TWI881004B - 用於治療ｈｂｖ之靶向ｈｂｖ的治療性寡核苷酸及ｔｌｒ７促效劑之醫藥組合 - Google Patents

用於治療ｈｂｖ之靶向ｈｂｖ的治療性寡核苷酸及ｔｌｒ７促效劑之醫藥組合 Download PDF

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TWI881004B
TWI881004B TW109145408A TW109145408A TWI881004B TW I881004 B TWI881004 B TW I881004B TW 109145408 A TW109145408 A TW 109145408A TW 109145408 A TW109145408 A TW 109145408A TW I881004 B TWI881004 B TW I881004B
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oligonucleotide
administered
tlr7 agonist
therapeutic oligonucleotide
nucleotides
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TW109145408A
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Chinese (zh)
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TW202137987A (zh
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高璐
永红 朱
索倫 歐特森
翰瑞克 慕勒
周雪
弗朗索瓦 茱莉 伊麗莎白 布雷辛
金玉燕
卜擎燕
葛拉芙 提雅吉
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瑞士商赫孚孟拉羅股份公司
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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TW109145408A 2019-12-24 2020-12-22 用於治療ｈｂｖ之靶向ｈｂｖ的治療性寡核苷酸及ｔｌｒ７促效劑之醫藥組合 TWI881004B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
WOPCT/CN2019/127972 2019-12-24
CN2019127972 2019-12-24
CN2020107002 2020-08-05
WOPCT/CN2020/107002 2020-08-05

Publications (2)

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TW202137987A TW202137987A (zh) 2021-10-16
TWI881004B true TWI881004B (zh) 2025-04-21

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TW109145408A TWI881004B (zh) 2019-12-24 2020-12-22 用於治療ｈｂｖ之靶向ｈｂｖ的治療性寡核苷酸及ｔｌｒ７促效劑之醫藥組合

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US (1) US20230119360A1 (https=)
EP (1) EP4081639A1 (https=)
JP (2) JP2023509870A (https=)
CN (1) CN114846140A (https=)
AU (1) AU2020410993A1 (https=)
CA (1) CA3163490A1 (https=)
MX (1) MX2022007908A (https=)
TW (1) TWI881004B (https=)
WO (1) WO2021130266A1 (https=)

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