TWI900672B - 乙醯胺基－苯基四唑衍生物及其使用方法 - Google Patents
乙醯胺基－苯基四唑衍生物及其使用方法Info
- Publication number
- TWI900672B TWI900672B TW110137339A TW110137339A TWI900672B TW I900672 B TWI900672 B TW I900672B TW 110137339 A TW110137339 A TW 110137339A TW 110137339 A TW110137339 A TW 110137339A TW I900672 B TWI900672 B TW I900672B
- Authority
- TW
- Taiwan
- Prior art keywords
- heteroatoms selected
- alkyl
- membered
- alkenyl
- alkynyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063088788P | 2020-10-07 | 2020-10-07 | |
| US63/088,788 | 2020-10-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202233593A TW202233593A (zh) | 2022-09-01 |
| TWI900672B true TWI900672B (zh) | 2025-10-11 |
Family
ID=78483546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110137339A TWI900672B (zh) | 2020-10-07 | 2021-10-07 | 乙醯胺基－苯基四唑衍生物及其使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11739089B2 (enExample) |
| EP (1) | EP4225747A1 (enExample) |
| JP (2) | JP7823036B2 (enExample) |
| KR (1) | KR20230104151A (enExample) |
| CN (1) | CN116964044B (enExample) |
| AU (1) | AU2021358074A1 (enExample) |
| CA (1) | CA3194694A1 (enExample) |
| IL (1) | IL301516A (enExample) |
| MX (1) | MX2023003933A (enExample) |
| TW (1) | TWI900672B (enExample) |
| WO (1) | WO2022076663A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| CN110312130B (zh) * | 2019-06-25 | 2021-10-15 | 浙江大华技术股份有限公司 | 基于三角模式的帧间预测、视频编码方法及设备 |
| WO2022076663A1 (en) | 2020-10-07 | 2022-04-14 | Athenex, Inc. | Acetamido-phenyltetrazole derivatives and methods of using the same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005033097A1 (en) * | 2003-10-07 | 2005-04-14 | Hanmi Pharm. Co., Ltd. | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5663179A (en) | 1992-07-10 | 1997-09-02 | Laboratoires Glaxo Sa | Certain isoquinoline derivatives having anti-tumor properties |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| GB9717576D0 (en) | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
| KR101466245B1 (ko) * | 2010-01-15 | 2014-12-01 | 한미사이언스 주식회사 | 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 |
| KR101986683B1 (ko) * | 2012-12-13 | 2019-06-10 | 한미약품 주식회사 | 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체 |
| WO2015152433A1 (en) | 2014-03-31 | 2015-10-08 | Hanmi Pharm. Co., Ltd. | Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same |
| KR102293907B1 (ko) | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
| TWI715636B (zh) | 2015-09-30 | 2021-01-11 | 香港商慧源香港創新有限公司 | 口服紫杉烷組合物及方法 |
| TWI833710B (zh) | 2017-10-06 | 2024-03-01 | 香港商慧源香港創新有限公司 | 高單位含量口服型紫杉烷組合物及方法 |
| WO2022076663A1 (en) | 2020-10-07 | 2022-04-14 | Athenex, Inc. | Acetamido-phenyltetrazole derivatives and methods of using the same |
-
2021
- 2021-10-07 WO PCT/US2021/053937 patent/WO2022076663A1/en not_active Ceased
- 2021-10-07 MX MX2023003933A patent/MX2023003933A/es unknown
- 2021-10-07 US US17/495,935 patent/US11739089B2/en active Active
- 2021-10-07 CA CA3194694A patent/CA3194694A1/en active Pending
- 2021-10-07 IL IL301516A patent/IL301516A/en unknown
- 2021-10-07 CN CN202180079852.2A patent/CN116964044B/zh active Active
- 2021-10-07 AU AU2021358074A patent/AU2021358074A1/en active Pending
- 2021-10-07 TW TW110137339A patent/TWI900672B/zh active
- 2021-10-07 JP JP2023521299A patent/JP7823036B2/ja active Active
- 2021-10-07 KR KR1020237015140A patent/KR20230104151A/ko active Pending
- 2021-10-07 EP EP21801761.4A patent/EP4225747A1/en active Pending
-
2026
- 2026-02-18 JP JP2026024155A patent/JP2026090442A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005033097A1 (en) * | 2003-10-07 | 2005-04-14 | Hanmi Pharm. Co., Ltd. | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
Non-Patent Citations (1)
| Title |
|---|
| 期刊 Paek et al. Metabolism of a new P-glycoprotein inhibitor HM-30181 in rats using liquid chromatography/electrospray mass spectrometry Rapid Communications in Mass Spectrometry 20(9) 2006 1457-1462 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023544615A (ja) | 2023-10-24 |
| CN116964044B (zh) | 2026-03-06 |
| KR20230104151A (ko) | 2023-07-07 |
| US11739089B2 (en) | 2023-08-29 |
| AU2021358074A1 (en) | 2023-04-27 |
| MX2023003933A (es) | 2023-07-05 |
| CN116964044A (zh) | 2023-10-27 |
| IL301516A (en) | 2023-05-01 |
| CA3194694A1 (en) | 2022-04-14 |
| US20220106312A1 (en) | 2022-04-07 |
| TW202233593A (zh) | 2022-09-01 |
| JP7823036B2 (ja) | 2026-03-03 |
| EP4225747A1 (en) | 2023-08-16 |
| JP2026090442A (ja) | 2026-06-02 |
| WO2022076663A1 (en) | 2022-04-14 |
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