TWI857071B - 2,3,5-三取代吡唑并[1,5-a]嘧啶化合物 - Google Patents

2,3,5-三取代吡唑并[1,5-a]嘧啶化合物 Download PDF

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TWI857071B
TWI857071B TW109118850A TW109118850A TWI857071B TW I857071 B TWI857071 B TW I857071B TW 109118850 A TW109118850 A TW 109118850A TW 109118850 A TW109118850 A TW 109118850A TW I857071 B TWI857071 B TW I857071B
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cancer
hydroxyalkyl
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TW109118850A
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TW202110850A (zh
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喬伊爾 華里 比提
山謬 勞瑞 卓爾
傑瑞米 湯瑪士 安德烈 佛尼爾
珍那 梨 傑佛瑞
肯尼斯 維克特 勞森
曼摩漢 瑞迪 賴勒提
雅圖 喀連那維卡 梅蓮恩
吉勞米 瑪塔
迪倫 哈汀 邁爾斯
傑 派翠克 包爾斯
荷森 厄爾 莎瑞菲
崔恩 瑞亞納恩 湯馬士
雪蕾 閆
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美商阿克思生物科學有限公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0635Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0636Irradiating the whole body

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW109118850A 2019-06-04 2020-06-04 2,3,5-三取代吡唑并[1,5-a]嘧啶化合物 TWI857071B (zh)

Applications Claiming Priority (2)

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US201962857148P 2019-06-04 2019-06-04
US62/857,148 2019-06-04

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TW202110850A TW202110850A (zh) 2021-03-16
TWI857071B true TWI857071B (zh) 2024-10-01

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US (1) US12410170B2 (enExample)
EP (1) EP3980010A4 (enExample)
JP (1) JP7665534B2 (enExample)
KR (1) KR20220047247A (enExample)
CN (1) CN114206332B (enExample)
AR (1) AR119088A1 (enExample)
AU (1) AU2020288610A1 (enExample)
CA (1) CA3142712A1 (enExample)
TW (1) TWI857071B (enExample)
UY (1) UY38742A (enExample)
WO (1) WO2020247496A1 (enExample)

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CN119072476A (zh) * 2022-03-02 2024-12-03 上海海雁医药科技有限公司 六元芳环并吡咯酮衍生物、其药物组合物及应用
AU2023264591A1 (en) 2022-05-02 2024-11-07 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
WO2024015251A1 (en) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
EP4558501A1 (en) 2022-07-20 2025-05-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
CN119768404A (zh) * 2022-09-01 2025-04-04 上海海雁医药科技有限公司 杂芳基取代的吡啶并吡咯酮衍生物、其药物组合物及应用
CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
US20240180947A1 (en) 2022-10-20 2024-06-06 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds
WO2024233360A1 (en) 2023-05-05 2024-11-14 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
EP4720055A1 (en) 2023-05-25 2026-04-08 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
US20260116868A1 (en) 2023-10-06 2026-04-30 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025146216A1 (zh) * 2024-01-05 2025-07-10 成都赜灵生物医药科技有限公司 六并五氮杂环酰胺类化合物及其用途
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound

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Also Published As

Publication number Publication date
JP7665534B2 (ja) 2025-04-21
UY38742A (es) 2020-12-31
AR119088A1 (es) 2021-11-24
CA3142712A1 (en) 2020-12-10
CN114206332A (zh) 2022-03-18
TW202110850A (zh) 2021-03-16
US12410170B2 (en) 2025-09-09
JP2022535120A (ja) 2022-08-04
EP3980010A1 (en) 2022-04-13
KR20220047247A (ko) 2022-04-15
AU2020288610A1 (en) 2022-01-27
WO2020247496A1 (en) 2020-12-10
US20230024302A1 (en) 2023-01-26
CN114206332B (zh) 2024-08-23
EP3980010A4 (en) 2023-06-07

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