞凋亡原理的治療,不能單獨使用,仍必須搭配治癌的三大療程來進行,這樣,它會是更有加分的治療。The treatment of the principle of apoptosis cannot be used alone, and it must be carried out in conjunction with the three major courses of cancer treatment, so that it will be a more extravagant treatment.

由此,本案創作人鑑於上述衍生之缺失,乃亟思加以改良創 新,除了研發一牛樟芝粉末,其中之活性成分具有誘導癌細胞逆轉及凋亡;此外,搭配本創作之膠囊結構,可供使用者易於攝取足夠之牛樟芝粉末,並藉此誘導癌細胞逆轉及凋亡。是故,提出本件『一種誘導癌細胞逆轉及凋亡之牛樟芝粉末膠囊結構』。Therefore, the creators of this case, in view of the above-mentioned lack of derivative, In addition to the development of a burdock powder, the active ingredient has the effect of inducing cancer cell reversal and apoptosis; in addition, with the capsule structure of the creation, the user can easily ingest enough of the burdock powder, and thereby induce the cancer cell to reverse and wither Die. Therefore, this article "a structure of a capsule of Astragalus membranaceus that induces the reversal and apoptosis of cancer cells" is proposed.

本創作之目的即在於提供一種誘導癌細胞逆轉及凋亡之牛樟芝粉末膠囊結構。The purpose of the present invention is to provide a capsule structure of Antrodia camphorata which induces the reversal and apoptosis of cancer cells.

本創作之次一目的在於提供一種膠囊結構,以使其中之牛樟芝粉末之活性成分得以於服用者體內發揮其誘導癌細胞逆轉及凋亡之效用。A second object of the present invention is to provide a capsule structure in which the active ingredient of the Antrodia camphorata powder can exert its effect of inducing cancer cell reversal and apoptosis in a user.

可達成上述創作目的之一種誘導癌細胞逆轉及凋亡之牛樟芝粉末膠囊結構,包括:一囊殼、一保護層、及一核心;該核心係被該保護層所披覆,該保護層再以一囊殼包覆之。The invention relates to a structure of an Antrodia camphorata powder capsule for inducing cancer cell reversal and apoptosis, comprising: a capsule shell, a protective layer, and a core; the core layer is covered by the protective layer, and the protective layer is further Covered by a capsule.

本創作所提供之牛樟芝粉末膠囊結構,除了可供內含之牛樟芝粉末(及其活性成分)得以被長時間保存外;此外,其核心所含之牛樟芝粉末(及其活性成分)亦可誘導癌細胞逆轉及凋亡。本創作提供之膠囊結構可易於使使用者服用,因此,除可用於日常保健外,亦可搭配其他療程一併使用之。The structure of the Antrodia camphorata powder capsule provided by the present invention can be preserved for a long time in addition to the contained Antrodia camphorata powder (and its active ingredient); in addition, the core of the Antrodia camphorata powder (and its active ingredient) can also induce cancer. Cell reversal and apoptosis. The capsule structure provided by this creation can be easily taken by the user, so that it can be used in combination with other treatments in addition to daily health care.

1‧‧‧膠囊結構1‧‧‧Capsule structure

11‧‧‧囊殼11‧‧‧ capsule

12‧‧‧保護層12‧‧‧Protective layer

13‧‧‧核心13‧‧‧ core

圖一為一種誘導癌細胞逆轉及凋亡之牛樟芝粉末膠囊結構 的剖面圖。Figure 1 shows the structure of A. angustifolia powder capsules that induce the reversal and apoptosis of cancer cells. Sectional view.

本創作係提供一種誘導癌細胞逆轉及凋亡之牛樟芝粉末膠囊結構,根據本創作詳細說明之,並請參閱第一圖說明。The present invention provides a structure of an Antrodia camphorata powder capsule which induces the reversal and apoptosis of cancer cells, and is described in detail according to the present creation, and please refer to the description of the first figure.

本創作之誘導癌細胞逆轉及凋亡之牛樟芝粉末膠囊結構1,由外至內依序包括:一囊殼11、一保護層12、及一核心13;該核心13係被該保護層12所披覆,除了可用以阻隔外界環境與該核心13之間的氧化作用外,亦可用以保護核心13中之牛樟芝活性成分不受胃酸等因素所破壞。另,該保護層12再以一囊殼11包覆,以保護核心13及保護層12免於受物理性因子(如:重壓、尖刺等)之破壞。The invention relates to the structure 1 of the A. angustifolia powder capsule which induces the reversal and apoptosis of the cancer cells, and includes, from the outside to the inside, a capsule shell 11, a protective layer 12, and a core 13; the core 13 is protected by the protective layer 12. The coating, in addition to blocking the oxidation between the external environment and the core 13, can also be used to protect the active ingredient of the Antrodia camphorata in the core 13 from being damaged by factors such as stomach acid. In addition, the protective layer 12 is further covered by a capsule 11 to protect the core 13 and the protective layer 12 from physical factors such as heavy pressure, spikes, and the like.

其中該囊殼11所用之成分包含但不限於:明膠(吉利丁(Gelatin))、甲基纖維素(Methyl cellulose)、羥丙基甲基纖維素(Hydroxymethyl propyl cellulose)、羥丙基纖維素(Hydroxymethyl propyl cellulose)、聚乙烯醇(Polyvinyl alcohol)、聚乙烯吡咯酮(Polyvinyl pyrrolidone)、鄰苯二甲酸醋酸纖維素(Cellulose acetate phthalate)、鄰苯二甲酸羥丙基纖維素(Hydroxypropyl methylcellulose phthalate)或其它適用於本創作的材料;其中該明膠可包含動物性明膠(由魚皮、豬皮等動物性來源所製成)及植物性明膠(如:羥丙基甲基纖維素(HPMC))。The components used in the capsule 11 include, but are not limited to, gelatin (Gelatin), Methyl cellulose, Hydroxymethyl propyl cellulose, Hydroxypropyl cellulose ( Hydroxymethyl propyl cellulose), polyvinyl alcohol, polyvinyl pyrrolidone, Cellulose acetate phthalate, Hydroxypropyl methyl phthalate or Other materials suitable for use in the present invention; wherein the gelatin may comprise animal gelatin (made from animal sources such as fish skin, pig skin, etc.) and vegetable gelatin (eg, hydroxypropyl methylcellulose (HPMC)).

其中該保護層12之可包含但不限於:賦形劑、崩解劑、腸溶衣、黏合劑、稀釋劑、包覆劑、潤脹劑、潤滑劑、調味劑、甜味劑、增溶劑、或其之任意組合。The protective layer 12 may include, but is not limited to, an excipient, a disintegrant, an enteric coating, a binder, a diluent, a coating agent, a swelling agent, a lubricant, a flavoring agent, a sweetener, a solubilizing agent. Or any combination thereof.

其中,如賦形劑可為糖類,包括乳糖、蔗糖、甘露醇、山梨醇;纖維素製備物像是,例如,玉米澱粉、小麥澱粉、稻米澱粉、馬鈴薯澱粉、明膠、黃蓍膠等或其他適用本創作之材料;其可用以增加口感、支撐整體之結構、及保護核心13。Wherein, the excipient may be a sugar, including lactose, sucrose, mannitol, sorbitol; the cellulose preparation is, for example, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, etc. or other Materials suitable for this creation; they can be used to increase the mouthfeel, support the overall structure, and protect the core 13.

其中該核心13中包含牛樟芝粉末(活性物質),其可用以誘導癌細胞逆轉及凋亡。該牛樟芝粉末可從牛樟芝子實體中製成。The core 13 contains an Antrodia camphorata powder (active substance) which can be used to induce cancer cell reversal and apoptosis. The Antrodia camphorata powder can be made from the fruit body of Antrodia camphorata.

上述膠囊結構1亦可視需要適宜地添加一或多種以上該領域通常會使用的保存劑、著色劑、香料及風味劑或其它適用於本創作的添加物,以使其賦形、保存、上色、增添風味。The above-mentioned capsule structure 1 may also be suitably added with one or more kinds of preservatives, colorants, flavors and flavors or other additives suitable for the present invention which are commonly used in the field, so as to shape, preserve and color. Add flavor.

上述粉末膠囊結構可藉由製備於膠囊內以供口服外,亦可直接服用、或藉由其他適用本創作之形式服用。The above powder capsule structure can be prepared by taking it in a capsule for oral administration, or by taking it directly or by other forms suitable for the present invention.

上列詳細說明係針對本創作之一可行實施方式之具體說明,惟該實施例並非用以限制本創作之專利範圍,凡未脫離本創作技藝精神所為之等效實施或變更,均應包含於本案之專利範圍中。The detailed description above is a detailed description of one of the possible implementations of the present invention, but the embodiment is not intended to limit the scope of the patents of the present invention, and equivalent implementations or modifications that are not departing from the spirit of the present invention should be included in The patent scope of this case.

綜上所述,本案所揭露之技術特徵已充分符合新穎性、進步性及產業利用性之法定專利要件,爰依法提出申請,懇請 貴局核准本件新型專利申請案,以勵發明,至感德便。In summary, the technical features disclosed in this case have fully met the statutory patent requirements for novelty, advancement and industrial applicability. If you apply in accordance with the law, you are requested to approve the new patent application for your invention. Will.

1‧‧‧膠囊結構1‧‧‧Capsule structure

11‧‧‧囊殼11‧‧‧ capsule

12‧‧‧保護層12‧‧‧Protective layer

13‧‧‧核心13‧‧‧ core

Claims (5)

一種誘導癌細胞逆轉及凋亡之牛樟芝粉末膠囊結構,由外至內依序包含:一囊殼、一保護層、及一核心;該核心係被該保護層所披覆,該保護層再以一囊殼包覆之。 A structure of a capsule of A. angustifolia which induces reversal and apoptosis of cancer cells, comprising: a capsule shell, a protective layer, and a core from the outside to the inside; the core layer is covered by the protective layer, and the protective layer is further Covered by a capsule. 如申請專利範圍第1項所述之膠囊結構,其中該囊殼之成分包含明膠、甲基纖維素、羥丙基甲基纖維素、羥丙基纖維素、聚乙烯醇、聚乙烯吡咯酮、鄰苯二甲酸醋酸纖維素、鄰苯二甲酸羥丙基纖維素。 The capsule structure according to claim 1, wherein the composition of the capsule comprises gelatin, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, Cellulose acetate phthalate, hydroxypropyl cellulose phthalate. 如申請專利範圍第1項所述之膠囊結構,其中該保護層之成分包含賦形劑、崩解劑、腸溶衣、黏合劑、稀釋劑、包覆劑、潤脹劑、潤滑劑、調味劑、甜味劑、增溶劑。 The capsule structure according to claim 1, wherein the protective layer component comprises an excipient, a disintegrating agent, an enteric coating, a binder, a diluent, a coating agent, a swelling agent, a lubricant, and a seasoning. Agent, sweetener, solubilizer. 如申請專利範圍第3項所述之膠囊結構,其中該賦形劑之成分包含乳糖、蔗糖、甘露醇、山梨醇、玉米澱粉、小麥澱粉、稻米澱粉、馬鈴薯澱粉、明膠、黃蓍膠。 The capsule structure of claim 3, wherein the component of the excipient comprises lactose, sucrose, mannitol, sorbitol, corn starch, wheat starch, rice starch, potato starch, gelatin, tragacanth. 如申請專利範圍第1項所述之膠囊結構,其中該核心包含從牛樟芝子實體中製成之牛樟芝粉末。The capsule structure of claim 1, wherein the core comprises anthraquinone powder prepared from a body of A. nigra.
TW102220986U 2013-11-08 2013-11-08 Antrodia camphorate powder capsule structure for inducing reversion and apoptosis of cancer cells TWM478485U (en)

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