TWM478465U - Embedding structure of Antrodia cinnamomea particle for promoting wound healing - Google Patents
Embedding structure of Antrodia cinnamomea particle for promoting wound healing Download PDFInfo
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- TWM478465U TWM478465U TW102223179U TW102223179U TWM478465U TW M478465 U TWM478465 U TW M478465U TW 102223179 U TW102223179 U TW 102223179U TW 102223179 U TW102223179 U TW 102223179U TW M478465 U TWM478465 U TW M478465U
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Description
本創作係關於一種可包埋多種顆粒之包埋結構的技術領域。This creation relates to a technical field in which an embedded structure of a plurality of particles can be embedded.
牛樟芝(Antrodia camphorata),又稱樟芝或牛樟菇等,於分類學上屬於真菌界(Fungi)、擔子菌門(Basidiomycota)、擔子菌亞門(Basidiomycotina)、同擔子菌綱(Homobasidiomycetes)、無褶菌目(Aphyllophorales)、多孔菌科(Polyporaceae)、薄孔菌屬(Antrodia)。Antrodia camphorata, also known as Antrodia camphorata or Burdock mushroom, belongs to the fungi community (Fungi), Basidiomycota, Basidiomycotina, Homobasidiomycetes, and taxonomy. Aphyllophorales, Polyporaceae, Antrodia.
牛樟芝子實體生長於台灣保育類牛樟樹(Cinnamoum kanehirai Hay)之心材內壁,週邊向內彎曲,能分解木材之纖維素而造成木頭腐朽,為木頭腐朽菌。野生牛樟芝生長環境均屬於幽暗、潮濕且溫度較低之中海拔地區,特別是野生牛樟芝生長緩慢,因此產生子實體需要相當長的時間。由於牛樟樹為保育類樹種且分布數量極為稀少,再加上人為的盜採,使得野生牛樟芝數量相當稀少,使得牛樟芝價格昂貴,所以具有「森林中的紅寶石」之美稱。The body of the burdock is grown on the inner wall of the heartwood of the Cinnamoum kanehirai Hay in Taiwan. The periphery is curved inward and can decompose the cellulose of the wood and cause the wood to decay. It is a decaying wood. The growth environment of wild Antrodia camphorata belongs to the dark, humid and low temperature middle altitude areas, especially the wild Antrodia camphora grows slowly, so it takes a long time to produce fruiting bodies. Because burdock is a kind of conservation tree species and the distribution is extremely rare, coupled with artificial piracy, the number of wild burdock is quite rare, making the burdock an expensive price, so it has the reputation of "the ruby in the forest".
牛樟芝子實體為多年生,無柄且為木栓質至木質,具有濃厚的樟樹香氣,形態多變,有板狀、鐘狀、馬蹄狀或塔狀,緊貼於木材表面,菇體表面孔狀,初生時鮮紅色,隨著生長逐變為乳白色、淡紅褐色、淡褐 色或淡黃褐色,週邊常呈放射狀,並往四週擴展生長,呈半圓狀或不規則形。The body of Ox sylvestris is perennial, sessile and cork-to-wood. It has a strong aroma of eucalyptus and has a variety of shapes. It has a plate shape, a bell shape, a horseshoe shape or a tower shape. It is close to the surface of the wood and has a pore shape on the surface of the mushroom. Fresh red at birth, with milky white, reddish brown, and light brown Color or yellowish brown, the periphery is often radial, and grows around, semi-circular or irregular.
牛樟芝經科學研究發現其成份含有多醣體(如葡聚醣)、三萜類化合物、超氧歧化酵素、腺苷、蛋白質(含免疫蛋白)、維生素類(如維生素B、菸鹼酸、麥角醇類)、微量元素(如鈣、磷、鍺)、核酸、凝集素、氨基酸、固醇類、木質素、血壓穩定物質等。Niuzhizhi has been scientifically discovered to contain polysaccharides (such as dextran), triterpenoids, superoxide dismutase, adenosine, protein (including immune proteins), vitamins (such as vitamin B, niacin, ergot). Alcohols), trace elements (such as calcium, phosphorus, strontium), nucleic acids, lectins, amino acids, sterols, lignin, blood pressure stabilizing substances, and the like.
。.
傷口的一般定義為因受傷或手術導致任何組織的連續性遭受破壞。廣泛性定義為身體組織結構或器官,遭受到破壞,如刀傷,手術傷口。狹義性定義:即指皮膚組織受損,大都需要醫療照護才會癒合的,如壓瘡。A general definition of a wound is the destruction of the continuity of any tissue due to injury or surgery. Extensively defined as the structure or organ of the body, suffering from damage, such as a knife wound, a surgical wound. Narrow definition: refers to the damage of skin tissue, most of which require medical care to heal, such as pressure sores.
傷口癒合是創傷後人體皮膚和表皮組織再生的自然過程。正常來說,皮膚的表皮和真皮存在於一個平衡的狀態,以形成一個保護傷口的屏障。Wound healing is a natural process of regeneration of human skin and epidermal tissue after trauma. Normally, the epidermis and dermis of the skin exist in a balanced state to form a barrier to protect the wound.
當皮膚受傷後,一套複雜的生化程序將修復其損傷。在受傷後的幾分鐘內,血小板將在創傷附近處形成纖維蛋白凝塊,以用作止血,正常的傷口癒合過程便會迅速地開始,其基本過程包括止血期、炎症期、增生期、成熟及重塑期。傷口癒合的時間拖的愈久,膠原蛋白堆積越多,疤痕增生及攣縮的機會也就越大。疤痕增生除了美觀上的問題,其肥厚的疤痕也會造成的癢痛及功能上的障礙。When the skin is injured, a complex biochemical procedure will repair the damage. Within a few minutes after the injury, the platelets will form a fibrin clot near the wound for use as a hemostasis, and the normal wound healing process will begin rapidly. The basic processes include hemostasis, inflammation, proliferative phase, and maturation. And remodeling period. The longer the wound healing time, the more collagen is accumulated, and the greater the chance of scar hyperplasia and contracture. In addition to aesthetic problems, scar hyperplasia can cause itching and functional disorders.
研究顯示,牛樟芝子實體包含多醣(30-50%)、三萜類(30%)、類固醇類、超氧化物歧化酶和氨基酸類。將牛樟芝子實體細磨成乾燥粉末 或以熬煮方式口服,為民間流傳具療效的食藥菇類。中醫臨床經驗發現,牛樟芝能促進傷口癒合。Studies have shown that the body complex of A. angustifolia contains polysaccharides (30-50%), triterpenoids (30%), steroids, superoxide dismutase and amino acids. Finely grind the body of A. angustifolia into a dry powder Or take it orally, and spread the curative effect of the mushroom for the folk. The clinical experience of traditional Chinese medicine found that Antrodia camphorata can promote wound healing.
因此,人們可透過攝取牛樟芝,來促進傷口癒合。然而,攝取之牛樟芝仍會因個人之消化吸收能力而受限,因此,如何提供人體足夠之牛樟芝,亦是研究藥物遞送方式之另一研究趨勢。Therefore, people can promote wound healing by ingesting Antrodia camphor. However, the intake of Antrodia camphorata is still limited by the individual's ability to digest and absorb. Therefore, how to provide enough Astragalus sinensis is another research trend in the study of drug delivery methods.
由此,本案創作人鑑於上述衍生之缺失,乃亟思加以改良創新,除了研發一可緩釋牛樟芝活性成分之包埋結構外,亦提供一可促進傷口癒合的牛樟芝活性成分;藉由搭配該結構,可供使用者易於攝取足夠之牛樟芝活性成分,並藉此促進傷口癒合。是故,提出本件『用以促進傷口癒合之牛樟芝顆粒包埋結構』。Therefore, in view of the above-mentioned lack of the above-mentioned derivatives, the creators of this case have improved and innovated. In addition to developing an embedding structure that can release the active ingredient of Antrodia camphorata, it also provides an active ingredient of Antrodia camphorata which can promote wound healing; The structure allows the user to easily ingest enough active ingredients of Antrodia camphorata to promote wound healing. Therefore, the article "Embedded structure of Antrodia camphorata granules to promote wound healing" was proposed.
本創作之目的即在於提供一種用以促進傷口癒合之牛樟芝顆粒包埋結構。The purpose of this creation is to provide a burdock granule embedding structure for promoting wound healing.
本創作之次一目的在於提供一種顆粒包埋結構,以使其中之牛樟芝活性成分得以於服用者體內發揮其促進傷口癒合之效用。A second objective of the present invention is to provide a granule-embedded structure in which the active ingredient of Antrodia camphorata can exert its effect of promoting wound healing in a user.
本創作之再一目的在於提供一種顆粒包埋結構,藉此包埋具有緩釋效果之成分,以於使用者體內緩釋活性成分A further object of the present invention is to provide a granule-embedded structure for embedding a component having a sustained release effect for sustained release of an active ingredient in a user.
可達成上述創作目的之用以促進傷口癒合之牛樟芝顆粒包埋結構,包括:一包衣層、一支撐層、一緩釋層、及牛樟芝顆粒;該包衣層係包覆於該支撐層上,該支撐層係包覆於該緩釋層上,且該牛樟芝顆粒係均勻包埋於緩釋層中。The invention relates to a burdock granule embedding structure for promoting wound healing, comprising: a coating layer, a supporting layer, a sustained-release layer, and an oregano granule; the coating layer is coated on the supporting layer The support layer is coated on the sustained release layer, and the Antrodia camphorata particles are uniformly embedded in the sustained release layer.
本創作所提供之牛樟芝顆粒包埋結構,除了可供內含之牛樟芝成分得以長時間被保存外;此外,其所含之緩釋成分亦可使牛樟芝成分得以於使用者體內緩慢釋放,藉此用以促進傷口癒合。也因如此,藉由該包埋結構之緩釋效果及保護活性成分之結構,可使使用者易於日常生活中服用,以達日常保健之效。The burdock granule embedding structure provided by the present invention can be stored for a long time in addition to the contained burdock ingredient, and the sustained release component contained therein can also slowly release the burdock ingredient in the user body. Used to promote wound healing. Because of this, the sustained release effect of the embedded structure and the structure of the protective active ingredient enable the user to take it in daily life for daily health care.
1‧‧‧顆粒包埋結構1‧‧‧particle embedded structure
11‧‧‧包衣層11‧‧‧coating layer
12‧‧‧支撐層12‧‧‧Support layer
13‧‧‧緩釋層13‧‧‧Slow release layer
14‧‧‧牛樟芝顆粒14‧‧‧Niuzhizhi Granules
圖一為一種用以促進傷口癒合之牛樟芝顆粒包埋結構的剖面圖。Figure 1 is a cross-sectional view of a burdock granule embedding structure for promoting wound healing.
本創作係提供一種用以促進傷口癒合之牛樟芝顆粒包埋結構,根據本創作詳細說明之,並請參閱第一圖說明。This creation provides a burdock granule embedding structure to promote wound healing, as detailed in this creation, and please refer to the first illustration.
本創作之用以促進傷口癒合之牛樟芝顆粒包埋結構1,由外至內依序包括:一包衣層11、一支撐層12、一緩釋層13、及牛樟芝顆粒14;該包衣層11係包覆於該支撐層12上,該支撐層12係包覆於該緩釋層13上,且該牛樟芝顆粒14係均勻包埋於緩釋層13中。The burdock granule embedding structure 1 for promoting wound healing comprises: a coating layer 11, a supporting layer 12, a sustained-release layer 13, and an oregano granule 14; the coating layer The 11 series is coated on the support layer 12, the support layer 12 is coated on the sustained release layer 13, and the Antrodia camphorata particles 14 are uniformly embedded in the sustained release layer 13.
其中該包衣層11所用之成分包含但不限於:甲基纖維素(Methyl cellulose)、羥丙基甲基纖維素(Hydroxymethyl propyl cellulose)、羥丙基纖維素(Hydroxymethyl propyl cellulose)、聚乙烯醇(Polyvinyl alcohol)、聚乙烯吡咯酮(Polyvinyl pyrrolidone)、鄰苯二甲酸醋酸纖維素(Cellulose acetate phthalate)、鄰苯二甲酸羥丙基纖維素(Hydroxypropyl methylcellulose phthalate)或其它適用於本創作的材料。The components used in the coating layer 11 include, but are not limited to, Methyl cellulose, Hydroxymethyl propyl cellulose, Hydroxymethyl propyl cellulose, Polyvinyl alcohol. (Polyvinyl alcohol), polyvinylpyrrolidone (Polyvinyl pyrrolidone), Cellulose acetate phthalate, Hydroxypropyl methylcellulose Phthalate) or other materials suitable for this creation.
其中該支撐層12之成分包含但不限於乳糖、甘露糖、水蘇糖、或其他適用本創作之材料;其可用以增加口感、支撐整體之結構。The components of the support layer 12 include, but are not limited to, lactose, mannose, stachyose, or other materials suitable for use in the present invention; they can be used to increase the mouthfeel and support the overall structure.
其中該緩釋層13所用之成分包含但不限於:纖維素、多醣體或其它適用於本創作的材料。The ingredients used in the sustained release layer 13 include, but are not limited to, cellulose, polysaccharides or other materials suitable for use in the present invention.
其中該牛樟芝顆粒14中所含之桑黃活性成分係包含但不限於:從牛樟芝子實體中所萃取之活性物質;其中所萃取之活性物質,經動物試驗發現,可有效促進傷口癒合。The active ingredient of the mulberry yellow contained in the burdock granule 14 includes, but is not limited to, an active substance extracted from the body of the burdock, and the active substance extracted therein is effectively tested by an animal to promote wound healing.
上述牛樟芝顆粒14亦可視需要適宜地添加一或多種以上該領域通常會使用的賦型劑、保存劑、著色劑、香料及風味劑或其它適用於本創作的添加物,以使其賦形、保存、上色、增添風味。The above Antrodia sinensis granules 14 may also be suitably added with one or more excipients, preservatives, colorants, flavors and flavors or other additives suitable for the present invention which are commonly used in the field, so as to be shaped, Save, color, and add flavor.
上述包埋結構可藉由製備於膠囊內以供口服外,亦可直接服用、或藉由其他適用本創作之形式服用。The above-described embedding structure can be prepared by taking it in a capsule for oral administration, or directly, or by other forms suitable for the present invention.
在本創作所指的『纖維素』意指天然纖維或無毒性的纖維(包含人造纖維);無毒性的纖維,意指對人體或動物體不會產生明顯毒害作用(例如噁心、暈眩、嘔吐、中毒等)的纖維,其中無毒性的人造纖維可為羧甲基纖維素或羧甲基幾丁聚醣或其類似物。"Cellulose" as used in this creation means natural fiber or non-toxic fiber (including rayon); non-toxic fiber means no obvious toxic effect on human or animal body (such as nausea, dizziness, The fiber of vomiting, poisoning, etc., wherein the non-toxic rayon may be carboxymethylcellulose or carboxymethyl chitosan or the like.
在本創作所指的『天然纖維』或『無毒人造纖維』意指不能被動物的消化酵素所水解的多醣類,在本創作中尤指植物性食物中不能被人類的消化酵素所水解的多醣類,該纖維對不具動物(包括人類)毒性或傷害。"Natural fiber" or "non-toxic rayon" as used in this creation means a polysaccharide that cannot be hydrolyzed by animal digestive enzymes. In this creation, especially in plant foods, it cannot be hydrolyzed by human digestive enzymes. A polysaccharide that is toxic or harmful to animals (including humans).
在本創作所指的『緩慢釋放』或『緩釋』或『緩釋配方』意 指在一定時間內,以穩定速率逐漸釋放活性物質的狀態或配方。緩慢釋放或緩釋狀態係可活性物質,在受試體(如動物體、人類)的體內或血液內維持一定濃度,以避免突然提高濃度所造成的不適。In the context of this creation, "slow release" or "slow release" or "slow release formula" means Refers to the state or formula of gradually releasing the active substance at a steady rate for a certain period of time. The slow release or sustained release state is an active substance which is maintained in a certain concentration in the body or blood of the test subject (such as an animal body, a human body) to avoid the uncomfort caused by a sudden increase in concentration.
上列詳細說明係針對本創作之一可行實施方式之具體說明,惟該實施例並非用以限制本創作之專利範圍,凡未脫離本創作技藝精神所為之等效實施或變更,均應包含於本案之專利範圍中。The detailed description above is a detailed description of one of the possible implementations of the present invention, but the embodiment is not intended to limit the scope of the patents of the present invention, and equivalent implementations or modifications that are not departing from the spirit of the present invention should be included in The patent scope of this case.
綜上所述,本案所揭露之技術特徵已充分符合新穎性、進步性及產業利用性之法定專利要件,爰依法提出申請,懇請 貴局核准本件新型專利申請案,以勵發明,至感德便。In summary, the technical features disclosed in this case have fully met the statutory patent requirements for novelty, advancement and industrial applicability. If you apply in accordance with the law, you are requested to approve the new patent application for your invention. Will.
1‧‧‧顆粒包埋結構1‧‧‧particle embedded structure
11‧‧‧包衣層11‧‧‧coating layer
12‧‧‧支撐層12‧‧‧Support layer
13‧‧‧緩釋層13‧‧‧Slow release layer
14‧‧‧牛樟芝顆粒14‧‧‧Niuzhizhi Granules
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TWI776389B (en) * | 2021-02-09 | 2022-09-01 | 元樟生物科技股份有限公司 | Hydrogel spray device and manufacturing method |
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TWI776389B (en) * | 2021-02-09 | 2022-09-01 | 元樟生物科技股份有限公司 | Hydrogel spray device and manufacturing method |
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