TWI875712B - 孟魯司特與肽的新共軛物 - Google Patents

孟魯司特與肽的新共軛物 Download PDF

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Publication number
TWI875712B
TWI875712B TW108133243A TW108133243A TWI875712B TW I875712 B TWI875712 B TW I875712B TW 108133243 A TW108133243 A TW 108133243A TW 108133243 A TW108133243 A TW 108133243A TW I875712 B TWI875712 B TW I875712B
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TW
Taiwan
Prior art keywords
peptide
containing compound
hyp
lys
pharmaceutically
Prior art date
Application number
TW108133243A
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English (en)
Chinese (zh)
Other versions
TW202023623A (zh
Inventor
班傑特 英格瑪 山謬森
顧銘
Original Assignee
大陸商江陰貝瑞森製藥有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW108133243A 2018-09-14 2019-09-16 孟魯司特與肽的新共軛物 TWI875712B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
WOPCT/CN2018/105703 2018-09-14
CN2018105703 2018-09-14
WOPCT/CN2018/119072 2018-12-04
CN2018119072 2018-12-04

Publications (2)

Publication Number Publication Date
TW202023623A TW202023623A (zh) 2020-07-01
TWI875712B true TWI875712B (zh) 2025-03-11

Family

ID=69777394

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108133243A TWI875712B (zh) 2018-09-14 2019-09-16 孟魯司特與肽的新共軛物

Country Status (27)

Country Link
US (2) US11680082B2 (https=)
EP (2) EP4253404A3 (https=)
JP (1) JP7759693B2 (https=)
KR (1) KR102946621B1 (https=)
CN (2) CN111601618A (https=)
AU (1) AU2019338582B2 (https=)
BR (1) BR112021004823A2 (https=)
CA (1) CA3112420A1 (https=)
DK (1) DK3678705T5 (https=)
ES (1) ES2956509T3 (https=)
FI (1) FI3678705T3 (https=)
HR (1) HRP20230946T1 (https=)
HU (1) HUE062848T2 (https=)
IL (1) IL281426A (https=)
LT (1) LT3678705T (https=)
MX (1) MX2021002657A (https=)
MY (1) MY205435A (https=)
PL (1) PL3678705T3 (https=)
PT (1) PT3678705T (https=)
RS (1) RS64436B1 (https=)
SA (1) SA521421448B1 (https=)
SG (1) SG11202102119RA (https=)
SI (1) SI3678705T1 (https=)
SM (1) SMT202300210T1 (https=)
TW (1) TWI875712B (https=)
WO (1) WO2020052677A1 (https=)
ZA (1) ZA202101398B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020000029A (es) * 2017-07-05 2020-08-06 Jiangyin Mucocare Pharmaceutical Co Ltd Formulaciones topicas que comprenden montelukast y combinaciones con proteinas adhesivas del mejillon.
MX2022003057A (es) * 2019-09-14 2022-06-16 Jiangyin Usun Pharmaceutical Co Ltd Nuevos peptidos.
CA3160167A1 (en) * 2019-12-02 2021-06-10 Ming Gu Peptides and their use in the treatment of inflammation
WO2021207606A1 (en) * 2020-04-10 2021-10-14 University Of Georgia Research Foundation, Inc. Methods for treatment of coronavirus infections
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
KR102596264B1 (ko) * 2020-11-30 2023-11-01 주식회사 바이오빛 기능성 펩티드가 결합된 생체적합 폴리펩티드를 포함하는 염증 질환의 억제용 조성물
US20240165247A1 (en) * 2021-03-17 2024-05-23 Jiangyin Usun Pharmaceutical Co., Ltd. New peptide conjugates
WO2022193186A1 (en) * 2021-03-17 2022-09-22 Jiangyin Usun Pharmaceutical Co., Ltd. New diagnostic and therapeutic agents
WO2023225107A1 (en) * 2022-05-17 2023-11-23 Emory University Diroximel fumarate, inhalation administration methods, pharmaceutical uses and compositions
EP4665372A1 (en) * 2023-02-13 2025-12-24 EnliTISA (Shanghai) Pharmaceutical Co., Ltd. New multi-functional oligopeptides
WO2024260465A1 (en) * 2023-06-22 2024-12-26 Enlitisa (Shanghai) Pharmaceutical Co., Ltd. New multi-functional oligopeptides
TW202535906A (zh) * 2023-10-23 2025-09-16 大陸商安利提沙（上海）製藥有限公司 新型短鏈肽及其衍生物
KR20250075990A (ko) * 2023-11-22 2025-05-29 한도숙 상처 치료 또는 피부 주름형성 억제용 조성물
WO2025195444A1 (en) 2024-03-20 2025-09-25 Enlitisa (Shanghai) Pharmaceutical Co., Ltd. New use of peptides derived from vasoactive intestinal peptide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200740441A (en) * 2005-06-17 2007-11-01 Combinatorx Inc Methods and reagents for the treatment of inflammatory disorders

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6669951B2 (en) 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
WO2003020200A2 (en) * 2000-11-16 2003-03-13 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
EP2316468A1 (en) * 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
PL374646A1 (en) 2002-07-08 2005-10-31 Pliva-Istrazivacki Institutt D.O.O. Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
US20050107612A1 (en) 2002-12-30 2005-05-19 Dr. Reddy's Laboratories Limited Process for preparation of montelukast and its salts
CA2522007A1 (en) * 2003-04-11 2004-10-28 Medimmune, Inc. Methods of preventing or treating respiratory conditions
JP4764818B2 (ja) * 2003-04-11 2011-09-07 メディミューン，エルエルシー 組換えｉｌ−９抗体およびその使用
CN101123878A (zh) 2003-07-29 2008-02-13 信号研发控股有限责任公司 氨基酸前药
US8173840B2 (en) 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
ES2337915T3 (es) 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
CA2773737C (en) * 2009-09-09 2021-11-16 Pharmain Corporation Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same
CN102068432A (zh) 2011-01-11 2011-05-25 李仲昆 一种由他定类和白三烯拮抗剂组成的外用复方组合物
WO2012112690A2 (en) * 2011-02-16 2012-08-23 Fabius Biotechnology Targeting of therapeutic drugs and diagnostic agents employing collagen binding domains
CN116898848A (zh) 2012-01-18 2023-10-20 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
WO2014164285A2 (en) * 2013-03-13 2014-10-09 Inflammatory Response Research, Inc. Use of levocetirizine and montelukast in the treatment of vasculitis
US20160060328A1 (en) * 2013-10-25 2016-03-03 Lpath, Inc. Compositions and methods for binding cysteinyl leukotrienes (cyslts) for treatment of disease
WO2016044095A1 (en) * 2014-09-15 2016-03-24 Inflammatory Response Research, Inc. Levocetirizine and montelukast in the treatment of inflammation mediated conditions
KR102468519B1 (ko) * 2015-07-20 2022-11-21 장인 벵트 아이. 사무엘손 인스티튜트 오브 라이프 사이언스 컴퍼니 리미티드 피부 염증의 억제에서의 홍합 접착 단백질 제품 및 이의 적용
BR112019024563A2 (pt) 2017-05-24 2020-06-23 Transfert Plus S.E.C. Compostos peptídicos, compostos conjugados e usos dos mesmos para tratar doenças inflamatórias
JP7198785B2 (ja) * 2017-07-05 2023-01-04 ジャンイン ユスン ファーマシューティカル カンパニー，リミテッド ペプチドの抗炎症的使用
MX2020000029A (es) * 2017-07-05 2020-08-06 Jiangyin Mucocare Pharmaceutical Co Ltd Formulaciones topicas que comprenden montelukast y combinaciones con proteinas adhesivas del mejillon.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200740441A (en) * 2005-06-17 2007-11-01 Combinatorx Inc Methods and reagents for the treatment of inflammatory disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Goksel Sener Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs Burns 31 2005 587-596 *

Also Published As

Publication number Publication date
FI3678705T3 (fi) 2023-07-04
KR102946621B1 (ko) 2026-04-01
DK3678705T5 (da) 2024-09-16
EP4253404A2 (en) 2023-10-04
KR20210061372A (ko) 2021-05-27
AU2019338582B2 (en) 2026-01-15
US20210309696A1 (en) 2021-10-07
LT3678705T (lt) 2023-08-10
JP2022500437A (ja) 2022-01-04
SMT202300210T1 (it) 2023-09-06
EP4253404A3 (en) 2023-12-13
CA3112420A1 (en) 2020-03-19
IL281426A (en) 2021-04-29
JP7759693B2 (ja) 2025-10-24
US11680082B2 (en) 2023-06-20
SI3678705T1 (sl) 2023-10-30
EP3678705A4 (en) 2021-06-09
HUE062848T2 (hu) 2023-12-28
TW202023623A (zh) 2020-07-01
SG11202102119RA (en) 2021-04-29
ES2956509T3 (es) 2023-12-22
DK3678705T3 (en) 2023-06-26
RS64436B1 (sr) 2023-09-29
ZA202101398B (en) 2022-09-28
MX2021002657A (es) 2021-07-21
MY205435A (en) 2024-10-21
HRP20230946T1 (hr) 2023-11-24
BR112021004823A2 (pt) 2021-06-08
AU2019338582A1 (en) 2020-11-19
CN116785447A (zh) 2023-09-22
CN116785447B (zh) 2024-11-22
WO2020052677A1 (en) 2020-03-19
EP3678705A1 (en) 2020-07-15
US20230348536A1 (en) 2023-11-02
CN111601618A (zh) 2020-08-28
PT3678705T (pt) 2023-07-19
PL3678705T3 (pl) 2023-10-09
SA521421448B1 (ar) 2024-03-14
EP3678705B1 (en) 2023-05-31

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