TWI873145B - 用於治療與sting活性相關之病狀的化合物及組合物 - Google Patents

用於治療與sting活性相關之病狀的化合物及組合物 Download PDF

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TWI873145B
TWI873145B TW109120089A TW109120089A TWI873145B TW I873145 B TWI873145 B TW I873145B TW 109120089 A TW109120089 A TW 109120089A TW 109120089 A TW109120089 A TW 109120089A TW I873145 B TWI873145 B TW I873145B
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TW202112744A (zh
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傑森 凱茲
山可 文卡特曼
威廉 R 羅西
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瑞士商諾華製藥公司
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW109120089A 2019-06-14 2020-06-15 用於治療與sting活性相關之病狀的化合物及組合物 TWI873145B (zh)

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US201962861714P 2019-06-14 2019-06-14
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Publication number Priority date Publication date Assignee Title
CN112823036B (zh) 2018-07-03 2024-11-08 艾福姆德尤股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物
MA54753A (fr) * 2019-01-17 2021-11-24 Ifm Due Inc Composés et compositions pour traiter des états pathologiques associés à une activité de sting
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法
WO2022133098A2 (en) * 2020-12-16 2022-06-23 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN117222634A (zh) * 2020-12-16 2023-12-12 艾福姆德尤股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物
WO2022140397A1 (en) 2020-12-22 2022-06-30 Ifm Due, Inc. Methods of treating cancer
US20240060982A1 (en) 2020-12-22 2024-02-22 Ifm Due, Inc. Methods of treating cancer
EP4267128A1 (en) 2020-12-22 2023-11-01 IFM Due, Inc. Methods of treating cancer
EP4267129A1 (en) 2020-12-22 2023-11-01 IFM Due, Inc. Methods of treating cancer
TW202235073A (zh) 2021-01-08 2022-09-16 美商Ifm Due有限公司 用於治療與sting活性相關的病狀之化合物及組合物
CN112920170B (zh) * 2021-01-29 2023-06-20 中国医科大学 N-(吲哚-5-基)芳香杂环酰胺类化合物及其制备方法和用途
CN116981668A (zh) * 2021-04-09 2023-10-31 百济神州(北京)生物科技有限公司 制备bcl-2抑制剂的中间体的方法
UY39892A (es) 2021-08-10 2023-03-31 Novartis Pharma Ag Compuestos y composiciones para tratar afecciones asociadas con la actividad de STING
CN115710255B (zh) * 2021-08-23 2025-05-06 上海交通大学 一类含有苯并杂环取代的脲类衍生物及其制备和用途
WO2024064358A1 (en) 2022-09-23 2024-03-28 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
WO2024096753A1 (en) 2022-11-02 2024-05-10 Captor Therapeutics S.A. Nek7 degraders and methods of use thereof
IT202200024963A1 (it) * 2022-12-05 2024-06-05 Angelini Pharma S P A Composti attivatori dei canali potassio Kv7.2/Kv7.3
CN117756698A (zh) * 2022-12-16 2024-03-26 中国药科大学 脲类化合物及其作为sting抑制剂的医药用途
WO2024151919A1 (en) * 2023-01-13 2024-07-18 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
EP4709708A1 (en) * 2023-05-09 2026-03-18 Angelini Pharma S.P.A. Novel carboxamide derivatives
WO2024263860A1 (en) * 2023-06-22 2024-12-26 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
IL326865A (en) * 2023-08-30 2026-04-01 Jiangsu Chia Tai Fenghai Pharmaceutical Co Ltd Compound for regulating microRNA activity A-124
WO2025079045A1 (en) * 2023-10-12 2025-04-17 Novartis Pharma Ag Compounds and compositions for treating conditions associated with sting activity
WO2025153990A1 (en) * 2024-01-19 2025-07-24 Novartis Pharma Ag Compounds and compositions for treating conditions associated with sting activity
WO2025188646A1 (en) * 2024-03-04 2025-09-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for treating cancer
CN120794982A (zh) * 2024-05-14 2025-10-17 中国药科大学 吡唑类sting抑制剂及其医药用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201920120A (zh) * 2017-06-22 2019-06-01 英商克拉德夫製藥有限公司 人類sting之小分子調節調

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930702334A (ko) * 1990-09-13 1993-09-08 데이비드 로버트 5 하이드록시트립타민 수용체 길항제로서의 인돌우레아
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
GB9823873D0 (en) * 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
AU2804400A (en) * 1999-02-12 2000-08-29 Smithkline Beecham Plc Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
US6387900B1 (en) * 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
EP1256578B1 (en) * 2001-05-11 2006-01-11 Pfizer Products Inc. Thiazole derivatives and their use as cdk inhibitors
JP2003192587A (ja) * 2001-12-26 2003-07-09 Bayer Ag 尿素誘導体
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7557129B2 (en) * 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
RU2402544C2 (ru) * 2005-01-14 2010-10-27 Си Джи Ай ФАРМАСЬЮТИКАЛЗ, ИНК. 1,3-диарилзамещенные мочевины как модуляторы киназной активности
BRPI0615307A2 (pt) * 2005-08-25 2009-08-04 Schering Corp agonistas de adrenorreceptor alfa2c
CA2674865A1 (en) * 2007-01-15 2008-07-24 Santen Pharmaceutical Co., Ltd. Indole derivative having i.kappa.b kinase .beta. inhibitory activity
WO2009084695A1 (ja) * 2007-12-28 2009-07-09 Carna Biosciences Inc. 2-アミノキナゾリン誘導体
WO2012075380A1 (en) 2010-12-03 2012-06-07 The Trustees Of The University Of Pennsylvania Tip60 inhibitors
CN109394752A (zh) 2013-10-21 2019-03-01 德雷克塞尔大学 治疗慢性乙型肝炎病毒感染的sting激动剂的用途
CA2993809C (en) * 2015-07-30 2023-09-05 Taipei Medical University Compounds and pharmaceutical composition associated with ubiquitination-proteasome system
US20170146519A1 (en) * 2015-11-20 2017-05-25 Oregon Health & Science University Sting agonists and methods of selecting sting agonists
JP2020524718A (ja) * 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドCuradev Pharma Limited ヒトstingの複素環式小分子調節因子
MX2020002183A (es) * 2017-08-31 2020-10-05 Abbvie Inc Inhibidores de la ectonucleótido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos.
EP3556362A1 (en) * 2018-04-16 2019-10-23 Ecole Polytechnique Federale De Lausanne (Epfl) Sting inhibitors
CN112823036B (zh) * 2018-07-03 2024-11-08 艾福姆德尤股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物
US20210236466A1 (en) * 2018-07-03 2021-08-05 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN109734677A (zh) * 2019-03-07 2019-05-10 四川大学 抑制组蛋白赖氨酸甲基转移酶nsd2的小分子化合物及其应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201920120A (zh) * 2017-06-22 2019-06-01 英商克拉德夫製藥有限公司 人類sting之小分子調節調

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
期刊 BRADLEY M. MINROVIC ET AL "Second-Generation Tryptamine Derivatives Potently Sensitize Colistin Resistant Bacteria to Colistin" ACS MEDICINAL CHEMISTRY LETTERS vol. 10, no. 5 17 April 2019 pages 828 - 833; *
期刊 DRIZIN I ET AL "Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists" BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, NL vol. 14, no. 14 15 July 2006 pages 4740 - 4749 *
期刊 HAAG SIMONE M ET AL: "Targeting STING with covalent small-molecule inhibitors" NATURE, NATURE PUBLISHING GROUP UK, LONDON vol. 559, no. 7713 4 July 2018 pages 269 – 273; *
期刊 NAMPALLY SREENIVASACHARY ET AL "Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of [beta]-amyloid-42 aggregation for the treatment of Alzheimer's disease" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 27, no. 6 March 2017 pages 1405 - 1411; *

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