TWI873098B - 用於治療與sting活性相關之病症的化合物及組合物 - Google Patents
用於治療與sting活性相關之病症的化合物及組合物 Download PDFInfo
- Publication number
- TWI873098B TWI873098B TW108123334A TW108123334A TWI873098B TW I873098 B TWI873098 B TW I873098B TW 108123334 A TW108123334 A TW 108123334A TW 108123334 A TW108123334 A TW 108123334A TW I873098 B TWI873098 B TW I873098B
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- alkyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862693768P | 2018-07-03 | 2018-07-03 | |
| US62/693,768 | 2018-07-03 | ||
| US201962861825P | 2019-06-14 | 2019-06-14 | |
| US62/861,825 | 2019-06-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202014408A TW202014408A (zh) | 2020-04-16 |
| TWI873098B true TWI873098B (zh) | 2025-02-21 |
Family
ID=67441650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108123334A TWI873098B (zh) | 2018-07-03 | 2019-07-02 | 用於治療與sting活性相關之病症的化合物及組合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11618749B2 (enExample) |
| EP (1) | EP3817820A1 (enExample) |
| JP (2) | JP7566731B2 (enExample) |
| CN (2) | CN120004785A (enExample) |
| MA (1) | MA53095A (enExample) |
| TW (1) | TWI873098B (enExample) |
| WO (1) | WO2020010092A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019046511A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
| CN120004785A (zh) * | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| TW202043198A (zh) * | 2019-01-17 | 2020-12-01 | 美商Ｉｆｍ Ｄｕｅ有限公司 | 用於治療與sting活性相關之病況的化合物及組合物 |
| JP2022517797A (ja) * | 2019-01-17 | 2022-03-10 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| WO2020252240A1 (en) * | 2019-06-14 | 2020-12-17 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN114761804A (zh) | 2019-06-21 | 2022-07-15 | 艾福姆德尤股份有限公司 | 治疗癌症的方法 |
| JP2023509421A (ja) | 2019-12-31 | 2023-03-08 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| CA3166358A1 (en) * | 2020-02-12 | 2021-08-19 | Monali BANERJEE | Small molecule sting antagonists |
| US20230151024A1 (en) * | 2020-04-10 | 2023-05-18 | Ono Pharmaceutical Co., Ltd. | Sting agonistic compound |
| TW202200136A (zh) | 2020-04-10 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 癌治療方法 |
| JP6912016B1 (ja) * | 2020-04-10 | 2021-07-28 | 小野薬品工業株式会社 | Ｓｔｉｎｇ作動化合物 |
| AU2021381469A1 (en) * | 2020-11-23 | 2023-06-15 | Regor Pharmaceuticals, Inc. | Sting antagonists and uses thereof |
| JP2024500874A (ja) | 2020-12-22 | 2024-01-10 | アイエフエム デュー インコーポレイテッド | がんを処置する方法 |
| US20240060982A1 (en) * | 2020-12-22 | 2024-02-22 | Ifm Due, Inc. | Methods of treating cancer |
| EP4267128A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| EP4267129A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| JP2024502470A (ja) * | 2021-01-08 | 2024-01-19 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| EP4274824A1 (en) | 2021-01-08 | 2023-11-15 | IFM Due, Inc. | Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity |
| JP2024502473A (ja) * | 2021-01-08 | 2024-01-19 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するためのオキサルアミド化合物および組成物 |
| CN117561253A (zh) | 2021-01-08 | 2024-02-13 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性有关的病症的化合物和组合物 |
| US11964978B2 (en) * | 2021-03-18 | 2024-04-23 | Pfizer Inc. | Modulators of STING (stimulator of interferon genes) |
| US12065427B2 (en) | 2021-04-29 | 2024-08-20 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds capable of activating STING |
| IL310724A (en) | 2021-08-10 | 2024-04-01 | Ifm Due Inc | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH STING ACTIVITY |
| WO2023017451A1 (en) * | 2021-08-11 | 2023-02-16 | Curadev Pharma Pvt. Ltd. | Small molecule sting antagonists |
| CN115710255B (zh) * | 2021-08-23 | 2025-05-06 | 上海交通大学 | 一类含有苯并杂环取代的脲类衍生物及其制备和用途 |
| CN116789641A (zh) * | 2022-03-17 | 2023-09-22 | 中国科学院上海药物研究所 | 二氢异喹啉类化合物及其医药用途 |
| CN119677718A (zh) * | 2022-08-11 | 2025-03-21 | 杭州中美华东制药有限公司 | 具有sting抑制作用的酰胺类化合物及其药物组合物和用途 |
| WO2024064358A1 (en) | 2022-09-23 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2024089006A1 (en) * | 2022-10-26 | 2024-05-02 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds capable of activating sting |
| JP2026512969A (ja) * | 2022-10-26 | 2026-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｔｉｎｇを活性化することができる複素環式化合物 |
| CA3266173A1 (en) * | 2022-10-26 | 2024-05-02 | Boehringer Ingelheim International Gmbh | HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING |
| CN120476113A (zh) * | 2022-12-20 | 2025-08-12 | 杭州中美华东制药有限公司 | 具有sting抑制作用的含肟化合物及其药物组合物和用途 |
| CN116023321B (zh) * | 2022-12-30 | 2024-11-29 | 中国药科大学 | Sting抑制剂前药及其医药用途 |
| CN120794957A (zh) * | 2024-05-14 | 2025-10-17 | 中国药科大学 | 苯并含氮杂环类sting抑制剂及其医药用途 |
| CN121342824A (zh) * | 2024-07-16 | 2026-01-16 | 中国药科大学 | 四氢萘啶类sting抑制剂及其医药用途 |
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| CN120004785A (zh) | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| JP2022507697A (ja) | 2018-11-19 | 2022-01-18 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| WO2020106741A1 (en) | 2018-11-19 | 2020-05-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| JP2022517797A (ja) | 2019-01-17 | 2022-03-10 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| TW202043198A (zh) | 2019-01-17 | 2020-12-01 | 美商Ｉｆｍ Ｄｕｅ有限公司 | 用於治療與sting活性相關之病況的化合物及組合物 |
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| WO2020252240A1 (en) | 2019-06-14 | 2020-12-17 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN114761804A (zh) * | 2019-06-21 | 2022-07-15 | 艾福姆德尤股份有限公司 | 治疗癌症的方法 |
| WO2021067791A1 (en) | 2019-10-03 | 2021-04-08 | Ifm Due, Inc. | Oxalamide compounds and compositions for treating conditions associated with sting activity |
| UY38905A (es) | 2019-10-03 | 2021-04-30 | Ifm Due Inc | Compuestos y composiciones para tratar afecciones asociadas con la actividad de sting |
| WO2021067801A1 (en) | 2019-10-03 | 2021-04-08 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN115348957B (zh) | 2019-12-31 | 2025-11-25 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| JP2023509421A (ja) | 2019-12-31 | 2023-03-08 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| US20230250088A1 (en) | 2020-07-15 | 2023-08-10 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2022015975A1 (en) | 2020-07-15 | 2022-01-20 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US20220024919A1 (en) | 2020-07-15 | 2022-01-27 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| PY2157405A (es) | 2020-07-15 | 2022-04-22 | Ifm Due Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad del sting |
| JP2023540674A (ja) | 2020-07-15 | 2023-09-26 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| US20230250106A1 (en) | 2020-07-15 | 2023-08-10 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US20220024906A1 (en) | 2020-07-15 | 2022-01-27 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
-
2019
- 2019-07-02 CN CN202411419807.9A patent/CN120004785A/zh active Pending
- 2019-07-02 TW TW108123334A patent/TWI873098B/zh active
- 2019-07-02 WO PCT/US2019/040317 patent/WO2020010092A1/en not_active Ceased
- 2019-07-02 EP EP19745408.5A patent/EP3817820A1/en active Pending
- 2019-07-02 MA MA053095A patent/MA53095A/fr unknown
- 2019-07-02 JP JP2021522931A patent/JP7566731B2/ja active Active
- 2019-07-02 US US16/460,381 patent/US11618749B2/en active Active
- 2019-07-02 CN CN201980057319.9A patent/CN112823036B/zh active Active
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2023
- 2023-03-01 US US18/116,183 patent/US20240083895A1/en active Pending
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2024
- 2024-06-11 JP JP2024094148A patent/JP2024116295A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1678589A (zh) * | 2002-09-05 | 2005-10-05 | 安万特医药股份有限公司 | 作为药物的新氨基吲唑衍生物与含有它们的药物组合物 |
| WO2016049774A1 (en) * | 2014-10-03 | 2016-04-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024116295A (ja) | 2024-08-27 |
| US20200172534A1 (en) | 2020-06-04 |
| CN112823036A (zh) | 2021-05-18 |
| JP7566731B2 (ja) | 2024-10-15 |
| CN120004785A (zh) | 2025-05-16 |
| JP2021529833A (ja) | 2021-11-04 |
| CN112823036B (zh) | 2024-11-08 |
| TW202014408A (zh) | 2020-04-16 |
| MA53095A (fr) | 2021-05-12 |
| EP3817820A1 (en) | 2021-05-12 |
| US11618749B2 (en) | 2023-04-04 |
| WO2020010092A1 (en) | 2020-01-09 |
| US20240083895A1 (en) | 2024-03-14 |
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